Clinical trials: sponsored by Murdoch Childrens Research Institute
Pneumococcal Vaccines
Trial of Pneumococcal Vaccine Schedules in Ho Chi Minh City, Vietnam
Pneumococcus is a group of bacteria that can cause pneumonia, meningitis and other diseases. These bacteria normally live in the nose of humans and are spread from person to person by touching or sneezing.
- Trial name
- NCT01953510
- Testing
- PCV10, PCV13
- Where
- Vietnam
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Hypoplastic Left Heart Syndrome, Heart Defects, Congenital
Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery
This study aims to evaluate the safety and feasibility of coronary infusion of autologous placental cord blood mononuclear cells during the Norwood heart operation in newborn hypoplastic left heart syndrome (HLHS) patients.
- Conditions
- Hypoplastic Left Heart Syndrome, Heart Defects, Congenital, Pediatric Disorder
- Trial name
- NCT03431480
- Testing
- Autologous Human Placental Cord Blood Mononuclear Cells
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Murdoch Childrens Research Institute
Invasive Pneumococcal Disease, Recurrent Isolated, 1, Invasive Pneumococcal Disease, Recurrent Isolated, 2
What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?
This is a multicentre prospective audit to determine the incidence of immunodeficiency in children with IPD. Aims and/or research question of the project 1.
- Conditions
- Invasive Pneumococcal Disease, Recurrent Isolated, 1, Invasive Pneumococcal Disease, Recurrent Isolated, 2, Invasive Pneumococcal Disease, Protection Against, Primary Immunodeficiency
- Trial name
- NCT03815357
- Testing
- Referral to Immunology
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Pediatric Cancer
CanMove: A Physical Activity Program for Children With Cancer
This study will evaluate a physical activity intervention for children during acute cancer treatment. The intervention aims to encourage children to participate in increased levels of physical activity and reduce the amount of…
- Trial name
- NCT04483362
- Testing
- Complex physical activity intervention
- Where
- Australia
- Volunteers
- 21 people
- Sponsor
- Murdoch Childrens Research Institute
Homeless Youth
Vaccination Coverage and Uptake in Young People Experiencing or at Risk of Homelessness
This retrospective audit will investigate if young people who are homeless or at risk of homelessness in Melbourne were up-to-date with routine childhood and adolescent vaccines on first encounter with a nurse-led primary health…
- Trial name
- NCT04864678
- Testing
- Referral to the Young People's Health Service immunisation nurse
- Where
- Australia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Sepsis, Infection
Improving Dosing of Vancomycin in Young Infants With Infections
Current dosing regimens for vancomycin result in many young infants not reaching the target level of vancomycin in the blood at steady state (when the blood is in equilibrium at 24-48 hours).The purpose of this study is to assess…
- Conditions
- Sepsis, Infection, Bacteremia
- Trial name
- VANCAPP (NCT04044703)
- Testing
- Vancomycin - model-based dosing regimen
- Where
- 4 sites in Australia
- Volunteers
- 44 people
- Sponsor
- Murdoch Childrens Research Institute
Cerebral Palsy
Stem Cells in Umbilical Blood Infusion for CP
This study will investigate the safety of single dose intravenous infusion of cord blood cells which were cryopreserved after the birth of a brother or sister to a child with cerebral palsy.
- Trial name
- SCUBI-CP (NCT03087110)
- Testing
- Matched sibling donor cord blood cell infusion
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Murdoch Childrens Research Institute
Preterm Infant, Motor Activity
Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age
Research question: The primary aim of this study is to compare the prevalence of motor impairment from birth to five years of age between children born <30 weeks and term-born controls, and to determine whether persistent…
- Conditions
- Preterm Infant, Motor Activity, Neurodevelopmental Disorders, Developmental Coordination Disorder
- Trial name
- VIBeS-2 (NCT03172104)
- Where
- Australia
- Volunteers
- 251 people
- Sponsor
- Murdoch Childrens Research Institute
Dermatitis, Atopic
Does Treatment With Montelukast Improve Symptoms of Atopic Dermatitis in Children?
An open-label (outcome assessor blinded) prospective crossover cohort study of children 6-16 years assessing effects of Montelukast on moderate to severe atopic dermatitis.
