Clinical trials: sponsored by NYU Langone Health
Blood Pressure
Reducing AIR Pollution Exposure to Lower Blood PRESSURE Among New York City Public Housing Residents
Fine particulate matter <2.5 µm (PM2.5) air pollution is the fifth leading risk factor for global mortality, with the largest portion of deaths due to cardiovascular disease (CVD).
- Trial name
- AirPressureNYC (NCT05874479)
- Testing
- Active PAC
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- NYU Langone Health
ACL Reconstruction (ACLR) With a Bone-patellar Tendon-bone (BPTB) Autograft
Cryoneurolysis in Anterior Cruciate Ligament Reconstruction (ACLR)
The purpose of this research study is to assess whether cryoneurolysis will help control pain after ACLR surgery and decrease the need of opioid medications.
- Trial name
- NCT07731178
- Testing
- Pacira Iovera Cryoneurolysis device
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Dry Eye Disease (DED)
TRYPTYR as a Treatment for Patients With Dry Eye Disease (DED)
The purpose of this research study is to determine the effectiveness of TRYPTYR as a treatment for Dry Eye Disease. The primary efficacy variable is change from baseline in the Ocular Surface Disease Index (OSDI) at week 2.
- Trial name
- NCT07732010
- Testing
- TRYPTYR (Acoltremon ophthalmic solution 0.003%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Cardiovascular Health
Community Engagement for Cardiovascular Health Promotion in Mothers (MomHeartHealth2.0)
This project will test the feasibility, acceptability, and preliminary effects of a tailored cardiovascular (CV) health promotion program, Mom♥Health2.0, leveraging childcare centers as platforms for maternal engagement.
- Trial name
- NCT07724821
- Testing
- Mom♥Health2.0
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Early-stage Breast Cancer, Invasive Ductal Carcinoma of Female Breast
Radiation After No Axillary Nodal Sampling
This is a single arm, pilot, prospective study to evaluate the safety of partial breast irradiation in women who undergo breast conserving surgery without sentinel lymph node biopsy (SLNB) or axillary lymph node dissection…
- Trial name
- RADIANS (NCT07723209)
- Testing
- Partial Breast Irradiation (PBI)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- NYU Langone Health
Mental Health Literacy, Depression, Anxiety
Promoting Mental Health of Teachers and Caregiver Using a Personalized mHealth Toolkit in Uganda
This study record describes a two-phase of clinical trial study. The first phase is a pilot study phase (to study feasibility and efficacy of the intervention), and the second phase is an effectiveness study phase (a fully…
- Trial name
- NCT06087159
- Testing
- mHealth Toolkit for Wellness & Empowering Lives of School Community (mWEL)
- Where
- 2 sites in Uganda
- Volunteers
- 1,180 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Mental Health
Testing Multi-level Scale-Up Strategies: Ugandan School System
The overall objective of the project is to address the school mental health evidence-based interventions (EBIs) scale-up and sustainability challenges in low-and-middle-income countries (LMICs) by studying "system level…
- Trial name
- NCT07466563
- Testing
- Mental Health Evidence-Based Interventions (EBIs)., EBI Support
- Where
- 2 sites in Uganda
- Volunteers
- 1,536 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Children With Medical Complexity (CMC)
A Multi-Phase Study Examining Hospital to Home Transitions for Children With Medical Complexity
The overarching objective of this study is to make it easier for parents of children with medical complexity (CMC) to take care of their children after discharge home from the hospital and reduce the chance of…
- Trial name
- NCT04867395
- Testing
- HELPix Care Plan
- Where
- United States
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Ischemia, Reperfusion Injury
Goal-directed CPR Using Cerebral Oximetry
The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological targets to predict survival and…
- Trial name
- NCT04924985
- Testing
- Non-Physiological Feedback CPR, Physiological Feedback CPR
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- NYU Langone Health
Opioid-use Disorder, Substance Use Disorders
Coaching Performance Driven Practice Change in the Context of Value Based Purchasing Under New York Medicaid
This project will develop and test quality measures for and a facilitation model to help addictions treatment clinics increase use of medicines for opioid use disorders, retain clients longer in care, and help more people move…
- Trial name
- NCT04632238
- Testing
- Metrics-driven quality improvement (MDQI)
- Where
- 4 sites in United States
- Volunteers
- 7,950 people
- Sponsor
- NYU Langone Health
Hypertension
Optimizing Care For Management Of Hard To Control Hypertension In Low-Income Patients Across Family Health Centers In New York City
This study will develop and evaluate a multilevel implementation strategy to improve management of hard-to-control hypertension among low-income adults receiving care at the Family Health Centers at NYU Langone Health, a network…
- Trial name
- NCT07703423
- Testing
- Multilevel Hypertension Care Model
- Where
- United States
- Volunteers
- 628 people
- Sponsor
- NYU Langone Health
Mental Health
OurChild: A Health IT Solution to Reduce Minority Health Disparities
Chinese American immigrant families are a fast-growing immigrant group with unmet early childhood mental health needs. The team proposes to design, build, and implement OurChild, an integrated mHealth/EHR solution to increase…
- Trial name
- NCT04677647
- Testing
- OurChild mHealth Digital Platform
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Health Services Research
Person-Centered Quality Measurement and Management in a System for Addictions Treatment in New York State (Project 3)
The goal of this study is to implement Opioid Use Disorder Quality Measurement and Management (OUD-QM2) strategy by the Office of Addiction Services and Supports (OASAS) to drive change and improve treatment practices.
