Clinical trials: sponsored by NYU Langone Health
MGMT-unmethylated Glioblastoma (GBM), GBM
Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma
This is a single arm, open-label, phase II trial of nivolumab, ipilimumab and short-course radiation therapy in adult patients with newly diagnosed, MGMT unmethylated GBM with the primary objective of determining the overall…
- Trial name
- NCT03367715
- Testing
- Nivolumab, Ipilimumab, Radiation Therapy (RT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
ACL Injury
TeleRehabilitation Following ACL Reconstruction
Telerehabilitation is a form of tele-treatment in which rehabilitation services are dispensed at patients' home utilizing video telecommunication services with real-time synchronous exchange of information.
- Trial name
- NCT04541940
- Testing
- Telerehabilitation Therapy, In-person Rehabilitation Therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health
Glioblastoma
Avelumab With Hypofractionated Radiation Therapy in Adults With Isocitrate Dehydrogenase (IDH) Mutant Glioblastoma
The purpose of this study is to test how safe and effective treatment with the combination of Avelumab and radiation is for IDH mutant gliomas that have transformed to glioblastoma after chemotherapy.
- Trial name
- NCT02968940
- Testing
- Avelumab, Hypofractionated radiation therapy (HFRT)
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Intervertebral Disc Disorders With Radiculopathy, Lumbar Region
The Effects of Perioperative Nutritional Optimization on Blood Markers
The purpose of this study is to see if taking an oral nutrition supplement (Ensure Nutrition Shake) before and after lumbar spine surgery affects blood tests related the nutritional status of patients.
- Trial name
- NCT04464161
- Testing
- Ensure
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Crush Injury
Use of Hyperbaric Oxygen Therapy for the Treatment of Crush Injuries
The purpose of this study is to determine whether using hyperbaric oxygen (HBO) improves wound healing for patients who have a crush injury.
- Trial name
- NCT04049721
- Testing
- HBO, Standard of Care
- Where
- United States
- Sponsor
- NYU Langone Health
COVID-19
A Randomized Placebo-controlled Safety and Dose-finding Study for the Use of the IL-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection
In this study invetigators propose to administer clazakizumab to patients with life-threatening COVID-19 infection manifest by pulmonary failure and a clinical picture consistent with a cytokine storm syndrome.
- Trial name
- NCT04343989
- Testing
- Clazakizumab 25 mg, Clazakizumab 12.5 mg
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- NYU Langone Health
Spinal Stenosis, Scoliosis
Effects of a Spine Navigation System on Op-time and Radiation Exposure
The goal of this study is to prospectively collect information about the operative time and intraoperative radiation experienced by patients undergoing posterior spinal fusion procedures guided by the MvIGS spine navigation…
- Conditions
- Spinal Stenosis, Scoliosis, Spondylolisthesis
- Trial name
- NCT04461964
- Testing
- Machine-vision Image Guided Surgery (MvIGS) spine navigation system.
- Sponsor
- NYU Langone Health
Diabetes Mellitus
Integrating Community Health Workers to Improve Diabetes Prevention
Cluster randomized trial to test the impact of peer health coaches on prediabetic patients. This study will test a scalable model of peer health coaching to address the millions of patients at risk for Diabetes Mellitus, using…
- Trial name
- NCT03006666
- Testing
- CHW Training, Data Only
- Where
- United States
- Volunteers
- 773 people
- Sponsor
- NYU Langone Health
Coronary Artery Disease
Anti-inflammatory Effects of Colchicine in PCI
Peri-procedural inflammation is associated with increased rates of post-procedural myocardial infarction (MI), which occur in up to 35% of PCI patients and are themselves associated with increased risk of later MI and death.
- Trial name
- NCT01709981
- Testing
- Colchicine
- Where
- 3 sites in United States
- Volunteers
- 280 people
- Sponsor
- NYU Langone Health
Alcohol Dependence, Alcohol Use Disorder
Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users
Our primary aim is to assess the feasibility of initiating treatment in the ED with extended-release naltrexone (XR-NTX) plus care management (CM) vs.
