Clinical trials: sponsored by NYU Langone Health
Lung Transplant; Complications
CMV Immunity Monitoring in Lung Transplant Recipients
The purpose of this study is to determine the safety and feasibility of using a laboratory test to guide duration of antiviral prophylaxis with valganciclovir (medication used to prevent viral infections) after lung transplant.
- Trial name
- NCT05708755
- Testing
- Cytomegalovirus T Cell Immunity Panel (CMV-TCIP), Donor-Derived Cell-Free DNA (dd-cfDNA) Assay, Valganciclovir
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
COVID-19, SARS CoV 2 Infection
NIH RECOVER Tissue Pathology: Understanding the Long-Term Impact of COVID-19
The Post-Acute Sequelae of SARS-CoV-2 (PASC) Autopsy Study is a cross-sectional study designed to define and characterize the epidemiology, natural history, clinical spectrum, and underlying mechanisms of post-acute effects of…
- Trial name
- NCT05292274
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- NYU Langone Health
Alzheimer Disease
Locus-coeruleus Function in Normal Elderly and AD Risk
Growing evidence suggests that Alzheimer's disease (AD) pathological changes begin decades before clinical symptoms and tau abnormalities in the locus coeruleus (LC) can be observed since midlife.
- Trial name
- LEAD (NCT04403165)
- Testing
- Nocturnal polysomnography (NPSG), Lumbar Puncture (LP), PET-MR measurement with a norepinephrine transporter (NET)-selective radiotracer (S,S)-[11C]Omethylreboxetine ([11C]MRB)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
ER Positive, HER2 Positive Breast Cancer
Elacestrant in Advanced Triple Positive Breast Cancer
The purpose of this study to assess the safety and efficacy of elacestrant, a selective estrogen receptor degrader (SERD) and dual biologic therapy, trastuzumab and pertuzumab, in patients with triple-positive breast cancer with…
- Trial name
- NCT07612215
- Testing
- Elacestrant, Trastuzumab, Pertuzumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
High Blood Pressure
Behavioral Economics Trial To Enhance Regulation of Blood Pressure (BETTER-BP)
BETTER-BP (Behavioral Economics Trial To Enhance Regulation of Blood Pressure) is a phase II, single-center, prospective, pragmatic randomized clinical trial within the New York City Health and Hospitals (NYC-H+H) system and NYU…
- Trial name
- BETTER-BP (NCT04114669)
- Testing
- Control Condition, Regret Lottery
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- NYU Langone Health
Percutaneous Coronary Intervention, Valve Repair/Replacement
Cardiac Rehab Referral Nudges
Investigators will evaluate the effectiveness of two different EHR-embedded nudges to improve referral to cardiac rehabilitation.
- Conditions
- Percutaneous Coronary Intervention, Valve Repair/Replacement, Coronary Artery Bypass Grafting
- Trial name
- NCT07607522
- Testing
- EHR Nudges
- Where
- United States
- Volunteers
- 7,000 people
- Sponsor
- NYU Langone Health
Non Small Cell Lung Cancer
DRP-104 in Patients With NFE2L2/KEAP1-altered Non-Small Cell Lung Cancer
This is a Phase 2 Study of DRP-104, a Glutamine Antagonist, in Patients with NFE2L2/KEAP1-altered Non-Small Cell Lung Cancer following standard of care treatment with chemotherapy and immunotherapy.
- Trial name
- NCT07249372
- Testing
- DRP-104
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- NYU Langone Health
Anxiety
Exercise for Anxiety
90 sedentary adults with a primary anxiety disorder and high anxiety sensitivity will be randomized to either 8 weeks of 1) low intensity exercise, or 2) flexible titration to high intensity exercise (HIE).
- Trial name
- NCT04638946
- Testing
- Titration to high intensity exercise (T-HIE), Low intensity exercise prescription
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- NYU Langone Health
Heart Failure, Cardiogenic Shock
Oxygen Delivery Index (ODIN) Study
The objective of this study is to test the feasibility and efficacy of a novel, non-invasive electronic device to monitor the adequacy of tissue perfusion in patients with advanced heart failure or cardiogenic shock in the ICU.
- Trial name
- NCT07601828
- Testing
- Oxygen Delivery Index (ODIN) Device
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Spondyloarthritis, Inflammatory Bowel Diseases
Guselkumab for Overlap Inflammatory Bowel Disease and Spondyloarthritis
This is an observational study of a prospective cohort of guselkumab-initiating Crohn's Disease (CD) and Ulcerative Colitis (UC) patients to identify new or incident spondyloarthritis.