- Trial name
- NCT06408233
- Testing
- Performance Coaching
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Weight Loss
High-protein plUs reSistance Training in gLucagon-like pEptide 1 Receptor Agonist Users (HUSTLE)
The primary objective of this study is to examine the effects of a high-protein diet (HP) paired with resistance training (RT) compared with a HP diet alone, on skeletal muscle mass (SMM) volume of the (a) quadriceps and (b)…
- Trial name
- NCT07700030
- Testing
- High protein diet, Resistance Training (RT) Programs
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- NYU Langone Health
Bilateral Sensorineural Hearing Loss
Noise Reduction With Hearing Aids
The purpose of this study is to use an optimized version of the SEDA algorithm (SEDA-HA) for hearing aids to evaluate the benefit for listeners with varying degrees of hearing loss in realistic environments and evaluate its…
- Trial name
- NCT07700043
- Testing
- Speech Enhancement using Decomposition Approach-Hearing Aid (SEDA-HA) algorithm, Hearing aid (HA) prototype with SEDA-HA algorithm
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Generalized Anxiety Disorder
MBSR Mechanisms in GAD
The purpose of this study is to understand the neural mechanisms that drive response to MBSR compared to stress education in patients with generalized anxiety disorder (GAD), and to examine the degree to which sex differences in…
- Trial name
- NCT05064813
- Testing
- Mindfulness Based Stress Reduction MBSR Intervention, Stress Education Control Condition (SE)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- NYU Langone Health
Dementia
Paradoxical Lucidity in Severe End-Stage Dementia
Cognitive decline in dementia is considered irreversible, however episodes of paradoxical lucidity (PL) in severe dementia suggest other mechanisms may be in play.
- Trial name
- NCT05234866
- Where
- United States
- Volunteers
- 520 people
- Sponsor
- NYU Langone Health
Intraprostatic Prostate Cancer
Trial Evaluating the Safety and Efficacy Of MR-Linac-Guided Radiotherapy as Salvage Treatment After External Beam Radiotherapy Recurrence (TUMORNATOR II)
The purpose of this study is to assess the impact of prostate-specific membrane antigen/positron emission tomography (PSMA/PET)-informed magnetic resonance (MR)-guided radiation therapy on serious toxicity outcomes in patients…
- Trial name
- NCT07142967
- Testing
- Stereotactic Body Radiation Therapy (SBRT), Androgen Deprivation Therapy (ADT)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- NYU Langone Health
Rotator Cuff Tears
Optimal Dosing of IC-Green for Visualization of Rotator Cuff Vascularity Using Advanced Imaging Modality Arthroscopy
Rotator cuff re-tear is a common delayed complication of arthroscopic rotator cuff repair. This process of re-tear is multifactorial and there has not been any readily identifiable perioperative measure that is predictive of…
- Trial name
- NCT04340752
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Rheumatic Disease
Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty
The purpose of this study is to assess the incidence of rheumatologic flares, changes in pain scores (VAS), changes in functional outcomes (PROMIS), wound complications, surgical site infections, and return trips to the operating…
- Trial name
- NCT07138898
- Testing
- Methotrexate, Sulfasalazine, Hydroxychloroquine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- NYU Langone Health