Clinical trials: sponsored by Mayo Clinic
Peyronie Disease, Erectile Dysfunction
Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease
The purpose of this research is to determine whether or not low-intensity shockwave therapy (LiSWT) with Xiaflex treatment will result in greater improvements to the curvature of the penis.
- Trial name
- NCT06065436
- Testing
- Collagenase Clostridium Histolyticum, Storz Duolith LiSWT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Emergency Care
Descriptions and Practices of Family Engagement in Emergency Care Setting
The purpose of this study is to explore and describe nurses' perceptions of their levels and practices of family engagement in Emergency Departments and the experiences of family members in delivery of Emergency Department care.
- Trial name
- NCT07739576
- Testing
- Nurse Interview, Family Interview
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Hypertension, Renovascular
A Study to Evaluate Renal Fibrosis Using MRI Techniques
The purpose of this study is to evaluate whether or not an MRI technique (quantitative magnetization transfer or qMT) in narrowing human kidneys is feasible, reproducible, and predicts recovery.
- Trial name
- NCT04508049
- Testing
- qMT-MRI to detect fibrosis.
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Cirrhosis
A Study to Detect Advanced Liver Disease Via AI-enabled Electrocardiogram
The overall objectives of this study are to determine the effectiveness of ACE 2.0 model in early detection of advanced liver fibrosis, and to determine the acceptance and barriers for use of an AI-enabled algorithm for…
- Trial name
- ADVANCE (NCT05782283)
- Testing
- ACE (AI-Cirrhosis-ECG) 2.0
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Mayo Clinic
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)
Intravenous Ketamine for Treatment-Resistant Depression
The purpose of this study is to to evaluate the relationships between peak (% change from baseline) central GABA and Glu levels during a 40-min IV ketamine or normal saline infusion utilizing fMRS, and change in peripheral GABA…
- Trial name
- G2K (NCT06668571)
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Estrogen Receptor-Positive Breast Carcinoma, HER2-Negative Breast Carcinoma
Turkey Tail Mushroom for Treating Post-Menopausal Women With HER2-Negative ER-Positive Breast Cancer Undergoing Surgery
This phase II trial tests how well turkey tail mushroom (TTM) works in treating post-menopausal women with HER2-negative, estrogen receptor (ER)-positive breast cancer undergoing surgery. TTM is a common mushroom.
- Trial name
- NCT06450873
- Testing
- Coriolus Versicolor Extract, Questionnaire Administration
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Cancer, Cancer Gene Mutation
INTERogating Cancer for Etiology, Prevention and Therapy Navigation
This study is being done to identify markers and causes of cancer by analyzing patient's DNA (i.e., genetic material), RNA, plasma, tissues, or other samples that could be informative for patients with cancer.
- Conditions
- Cancer, Cancer Gene Mutation, PAN Gene Mutation, Hematopoietic and Lymphoid System Neoplasm
- Trial name
- INTERCEPTioN (NCT06008392)
- Testing
- Pan-genomic Testing
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Rehabilitation Exercise
Evaluating the Efficacy of a "Quiet Knee Protocol" in Primary Total Knee Arthroplasty (TKA): A Prospective Randomized Study
The goal of this randomized clinical trial is to access the following: 1. Compare the effectiveness of the QKP versus a standard rehabilitation protocol in improving postoperative pain control, ROM, and functional recovery…
- Trial name
- QKP (NCT07879014)
- Testing
- Quiet Knee Protocol, Post Operative Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Mayo Clinic
Major Depressive Disorder (MDD), Treatment Resistant Depression
EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
The purpose of this research is to see if an experimental treatment for depression called intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation (TMS) can be improved for better results using…
- Conditions
- Major Depressive Disorder (MDD), Treatment Resistant Depression, Major Depression
- Trial name
- CLEOPATRA (NCT07862205)
- Testing
- MagVenture TMS Therapy System with Localite Navigation System and actiCHamp EEG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm
Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal, Gynecological, Breast, or Lung Cancer
This phase II trial tests how well fucoidan works in preventing chemotherapy-related fatigue compared to a placebo in patients with gastrointestinal (GI), gynecological (GYN), breast, or lung cancer.
