Clinical trials: sponsored by NYU Langone Health
Alzheimer Disease
Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD
Aging is the primary risk factor in aging-related dementia. An important initiating factor for the development and progression of cognitive impairment is disruption of the blood-brain barrier (BBB).
- Trial name
- NCT03389698
- Testing
- GRASP Dynamic Contrast-Enhanced (DCE) MRI, 3T Brain Scan, Gadolinium-based Contrast Agent (GBCA) for MRI
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Dementia
Dementia Symptom Management at Home Program
Alzheimer's Disease and Related Disorders (dementia) poses a significant challenge to our public health. While many persons with dementia are cared for by friends and family in the community with the assistance of home…
- Trial name
- NCT03255967
- Testing
- DSM-H, Standard of Care
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- NYU Langone Health
Obesity
Using Online Food Retail "Nudges" to Promote Healthier Beverage Intake Among Low-Income Children
The specific aims of this proposal are to 1) develop online food retail nudges to discourage sugary drink purchases and promote healthier substitutes; 2) examine the impact of online store nudges on purchases of sugary drinks in…
- Trial name
- NCT06222541
- Testing
- "Nudges" in Web-Based Supermarket
- Where
- United States
- Volunteers
- 2,241 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Lung Transplant
Envarsus XR in Lung Transplant
Patients undergoing a lung transplant will be enrolled. All patients will undergo lung transplantation with standard post-operative management, including triple immunosuppression.
- Trial name
- NCT04420195
- Testing
- Extended-Release Tacrolimus, Immediate-Release Tacrolimus
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis
At-Home Gait Assessment
The goal of this study is to validate an MS Gait Remote Capture and Analysis (MS-GRCA) system based on wearable shoe-based motion sensors for home-based and repeatable gait assessments.
- Trial name
- NCT05724901
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Multiple Sclerosis
Assessment of tDCS-Induced Neuronal Responses in Multiple Sclerosis (MS) With Advanced MRI
The objective of this trial is to measure the changes in neural activities during tDCS session using Magnetic Resonance Imaging (MRI). Participants (N=60) (20 Healthy Controls and 40 participants with neurological disorders, ie.
- Trial name
- NCT03564496
- Testing
- tDCS Administration during MRI, Remotely-supervised Daily tDCS Administration, Optional 15 minutes of imaging + simultaneous tDCS up to 4.0mA
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Arthritis
Autologous Intra-Articular Micro-Fragmented Adipose Transfer for the Treatment of Thumb Carpometacarpal Joint Arthritis
32 patients with Eaton-Glickel stage 2-3 CMC arthritis will be randomized to receive intraarticular MFAT or intraarticular corticosteroid injection.
- Trial name
- NCT05005000
- Testing
- Micro-Fragmented Adipose Tissue (MFAT), Triamcinolone Acetonide 10mg/mL
- Where
- United States
- Sponsor
- NYU Langone Health
Mental Health
Making Resident Well-Being a (Virtual) Reality
This study is a prospective cross-over trial examining the effect of virtual reality assisted meditation on resident reported well-being using validated scoring systems.
- Trial name
- NCT05395221
- Testing
- Guided Mediation Virtual Reality App
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Depression
A Pilot Study of the Immediate Effects of DLPFC tDCS on Attention Bias in Depression
Depression and other psychiatric conditions are marked by exaggerated, preferential processing (or attention bias) of negative information relative to neutral or positive information.
- Trial name
- NCT05188248
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- NYU Langone Health
Migraine, Headache
RELAXaHEAD for Headache Patients (Phase II)
The goal of this research is to assess the utility of smartphone-based progressive muscle relaxation (PMR) for the treatment of migraine and sleep.
