Clinical trials: sponsored by Massachusetts General Hospital
Fibromyalgia
Phase II Clinical Trial: Multi-dosing the BCG Vaccine for Fibromyalgia
The investigators are doing this research study to explore whether the bacillus Calmette-Guérin (BCG) vaccine can be an effective treatment for fibromyalgia.
- Trial name
- NCT03582085
- Testing
- Bacillus Calmette Guerin Vaccine, Saline Injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
ADHD
Refining the Shared Decision Making Process Survey in ADHD Medication Decisions
This is a retrospective observational survey study. We will survey a sample of adult parents or legal guardians who have a child who has been diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) and who discussed ADHD…
- Trial name
- NCT05048186
- Testing
- Attention Deficit Hyperactivity Disorder Treatment Decision Aid
- Where
- United States
- Volunteers
- 512 people
- Sponsor
- Massachusetts General Hospital
Temporomandibular Joint Disorders
The Effect of Opioid-Free Anesthesia in TMJ Surgery
This study aims is to evaluate the effect of opioid free total intravenous anesthesia on postoperative quality of recovery in patients undergoing oral and maxillofacial surgery (OMF) temporomandibular joint (TMJ) surgery.
- Trial name
- NCT04724759
- Testing
- Dexmedetomidine / Ketamine / Lidocaine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Depression
Examining Cognitive Mechanisms of Clinical Improvement Following Mindfulness Based Therapy for Depressed Individuals
Depression one of the leading causes of disability worldwide. Individuals suffering from depression typically exhibit impairments in various mental abilities, such as the ability to effectively direct and control attention and…
- Trial name
- NCT02457936
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
Heart Failure, Systolic
TRANSFORM Heart Failure with Reduced Ejection Fraction
The goal of the TRANSFORM-HFrEF trial will be to study the current guideline-directed medical therapy (GDMT) landscape for HFrEF and determine effective methods and models of increasing adherence to GDMT and improving Quality of…
- Trial name
- TRANSFORMHFrEF (NCT04872959)
- Testing
- HealthReveal
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Afatinib With CT and RT for EGFR-Mutant NSCLC
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug to learn whether the drug works in treating a specific cancer.
- Trial name
- NCT01553942
- Testing
- Afatinib, Radiation, Cisplatin
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts General Hospital
Acetabular Labrum Tear, Femoro Acetabular Impingement
Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies
The goal of this clinical trial is to assess the effect of PRP/PPP/BMAC application on functional outcomes after hip arthroscopy to address acetabular labral pathologies. The main questions it aims to answer are: 1.
- Conditions
- Acetabular Labrum Tear, Femoro Acetabular Impingement, Chondral Defect, Bone Marrow Aspirate Concentrate
- Trial name
- PRP; PPP; BMAC (NCT06003101)
- Testing
- Bone marrow aspirate concentrate (BMAC), Control
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Massachusetts General Hospital
Depression
PEERS Using Peer Mentors to Deliver Depression Care
Fifteen to twenty percent of older Americans (6 to 8 million people) suffer from depression but more than one-half do not receive any services, a burden disproportionately shared by low-income and minority older adults who…
- Trial name
- NCT04319094
- Testing
- PEERS, Social interaction
- Where
- 2 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis
Supporting Patient Care With Electronic Resources in the United States
This proof-of-concept randomized trial evaluates the effectiveness of using an online decision aid (US-ANSWER-2) in the decision-making to start or switch biologic therapy in US patients with rheumatoid arthritis.
- Trial name
- SuPER-US (NCT02787538)
- Testing
- US-ANSWER-2 decision aid, Control group (Online medication guide)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Chronic Low Back Pain, Chronic Neck Pain
Effect of Combined Morphine and Duloxetine on Chronic Pain
A double-blind, randomized, and placebo-controlled clinical study examining whether duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), could enhance opioid analgesia and reduce overall opioid use.
