Clinical trials: sponsored by NYU Langone Health
Osteoarthritis
Reduction of Pro-Inflammatory Synovial Fluid Biomarkers in Osteoarthritis of the Knee With Alpha-2 Macroglobulin
The purpose of the current study is to assess the ability of alpha-2-macroglobulin treatment to reduce the level of pro-inflammatory synovial fluid biomarkers in patients with osteoarthritis of the knee.
- Trial name
- NCT03656575
- Testing
- synovial fluid biomarker concentrations
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- NYU Langone Health
Physical Medicine
Association Between Inpatient Steps Per Day and Patient Functional Status/Disposition
This study will incorporate the use of wearable actigraphy devices (Fitbit) on research participants admitted to medicine inpatient units at Tisch Hospital and/or NYU Brooklyn.
- Trial name
- NCT03595605
- Testing
- Ambulation, Standard of Care
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- NYU Langone Health
Schizophrenia
Imaging Dopamine D2 Agonist Binding Sites in Schizophrenia
The goals of this study is to determine (1) if differences in D2/3 receptor affinity states exist between medication-free subjects with SCH (MF-S) compared with healthy controls (HC), (2) the degree to which pre- and…
- Trial name
- NCT03999190
- Testing
- NPA radiotracer, Raclopride radiotracer, Dextroamphetamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Finger Injuries, Amputation, Traumatic
A Comparison of the Outcomes of Distal Fingertip Amputations Treated With Either Artificial (Xeroform) or Biological Dressings
This is a prospective study looking to evaluate whether the treatment outcomes for patients who sustain a distal fingertip amputation are improved or no different when using biological dressings versus artificial dressings.
- Trial name
- NCT03968835
- Testing
- Bacitracin, Skin Graft
- Where
- United States
- Sponsor
- NYU Langone Health
Cochlear Implant, Cochlear Hearing Loss
Degree of Benefit From Low-Frequency Acoustic Amplification Using the Advanced Bionics Acoustic Earhook
The primary objective of this study is to obtain a greater understanding of the range in benefit from acoustic amplification combined with electric stimulation in cochlear implant recipients with low-frequency hearing who do not…
- Trial name
- NCT04041596
- Testing
- Advanced Bionics' Acoustic Earhook
- Where
- United States
- Sponsor
- NYU Langone Health
Patellofemoral Pain Syndrome
Blood Flow Restriction Therapy in Patellofemoral Pain Syndrome
The purpose of this study is to determine the efficacy of blood restriction therapy by comparing increase in muscle mass and strength in patients that receive blood restriction therapy to patients who receive a placebo.
- Trial name
- NCT03717532
- Testing
- Personalized Tourniquet System for Blood Flow Restriction
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- NYU Langone Health
COPD, Dyspnea
Making Sense of Dyspnea Assessment
Dyspnea, or uncomfortable labored breathing, is an important patient-reported outcome (PRO). It is the primary and most disabling symptom of chronic obstructive pulmonary disease (COPD).
- Trial name
- SODA (NCT02771262)
- Testing
- Pulmonary Rehabilitation
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- NYU Langone Health
Cancer, Hematological Malignancy
Dual PD-1 and JAK2 Inhibition in Hematological Malignancies
Pembrolizumab will have significant clinical activity in patients with Intermediate and high risk MF, advanced PV who have been resistant, failed or are intolerant to JAK2 inhibitor therapy and the activity may be enhanced in…
- Trial name
- NCT04016116
- Testing
- Pembrolizumab, Ruxolitinib
- Where
- United States
- Sponsor
- NYU Langone Health
Cardiac Disease, Pulmonary Disease
Cardiopulmonary Outpatient Rehabilitation Using Mobile Technology
This is a randomized controlled trial of the feasibility and utility of implementing a smartphone application (MVN) to maintain compliance with a Heart Healthy lifestyle after discharge from a cardiac outpatient rehabilitation…
- Conditions
- Cardiac Disease, Pulmonary Disease, Cardiopulmonary Disease
- Trial name
- NCT02671669
- Testing
- Usual Care, Movn application (MVN)
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- NYU Langone Health
Strep Throat, Pneumonia
Integrated Clinical Prediction Rules: Bringing Evidence to Diverse Primary Care Settings
The study is a randomized controlled trial, with an Intervention Group and a Control Group at the University of Utah (U of U) and University of Wisconsin (UW). BU serves as the primary award and coordinating institution.