- Conditions
- Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm, Breast Carcinoma, Lung Carcinoma
- Trial name
- NCT06855524
- Testing
- Biospecimen Collection, Oligo-fucoidan, Questionnaire Administration
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Estrogen Receptor-Positive Breast Carcinoma
Reishi Mushroom Extract for Fatigue and/or Arthralgias/Myalgias in Patients With Breast Cancer on Aromatase Inhibitors
This phase II trial tests how well Reishi mushroom extract works in treating fatigue and/or joint/muscle pain (arthralgias/myalgias) in patients with breast cancer on aromatase inhibitors.
- Trial name
- NCT06028022
- Testing
- Mushroom Extract, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 23 sites in United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Grid Radiation Therapy for the Treatment of Stage IV Non-Small Cell Lung Cancer
This phase II trial tests the safety and effectiveness of the combination of grid radiation therapy and standard of care (SOC) immunotherapy in treating patients with stage IV non-small lung cancer (NSCLC).
- Trial name
- NCT06660407
- Testing
- Biospecimen Collection, Computed Tomography, Immunotherapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Platinum-Resistant Lung Small Cell Carcinoma, Platinum-Sensitive Lung Small Cell Carcinoma
Durvalumab and Lurbinectedin for the Treatment of Relapsed or Refractory Small Cell Lung Cancer
This phase II trial studies the effects of durvalumab and lurbinectedin in treating patients with extensive stage small cell lung cancer that has come back (relapsed) or has not responded to previous treatment with chemotherapy…
- Conditions
- Platinum-Resistant Lung Small Cell Carcinoma, Platinum-Sensitive Lung Small Cell Carcinoma, Recurrent Extensive Stage Lung Small Cell Carcinoma, Refractory Extensive Stage Lung Small Cell Carcinoma
- Trial name
- NCT04607954
- Testing
- Durvalumab, Lurbinectedin
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Prostate Carcinoma
Evaluation of the Impact of Empty Versus Full Bladder in Patients With Prostate Cancer, RELIEF Trial
This clinical trial evaluates the effects of an empty bladder versus (vs.) a full bladder prior to undergoing a computed tomography (CT) simulation for radiation therapy in patients with prostate cancer.
- Trial name
- NCT06037863
- Testing
- Best Practice, Computed Tomography, Electronic Health Record Review
- Where
- 7 sites in United States
- Volunteers
- 168 people
- Sponsor
- Mayo Clinic
Lower Back Pain
Electronic Approach to the Human Massage Therapist
The purpose of this study is to gather information about patient experience receiving a massage through a robotic EMMA (Expert Manipulative Massage Automation) compared to receiving a massage from a massage therapist.
- Trial name
- NCT07040397
- Testing
- EMMA massage therapy, Clinical massage treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome
Comparison of Rimegepant and Placebo for Pain in IBS
The primary aim of this study is to evaluate the efficacy of rimegepant on abdominal pain scores in participants with non-constipation IBS.
- Trial name
- NCT06221111
- Testing
- Rimegepant 75 MG [Nurtec]
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Epilepsy
Acute Recording of Stereotyped High-Frequency Oscillations
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver…
- Trial name
- NCT05439655
- Testing
- Brain Interchange System
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Metastatic Pancreatic Carcinoma, Stage IV Pancreatic Cancer AJCC v8
Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis
This phase II trial studies the effects of hyperthermic intraperitoneal chemotherapy (HIPEC) in treating patients with pancreatic cancer that has spread to the internal abdominal area (peritoneal metastasis).
- Conditions
- Metastatic Pancreatic Carcinoma, Stage IV Pancreatic Cancer AJCC v8, Metastatic Malignant Neoplasm in the Peritoneum
- Trial name
- NCT04858009
- Testing
- Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Nab-paclitaxel
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Patient Satisfaction, Communication
Optimizing the Patient Experience Through Provider Coaching or Communication Intervention
Hypothesis: Clinicians who receive patient experience coaching or communication classes have improved patient satisfaction scores and improved clinician satisfaction.
- Trial name
- NCT06329557
- Testing
- Intervention 1
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Bladder Carcinoma
Bladder Bank (a Prospective Banking Study)
This study collects blood and urine samples from patients with bladder cancer to support the development of tests for early detection of bladder cancer.
- Trial name
- NCT06109857
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Mayo Clinic