Clinical trials: sponsored by NYU Langone Health
Femoral Shaft Fracture, Tibial Shaft Fracture
MAGIK for Femoral/Tibial Shaft Fractures
The purpose of this phase 2 randomized control trial will be to evaluate the effect of glucose-insulin-potassium (GIK) therapy in the setting of lower extremity trauma to reduce short- and long-term muscle damage, acute…
- Trial name
- MAGIK (NCT05627479)
- Testing
- GIK solution, Isotonic Normal Saline Solution
- Where
- United States
- Sponsor
- NYU Langone Health
Lung Transplantation
Transplanting Lungs From Uncontrolled Donation After Circulatory Death
The study team developed an uncontrolled donation after circulatory death (uDCD) protocol that preserves lungs for just over 3 hours after death using positive end expiratory pressure (PEEP) and supplemental oxygen.
- Trial name
- NCT06327945
- Testing
- Lung uDCD Protocol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NYU Langone Health
Exercise
Pro-rEsolving and pRo-inflammatory reSPonses to Acute exhaustIve exeRcisE in Healthy Individuals
This is a study of the effects of acute, exhaustive exercise on pro-resolving and pro-inflammatory responses in healthy, trained and untrained adults.
- Trial name
- PERSPIRE (NCT05923125)
- Testing
- Graded-Intensity Treadmill Exercise Protocol
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Type2 Diabetes
i-Matter: Investigating an mHealth Texting Tool for Embedding Patient-reported Data Into Diabetes Management
This study will integrate a technology-based patient-reported outcome (PRO) system [herein MJS DIABETES] that incorporates patients' perspective of their disease and functional status into the management of type 2 diabetes (T2D)…
- Trial name
- NCT03652389
- Testing
- MJS Diabetes
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- NYU Langone Health
Type2 Diabetes
A Mobile Health Intervention to Reduce Diabetes Disparities in Chinese Americans
Chinese Americans are one of the fastest growing immigrant groups in the US, who suffer disproportionately high type 2 diabetes (T2D) burden and have poorly controlled T2D.
- Trial name
- NCT03557697
- Testing
- Standard of Care, SMS Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Osteoarthritis, Osteo Arthritis Knee
Colchicine for the Treatment of Osteoarthritis of the Knee
This prospective, double-blinded, placebo-controlled, randomized trial will enroll 120 SKOA subjects at the NYU Center for Musculoskeletal Care.
- Trial name
- CLOAK (NCT03913442)
- Testing
- Colchicine 0.8 mg or 0.6 mg orally once daily
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Type 2 Diabetes Mellitus
Targeting Hyaluronan Accumulation Through Exercise in T2DM
A pilot longitudinal study to examine hyaluronan (HA) accumulation in muscles of individuals with Type 2 diabetes mellitus (T2DM), and the effects of exercise on HA accumulation, muscle stiffness, strength, ankle joint mobility…
- Trial name
- NCT04383314
- Testing
- 10-week exercise program on HA accumulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Keratoconus, Glaucoma
Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus
The mechanism by which vision loss in glaucoma occurs is still unknown, but it is clear that increased Intraocular Pressure (IOP) is a major risk factor.
- Trial name
- NCT03560609
- Testing
- Ophthalmodynamometer, Goldmann applanation tonometer, Pentacam
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- NYU Langone Health
Breast Cancer
Phase II Study of Pembrolizumab and Nab-paclitaxel in HER-2 Negative Metastatic Breast Cancer
This is a single-arm open-label multi-cohort Phase II study evaluating the safety/tolerability and clinical activity of the combination of nab-paclitaxel and the antibody against programmed cell death 1 (PD-1), pembrolizumab, in…
- Trial name
- NCT02752685
- Testing
- Pembrolizumab, Nab-Paclitaxel
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- NYU Langone Health
Cultural Competency, Personal Reflection
Impact of Visual Arts Immersion
The purpose of this study is to enhance engagement, coping and self-reflection by attuning nurses to creative and observational skills drawn from a visual arts pedagogical framework.