- Trial name
- iCPR2 (NCT02534987)
- Testing
- iCPR2
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- NYU Langone Health
Melanoma
A Phase 1b Study of the Selective HDAC Inhibitor Mocetinostat in Combination With Ipilimumab and Nivolumab in Patients With Unresectable Stage III or Stage IV Melanoma
This is a Phase 1b, open-label, dose-escalation cohort study. The study will consist of a dose escalation assessment of the safety and tolerability of Mocetinostat administered concurrently in combination with ipilimumab and…
- Trial name
- NCT03565406
- Testing
- Mocetinostat Induction Phase + Ipilimumab + Nivolumab, Mocetinostat Maintenance Phase + Ipilimumab + Nivolumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- NYU Langone Health
Epilepsy
Adapting Project UPLIFT for Hispanic Patients With Epilepsy II
The purpose of this study is to adapt Project UPLIFT for Hispanic adults with epilepsy and depression. Project UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a home-based intervention that teaches…
- Trial name
- NCT03000725
- Testing
- Using Practice and Learning to Increase Favorable Thoughts, Usual Care
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Acne
The Comparative Efficacy of an Over the Counter Light Therapy Mask vs Over the Counter Topical Benzoyl Peroxide 2.5% and Used in Combination With Over the Counter Adapalene Gel 0.1% for Mild to Moderate Acne
This is a single-center prospective study of two standard-of-care treatments to evaluate the efficacy of the Neutrogena® Light Therapy Acne Mask an Over the Counter (OTC) Blue/Red light LED mask, as compared to the combination of…
- Trial name
- NCT03650881
- Testing
- Neutrogena ® Light Therapy Acne Mask (MASK), Topical OTC benzoyl peroxide 2.5% gel and OTC adapalene
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Melanoma
Study of CDX-3379, a Human Monoclonal Antibody Targeting ERBB3, in Combination With the MEK Inhibitor, Trametinib, in Patients With Advanced Stage NRAS Mutant and BRAF/NRAS Wildtype (WT) Melanoma
The main goal of this study is to test if it is safe and effective to give CDX-3379 together to treat advanced melanoma in patients with the NRAS mutation and BRAF/NRAS wildtype.
- Trial name
- NCT03580382
- Testing
- Trametinib daily Until PD, CDX-3379 (ERBB3 antibody)
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- NYU Langone Health
Mood Disorders, Anxiety Disorders
Anti-stigma Intervention for Chinese American Older Adults
Approximately 50 participants will be enrolled and screened to achieve 45 eligible patients with mood/anxiety disorders to complete a 10 weekly anti-stigma group intervention (ASGI) in addition to several self-report internalized…
- Trial name
- NCT03820297
- Testing
- 10 sessions of ASGI
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health
Hypertension
Project IMPACT: CHW Intervention
The proposed study "Project IMPACT: CHW Intervention" is part of a larger study examining the efficacy, adoption, and impact of integrated EHR-based decision-support and physician feedback interventions with community health…
- Trial name
- IMPACT (NCT03159533)
- Testing
- CHW Intervention, Wait List Control Group
- Where
- United States
- Volunteers
- 305 people
- Sponsor
- NYU Langone Health
Non-ischemic Cardiomyopathy
Development of an Evidenced-Based Tool for Prediction of Sudden Death in Patients With Non-Ischemic Cardiomyopathy
This study is an observational study to determine predictors of sudden cardiac death or appropriate ICD therapy in patients with non-ischemic cardiomyopathy.
- Trial name
- NICMR (NCT02657967)
- Where
- 3 sites in United States, Canada
- Volunteers
- 57 people
- Sponsor
- NYU Langone Health
Anxiety, Depression
Mindfulness for Breast Cancer
The primary purpose of this study is to evaluate the effects of Mindfulness Based Cognitive Therapy (MBCT) vs. Treatment as Usual (TAU) for depression and anxiety symptoms in breast cancer patients in recovery.
- Conditions
- Anxiety, Depression, Breast Cancer
- Trial name
- NCT02647216
- Testing
- Mindfulness Based Cognitive Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Sleep, Metabolic Syndrome
Extending Sleep to Reverse Metabolic Syndrome in Middle-aged Adults: Acceptability and Feasibility of a Sleep Intervention
This pilot study will test acceptability and feasibility of a sleep extension intervention in community dwelling, short sleeping, racially/ethnically diverse middle aged adults with Metabolic Syndrome (METs).
- Trial name
- NCT03599388
- Testing
- Self- management for adequate sleep intervention (SASI)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Screening Colonoscopy
Deep-Learning for Automatic Polyp Detection During Colonoscopy
The primary objective of this study is to examine the role of machine learning and computer aided diagnostics in automatic polyp detection and to determine whether a combination of colonoscopy and an automatic polyp detection…
- Trial name
- NCT03637712
- Testing
- Computer Algorithm
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- NYU Langone Health
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