Clinical trials: sponsored by Massachusetts General Hospital
Healthy
A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser
This research study aims assess whether the Difference Frequency Generation (DFG) laser could be a better alternative to the CO2 laser in terms of reduced side effects and patient downtime.
- Trial name
- NCT06295471
- Testing
- DFG Laser, CO2 Laser, Optical coherence tomography (OCT)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Volunteers
Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study
The purpose of this study is to define the safety and the biochemical-physiological response of prolonged exposure to a normobaric low-oxygen environment in healthy volunteers.
- Trial name
- MGH-nitrogen (NCT02860975)
- Testing
- Inhaled Nitrogen
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
IBD, Inflammatory Bowel Diseases
Adjunctive Treatment With Vitamin D3 in Patients With Active IBD
Inflammatory bowel disease ((IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC)), is a chronic, immune-mediated disease characterized by recurrent episodes of relapse.
- Conditions
- IBD, Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- ACTIVATED (NCT04225819)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Down Syndrome, Health, Subjective
Developing a Down Syndrome Health Instrument
Although over 200,000 individuals with DS live in the United States, studies to date have focused on outcomes apart from health.
- Trial name
- NCT04631237
- Testing
- Observational, no intervention
- Where
- United States
- Volunteers
- 758 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder
Participant Database for Autism Research Studies
The purpose of this study is to create a subject database to recruit for current and future studies in research on autism and other neurodevelopmental disabilities.
- Trial name
- NCT00549731
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anxiety Disorder
Early Intervention for Children at Risk for Anxiety
The aim of this study was to develop and pilot a cognitive-behavioral therapy (CBT) parent-child intervention for 4-7-year-old children at risk for anxiety disorders.
- Trial name
- NCT00865306
- Testing
- "Being Brave: A Program for Coping with Anxiety for Young Children and Their Parents."
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder
Sensory and Connectivity Abnormalities in Autism Spectrum Disorders
Study the neural substrates of autism spectrum disorders using neuroimaging methods such as MEG/EEG/MRI.
- Trial name
- NCT00956579
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Disorders of Consciousness Due to Severe Brain Injury
Prognostication of Recovery in Early Disorders of Consciousness Study
By collecting multimodal metrics (e.g., clinical factors, neuroimaging, and EEG) in the early phase of severe brain injury (i.e., during the acute hospitalization when a patient has impaired consciousness), and measuring the…
- Trial name
- PREDICT (NCT04692922)
- Testing
- MRI, EEG
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Benign Neoplasm, Malignant Neoplasm
Intraoperative Tumor Margin Identification With ICG Dye Imaging
In this research study we want to learn more about the use of indocyanine green (ICG) during bone or soft tissue mass resections. Indocyanine green (ICG) is a type of dye that is used in medical diagnostics.
- Trial name
- NCT04752137
- Testing
- Indocyanine green, SPY-PHI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Hematopoietic Cell Transplant, Hematologic Malignancy
Feasibility and Acceptability of Primary Palliative Care Intervention in Patients Undergoing Hematopoietic Stem Cell Transplantation
Primary PC - or training HCT clinicians to deliver PC domains as part of routine practice - is an alternative model of supportive care. We have developed Sentinel, a primary PC intervention for HCT clinicians and patients.
- Trial name
- Primary PC HCT (NCT06676852)
- Testing
- Primary palliative care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Analgesia, Anesthesia
Neuroimaging Study of Dexmedetomidine-Induced Analgesia
Neuroimaging data will be collected for patients that are given low doses of dexmedetomidine in order to understand its analgesic effects.
