Clinical trials: sponsored by Massachusetts General Hospital
Fatty Liver, Intermittent Fasting
Intermittent Fasting for NAFLD in Adults
NAFLD is a growing threat to public health. Currently, there is a significant need for highly effective treatments for NAFLD. Non-obese NAFLD (BMI<30kg/m2) is an increasingly recognized condition, sometimes described as "lean…
- Conditions
- Fatty Liver, Intermittent Fasting, Fatty Liver, Nonalcoholic, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT04899102
- Testing
- Time-Restricted, Intermittent Fasting
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Lynch Syndrome, Crohn Disease
A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule
The investigators have developed an inexpensive tool to take pictures in the lower GI tract without sedation and to look for signs of disease.
- Conditions
- Lynch Syndrome, Crohn Disease, Inflammatory Bowel Diseases, Healthy
- Trial name
- NCT07219537
- Testing
- Feasibility of using an OCT-based Retrograde Tethered Capsule Endomicroscope device to image the lower GI tract
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Non-small Cell Lung Cancer Metastatic, Targetable Oncogenes (EGFR, ALK, ROS1)
A Trial of Integrating SBRT With Targeted Therapy in Stage IV Oncogene-driven NSCLC
This research study is studying a type of radiation therapy called Stereotactic Body Radiation Therapy (SBRT) as a possible treatment for stage IV non-small cell lung cancer (NSCLC) that has a mutated epidermal growth factor…
- Trial name
- NCT02314364
- Testing
- SBRT with protons or photons
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Bipolar I Disorder, Depression
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
This is a sequential multiple assignment randomized trial for adults (ages > 18) with a bipolar disorder type 1 and type 2 diagnosis currently experiencing a depressive episode.
- Trial name
- SMART-BD (NCT06433635)
- Testing
- Cariprazine, Aripiprazole/Escitalopram combination, Quetiapine
- Where
- 18 sites in United States, Canada
- Volunteers
- 2,726 people
- Sponsor
- Massachusetts General Hospital
Cystic Fibrosis (CF), Pain Management
PACE CF, a 3-session Mind-body Pain Management Program for Adults With Cystic Fibrosis
Many people living with cystic fibrosis (CF) experience pain. However, pain is sometimes unrecognized and under-managed in people with CF.
- Trial name
- NCT06606457
- Testing
- Pain Acknowledgment Coping and Empowerment in CF (PACE CF)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder, Depression
Mechanism of Action of Transcranial Magnetic Stimulation
This is an observational neuroimaging study assessing the effects of TMS on the brains of patients with unipolar depression.
- Trial name
- NCT04278521
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Massachusetts General Hospital
Attention Deficit Hyperactivity Disorder
A Dose-Response Study of the Cognitive and Physiological Effects of tDCS to the DLPFC
To determine the cognitive and neurophysiological dose-response relationships of anodal tDCS to the left DLPFC as a function of absolute current intensity, individualized E-field intensity, and stimulation duration.
- Trial name
- NCT04175041
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large…
- Trial name
- NCT05450432
- Testing
- Ketamine, Esketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Healthy
A Pilot Study of the Effects of BCG Immunization on CSF and Blood-based Biomarkers in Older Adults.
A pilot study of the effects of Bacillus Calmette-Guérin (BCG) immunization on cerebrospinal fluid and blood-based biomarkers in older adults.
- Trial name
- NCT04507126
- Testing
- Bacillus Calmette-Guerin (BCG)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Attention Deficit Hyperactivity Disorder
Neuromodulation of Executive Function in the ADHD Brain
This study aims to determine the transient, modulatory effects of transcranial direct current stimulation (tDCS) on executive function and inhibitory control in patients with ADHD compared to healthy controls.
- Trial name
- NCT04175028
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCD
The study aims to improve patient-specific anatomical targeting of the Deep Brain Stimulation for the treatment of intractable OCD.
- Trial name
- PERFECT DBS (NCT03244852)
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Attention Deficit Disorder, Attention Deficit Disorder With Hyperactivity
Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Attention-deficit/Hyperactivity Disorder (ADHD)
The investigators are investigating whether home-based tDCS over the course of four weeks can improve ADHD symptom severity and improve dysexecutive functioning (cognitive control).
- Trial name
- NCT05354232
- Testing
- 2 mA transcranial direct current stimulation (tDCS), 1 mA transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Viral Infection
School Inner City Air Study
The goal of this randomized clinical trial is to test the efficacy of high efficiency particulate air (HEPA) cleaners in reducing respiratory viral exposure and infections in elementary school classrooms.
- Trial name
- NCT05953233
- Testing
- Active classroom HEPA cleaner
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Low Grade Glioma, WHO Grade 3 Glioma With IDH1 Mutation
Proton Radiation Therapy for Gliomas
In this research study the investigators are looking at a type of radiation called proton radiation. Proton radiation has been shown to deliver virtually no radiation beyond the area of the tumor, sparing surrounding normal…
- Conditions
- Low Grade Glioma, WHO Grade 3 Glioma With IDH1 Mutation, WHO Grade 3 Glioma With 1p/19q Codeletion
- Trial name
- NCT01358058
- Testing
- Proton radiation
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Massachusetts General Hospital
Healthy
Polarization Sensitive Optical Coherence Tomography (PS-OCT) for Retinal Imaging
The aim of this pilot study is to assess the ability of a new polarization sensitive optical coherence tomography system to obtain high-quality images of retinal birefringence.
- Trial name
- NCT02441777
- Testing
- Polarization-Sensitive OFDI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autism, Attention Deficit Hyperactivity Disorder
Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD
An open label trial to assess the safety and efficacy of transcranial photobiomodulation (tPBM) in improving autistic traits in ADHD youth.
- Trial name
- NCT04569058
- Testing
- Transcranial Photobiomodulation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Massachusetts General Hospital
Aging, HIV
Cognitive Behavior Therapy (CBT)-Based Group Intervention to Reduce Inflammation in Older People With HIV
In this study, the investigators will assess the feasibility and acceptability of an evidence-based CBT group intervention, developed for older people with HIV, and research methods in a pilot randomized controlled trial…
- Trial name
- CHAMP (NCT05434741)
- Testing
- Weekly Group Skills, One-time Trifold Brochure titled "HIV: 50 Years or Older"
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Hiv, Substance Use Disorders
Intervention to Improve HIV Self-care Among People Who Inject Drugs
This study will implement a pilot randomized controlled trial (RCT, N=50) to refine and assess the feasibility and acceptability of an emotion regulation and communication skills intervention designed to improve engagement in…
- Trial name
- iSTRIVE (NCT05819411)
- Testing
- Project iSTRIVE, incentivized Directly Observed Therapy (iDOT)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Massachusetts General Hospital
Substance Use Disorders, HIV/AIDS
Project Matter: Intervention to Improve HIV Self-care Among Men Who Have Sex With Men (MSM) With Substance Use Disorders
This study will implement a pilot randomized controlled trial (RCT, N=60) to assess the feasibility and acceptability a refined emotion regulation intervention designed to improve engagement in HIV-care among substance using HIV+…
- Conditions
- Substance Use Disorders, HIV/AIDS, Homosexuality, Male
- Trial name
- NCT03899220
- Testing
- Project Matter
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation New Onset
A Pharmaco-surgical Approach to Reduce Postoperative Atrial Fibrillation After Cardiac Surgery
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery with an estimated incidence around 35%.
- Trial name
- NCT05780320
- Testing
- Prophylactic amiodarone and posterior pericardiotomy
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Massachusetts General Hospital
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