Clinical trials: sponsored by Massachusetts General Hospital
Orofacial Pain, Facial Pain
Feasibility Testing of the "Face-Forward-Web" Program for Chronic Orofacial Pain
The goal of this study is to conduct a feasibility open pilot study (N=Up to 20) with exit interviews to assess the feasibility, acceptability, and credibility of the study protocol and Face-Forward-Web; a web-based mind-body…
- Trial name
- NCT06754917
- Testing
- Face-Forward-Web
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Boston Lung Cancer Study (Molecular and Genetic Analysis of Lung Cancer)
Investigators use a genome-wide approach within a case-control design to identify SNPs that show evidence of association with lung cancer risk and survival.
- Trial name
- NCT03029325
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- Massachusetts General Hospital
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Malignant Brain Tumor, Glioma
Supportive Psychoeducational Intervention for Patients With Brain Tumors (Acceptance and Commitment Therapy-based Supportive Intervention for Patients With Central Nervous System Tumors)
The goal of this study is to refine and test a psychosocial intervention called ASCENT (ACT-based Supportive intervention for patients with CENTral nervous system tumors).
- Conditions
- Malignant Brain Tumor, Glioma, Coping Skills, Distress, Emotional
- Trial name
- ASCENT (NCT06099743)
- Testing
- Psychosocial intervention, Usual supportive care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Multiple Sclerosis
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and…
- Trial name
- NCT04699747
- Testing
- F-18 3F4AP
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lung Cancer
DNA Analysis of Blood and Tissue From Patients With Lung Cancer
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00471978
- Where
- 2 sites in United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Working Memory
Modulation of Brain Oscillations Underlying Working Memory
This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory.
- Trial name
- NCT05923606
- Testing
- Active tACS
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Esophageal Cancer
Genetic and Environmental Risk Factors Related to Esophageal Cancer
RATIONALE: Gathering information about genes, cigarette smoking, and diet may help doctors learn more about risk factors that may cause esophageal cancer.
- Trial name
- NCT01035398
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cirrhosis, End Stage Liver DIsease
HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease
This research study is evaluating a program that entails a healthcare at home intervention for people with advanced liver disease.
- Conditions
- Cirrhosis, End Stage Liver DIsease, Liver Cirrhosis, Liver Disease Chronic
- Trial name
- NCT05205954
- Testing
- Hepatology Home Hospital
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Depression / Major Depressive Disorder, Mental Health (Depression)
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Many Asian Americans with depression also struggle with physical symptoms-such as pain, fatigue, or other forms of bodily discomfort-that occur at the same time.
- Trial name
- NCT07610928
- Testing
- Stress Management and Resiliency Training with Qigong/Tai Chi, Healthy Living Program
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Hormone Receptor Positive Breast Cancer
Telehealth Intervention for Symptom Management and Adherence to Adjuvant Endocrine Therapy
The goal of this study is to demonstrate the efficacy of an evidence-based, small-group, telehealth intervention ('STRIDE') for improving patients' ability to cope with side effects from adjuvant endocrine therapy (AET) and…
- Trial name
- STRIDE (NCT07759947)
- Testing
- STRIDE, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Hip Pain, Hip Pain Chronic
Open Pilot Trial of a Mind-Body Intervention for Patients With Chronic Hip Pain
The goal of this study is to conduct a feasibility open pilot study (N=5) of HIPS with virtual exit interviews among adult patients with chronic hip joint-related pain (HRP).
- Conditions
- Hip Pain, Hip Pain Chronic, Mind-Body Therapies
- Trial name
- HIPS Pilot (NCT06820242)
- Testing
- HIPS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder (BD), Bipolar Disorder Depression
Time Restricted Eating (TRE) in Bipolar Disorder
This is a randomized controlled trial investigating the effects of an 8-TRE intervention compared to a wait list (control) on metabolic health and body composition in people diagnosed with BD and who are currently obese and at…
- Conditions
- Bipolar Disorder (BD), Bipolar Disorder Depression, Overweight (BMI > 30)
- Trial name
- TREBD (NCT07211217)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Smoldering Multiple Myeloma
A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MM
This research study is studying a targeted therapy as a possible treatment for Smoldering Multiple Myeloma. The following intervention will be involved in this study: Lenalidomide Citarinostat (CC-96241) PVX-410
- Trial name
- NCT02886065
- Testing
- Hiltonol, Citarinostat, Lenalidomide
- Where
- 6 sites in United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder
Impact of Cognitive Behavioral Therapy on PTSD-CVD Link
This is a pilot randomized controlled trial to assess the impact of a first-line treatment for posttraumatic stress disorder (PTSD) (Cognitive Processing Therapy; CPT) versus waitlist control on mechanisms of cardiovascular…
- Trial name
- NCT06429293
- Testing
- Cognitive processing therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Breast Benign, Malignant Neoplasm of Breast
Low-field MRI for Breast Cancer Screening
This research study wants to learn more about improving the attainable image quality for ultra-low field MRI of the breast using new data acquisition methods(also called MRI pulse sequences) and image reconstruction algorithms.
- Conditions
- Breast Benign, Malignant Neoplasm of Breast, Breast Malignant Tumor
- Trial name
- NCT05486520
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
Family Members at INcreased-risk for Developing Inflammatory Bowel Disease
First-degree relatives of people with inflammatory bowel disease ("IBD," including Crohn's disease and ulcerative colitis) have an increased risk for developing IBD themselves.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), IBD-unclassified (IBD-U), Indeterminate Colitis
- Trial name
- FIND-IBD (NCT06655415)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Medical History Taking, Artificial Intelligence in Clinical Workflow
Augmenting Clinical Workflow With a Structured Chatbot for Patient History Collection and Diagnostic Support
Doctors spend much of each visit collecting the patient's medical history, and incomplete histories can delay diagnosis. This study tests an AI chatbot that interviews patients before their appointment and produces a structured…
- Conditions
- Medical History Taking, Artificial Intelligence in Clinical Workflow, Outpatient Clinical Encounter
- Trial name
- CHAT-HX (NCT07860762)
- Testing
- AI-Based Structured History-Taking Chatbot
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Peer Recovery Coaching for TUD
Peer Recovery Coaching for Tobacco Abstinence in People With Opioid Use Disorder
Tobacco use is a leading cause of premature death among individuals with opioid use disorder (OUD). Nearly 75% of individuals receiving medication treatment for OUD report concurrent tobacco use disorder (MOUD-TUD), yet…
- Trial name
- PeerTTS (NCT06965153)
- Testing
- Dual NRT, PeerTTS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Multiple Myeloma
KRDI in Transplant-Eligible MM
This research study is testing the efficacy of an experimental drug combination for people with newly diagnosed multiple myeloma that are eligible for a stem cell transplant.
- Trial name
- NCT04430894
- Testing
- Carfilzomib, Isatuximab, Lenalidomide
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
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