Clinical trials: sponsored by Montefiore Medical Center
Heart Transplant Infection Prevention
MISP 60528 Pneumococcal Vaccination
This study aims to use two different blood tests (ELISA and OPA) to study response to pneumococcal vaccination administered as per standard guidelines in patients who are undergoing workup for heart transplant (whether or not…
- Trial name
- NCT04845945
- Testing
- PCV15
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Pain, Postoperative, Narcotic Use
Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery
The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption.
- Trial name
- NCT04791943
- Testing
- Melatonin 10 MG, Lactose pill
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Anesthesia, Block
Evaluating the Effectiveness of Bilateral ESPB in Addition to Standard Analgesia at Reducing Opioid Consumption
Study the benefits of a Erector Spinae nerve block for pain control and decrease narcotics usage after mammoplasty in an ambulatory setting
- Trial name
- NCT03954249
- Testing
- Erecto Spinae nerve block, Multimodal Analgesia
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Prostatic Neoplasms
Abiraterone With Discontinuation of Gonadotropin-Releasing Hormone Analogues in Metastatic Prostate Cancer
The goal of this study is to find out if patients with prostate cancer being treated with the medications abiraterone and prednisone can discontinue hormone injections (examples include leuprolide, goserelin, triptorelin and…
- Trial name
- NCT03565835
- Testing
- Abiraterone Acetate, Prednisone
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Montefiore Medical Center
Vascular Diseases
Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support
Contemporary left ventricular assist device (LVAD) therapy improves survival during advanced heart failure but vascular aging develops rapidly leading to major adverse events including stroke and bleeding in nearly half of…
- Trial name
- NCT06510322
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Pain, Postoperative
Preoperative Mindfulness: Minimally Invasive Hysterectomy
This is a randomized control trial investigating the effects of a preoperative mindfulness intervention on postoperative pain, quality of recovery and stress scores in women undergoing minimally invasive hysterectomy.
- Trial name
- NCT05157490
- Testing
- Mindfulness training
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Montefiore Medical Center
Parenting, Family Relations
Supporting Responsible Fatherhood Program (Fatherhood FIRE)
Montefiore Medical Center (in partnership with BronxWorks) is implementing a large-scope program to promote responsible fatherhood in the Bronx among low-income adult (18 years or older) fathers with non-custodial children (under…
- Conditions
- Parenting, Family Relations, Father-Child Relations
- Trial name
- FIRE (NCT05311592)
- Testing
- HERO Dads Program
- Where
- United States
- Volunteers
- 496 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Transthyretin Cardiac Amyloidosis, Transthyretin Amyloid Cardiomyopathy
Bronx Transthyretin Amyloid Cardiomyopathy Database
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a commonly undiagnosed and potentially fatal disease. Contemporary studies on this condition often underrepresent the female gender and diverse patient populations.
- Trial name
- NCT06257485
- Testing
- 99mTc-pyrophosphate Single Photon Emission Computed Tomography
- Where
- United States
- Volunteers
- 476 people
- Sponsor
- Montefiore Medical Center
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Venetoclax Plus Intensive Chemotherapy in AML and Advanced MDS
This is a Phase 1b, open-label study evaluating Venetoclax in combination with intensive induction and consolidation chemotherapy in previously untreated, adult patients with acute myeloid leukemia.
- Trial name
- Venetoclax AML (NCT05342584)
- Testing
- Venetoclax Oral Tablet, Daunorubicin, Cytarabine
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Montefiore Medical Center
Shock
Central Line Study
Two different techniques for placing a central venous catheter will be compared. The studyu team hypothesizes that clinicians randomized to the peripheral catheter technique will have higher first attempt success rates, fewer…
- Trial name
- NCT05534971
- Testing
- Central venous catheter insertion
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Montefiore Medical Center
Myelodysplastic Syndromes, Acute Myeloid Leukemia
Metabolically Optimized, Non-cytotoxic Low Dose Weekly Decitabine/Venetoclax in MDS and AML
Myeloid malignancies which include AML (acute myeloid leukemia) and MDS (myelodysplatic syndrome) are cancers of the bone marrow which lead to bone marrow failure.