- Trial name
- NCT02445339
- Testing
- XR-NTX+CM (Extended-Release Naltrexone plus Care Management)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Addiction
Leveraging Technology to Address Unhealthy Drug Use in Primary Care Settings
This study will develop a clinical decision support tool that assists primary care providers in carrying out substance use interventions, and then compare (in Phase 2) two clinical scenarios, screening only (SO) vs.
- Trial name
- NCT02893514
- Testing
- Screening Only (SO) condition, SUSIT Condition
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Osteoarthritis
Antimicrobial Barrier Dressing Versus Closed-incision Negative Pressure Therapy in the Obese Primary Total Joint Arthroplasty
The purpose of this study is to determine whether an occlusive antimicrobial barrier dressing or portable negative pressure wound dressing is superior in preventing wound complications and infection rates in obese patients…
- Trial name
- NCT03345771
- Testing
- Antimicrobial Barrier Dressing, Negative Pressure Wound Therapy (NPWT)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- NYU Langone Health
COVID-19
Treating COVID-19 With Hydroxychloroquine (TEACH)
Treatments for COVID-19 are urgently needed. Hydroxychloroquine (HCQ) is an antimalarial and immunomodulatory agent being repurposed for COVID-19 therapy based off in vitro data suggesting a possible antiviral effect.
- Trial name
- NCT04369742
- Testing
- Hydroxychloroquine (HCQ)
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- NYU Langone Health
Obesity
Effects of a Three-Month Low Calorie Diet Weight Loss Intervention on Knee Replacement Outcomes
Total Knee Replacement (TKR) significantly improves function, pain, and overall quality of life in patients with end-stage arthritis of the knee.
- Trial name
- NCT04015011
- Testing
- LCD Intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- NYU Langone Health
First Episode Psychosis (FEP)
Use of Parent Connectors in First Episode Psychosis (FEP)
This study proposes to adapt an evidence based peer parent navigator (PPN) intervention, called Parent Connectors, in which trained and supervised PPNs deliver weekly telephone-based support for six to nine months to parents or…
- Trial name
- NCT04018521
- Testing
- PPN, CSC Usual Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Healthy
Technical Development of up to 7T Magnetic Field Strength
The objective of this study is to determine whether these new image acquisition strategies and techniques using of up to 7T can produce meaningful structural and physiological information that can serve to improve our…
- Trial name
- NCT02666638
- Testing
- Control Volunteers, Clinical Volunteers
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Esophageal Squamous Cell Carcinoma
Immune Checkpoint Therapy With Nivolumab Esophageal Squamous Cell Carcinoma
In this multi-institution phase I/II trial, the investigators have chosen paclitaxel and carboplatin using a schedule and doses identical to those used in the CROSS trial.
- Trial name
- NCT03278626
- Testing
- Nivolimumab+Carboplatin/paclitaxel+Radiation
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- NYU Langone Health
Social Emotional Competence
Teachers Thriving Together
This is a randomized, controlled, hybrid implementation-effectiveness design.whose primary aim is to examine the impact of ParentCorps plus Thrive Professional Learning, relative to Thrive Professional Learning and Inspire…
- Trial name
- NCT03980834
- Testing
- ParentCorps FUNdamentals, ParentCorps 101 E-learning, Training
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Prostate Cancer
Comparative Analysis of Transperineal Versus Transrectal Approaches for MRI-Targeted Biopsy of the Prostate for the Detection and Characterization of Prostate Cancer
The purpose of this study is to investigate a transperineal biopsy approach (outside of the rectum) using MRI targeting to facilitate better access to the whole prostate gland and provide limited risk of infectious complications…
- Trial name
- NCT03366792
- Testing
- Artemis™ software system
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- NYU Langone Health
Obesity, DM
Lap-Band Surgery on Adolescents for Safety and Efficacy
This study is to demonstrate the safety and efficacy of the use of the LAP-BAND surgery in the morbidly obese adolescent population.
- Trial name
- ALAGB (NCT00587301)
- Testing
- Lap-Band
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- NYU Langone Health
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