Clinical trials: sponsored by Massachusetts General Hospital
HIV, Substance Use Disorder (SUD)
Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs
The goal of this study is to determine the feasibility and impact of delivering long-acting injectable cabotegravir HIV pre-exposure prophylaxis and suite of support services to adults who inject non-prescription drugs who are…
- Conditions
- HIV, Substance Use Disorder (SUD), Injection Drug Use
- Trial name
- ASCEND (NCT07199335)
- Testing
- APRETUDE (cabotegravir)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis, Stress
The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease
This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with…
- Conditions
- Atherosclerosis, Stress, Inflammation
- Trial name
- NCT04505865
- Testing
- Stress Reduction
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
HIV Infections, AIDS
A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa
The RESOLVE trial is an open, parallel arm, randomized clinical trial which aims to determine the optimal strategy for management of virologic failure on antiretroviral therapy (ART) with tenofovir, lamivudine, and dolutegravir…
- Conditions
- HIV Infections, AIDS, Virologic Failure
- Trial name
- RESOLVE (NCT05373758)
- Testing
- Standard of Care treatment strategy, Individualized Care treatment strategy, Immediate Switch
- Where
- 3 sites in South Africa, Uganda
- Volunteers
- 648 people
- Sponsor
- Massachusetts General Hospital
PCOS (Polycystic Ovary Syndrome), Puberty
ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence
This study explores how a physical activity program can affect hormone health and diabetes risk in girls ages 8-12 who may be at higher risk.
- Conditions
- PCOS (Polycystic Ovary Syndrome), Puberty, Insulin Resistance, Physical Activity
- Trial name
- NCT07102797
- Testing
- ActiveGirls Physical Activity Program (Full), ActiveGirls Physical Activity Program (Delayed Lower Intensity)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Advanced Lung Cancer, Physical Function
A Digital Health Intervention to Improve Physical Function and Wellness of Lung Cancer Survivors
The rationale for the proposed project is to improve the experience and outcomes of individuals diagnosed with lung cancer treated for cure.
- Trial name
- NCT07227623
- Testing
- PROMOTE Digital Health App Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Sexual Dysfunction, Stem Cell Transplant Complications
A Novel Digital Application (SHIFT) to Improve Outcomes for Hematopoietic Stem Cell Transplant Survivors
This research study is evaluating the efficacy of a novel self-administered digital application for improving sexual health outcomes, quality of life, and psychological distress in hematopoietic stem cell transplant survivors.
- Conditions
- Sexual Dysfunction, Stem Cell Transplant Complications, Bone Marrow Transplant Complications
- Trial name
- SHIFT (NCT06541002)
- Testing
- SHIFT Intervention Group, Enhanced Usual Care Group
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease and Related Dementias, Dementia Alzheimers
MASC: Reducing Stress for Caregivers
Building on limitations of prior research, the investigators proposed to develop the Mindful and Self-Compassionate Care Program (MASC) to help caregivers of persons with Alzheimer Disease and Related Dementias (ADRD) manage…
- Trial name
- MASC (NCT05847153)
- Testing
- MASC
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mood Disturbance, Mood Disorders
A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth
This study consists of a 6-week, open-label, randomized clinical trial study to compare efficacy and tolerability of the natural treatments omega-3 fatty acids, inositol, and N-acetylcysteine (NAC) in the treatment of mood…
- Conditions
- Mood Disturbance, Mood Disorders, Natural Supplements, Alternative Treatment
- Trial name
- NCT03911414
- Testing
- Open-label Treatment with Omega-3 Fatty Acids + Inositol, Open-label Treatment with N-acetylcysteine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder (AUD)
Social Identity Mapping for Adolescent Recovery
The goal of this clinical trial is to address the gap between clinical treatment and adolescents' lived social environments by developing and testing a novel, interactive intervention-SIM-AiR-that directly targets social risk and…
- Trial name
- SIMAiR (NCT07474207)
- Testing
- SIM-AiR
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Chronic Low-back Pain
Modulation Effect of tACS on Chronic Low Back Pain
Investigating the modulation effect of tACS
- Trial name
- NCT06568198
- Testing
- Real tACS
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Cirrhosis, Liver, Acute Kidney Injury
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
The goal of this interventional study is to evaluate two strategies for how to provide intravenous (IV) fluids for treating patients with acute kidney injury (AKI) in cirrhosis.