- Conditions
- Myelodysplastic Syndromes, Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia
- Trial name
- NCT05184842
- Testing
- Venetoclax, Decitabine
- Where
- 3 sites in United States
- Volunteers
- 91 people
- Sponsor
- Montefiore Medical Center
Hidradenitis Suppurativa, Scarring
Efficacy and Tolerability of a Fractional Ablative Erbium Laser for Axillary Scarring for Hidradenitis Suppurativa Patients
Single center, open-label, baseline-controlled study evaluating the use of a Sciton fractionated ablative laser in the treatment of Hidradenitis Suppurativa (HS) scarring.
- Trial name
- NCT05470322
- Testing
- Er: YAG laser
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Orbital Edema, Orbital Ecchymosis
The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery
Tranexamic acid (TXA) is a synthetic reversible competitive inhibitor to plasminogen lysine receptor, which prevents plasmin formation and stabilizes the fibrin matrix, thus reducing bleeding.
- Trial name
- NCT06450392
- Testing
- Tranexamic acid injection, Tranexamic Acid in NaCl,Iso-Os 1,000 Mg/100 mL (10 Mg/mL) INTRAVEN INTRAVENOUS SOLUTION, PIGGYBACK (ML), normal saline - injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Montefiore Medical Center
Scarring Alopecia
Non-Ablative Laser to Treat Scarring Alopecia With Hair Follicle Gene Expression Analysis
The goal of this clinical trial is to evaluate the effectiveness of a non-ablative 1470 nm laser in treating scarring alopecia in adults.
- Trial name
- NCT06946550
- Testing
- 1470nm non-ablative fractional laser
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Opiate Addiction
Onsite Buprenorphine Treatment at Syringe Exchange Programs
This trial will recruit syringe exchange participants with opioid use disorder in New York City and test whether starting buprenorphine treatment at the syringe exchange program is more effective than referral to a community…
- Trial name
- O-BMT (NCT03150173)
- Testing
- Onsite treatment, Enhanced referral, Buprenorphine
- Where
- 3 sites in United States
- Volunteers
- 97 people
- Sponsor
- Montefiore Medical Center
Back Pain, Low
Duloxetine for LBP
This research study will help determine whether a medication called duloxetine can improve back pain. It is well documented that many participants who come to the ER with acute low back pain still have low back pain 3 months…
- Trial name
- NCT05851976
- Testing
- Naproxen, Duloxetine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Montefiore Medical Center
HIV Infections, Neuropathic Pain
Pain Inflammation and Cannabis in HIV
This study will examine how medical cannabis use affects neuropathic pain, inflammation and adverse events in people living with HIV (PLWH) with neuropathic pain.
- Conditions
- HIV Infections, Neuropathic Pain, Cannabis
- Trial name
- PITCH-E (NCT05554146)
- Testing
- Receipt of Coupon for High THC Soft-Gel Capsule, Receipt of Coupon for Equal THC and CBD Soft-Gel Capsule, Receipt of Coupon for High CBD Soft-Gel Capsule
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Montefiore Medical Center
Glaucoma
Pilocarpine Use After Kahook Goniotomy
The goal of this study is to determine whether using pilocarpine provides added benefit to the success of combined cataract + Kahook Dual Blade (KDB) surgery.
- Trial name
- PAACK (NCT03933631)
- Testing
- Pilocarpine, Prednisolone, Ofloxacin
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Montefiore Medical Center
Breast Cancer
TMEM-MRI: A Pilot Feasibility Study of MRI for Imaging of TMEM in Patients With Operable Breast Cancer
The aim of this study is to assess feasibility of a new imaging technology in the management of breast cancer - Tumor Microenvironment of Metastasis - Magnetic Resonance imaging (TMEM-MRI).
- Trial name
- TMEM-MRI (NCT03694756)
- Testing
- TMEM-MRI, FNA
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Montefiore Medical Center
PTSD
Post-Traumatic Stress Disorder Focused Psychodynamic Psychotherapy
This is a randomized controlled trial of Trauma-Focused Psychodynamic Psychotherapy (TFPP) in comparison with TAU (at the VA) in a 2:1 ratio in 75 Veterans with PTSD who have not responded to standard treatment at the VA.
- Trial name
- RCT of TFPP (NCT03755401)
- Testing
- TFPP, TAU
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Montefiore Medical Center