- Conditions
- Migraine, Headache, Multiple Sclerosis, Insomnia
- Trial name
- NCT05466682
- Testing
- Smartphone-Based Progressive Muscle Relaxation Therapy (PMR), Monitored Usual Care (MUC)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- NYU Langone Health
Calcific Tendinitis
Calcific Tendonitis Treatment: Barbotage vs. Barbotage With Cortisone Injection
The purpose of this study is to determine the efficacy of barbotage therapy by comparing the clinical and sonographic changes in patients that solely receive barbotage to patients receiving the standard of care, barbotage with…
- Trial name
- NCT04126278
- Testing
- Barbotage, Dexamethasone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis
TRPMS to Improve Mobility and Depression in Multiple Sclerosis
This study is aimed to test the efficacy of 10 sessions of Transcranial Rotating Permanent Magnetic Stimulation (TRPMS) paired with aerobic exercise or computerized cognitive training (CT) on mobility and depression symptoms in…
- Trial name
- NCT04578041
- Testing
- TRPMS (Transcranial Rotating Permanent Magnet Stimulation), Aerobic Exercise Program, Computerized CT (Cognitive Training)
- Sponsor
- NYU Langone Health
Peripheral Artery Disease
Directional Versus Orbital Atherectomy Plaque Modification and Luminal Area Assessment of the Femoro-popliteal Artery Via Intravascular Ultrasound
This single center prospective, randomized study will be conducted to investigate plaque removal and luminal gain using CSI's DIAMONDBACK 360® Peripheral Orbital Atherectomy System (OAS) (St.Paul, MN) versus Medtronic's Hawkone…
- Trial name
- NCT03495453
- Testing
- Percutaneous Revascularization of the Femoropopliteal Arteries using a DAS, Percutaneous Revascularization of the Femoropopliteal Arteries using a OAS device
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- NYU Langone Health
Breast Cancer
Trial of Nivolumab With Chemotherapy as Neoadjuvant Treatment in Inflammatory Breast Cancer (IBC)
Study of efficacy of nivolumab with neoadjuvant chemotherapy in patients with IBC
- Trial name
- NCT03742986
- Testing
- Nivolumab 360mg, Paclitaxel 80mg/m^2, Doxorubicin 60mg/m^2
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- NYU Langone Health
Prostate Cancer
A Parallel Arm Phase 1b/2a Study of DKN-01 as Monotherapy or in Combination With Docetaxel for the Treatment of Advanced Prostate Cancer With Elevated DKK1
This is a non-randomized multi-center Phase 1b/2a dose escalation and dose expansion study testing DKN-01 as monotherapy or in combination with docetaxel in metastatic castration-resistant prostate cancer.
- Trial name
- NCT03837353
- Testing
- DKN-01, Docetaxel
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- NYU Langone Health
Attention Deficit Hyper Activity
Process-instructed Self Neuro-Modulation (PRISM) for Attention Deficit/ Hyperactivity Disorder - Adults
This is a single-arm, open-label feasibility study. Participants will be assigned and will undergo a novel neurofeedback intervention, targeting down-regulation of deep limbic structures, specifically the amygdalae.
- Trial name
- NCT04640766
- Testing
- PRISM
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- NYU Langone Health
Parenting
Video Interaction Project in Brazil
Early exposure to poverty is associated with adverse impacts on long-term educational achievement. Support of positive parenting is a key strategy to prevent emergence of socioeconomic disparities in child development.
- Trial name
- NCT05198739
- Testing
- Video Interaction Project (VIP) program
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Arthrofibrosis
Losartan Use to Mitigate Arthrofibrosis Following Total Join Arthroplasty
Recent research has focused on methods to mitigate scar tissue formation and arthrofibrosis following surgery in hopes that patients may attain maximal range of motion goals, avoid manipulation and secondary surgery (i.e.
- Trial name
- NCT05157464
- Testing
- Losartan
- Where
- United States
- Sponsor
- NYU Langone Health
Cardiac Arrhythmia
Measuring Hydration Levels of Healthy and Heart Failure Patients Before, During, and After an Electrophysiology (EP) Procedure
Subjects will be consented to wear the AleriTM sensor prior to, during, and after an Electrophysiology Procedure. During this time, the system will measure the following parameters from subjects: HR, temperature, saline…
- Trial name
- NCT04609683
- Testing
- AleriTM sensors
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- NYU Langone Health
Eponychial Stent, Nail Bed Injury
Eponychial Stent Study
The study design is a prospective, randomized, controlled trial evaluating the cosmetic and functional outcomes of nail bed repairs with and without eponychial stents.
- Trial name
- NCT04409093
- Testing
- Nail bed repair with eponychial sent, Nail bed repair without eponychial stent
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- NYU Langone Health
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