Clinical trials: sponsored by Massachusetts General Hospital
Autism Spectrum Disorder, Anxiety
Heart Rate Variability Biofeedback for Anxiety in Autistic Youth
Heart rate variability biofeedback (HRVB) is a breathing-based intervention that reduces anxiety in a range of populations. Second-generation wearable HRVB devices not only deliver scheduled biofeedback practice sessions but also…
- Trial name
- NCT07812233
- Testing
- Lief Smart Patch
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Ventilated Patient in Intensive Care
Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning
Patients in the ICU who are being taken off of a breathing machine (ventilator weaning) commonly experience anxiety, agitation, sleep disruption, and physiologic stress.
- Trial name
- NCT07710469
- Testing
- Weighted blanket, Standard hospital linens
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Lymphoma, B-Cell, Relapsed Cancer
Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)
Participants are invited to take part in this research study because they have relapsed (cancer has come back) or refractory (cancer has not responded to treatment) B-cell Lymphoma and will be undergoing CAR T-cell Therapy.
- Conditions
- Lymphoma, B-Cell, Relapsed Cancer, Refractory Lymphoma, Diffuse Large B Cell Lymphoma
- Trial name
- NCT06004167
- Testing
- Adaptive Bridging Radiation Therapy (ABRT)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Back Pain, Depressive Symptoms
Cannabidiol for Reduction of Brain Neuroinflammation
This study will investigate whether cannabidiol (CBD), the primary centrally and peripherally active non-intoxicating compound in the cannabis plant, exerts anti-neuroinflammatory effects in patients with chronic low back pain…
- Trial name
- CBD (NCT05066308)
- Testing
- CBD
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Massachusetts General Hospital
Vascular Inflammation, ASCVD
Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal Hematopoiesis
The primary goal of this clinical trial is to test the hypothesis that the drug canakinumab (anti-IL-1B monoclonal antibody) decreases vascular inflammation when used by people with a history of coronary artery disease, including…
- Conditions
- Vascular Inflammation, ASCVD, ASCVD Management
- Trial name
- TECTONIC (NCT06691217)
- Testing
- CANAKINUMAB (ILARIS®)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Bacterial Vaginosis
A Study to Test New Investigational Drugs (LCFA-01and LC103) for Bacterial Vaginosis (BV) Treatment
This Phase 1b study will evaluate different combinations of LCFA-01, LC103, and the antibiotic metronidazole in women with bacterial vaginosis (BV).
- Trial name
- NCT07875673
- Testing
- metronidazole (MTZ)+ LC103+ LCFA-01, LCFA-01 + LC103
- Where
- 6 sites in Australia, South Africa
- Volunteers
- 280 people
- Sponsor
- Massachusetts General Hospital
PSC
PET/MRI of Primary Sclerosing Cholangitis
This study aims to use positron emission tomography (PET)/magnetic resonance imaging (MRI) to diagnose and quantify PSC-related biliary tract fibrosis and to improve upon the currently available non-invasive diagnostic…
- Trial name
- NCT06252610
- Testing
- Radiotracer Injection, Contrast Media, Magnetic Resonance, Imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Breast Cancer Detection
Non-Contrast-Enhanced Breast MRI in the Evaluation of Newly Diagnosed Breast Cancer: A Pilot Study
This pilot study is evaluating whether breast MRI without contrast dye can provide useful information in patients who have recently been diagnosed with breast cancer.
- Trial name
- NCT07874256
- Testing
- Non-Contrast-Enhanced Breast MRI
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Liver Cirrhosis, Hepatic Cell Carcinoma
Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
A total of fifty-five (55) patients with liver cirrhosis will be enrolled in this study to produce and validate dedicated Ga-PSMA-PET/MRI acquisition protocols.
- Conditions
- Liver Cirrhosis, Hepatic Cell Carcinoma, Portal Hypertension
- Trial name
- NCT06265272
- Testing
- Injection of a gadolinium contrast agen, Radiotracer Injection, Imaging
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Pregnancy Related, Burnout, Professional
The 4th Trimester Initiative: The Impact of Parental Support on Pregnant Trainee Wellbeing
The goal of this clinical trial is to determine the impact of a parental support package for new trainee mothers which focuses on mentorship, lactation, and sleep, and access to perinatal care.
- Conditions
- Pregnancy Related, Burnout, Professional, Wellness, Psychological
- Trial name
- NCT06014892
- Testing
- Snoo smart bassinet, Willow wearable breast pump, Maven Clinic on-demand perinatal consultation
- Where
- 7 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Kidney Failure Chronic, Stem Cell Transplant
Addition of Venetoclax to Combined Hematopoietic Stem Cell and Kidney Transplantation
The primary objective is to assess the safety of the addition of venetoclax to reduced intensity conditioning for HLA-matched and haploidentical combined HSC and kidney transplantation as measured by stable full donor…
- Conditions
- Kidney Failure Chronic, Stem Cell Transplant, Stem Cell Transplant Complications, Tolerance
- Trial name
- NCT07358195
- Testing
- Venetoclax, Hematopoietic Cell Transplantation Conditioning Regimen, Kidney Transplant
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Cornea, Skin Diseases
OCT Vibrography for Biomechanical Properties of Tissues
The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.
- Conditions
- Cornea, Skin Diseases, Gingival Diseases
- Trial name
- NCT05759780
- Testing
- Optical imaging of the tissues
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Angelman Syndrome, Neurodevelopmental Conditions
A Natural History Study of Angelman Syndrome
The goal of this observational study is to learn about the natural progression of Angelman syndrome (AS) in children and adults with a confirmed genetic diagnosis of AS.
- Trial name
- GLOW-AS (NCT07417137)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Mild Cognitive Impairment (MCI)
Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
This early phase, open label, single arm clinical trial will determine the intraindividual safety, tolerability and effects of NPC1 (parthenolide and ipriflavone) on blood-based biomarkers of Alzheimer's disease (AD) pathology…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- NPC1-AD (NCT07236190)
- Testing
- natural product combination-1 (NPC1)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Immune Thrombocytopenia
Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia
Individuals with immune thrombocytopenia (ITP) frequently report difficulties with attention and memory. The main question this study seeks to answer is: Do patients with ITP have evidence of cognitive impairment as detected by a…
- Trial name
- COGFIT (NCT06817395)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Smoking Cessation
Testing the mHealth App Intervention for Nondaily Smokers "SiS4"
The goal of this project is to test if a new behavioral treatment for people who smoke nondaily and wish to quit works. The new treatment is a smartphone app that engages users in positive psychology exercises and gives them…
- Trial name
- NCT06678243
- Testing
- Smiling instead of Smoking, QuitGuide
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- Massachusetts General Hospital
Tumor Surgery
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT
This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound complications.
- Trial name
- NCT02792270
- Testing
- Caloric Restriction Diet
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Memory Loss (Excluding Dementia), Lifestyle (Sedentary Behavior and Physical Activity)
Pilot Study of a Brain Health Program in Senior Centers
The investigators will evaluate a brain health programs in older adults with subjective cognitive decline. The primary aim of the study is to determine the credibility, expectancy, feasibility, acceptability, appropriateness…
- Conditions
- Memory Loss (Excluding Dementia), Lifestyle (Sedentary Behavior and Physical Activity), Lifestyle Risk Reduction, Healthy Lifestyle Behaviors
- Trial name
- NCT07424443
- Testing
- My Healthy Brain
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Hepatocellular Carcinoma
Psychoeducational Intervention for Patients With Hepatocellular Carcinoma
This study aims to refine and pilot test HARMONY, a psychoeducational intervention for patients with newly diagnosed hepatocellular carcinoma (HCC).
- Trial name
- HARMONY (NCT06541990)
- Testing
- HARMONY, Enhanced usual care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Rectal Cancer, Self Efficacy
An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer
The aim of this study is to evaluate the feasibility and acceptability of conducting a randomized trial of a brief psychoeducational intervention versus enhanced usual care for patients with locally advanced rectal cancer who are…
- Trial name
- PATHWAYS (NCT05914766)
- Testing
- PATHWAYS, Enhanced usual care
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
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