- Trial name
- NCT05877976
- Testing
- Visual Arts Immersion
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Advanced Cancer, End Stage Organ Failure
Emergency Medicine Palliative Care Access
This is a two-arm, multi-site randomized controlled trial of 1,350 older adults (50+ years) with either advanced cancer (defined as metastatic solid tumor) or poor prognosis end-stage organ failure (New York Heart Association…
- Trial name
- EMPallA (NCT03325985)
- Testing
- Nurse-led telephonic case management, Facilitated,outpatient specialty palliative care
- Where
- 18 sites in United States
- Volunteers
- 1,606 people
- Sponsor
- NYU Langone Health
Seizures, Focal Epilepsy
Efficacy of Intersectional Short Pulse Stimulation for Terminating Seizures
This is a study which seeks to develop a novel therapeutic approach, Intersectional Short Pulse (ISP) stimulation for seizure termination.
- Trial name
- NCT04998123
- Testing
- SeizureStop Device
- Sponsor
- NYU Langone Health
Colorectal Cancer
Flatbush FHC Proactive Colorectal Cancer Screening and Navigation
The proposed study is a randomized controlled pilot trial designed to assess the effectiveness and acceptability of a proactive screening outreach program on colorectal cancer screening rates on eligible patients in the Flatbush…
- Trial name
- NCT05646355
- Testing
- Proactive CRC Screening Outreach, Usual Care
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hypertension
Scaling Community-Clinical Linkage Models to Address Diabetes and Hypertension Disparities in the Southeast United States
The purpose of this study is to work with primary care physicians and their staff, and with community health workers (CHWs) to improve diabetes and hypertension management, health behaviors and improve blood pressure for South…
- Trial name
- NCT04263311
- Testing
- CHW
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Distal Radius Fracture
Timing of Bridge Plate Removal and Distal Radius Fracture Outcomes
The purpose of this randomized control trial will be to determine whether the duration of bridge plate fixation of distal radius fractures can be reduced to 6-8 weeks without worsening of functional outcomes relative to the…
- Trial name
- TORPEDO (NCT05578612)
- Testing
- Dorsal Spanning Bridge Plate Fixation, Dorsal Spanning Bridge Plate Removal
- Where
- United States
- Sponsor
- NYU Langone Health
Cigarette Smoking, Addiction
Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder
Patients in addiction treatment have exceptionally higher rate of cigarette smoking and very low quit rates compared to the general population.
- Conditions
- Cigarette Smoking, Addiction, E Cig Use
- Trial name
- NCT04063267
- Testing
- E cigarettes, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Nicotine Addiction
Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS
This is a research study to understand and determine the effectiveness of electronic cigarettes versus nicotine replacement therapy in adults who smoke and also live with HIV/AIDS in effort to reduce cigarette smoking.
- Trial name
- NCT04218708
- Testing
- Nicotine patch and gum, Minnesota Nicotine Withdrawal Scale (MNWS), ASSIST (the Alcohol, Smoking and Substance Involvement Screening)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- NYU Langone Health
Dementia
The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL)
The Aliviado Dementia Care Program (formerly known as the Dementia Symptom Management at Home Program, or DSM-H) was developed to implement dementia friendly care for persons with Dementia and their caregivers living in the…
- Trial name
- NCT04175977
- Testing
- Aliviado Dementia Care-Hospice Edition QAPI program, Usual Care
- Where
- United States
- Volunteers
- 44,143 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Migraine
NYU Langone Health Headache Center Learning Migraine Self-Management Techniques Study
The investigators aim to determine the feasibility of a migraine self-management program.
- Trial name
- NCT06077812
- Testing
- RELAXaHEAD Smartphone App, In-Person Training, Virtual Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Tendonitis
Pecs II Block Versus Surgeon Infiltration for Open Subpectoral Biceps Tenodesis
A phase IV, randomized, single-blind, single-center study measuring the effects of Pecs II block with 0.25% bupivacaine versus surgeon infiltration with 0.25% bupivacaine on postoperative pain control and opioid utilization in…
- Trial name
- NCT04867369
- Testing
- Bupivacaine 20mL 0.5%, Bupivacaine 20mL 0.25%, Bupivacaine up to 15mL 0.25%
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- NYU Langone Health
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