Clinical trials: sponsored by Massachusetts General Hospital
Emotional Distress, Cardiac Arrest
Open Pilot Trial of a Mind-body Program for Cardiac Arrest Survivors and Their Caregivers
The purpose of this study is to pilot a mind-body intervention for cardiac arrest survivors and their informal caregivers, Recovering Together after Cardiac Arrest.
- Trial name
- NCT06517394
- Testing
- Recovering Together after Cardiac Arrest
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Osteoarthritis, Knee
Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain
The aim of this study is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in knee osteoarthritis patients to elucidate the…
- Trial name
- NCT03261505
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain
Enhancing Acupuncture Treatment Effect Through Non-invasive Neuromodulation
In this study, investigators will examine the brain mechanism behind the synergistic effects of combining acupuncture and transcranial direct current stimulation (tDCS) treatments.
- Trial name
- NCT03716830
- Testing
- verum acupuncture, real tDCS
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Massachusetts General Hospital
Parkinson's Disease
Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease
Disruption of sleep and alertness is one of the most disabling non-motor symptoms of Parkinson's disease (PD). Mechanisms leading to impaired sleep and alertness in PD are not well understood, and treatment options remain…
- Trial name
- NCT02909192
- Testing
- Light Therapy Device
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Bone Density, Bone Loss
Effects of Denosumab on Bone Mineral Density in Women With Anorexia Nervosa: A Pilot Study
This protocol is a randomized, double-blind, placebo-controlled clinical trial which aims to investigate the effect of denosumab on BMD in women with anorexia nervosa.
- Conditions
- Bone Density, Bone Loss, Anorexia Nervosa, Eating Disorder
- Trial name
- NCT03292146
- Testing
- Denosumab 60 MG [Prolia], Alendronate 70Mg Tab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
IDH1 Mutation Myeloid Neoplasms
IDH1 Inhibition Using Ivosidenib as Maintenance Therapy for IDH1-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation
This research study is studying a drug as a possible treatment for IDH1-mutant myeloid neoplasms. -The drug involved in this study is ivosidenib (AG-120)
- Trial name
- NCT03564821
- Testing
- Ivosidenib
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Obstructive Sleep Apnea, Neurocognitive Disorders
Postoperative Neurocognitive Disorders
The purpose of this study is to examine the mechanisms of brain injury contributing to postoperative neurocognitive disorders (PNCD) in an at-risk population (obstructive sleep apnea (OSA)) undergoing surgery.
- Trial name
- PNCD (NCT04244162)
- Testing
- Brain Imaging, Cognitive testing, Blood Biomarkers
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Liver Cirrhoses
Developing Viability Index for Machine Perfused Livers
Machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable.
- Trial name
- NCT03694691
- Testing
- Liver Biopsy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Cardiometabolic Diseases, Noise Exposure
Impact of Earplugs on Mechanisms of Noise-Related Cardiovascular Disease
Noise from cars, planes, and trains affects all people and has been associated with heart disease. Almost 30% of Americans are exposed to harmful levels of noise and noise accounts for the loss of more than one million healthy…
- Trial name
- NCT07148817
- Testing
- Noise canceling earplugs, Usual care
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital
Childhood Cancer Survivors
Virtual Health Insurance Navigation Pilot Program for Childhood Survivors (HINTII)
The investigators are conducting a Type I hybrid effectiveness-implementation trial to assess the effectiveness of HINT-S (synchronous) compared to enhanced usual care (EUC) in promoting health insurance literacy, thus reducing…
- Trial name
- HINTII (NCT05527392)
- Testing
- Health Insurance Navigation Tools Program
- Where
- United States
- Volunteers
- 529 people
- Sponsor
- Massachusetts General Hospital
Liver Transplant
Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients.
- Trial name
- NCT06088758
- Testing
- Normothermic machine perfusion (NMP) of steatotic liver
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Blast Injury
Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure
This is a 4-year, longitudinal study of 100 active-duty Navy SEALs. The goal of the study is to determine whether repeated blast exposure affects SEAL brain health and to develop an initial diagnostic testing protocol that…
- Trial name
- NCT07131475
- Testing
- PBR28 TSPO PET
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Dementia of Alzheimer Type
Assess Fibrin in Brains With AD/ADRD
The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.
- Trial name
- NCT05336695
- Testing
- PET/MR Imaging, 64Cu-FBP8
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Physical Activity
Healthy Activities Improve Lives (HAIL)
The investigators have developed an online platform to support the 8-week, F\&S! exercise program called the Healthy Activity Improves Lives (HAIL) online platform.
- Trial name
- HAIL (NCT06267547)
- Testing
- HAIL Online Platform, Fit and Strong! Program
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cystic Fibrosis
Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in adolescents diagnosed with cystic fibrosis (CF) compared to healthy, matched controls.
- Trial name
- NCT06216704
- Testing
- Magnetic resonance relaxometry, Magnetic resonance spectroscopy, Blood Draw
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cystic Fibrosis, Quality of Life
Pragmatic Implementation Trial of a CF Primary Palliative Care Intervention
Five Cystic Fibrosis (CF) centers, key stakeholders, and a palliative care institute have collaborated to create a novel primary palliative care intervention for patients with CF, "Improving Life with CF: A Primary Palliative…
- Trial name
- NCT04923880
- Testing
- Implementation of Primary Palliative Care Intervention in CF Centers
- Where
- 5 sites in United States
- Volunteers
- 643 people
- Sponsor
- Massachusetts General Hospital
Inflammatory Bowel Disease, Crohn Disease
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls.
- Trial name
- NCT04508088
- Testing
- Coronal T1 weighted spin echo images, Spin-lattice relaxation (T1), Magnetic resonance spectroscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Substance Use, Harm Reduction
A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
The primary goal of this study is to test the effectiveness of the iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment) curriculum, a novel drug education and diversion program, in approximately 300…
- Conditions
- Substance Use, Harm Reduction, Adolescent Behavior
- Trial name
- NCT06115746
- Testing
- iDECIDE
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Bariatric Surgery Candidate, Bone Loss
Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery
Bariatric surgery leads to bone loss and increases fracture risk. This study evaluates whether denosumab can prevent the high-turnover bone loss that occurs after Roux-en-Y Gastric Bypass (RYGB) and sleeve gastrectomy (SG)…
- Trial name
- NCT04087096
- Testing
- Denosumab, Zoledronic Acid
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Pigmented Lesions, Pigmented Skin Lesion
Pilot Study of Imaging Human Skin With High-Speed Spectrally Encoded Confocal Microscopy
The aim of this study is to evaluate the imaging performance of Spectrally Encoded Confocal Microscopy (SECM) for imaging human skin and skin diseases.
- Conditions
- Pigmented Lesions, Pigmented Skin Lesion, Pigmented Moles, Skin Lesion
- Trial name
- NCT04566302
- Testing
- SECM Skin Imaging
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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