- Trial name
- NCT04656470
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mucolipidosis Type IV
Mucolipidosis Type IV Natural History Study
The primary objectives of the study are: to describe the characteristics of the current international MLIV population; to define the median age at which patients with MLIV achieve or lose developmental milestones; to define the…
- Trial name
- NCT05782387
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
FHA (Functional Hypothalamic Amenorrhea)
Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea
The goal of this study is to determine whether romosozumab will improve bone density in girls and women with functional hypothalamic amenorrhea (cessation of the menstrual period due to intense exercise, stress, or an eating…
- Trial name
- NCT06533865
- Testing
- Romosozumab, Zoledronic acid
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Massachusetts General Hospital
Trapeziometacarpal Arthrosis, Carpal Tunnel Syndrome
A Randomized Trial Measuring the Effect of Decision Aids on Patients' Satisfaction, Conflict of Decision-making and Clinical Outcome
The investigators plan a prospective randomized controlled study that compares the treatment decisions made by patients who receive decision aids, as compared to patients treated with usual care and the American Society for…
- Conditions
- Trapeziometacarpal Arthrosis, Carpal Tunnel Syndrome, Cubital Tunnel Syndrome, Distal Radius Fractures
- Trial name
- NCT01693094
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Massachusetts General Hospital
Neurofibromas, Cutaneous, Neurofibromatosis 1
Assessing the Efficacy of Repeat, Monthly Treatments of Deoxycholate for NF1 Associated Cutaneous Neurofibromas (cNFs)
The goal of this clinical trial is to evaluate the tolerability and effectiveness of multiple treatments of an FDA-approved drug in those with Neurofibromatosis Type 1 (NF1) Cutaneous Neurofibromas (cNFs).
- Trial name
- NCT06300502
- Testing
- Kybella
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
HIV/AIDS
PrEP My Way: A Hybrid Type 1 Clinical Effectiveness-implementation Trial to Promote PrEP Persistence Among Young Kenyan Women
PrEP My Way is a novel PrEP delivery system consisting of clinic-based PrEP initiation, followed by peer-delivered kits for HIV self-testing, PrEP refills, vaginal swabs for gonorrhea and chlamydia self-sampling, pregnancy tests…
- Trial name
- NCT06566430
- Testing
- PrEP My Way intervention, PrEP My Way intervention without STI testing, Enhanced standard of care
- Where
- Kenya
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pancreatic Cancer, GastroEsophageal Cancer
Supportive Oncology Care At Home RCT
This research study is evaluating a program that entails remote monitoring and home-based care for people with cancer who are receiving chemotherapy, radiotherapy, or chemoradiotherapy.
- Conditions
- Pancreatic Cancer, GastroEsophageal Cancer, Rectal Cancer, Head and Neck Cancer
- Trial name
- NCT04544046
- Testing
- Supportive Oncology Care at Home, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Depression, Anxiety
Positive Minds Strong Bodies Implementation
This study aims to address treatment and service disparities and prevent disability among racial/ethnic and linguistic minority elders.
- Conditions
- Depression, Anxiety, Physical Disability
- Trial name
- PMSB-E (NCT04545593)
- Testing
- Positive Minds Strong Bodies Enhanced, Enhanced Usual Care
- Where
- United States
- Volunteers
- 427 people
- Sponsor
- Massachusetts General Hospital
Hematologic Malignancy, Blood Cancer
Defining the Role of Palliative carE for Patients With Hematologic Malignancies Undergoing Adoptive CEllular Therapy
The goal of this study is to determine whether a palliative care intervention (PEACE) can improve the quality of life and experiences of participants with Lymphoma, Leukemia, or Multiple Myeloma receiving adoptive cellular…
- Conditions
- Hematologic Malignancy, Blood Cancer, Lymphoma, Leukemia
- Trial name
- PEACE (NCT05646576)
- Testing
- Palliative Care, Usual Care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Nutrition, Healthy
CHW Intervention to Improve Nutrition Security of Patients With Hypertension
The goal of this study is to implement and evaluate a randomized pilot study of a 4-month Nutrition-enhanced community health worker (CHW) intervention for primary care patients with nutrition insecurity and poorly controlled…
- Conditions
- Hypertension, Nutrition, Healthy, Food Insecurity, Community Health Worker
- Trial name
- HeartWell (NCT06358417)
- Testing
- Nutrition-enhanced CHW, Basic CHW
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital