Clinical trials: sponsored by Massachusetts General Hospital
Non-small Cell Lung Cancer
A Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLC
This research study is studying a drug combination as a possible treatment for anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer. The drugs involved in this study are: Alectinib Cobimetinib
- Trial name
- NCT03202940
- Testing
- Alectinib, Cobimetinib
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Language, Epilepsy
Computational Neuroscience of Language Processing in the Human Brain
Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings…
- Trial name
- NCT05222594
- Testing
- Behavioral tasks during intracranial monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
X-linked Hypophosphatemia, Hypophosphatemic Rickets
Calcitriol Monotherapy for X-Linked Hypophosphatemia
Children and adults with XLH recruited will be treated with calcitriol alone (without phosphate supplementation) for one year, during which the calcitriol dose will be escalated during the first 3 months of therapy.
- Conditions
- X-linked Hypophosphatemia, Hypophosphatemic Rickets, Hypophosphatemic Rickets, X-Linked Dominant
- Trial name
- NCT03748966
- Testing
- Calcitriol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Bipolar
Low-Intensity Focused Ultrasound of the Amygdala for Bipolar Disorder
The specific aim of this proposed study is to investigate the feasibility and therapeutic potential of transcranial focused ultrasound (tFUS) as a treatment for bipolar disorder (BD).
- Trial name
- NCT06482762
- Testing
- BrainSonix Pulsar 1002
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial
This research is to evaluate the effectiveness of Talazoparib as a potential treatment for metastatic breast cancer with a BRCA 1 or BRCA 2 mutation.
- Trial name
- NCT03990896
- Testing
- Talazoparib
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans
The SUGAR-MGH investigators are studying the influence of inherited gene variants on the response to two commonly prescribed type 2 diabetes medications, metformin and glipizide.
- Trial name
- SUGAR-MGH (NCT01762046)
- Testing
- Glipizide, Metformin, Oral Glucose Tolerance Test
- Where
- 3 sites in United States
- Volunteers
- 1,033 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Mild Cognitive Impairment
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Logopenic Progressive Aphasia, Amnestic Symptoms
- Trial name
- NCT06538311
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression, Brain Injuries, Traumatic
Buspirone and Melatonin for Depression Following Traumatic Brain Injury
Traumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination.
- Trial name
- NCT04400266
- Testing
- Buspirone, Mealatonin
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes, Type 2 Diabetes
Understanding and Optimizing Care for Young Adults With Type 1 and Type 2 Diabetes Mellitus Transitioning to Adult Care
In this study, we will determine the feasibility of an innovative care model for young adults with diabetes and compare the primary and secondary outcomes in the innovative model to those in the usual care model for adult…
- Trial name
- NCT05229718
- Testing
- Diabetes Collaborative Care Model for Young Adults, Usual Care Model
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Stress Disorders, Post-Traumatic
Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery
The proposed R21 project will attempt to further develop a novel intervention for posttraumatic stress symptoms inspired by the science of memory reconsolidation.
- Trial name
- NCT05853627
- Testing
- Memory reactivation procedures, Propranolol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Functional Gastrointestinal Disorders
NLP to Aid in the Evaluation and Diagnosis of FGIDs
The study has two arms, where the same natural language processing (NLP) and probabilistic graphical modeling technology will be utilized on patients' report of symptoms in both arms.
- Trial name
- NCT05501028
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Massachusetts General Hospital
Depression
Neuromodulation of Mind-Wandering in Depression
The specific aim of this proposed study is to investigate the feasibility and therapeutic potential of LIFUP in changing negative cognition in depression.
- Trial name
- NCT04832685
- Testing
- BrainSonix Pulsar 1002
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
MGMT-Methylated Glioblastoma, Glioblastoma (GBM)
G-CSF After Chemo-radiation in Patients With Glioblastoma
This research study involves the study of granulocyte colony stimulating factor (G-CSF) in patients with MGMT-methylated glioblastoma multiforme (GBM) that are undergoing standard chemoradiation.
- Conditions
- MGMT-Methylated Glioblastoma, Glioblastoma (GBM), Newly Diagnosed Glioblastoma Multiforme
- Trial name
- NCT06649851
- Testing
- Granulocyte Colony Stimulating Factor (G-CSF), Radiation Therapy + Temozolomide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Vulvar Cancer, Vulvar Squamous Cell Carcinoma
Cisplatin+Pembrolizumab+RT in Vulvar Cancer
This research is being done to see how well the combination of a standard of care drug, investigational drug, and radiation therapy work against unresectable vulvar squamous cell carcinoma.
- Trial name
- NCT04430699
- Testing
- Cisplatin, Pembrolizumab, Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer, Coffee
COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER
This is research study is assessing the effects of 6-g daily use of freeze-dried instant coffee on liver fat and fibrosis and the gut microbiome and metabolome in patients who have completed routine treatment (including surgery…
- Conditions
- Colorectal Cancer, Coffee, Gastrointestinal Microbiome, Stenosis
- Trial name
- COMMENCER (NCT05692024)
- Testing
- Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Fall Patients, Fall Injury
Predictive Analytics and Computer Visualization Enhances Patient Safety to Prevent Falls
Annually, in the United States there are 700,000 - 1,000,000 inpatient falls reported, and one-third of patients sustain an injury.
- Trial name
- NCT06339125
- Testing
- Fall prevention algorithm, Inspiren camera visualization
- Where
- United States
- Volunteers
- 5,350 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hepatocellular Carcinoma, Biliary Tract Cancer
Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer
This research study is studying a combination of drugs as a possible treatment for Hepatocellular Carcinoma or Biliary Tract Cancer. The interventions involved in this study are: Durvalumab Tremelimumab Radiation Therapy
- Trial name
- NCT03482102
- Testing
- Tremelimumab, Durvalumab, Radiation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Recurrent Respiratory Papillomatosis
Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients
This research study is evaluating an immune modulatory agent as a possible treatment for patients with Recurrent Respiratory Papillomatosis (RRP) with significant disease involving the larynx, trachea, and/or lungs.
- Trial name
- NCT02632344
- Testing
- Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Healthy
Radio-Frequency Microneedling Device
The specific aims of the study are as follows: Aim 1. Using the EC device, evaluate the cooling rate of in vivo tissue and the temperature profile of the tissue with various pre-cooling times (Phase 1). Aim 2.
- Trial name
- RFS (NCT06228144)
- Testing
- Candela Profound System with Dermal Handpiece, Experimental Dermal Cooling Device
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser
This research study aims assess whether the Difference Frequency Generation (DFG) laser could be a better alternative to the CO2 laser in terms of reduced side effects and patient downtime.
- Trial name
- NCT06295471
- Testing
- DFG Laser, CO2 Laser, Optical coherence tomography (OCT)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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