Clinical trials: sponsored by Massachusetts General Hospital
SARS (Severe Acute Respiratory Syndrome), Coronavirus
Nitric Oxide Gas Inhalation in Severe Acute Respiratory Syndrome in COVID-19
Severe acute respiratory syndrome (SARS-CoV2) due to novel Coronavirus (2019-nCoV) related infection (COVID-19) is characterized by severe ventilation perfusion mismatch leading to refractory hypoxemia.
- Trial name
- NOSARSCOVID (NCT04306393)
- Testing
- Nitric Oxide Gas
- Where
- 5 sites in United States, Sweden
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Myelofibrosis, Hematopoietic Cell Transplantation (HCT)
Momelotinib During and After HCT in Myelofibrosis
This is a single-center, open-label, phase I study to determine the safety and tolerability of momelotinib in patients with myelofibrosis during and after hematopoietic cell transplantation (HCT).
- Trial name
- NCT07104799
- Testing
- Momelotinib
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Sensory Science, Performance Assessment
Personalized Performance Optimization Platform
Crews of future long-duration exploration missions will have to cope with a wide range of stressors that present significant challenges for maintaining optimal performance.
- Conditions
- Sensory Science, Performance Assessment, Countermeasure Evaluation, Neurocognitive Function
- Trial name
- P-POP (NCT06979570)
- Testing
- AttentivU
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anaplastic Lymphoma Kinase Gene Translocation, Non-Small Cell Lung Cancer
Immune and Genomic Markers in ALK+ NSCLC
The purpose of this research study is to obtain and study clinical history, and tissue and saliva specimens if available from participants with Anaplastic Lymphoma Kinase-ALK+ Non-Small Lung Cancer(NSCLC)
- Trial name
- NCT04881916
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
The Transitions Project: Efficacy Trial
The aim of this study is to evaluate the efficacy of a brief psychoeducational intervention to improve quality of life in patients with lung cancer who are transitioning from active treatment to surveillance.
- Trial name
- NCT05087251
- Testing
- Five Psycho-educational Session(s), One Psycho-educational Session(s)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia
Inqovi Maintenance Therapy in Myeloid Neoplasms
This research is being done to see if the drug Inqov is effective in reducing the chance of myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) relapsing after standard of care stem cell transplant.
- Conditions
- Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Stem Cell Leukemia
- Trial name
- NCT04980404
- Testing
- Inqovi
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Non Small Cell Lung Cancer, Small-cell Lung Cancer
The Transitions Project: Supporting Adults During the Shift From Cancer Treatment to Surveillance
This research study is designed to develop and test a new supportive care program to help individuals with lung cancer improve their quality of life after cancer treatment is over.
- Conditions
- Non Small Cell Lung Cancer, Small-cell Lung Cancer, Mesothelioma, Cognitive Behavioral Therapy
- Trial name
- NCT04450043
- Testing
- Run-In Sessions 1-5, RCT Transitions Program Sessions 1-5, RCT Control Session
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Other Cancer
Development of an Intervention to Enhance Cancer Pain Management
This research study is being done to understand how patients with chronic cancer pain take their long-acting opioid medications, and to develop an intervention to enhance cancer pain management.
- Trial name
- NCT03752268
- Testing
- Enhancing Cancer Pain Management
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Obesity
Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity
In adults with obesity seeking treatment, weight loss would ideally be composed almost exclusively of fat mass. However, loss of muscle mass and bone are unintentional consequences of weight loss, which may have negative effects…
- Trial name
- NCT05933499
- Testing
- Bimagrumab, Tirzepatide, Calcium/Vitamin D
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Massachusetts General Hospital
Bariatric Surgery
Gaining Optimism After Weight Loss Surgery (GOALS) II
This randomized controlled trial examines the feasibility, acceptability, and preliminary impact of an adapted positive psychology-motivational interviewing (PP-MI) intervention for physical activity among patients who have…
- Trial name
- GOALS (NCT04868032)
- Testing
- Positive Psychology-Motivational Interviewing, Physical Activity Education Control
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Massachusetts General Hospital
Parkinson Disease
Deep Neural Network Approaches for Closed-Loop Deep Brain Stimulation
In this research study the researchers want to learn more about brain activity related to speech perception and production in patients with Parkinson's Disease who are undergoing deep brain stimulation (DBS).
- Trial name
- NCT04277689
- Testing
- Brain signal data collection
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission
Ruxolitinib + Allogeneic Stem Cell Transplantation in AML
This research study is studying a drug that may help decrease the chances of relapse after Allogeneic Stem Cell transplantation for Acute Myeloid Leukemia. The name of the study drug involved in this study is: Ruxolitinib
- Conditions
- Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission, Allogeneic Stem Cell Transplantation
- Trial name
- NCT03286530
- Testing
- Ruxolitinib
- Where
- 6 sites in United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Parkinson Disease, Essential Tremor
Cortical-Basal Ganglia Speech Networks
In this research study the researchers want to learn more about brain activity related to speech perception and production.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT04286308
- Testing
- electrophysiological data collection
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Trigger Finger
Early Postoperative Function After Open Versus Ultrasound-Guided Trigger Finger Release
Clinical outcomes after open trigger finger release are excellent. Minimally invasive techiques with ultrasound guidance theoretically offer advantages for faster recovery but this technique has not been compared prospectively…
- Trial name
- NCT07364695
- Testing
- UltraGuideTFR (Sonex Health, MN, USA)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health
The goal of this clinical trial is to evaluate whether disclosure of a polygenic risk score for coronary artery disease (CAD PRS) influences cardiovascular health and risk factor modification over one year among adults aged 30-75…
- Trial name
- PROACT 3 (NCT07087431)
- Testing
- Immediate disclosure of CAD PRS results, Deferred Disclosure of CAD PRS results
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
HIV Self-testing, Male Partners of HIV-negative Postpartum Women
HIV Self-testing for Partners of HIV-uninfected Postpartum Women
The purpose of this study is to test the feasibility and acceptability of a combination intervention to promote HIV self-testing (HIVST) for Partners and PrEP uptake for HIV-uninfected Postpartum Women ("H4P").
- Conditions
- HIV Self-testing, Male Partners of HIV-negative Postpartum Women, PrEP Uptake, Feasibility
- Trial name
- NCT07194902
- Testing
- HIVST for Partners and PrEP uptake for HIV-uninfected Postpartum Women ("H4P").
- Where
- South Africa
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (SARS-Cov-2) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
- Trial name
- NoCovid (NCT04305457)
- Testing
- Nitric Oxide
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Coronavirus Infections, Healthcare Associated Infection
NO Prevention of COVID-19 for Healthcare Providers
Thousands of healthcare workers have been infected with SARS-CoV-2 and contracted COVID-19 despite their best efforts to prevent contamination. No proven vaccine is available to protect healthcare workers against SARS-CoV-2.
- Trial name
- NOpreventCOVID (NCT04312243)
- Testing
- Inhaled nitric oxide gas
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cancer
Psychological Intervention for Caregivers of Patients Undergoing Stem Cell Transplant
This research study is evaluating the impact of a psychological intervention on the quality of life and mood of caregivers of patients undergoing stem cell transplant.
- Trial name
- NCT03328663
- Testing
- CARE, Standard Transplant Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Mild Cognitive Impairment
TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory
The purpose of this study is to assess the effects of non-invasive brain stimulation on memory in cognitively unimpaired older adults and in patients amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Aging
- Trial name
- NCT04294888
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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