- Trial name
- NCT02534467
- Testing
- Montelukast
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Murdoch Childrens Research Institute
Sepsis, Infection
RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates
Babies aged 0 to 90 days with a suspected infection requiring treatment with vancomycin will be recruited. They will be randomised to receive vancomycin as an intermittent infusion (over 1 hour) or as a continuous infusion (over…
- Conditions
- Sepsis, Infection, Bacteremia
- Trial name
- NCT02210169
- Testing
- Continuous infusion of vancomycin
- Where
- 2 sites in Australia
- Volunteers
- 111 people
- Sponsor
- Murdoch Childrens Research Institute
Innate Immune Response
A Trial Investigating the Influence of BCG and Hepatitis B Immunisation at Birth on Neonatal Immune Responses: The Early Life Vaccines and Immunity Study
Neonatal morbidity and mortality from infectious diseases is of global concern. Childhood disease-specific immunisation is irrefutably linked to the decline in deaths from these targeted infections over the last century.
- Trial name
- ELVIS (NCT02444611)
- Testing
- BCG Vaccine, Hepatitis B Vaccine
- Where
- Australia
- Volunteers
- 185 people
- Sponsor
- Murdoch Childrens Research Institute
PRD (Paediatric Rheumatological Disease), IBD (Inflammatory Bowel Disease)
HPV Vaccination in Special Risk Groups: 5 Year Follow-up
In 2007-2009 the investigators conducted a study to determine the immunogenicity response to HPV vaccine in special risk patients known to be at increased risk of abnormal cervical cytology.
- Trial name
- NCT01896986
- Where
- Australia
- Volunteers
- 37 people
- Sponsor
- Murdoch Childrens Research Institute
Surgical Procedures, Operative
The T REX Pilot Study: a Study to Investigate the Use of an Alternative Anaesthetic in Infants.
Animal studies suggest general anaesthetics harm the developing brain. It is unclear if these findings are relevant to humans but the issue has become a major concern.
- Trial name
- NCT02353182
- Testing
- Dexmedetomidine, Remifentanil, Bupivacaine
- Where
- 6 sites in United States, Australia and 1 more
- Volunteers
- 60 people
- Sponsor
- Murdoch Childrens Research Institute
Hereditary Haemochromatosis
Mi-iron - Moderately Increased Iron - is Reducing Iron Overload Necessary?
Haemochromatosis is a preventable genetic iron overload disorder. Untreated, it can shorten life due mainly to liver cirrhosis and cancer. It can be prevented by blood donation to maintain normal iron levels.
- Trial name
- Mi-iron (NCT01631708)
- Testing
- Erythrocytapheresis, Plasmapheresis
- Where
- 3 sites in Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Cervical Cancer, Anogenital Warts
Evaluation of Long Term Immunity Following HPV Vaccination
In Fiji, cervical cancer is the second most frequent cancer and the highest cause of cancer mortality in women. In 2008/9, the Ministry of Health in Fiji accepted a donation of 110,000 doses of quadrivalent HPV vaccine, Gardasil®…
- Trial name
- NCT02276521
- Testing
- Cervarix®
- Where
- Fiji
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Dermatitis, Atopic
Wool Clothing for the Management of Childhood Atopic Dermatitis
The study is a sequentially recruited, cross-over-cohort, outpatient-based evaluation of the effectiveness of wool clothing, as compared to standard clothing, in reducing the severity of childhood atopic dermatitis over two…
- Trial name
- NCT02534428
- Testing
- wool clothing
- Volunteers
- 39 people
- Sponsor
- Murdoch Childrens Research Institute
Friedreich Ataxia
A Study of Resveratrol as Treatment for Friedreich Ataxia
The purpose of this study is to determine the effect of two doses of resveratrol taken for a 12 week period, on frataxin levels in individuals with Friedreich ataxia.
- Trial name
- NCT01339884
- Testing
- Resveratrol
- Where
- Australia
- Volunteers
- 27 people
- Sponsor
- Murdoch Childrens Research Institute
Cervical Cancer
Protecting Young Special Risk Females From Cervical Cancer Through Human Papilloma Virus (HPV) Vaccination
A research project is currently being undertaken looking at Human Papilloma Virus (HPV) vaccination in special risk groups. It aims to see if young women with a chronic illness respond well to the HPV vaccine or whether they may…
- Trial name
- HPV (NCT00964210)
- Testing
- Licensed quadrivalent HPV vaccine, Gardasil
- Where
- Australia
- Volunteers
- 240 people
- Sponsor
- Murdoch Childrens Research Institute