- Trial name
- Duloxetine (NCT03249558)
- Testing
- Morphine, Duloxetine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Massachusetts General Hospital
Malignant Glioma
Psychological Intervention for Caregivers of Patients With Malignant Gliomas
This research study is evaluating a psychological intervention for caregivers of loved ones with malignant gliomas.
- Trial name
- NCT03735498
- Testing
- Psychological Intervention
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Uterine Cancer, Cervical Cancer
Proton Beam Teletherapy for Post-Hysterectomy Cancers of the Uterus and Cervix
Proton beam radiation therapy is known to spare surrounding normal tissues from radiation. Proton beam radiation delivers less radiation beyond the area of the target tissues.
- Trial name
- NCT01600040
- Testing
- Proton radiation therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Smoking, Tobacco
Assessing the Integration of Tobacco Cessation Treatment Into Lung Cancer Screening (LCS)
This randomized controlled trial seeks to evaluate the effectiveness of alternative strategies to integrate smoking cessation interventions into the delivery of low-dose CT (LDCT) lung cancer screening.
- Trial name
- ScreenASSIST (NCT03611881)
- Testing
- Counseling, Nicotine patch, Community Resource
- Where
- 6 sites in United States
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Disorder of Consciousness, Traumatic Brain Injury
Validity and Feasibility of the CRSR-FAST
The CRS-R is a standardized and validated bedside assessment of conscious awareness. It is used routinely for diagnosis and prognosis of patients with disorders of consciousness (DOC) as well as in research settings.
- Trial name
- CRSR-FAST (NCT03549572)
- Testing
- Coma Recovery Scale-Revised
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Complication of Transplant
Supportive Care Intervention In Patients Hospitalized For Hematopoietic Stem Cell Transplantation (Shield)
The main purpose of this study is to assess whether early integration of palliative and supportive care services in care of patients hospitalized for hematopoietic stem cell transplantation (HSCT) can improve patients' and family…
- Trial name
- SHIELD (NCT02207322)
- Testing
- transplant with early palliative care
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Peripheral Vascular Disease
Guided Meditation to Decrease Perioperative Anxiety and Increase Patient Intraoperative Compliance in Vascular Surgery
The primary purpose of this clinical trial is to test the feasibility of implementing a perioperative guided meditation program for patients undergoing peripheral vascular interventions that are performed under procedural…
- Trial name
- NCT05837481
- Testing
- Meditation
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Tc99m-MAA Bronchial Artery Injection During Bronchial Embolization for Pulmonary Mass Induced Hemoptysis for Dosimetry Planning
This research study will evaluate the administration of a particle called macro-aggregated albumin (MAA) labelled with the radiotracer technetium 99m (Tc99m) as a proxy to estimate the anticipated dose of radiation to tumor and…
- Trial name
- NCT04105283
- Testing
- Tc99m-MAA
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Prostatic Neoplasm, Prostate Cancer
Prostate Cancer Genetic Risk Evaluation and Screening Study
This study aims to define the natural history of men at high genetic risk for prostate cancer on the basis of specific germline genetic mutations, family history, or Black/African ancestry and evaluate the utility of prostate MRI…
- Conditions
- Prostatic Neoplasm, Prostate Cancer, BRCA2 Mutation, BRCA1 Mutation
- Trial name
- PROGRESS (NCT05129605)
- Testing
- Prostate cancer screening
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer, Tobacco Use
Lung Cancer Screening Navigation for Homeless People
The investigators will conduct a pragmatic clinical trial to test the effect of patient navigation on lung cancer screening (LCS) low-dose computed tomography (LDCT) completion among Boston Health Care for the Homeless Program…
- Conditions
- Lung Cancer, Tobacco Use, Homelessness
- Trial name
- NCT04308226
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Delirium, Sleep
Investigation of Sleep in the Intensive Care Unit
Sleep deprivation is common and often severe in critically ill patients cared for in intensive care units (ICUs) and is hypothesized to be a modifiable risk factor for delirium, which in turn is hypothesized to be a modifiable…
- Trial name
- ICU-SLEEP (NCT03355053)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 522 people
- Sponsor
- Massachusetts General Hospital
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