Clinical trials: sponsored by Massachusetts General Hospital
Hematologic Cancer, Hematologic Malignancy
Intervention for Fatigue in HCT Recipients
The purpose of this study is to assess whether a cognitive-behavioral therapy (CBT) for fatigue intervention is acceptable, feasible, and effective at managing fatigue and improving quality of life for patients following…
- Trial name
- NCT05715047
- Testing
- CBT for Fatigue, Usual Care
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Massachusetts General Hospital
Neurofibromatosis 1 (NF1), Neurofibromatosis Type I
Assessing the Efficacy of Repeat, Monthly Treatments of Alexandrite Laser for NF1-associated Cutaneous Neurofibromas (cNFs)
The goal of this clinical trial is to evaluate the tolerability and effectiveness of multiple treatments of Alexandrite (755 nm) Laser in those with Neurofibromatosis Type 1 (NF1) Cutaneous Neurofibromas (cNFs).
- Trial name
- NCT06934928
- Testing
- GentleMax Pro (with skin cooling), GentleMax Pro (without skin cooling)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis, Stress
Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study
The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in…
- Conditions
- Atherosclerosis, Stress, Inflammation
- Trial name
- NCT04496947
- Testing
- Stress Reduction
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression - Major Depressive Disorder, Cannabis Use Disorder
Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression.
- Conditions
- Depression - Major Depressive Disorder, Cannabis Use Disorder, Mental Disorder
- Trial name
- NCT06878859
- Testing
- Amplification of Positivity - Cannabis Use (AMP-C)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
HIV
Question-Order Effect Experiment to Measure HIV Stigma
Question-order effect experiment to measure HIV-related stigma among people living with HIV (PWH).
- Trial name
- NCT06969690
- Testing
- Survey questionnaire V1, Survey questionnaire V2
- Where
- Uganda
- Volunteers
- 180 people
- Sponsor
- Massachusetts General Hospital
Food Deprivation, Water Deprivation
List Experiment to Measure Food and Water Insecurity
List experiment to measure food and water insecurity
- Trial name
- NCT04832243
- Testing
- Survey questionnaire
- Where
- Uganda
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Tobacco Use, Alcohol Drinking
Eliciting Perceived Norms About Substance Use
Survey experiment to elicit perceived norms about substance use
- Trial name
- NCT04833972
- Testing
- Survey questionnaire
- Where
- Uganda
- Volunteers
- 1,531 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV Testing, HIV Stigma
Personalized Normative Feedback to Increase HIV Testing
Randomized trial to measure the effect of personalized normative feedback about local HIV testing rates and local rates of HIV-related stigma on self-reported HIV testing intentions and perceptions about others' HIV testing…
- Trial name
- NCT06969677
- Testing
- Survey questionnaire
- Where
- Uganda
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acne Vulgaris
Laser Treatment of Moderate to Severe Acne Vulgaris
The goal of this clinical trial is to learn if fractional ablative laser can treat active acne vulgaris in adults 18 to 40 years old with moderate to severe acne vulgaris.
- Trial name
- NCT04466527
- Testing
- Laser Intervention
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Massachusetts General Hospital
Preeclampsia, Hypertensive Disorders of Pregnancy (HDP)
Clinician Notification to Increase Aspirin Prophylaxis for Preeclampsia Prevention
Preeclampsia is a leading cause of maternal morbidity and mortality. Low-dose aspirin prophylaxis reduces preeclampsia risk among high-risk pregnant individuals but remains underused in routine clinical practice.
- Conditions
- Preeclampsia, Hypertensive Disorders of Pregnancy (HDP), Pregnancy Complications, Aspirin Prophylaxis
- Trial name
- NCT07614893
- Testing
- Clinician notification of elevated preeclampsia risk
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Massachusetts General Hospital
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage
The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT07614906
- Where
- 2 sites in United States, Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Eating Disorders, Hypoestrogenemia
The Role of Estrogen in the Neurobiology of Eating Disorders
This is a randomized, double blind, placebo-controlled study of the effects of transdermal estradiol versus placebo on cognitive flexibility, reward processing, and eating disorder pathology in hypoestrogenemic female adolescents…
- Trial name
- NCT03740204
- Testing
- 17-β estradiol transdermal patches with cyclic progesterone
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Kidney Transplant Recipients, Old Age
Neurocognitive Function Changes With Extended-Release Tacrolimus Among Older Kidney Transplant Recipients
The objective of this randomized controlled study is to assess the neurocognitive outcomes between individuals using immediate-release (IR) tacrolimus (Prograf®) and those who were converted to extended-release tacrolimus…
- Trial name
- Neuro-KTR (NCT06751992)
- Testing
- Conversion to extended-release tacrolimus, Maintenance of immediate-release tacrolimus
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Massachusetts General Hospital
Recovery, Treatment Complication
The Role of Wearable Devices in Predicting and Detecting Complications and Adverse Events
The overarching goal of this research is to use machine learning analysis of high-resolution data-collected by wearable technology-to predict complications and poor recovery in patients undergoing treatment for benign or…
- Trial name
- NCT04824066
- Testing
- Device: Wearable Device
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- Massachusetts General Hospital
Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension
A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia
In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies…
- Conditions
- Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension, Intrauterine Growth Restriction
- Trial name
- NCT07312227
- Where
- 2 sites in United States, Bolivia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Muscle Tension Dysphonia
Voice Therapy Per the Rehabilitation Treatment Specification System
The goal of this study is to evaluate if using evidence-based, standard ingredient and target codes from the Rehabilitation Treatment Specification System - Voice Therapy (RTSS-Voice) in standard of care voice therapy…
- Trial name
- RTSS-Voice (NCT06152627)
- Testing
- Standard of care voice therapy with novice clinician RTSS-Voice documentation, Standard of care voice therapy with expert clinician RTSS-Voice documentation
- Where
- 5 sites in United States
- Volunteers
- 600 people
- Sponsor
- Massachusetts General Hospital
Critical Illness, Pneumonia
iNO300 Therapy in Critically Ill Patients With Pneumonia
The goal of this clinical trial is to learn the formation and recovery rate of methemoglobin (MetHb) in severely sick patients with pneumonia who receive high doses of inhaled nitric oxide (iNO) therapy at 250 parts per million…
- Trial name
- iNO300 (NCT06950294)
- Testing
- High dose inhaled nitric oxide, standard therapy
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Massachusetts General Hospital
Depression, Suicide
Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural Connectome
Subanesthetic dose of intravenous ketamine (KET) has been found to be highly effective in rapid treatment depression and associated suicidality but its exact mechanism of remains uncertain.
- Trial name
- NCT06698848
- Testing
- ketamin
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Radiation Oncology
Radiation Treatment Plan Evaluation Learning Tool Pilot Project
This study involves both the development of a novel learning tool, the Radiation Treatment Plan Evaluation Learning Module, as well as a pilot program to validate this tool as an effective resource to teach treatment plan review…
- Trial name
- NCT06115811
- Testing
- Radiation Treatment Plan Evaluation Learning Tool
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Skin Lesion, Nevus
Genetic Risk Stratification of Pediatric Skin Lesions
A study to understand the clinical utility of noninvasive adhesive skin biopsies in pediatric patients by exploring whether DermTech Pigmented Lesion Assay (PLA) genetic risk analysis of suspicious lesions in children correlates…
- Trial name
- NCT05418959
- Testing
- DermTech PLA noninvasive adhesive biopsy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
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