Clinical trials: sponsored by NYU Langone Health
Myocardial Injury After Noncardiac Surgery
Post-Operative Biomarker-Guided Precision Medicine For Cardiovascular Risk Reduction
The goal of this pilot study is to assess enrollment feasibility of a randomized trial of direct oral anticoagulant and high-intensity statin therapy versus usual care in patients with Myocardial Injury after Noncardiac Surgery…
- Trial name
- NCT06961630
- Testing
- Rivaroxaban, Atorvastatin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Myocardial Infarction
Women's Heart Attack Research Program: Stress Ancillary Study
The Women's HARP study is a multi-center study focusing on women with clinical presentation of myocardial infarction (MI). Women will complete stress questionnaires following presentation to the medical center with elevated…
- Trial name
- HARP (NCT02914483)
- Testing
- Enhanced Usual Care, Stress Management, Actigraph
- Where
- 14 sites in United States, Canada
- Volunteers
- 153 people
- Sponsor
- NYU Langone Health
Medication Dosing Error
Working With Doctors and Pharmacists to Help Parents Give Children's Liquid Medicines Safely
The study objective is to assess the impact of an automated electronic health record (EHR)-based intervention that leverages e-prescriptions to support pharmacist adherence to recommended dispensing practices, with the goal of…
- Trial name
- NCT05146388
- Testing
- EHR-Based Approach
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Cardiac Arrythmias
Sparsity-based Magnetic Resonance Imaging of Cardiac Arrhythmias
The primary purpose of this study is to improve the quality of Magnetic Resonance Imaging in patients with heart arrhythmia. Investigators will recruit 105 patients with arrhythmia and 30 control volunteers over 3 years and will…
- Trial name
- NCT02741180
- Testing
- 3D Imaging, Late Gadolinium Enhancement (LGE)
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Post-Operative Pain, Total Knee Arthroplasty
The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty
The purpose of this study is to evaluate the efficacy of cryoablation use on patient-reported outcomes (PROMs) and opioid consumption following total knee arthroplasty.
- Trial name
- NCT06991231
- Testing
- Total knee arthroplasty (TKA), Cryoablation
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- NYU Langone Health
Treatment-resistant Schizophrenia
Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia
This pilot study aims to investigate the use of MRI-guided low-intensity focused ultrasound (LIFU) to modulate neuronal activity within the thalamus in human subjects with treatment-resistant schizophrenia.
- Trial name
- NCT05259306
- Testing
- Insightec Exablate Neuro MR-guided focused ultrasound transducer
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- NYU Langone Health
Distal Radius Fracture
Postoperative Immobilization and Physical Therapy Following Volar Locked Plating for Distal Radius Fractures
The purpose of this study is to see if splinting and formal physical therapy are necessary following surgical fixation (open reduction internal fixation) of distal radius fractures (broken wrist).
- Trial name
- NCT04324580
- Testing
- Splint, Formal Physical Therapy, Self directed physical therapy
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- NYU Langone Health
Anxiety Disorders
Biomarkers for Exercise
The overarching objective is to examine the brain-based biological mechanistic pathway by which exercise exerts anxiolytic effects.
- Trial name
- NCT07340281
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Leptomeningeal Metastasis
Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis
The purpose of this study is to confirm the safety and efficacy of linac based Volumetric Modulated Arc Therapy (VMAT) for craniospinal irradiation (CSI) in solid tumor cancer patients with leptomeningeal metastasis.
- Trial name
- NCT06984523
- Testing
- Varian Eclipse
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Alzheimer Disease, Sleep Apnea
Sleep Aging and Risk for Alzheimer's 2.0
Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly.
- Trial name
- SARA (NCT03278119)
- Testing
- PET Scan and nocturnal polysomnography
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Breast Cancer
Breast Cancer Implementation Science Study With Educational Intervention
A study uniquely focused on system-based practice change, measuring the impact of educational interventions on both patients and clinicians for the recognition and management of treatment-related adverse effects for HER2+/HER2…
- Trial name
- NCT06927895
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Post Partum Depression
ROSE in Sunset Park
The purpose of this study is to learn more about pregnant women's' experience with Reach Out, Stay Strong, Essentials for mothers of newborns (ROSE) and to evaluate the effectiveness of the ROSE program in preventing and reducing…
- Trial name
- NCT04940585
- Testing
- ROSE Program
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pancreatic Cancer
A Phase IB Study to Determine the Safety and Tolerability of Canakinumab and Tislelizumab in Combination With Nab-Paclitaxel and Gemcitabine in the Neo-adjuvant Treatment of Patients With Pancreatic Cancer
The goal of this Single Arm Phase Ib clinical trial is to test standard of care chemotherapy and anti PD1 and IL1b to evaluate the safety and preliminary toxicity of this quadruplet regimen prior to resection in patients with…
- Trial name
- NCT05984602
- Testing
- Canakinumab, Tislelizumab, Nab-Paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- NYU Langone Health
Depression, Anxiety
SilverCloud as a School-Based Intervention for Vulnerable Youth
The goal of this study is to test the efficacy and feasibility of a clinician-guided, app-based cognitive behavioral therapy (CBT) program, SilverCloud, as a school-based mental health intervention for vulnerable youth.
- Trial name
- NCT06004414
- Testing
- App-based Cognitive Behavioral Therapy (CBT), Psychotherapy
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Radiation Lymphedema, Radiation Fibrosis
Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients
Radiation fibrosis syndrome (RFS) is a general side effect of radiation therapy (RT) which can adversely impact patients chronically over years typically triggered by an acute inflammatory state that evolves into chronic…
- Conditions
- Radiation Lymphedema, Radiation Fibrosis, Head and Neck Cancer
- Trial name
- PBM-LEF (NCT06708754)
- Testing
- Photobiomodulation (PBM) Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Psoriasis
Multi-Center PAMPA Study
This is a multi-center (North-America), randomized, double-blind, placebo-controlled, wait-list, interventional, preventive trial of guselkumab in high-risk psoriasis patients compared to non-biologic standard of care.
- Trial name
- PAMPA (NCT05004727)
- Testing
- Guselkumab
- Where
- 5 sites in United States, Canada
- Volunteers
- 176 people
- Sponsor
- NYU Langone Health
Meniscus; Detachment, Current Injury
Effects of Contralateral Strength Training on Postoperative Strength Deficits in the Immobilized Lower Extremity
This is a prospective, randomized controlled trial that will enroll patients undergoing unilateral meniscal root repair or meniscus transplant.
- Trial name
- NCT03650374
- Testing
- Standard of Care Rehabilitation, Experimental Strength Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Knee Arthropathy
Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty
This study is a prospective double-blind randomized controlled trial to evaluate the effect of extended oral TXA after primary total TKA on short-term and mid-term postoperative outcomes, including function, pain, and…
- Trial name
- NCT07494032
- Testing
- Tranexamic acid (TXA)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- NYU Langone Health
Community-Centered Safety
Community Safety and Violence
This study will describe, estimate, and explore the effectiveness of community-centered safety models (CCSMs)-including co-response, alternative response, and community violence intervention modalities-implemented across U.S.
- Trial name
- NCT07494019
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Long COVID, Long Covid19
Understanding the Long-term Impact of COVID-19 in Adults
Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences.
- Trial name
- NCT07498504
- Where
- United States
- Volunteers
- 5,205 people
- Sponsor
- NYU Langone Health
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