- Trial name
- GLOBE-SpA (NCT07602517)
- Testing
- Guselkumab
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- NYU Langone Health
Pancreatic Surgery
Salvaged Red Blood Cell Transfusion During Pancreatic Adenocarcinoma Operations
The purpose of this study is to prospectively study the safety of salvage red blood cell (sRBC) transfusion during pancreatic surgery. Primary Objective: 1.
- Trial name
- NCT07598357
- Testing
- The Fresenius Kabi C.A.T.S®plus Continuous AutoTransfusion System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Diabetes Mellitus, Non Insulin Dependent Diabetes Mellitus
ED Diabetes Screening and Outpatient Care - Aim 3
This goal of this NIH funded R01 study is to identify risk factors for not being able to follow-up for a new diagnosis of diabetes in the emergency department and improve linkage of these newly diagnosed patients to appropriate…
- Trial name
- NCT05899023
- Testing
- Telehealth Bridge Visits, Standard of Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Type 2 Diabetes
South Asians With Type 2 Diabetes at Risk for Depression
This study will adapt a community health worker (CHW)-led Type 2 diabetes (T2D) intervention to include mental health and digital components using a trauma informed care approach, and test the feasibility and acceptability of…
- Trial name
- NCT07219667
- Testing
- CHW-led T2D Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Solid Tumor, High-grade Glioma
Concurrent Azeliragon With Craniospinal Irradiation
Single institution study to assess the safety of concurrent Azeliragon with craniospinal irradiation (CSI) in patients with leptomeningeal metastasis from solid tumor malignancies and high-grade gliomas.
- Conditions
- Solid Tumor, High-grade Glioma, Leptomeningeal Metastasis
- Trial name
- NCT06724926
- Testing
- Azeliragon, CSI
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- NYU Langone Health
Preeclampsia Possible
Aspirin Dosing in Pregnancy
The purpose of this study is assess platelet phenotypes based on aspirin dosing in pregnant patients at risk for the development preeclampsia who are taking 81mg twice a day aspirin.
- Trial name
- NCT07525635
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Chronic Hepatitis b, Viremia
Adaptability of an Undetectable = Untransmissible Model for HBV
Persons with chronic hepatitis B (HBV) infection and active viremia are infectious and may transmit virus to others through blood/body fluid exposure.
- Trial name
- NCT07449091
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pediatric ALL, Vaccination
Pediatric Vaccinations
As the Covid-19 pandemic hit New York City in the spring of 2020, many families were home-bound due to the city-wide lockdown. As a result, families in New York City were unable to attend their child's healthcare appointments and…
- Conditions
- Pediatric ALL, Vaccination, Immunization
- Trial name
- NCT04936776
- Testing
- Text messaging
- Where
- United States
- Volunteers
- 1,034 people
- Sponsor
- NYU Langone Health
BRCA-Mutated Ovarian Carcinoma, BRIP1 Gene Mutation
Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome
Identification of BRCA mutations in ovarian cancer patients may help guide cancer therapies, prognosis, post-operative screening, and other preventative treatments beyond the initial diagnosis.
- Conditions
- BRCA-Mutated Ovarian Carcinoma, BRIP1 Gene Mutation, MSH2 A636P, MLH1 Gene Mutation
- Trial name
- NCT04009148
- Testing
- CASCADE genetic screening
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Ischemia and Non-obstructive Coronary Arteries
Vascular Endothelial Inflammation and Health Status In INOCA (VISION-INOCA)
The purpose of this study is to evaluate coronary artery and peripheral vein vascular endothelial profiles in patients with ischemia with non-obstructive coronary arteries (INOCA) who undergo coronary function testing (CFT).
- Trial name
- NCT07586241
- Testing
- Invasive coronary angiography, Coronary Artery Endothelial Cell Sampling, Fitbit
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- NYU Langone Health
PreDiabetes
Cleaner Air for Lower Cardiometabolic Risk
The purpose of this interventional sham-controlled pilot study is to study the effects of using portable air cleaners (PACs) in outpatient adults with prediabetes.
- Trial name
- NCT05994937
- Testing
- PAC with HEPA filter intact, PAC with HEPA filter removed
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
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