- Conditions
- Cirrhosis, Liver, Acute Kidney Injury, Hepatorenal Syndrome
- Trial name
- RAKI-VAGA (NCT06525623)
- Testing
- Recommendation: No Further Resuscitation, Recommendation: Resuscitation with Crystalloid, Recommendation: Resuscitation with Colloid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Insomnia Chronic
Efficacy of Synchronous, Virtual Cognitive Behavioral Therapy for Insomnia Across Phases of Cancer Survivorship
This project is a single center, prospective randomized controlled trial (N=198) primarily evaluating the efficacy of the Survivorship Sleep Program vs. Enhanced Usual Care on insomnia severity among cancer survivors.
- Trial name
- NCT06807086
- Testing
- Cognitive Behavioral Therapy - Insomnia, Enhanced Usual Care
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Massachusetts General Hospital
Infant Development, Gut Microbiome
INF108F in Infants With Food Protein Induced Proctocolitis
Single-center, randomized, double-blind, placebo-controlled trail evaluating INF108F in breastfed infants with FPIAP
- Conditions
- Infant Development, Gut Microbiome, Food Protein Induced Allergic Proctocolitis
- Trial name
- RESTORE (NCT05793112)
- Testing
- INF108F probiotic
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Crohn Disease
Value of PET/MR Enterography in the Assessment of Crohn's Disease Using a Collagen-binding Radiotracer.
In this study twenty-five (25) subjects with Crohn's disease scheduled for possible surgical intervention will be recruited for this study and a PET/MR scan using the collagen-binding radiotracer will be performed.
- Trial name
- NCT06252493
- Testing
- Radiotracer Injection, Contrast Media, Magnetic Resonance, Blood Draw
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation (AF)
Atrial Fibrillation Risk Estimation With Single-lead Handheld Electrocardiograms
The goal of this prospective, non-randomized pilot study is to learn whether predictions from a previously validated 12-lead ECG-based artificial intelligence (AI) algorithm (ECG-AI) identify people more likely to have…
- Trial name
- AFRESHE (NCT07468123)
- Testing
- 1L ECG screening, Patch monitor
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer
Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer
This research study is studying a drug in combination with radiation therapy as a possible treatment for hepatic metastases from colorectal cancer.
- Trial name
- NCT03223779
- Testing
- TAS-102, Photon SBRT
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder, Alcohol-associated Liver Disease
Financial Rewards for Reducing Alcohol Use in Patients With Liver Disease
This study tests whether providing financial rewards based on a blood test result can help people with alcohol-associated liver disease (ALD) stop or reduce their drinking.
- Conditions
- Alcohol Use Disorder, Alcohol-associated Liver Disease, Liver Cirrhosis, Alcoholic, Alcohol-Associated Hepatitis
- Trial name
- REINFORCE (NCT07465588)
- Testing
- PEth Based Contingency Management, PEth Monitoring with Fixed Incentives
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Endometriosis, Endometrioma
PET/MRI for Evaluation of Endometriosis
This study aims to determine if PET/MRI can detect endometriosis and potentially improve upon currently available non-invasive diagnostic capabilities.
- Trial name
- NCT06377553
- Testing
- Radiotracer Injection, Imaging, Rectal Ultrasound Gel Injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Parenting, Stress
Resiliency Programming for Caregivers of Children With Learning and Attentional Difficulties
This is a randomized open pilot trial enrolling up to 40 co-primary caregivers of children with LAD. Participants will be randomized to receive either mind-body resiliency group (SMART-LAD, intervention) or an evidence-based…
- Conditions
- Parenting, Stress, Learning Disabilities, Child, Attention Difficulties
- Trial name
- SPARK (NCT06492278)
- Testing
- SMART-3RP, Health Education Program
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Stroke Rehabilitation, Stroke
Substrates for Post-Stroke Arm Rehabilitation
Difficulty moving the arm is very common and a major cause of disability after stroke. Although rehabilitation therapies (i.e., occupational and physical therapy) are the most common treatments used to improve arm motor function…
- Conditions
- Stroke Rehabilitation, Stroke, Neurorecovery
- Trial name
- SPARk (NCT06998485)
- Testing
- Arm Basis Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
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