Clinical trials: sponsored by Northwestern University
Kidney Calculi, Urologic Diseases
Tranexamic Acid to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)
This study is designed to assess if there is a significant difference in same day discharge rates after Holmium Laser Enucleation of the Prostate (HoLEP).
- Conditions
- Kidney Calculi, Urologic Diseases, Benign Prostatic Hypertrophy
- Trial name
- NCT05082142
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Northwestern University
Healthy
Effects of Tolvaptan in Healthy Adults
Tolvaptan is one of new class of medications approved for treatment of low blood sodium (hyponatremia). It works by interfering with the effect of the antidiuretic hormone, vasopressin, thereby increasing urine output and…
- Trial name
- NCT01973140
- Testing
- Tolvaptan, Hypertonic saline infusion
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Benign Prostatic Hyperplasia, Enlarged Prostate With Lower Urinary Tract Symptoms
Emsella for Reducing tSUI After HOLEP
This study aims to investigate the effectiveness of the Emsella chair treatments at different timepoints. Before and after the holmium laser enucleation of the prostate (HoLEP).
- Conditions
- Benign Prostatic Hyperplasia, Enlarged Prostate With Lower Urinary Tract Symptoms, Enlarged Prostate (BPH)
- Trial name
- NCT07580404
- Testing
- Emsella chair
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Arthritis, Psoriatic (PsA), Arthritis, Rheumatoid (RA)
Patient-Reported Outcomes Dashboard With Goal Setting to Support Shared Decision-Making in Inflammatory Arthritis
The goal of this clinical trial is to learn whether showing patient-reported symptoms and personal treatment goals to rheumatology clinicians on a dashboard in the electronic health record improves shared decision-making for…
- Trial name
- NCT07865390
- Testing
- Patient-Reported Outcomes Dashboard With Goal Setting
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Northwestern University
Ovary Cancer, Endometrial Cancer
Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy
Endometrial cancer is the most common gynecologic cancer and ovarian cancer is the most lethal. The management of both advanced cancers is a combination of chemotherapy and surgery.
- Conditions
- Ovary Cancer, Endometrial Cancer, Uterine Cancer
- Trial name
- FAST (NCT05990426)
- Testing
- FAST Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Contraception
Continuation of Subcutaneous and Intramuscular Depot Medroxyprogesterone Acetate in Post-abortion Patients
Multiple prior studies have compared self-administered Subcutaneous Depot Medroxyprogesterone Acetate(DMPA-SC) to both provider-administered DMPA-SC and Intramuscular Depot Medroxyprogesterone Acetate (DMPA-IM) and found that…
- Trial name
- NCT05505435
- Testing
- Depot-Medroxyprogestereone Acetate
- Where
- United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Enlarged Prostate (BPH), Benign Prostatic Hyperplasia
Moses 2.0 vs Magneto for HoLEP - a Randomized Controlled Trial
The objective of this study is to compare the Magneto 150 holmium laser to the current MOSES 2.0 technology to see if there is a benefit in decreased hemostasis time intraoperatively.
- Trial name
- NCT07632742
- Testing
- Magneto 150 holmium laser, Moses 2.0 holmium laser
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Lactation Suppressed, Second Trimester Abortion
Pharmacological Inhibition of Lactation After 16 to 20 Week Abortion
The goal of this clinical trial is to compare breast symptoms (lactation, engorgement, etc) of individuals who undergo a procedure for second trimester of pregnancy loss between 16 weeks and 20 weeks gestational age.
- Trial name
- NCT06123026
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cardiovascular Risk Factor
South Asian Healthy Lifestyle Initiative (SAHELI)
Research show that South Asians (SA) have a high burden of Cardiovascular Disease (CVD) risk factors of which, poor diet and physical inactivity remain the major lifestyle risk factors in SA.
- Trial name
- SAHELI (NCT03336255)
- Testing
- South Asian Healthy Lifestyle Initiative (SAHELI)
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Northwestern University
HIV
Combination Intervention to Enhance Treatment Engagement and Viral Suppression Among Sexual and Gender Minority Youth in Nigeria
The study will adapt and test a combination peer navigation and mHealth approach, Intensive Combination Approach to Rollback the Epidemic in Nigeria (iCARE Nigeria), to improve HIV treatment engagement, medication adherence and…
- Trial name
- NCT06190613
- Testing
- Combination Peer navigation and mHealth intervention
- Where
- Nigeria
- Volunteers
- 110 people
- Sponsor
- Northwestern University
Post-traumatic Stress Symptoms, Anxiety
Psychological Prehabilitation for Complex Gastrointestinal Surgery
The goal of this clinical trial is to learn if a psychological program before surgery can help adults who have lasting stress from past medical experiences. The program is called PREPARE-GI.
- Conditions
- Post-traumatic Stress Symptoms, Anxiety, Depression Disorder, Gastrointestinal Disease
- Trial name
- PREPARE-GI (NCT07865052)
- Testing
- PREPARE-GI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Metastatic Leiomyosarcoma, Unresectable Leiomyosarcoma
XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma
This phase II trial tests how well zanzalintinib (XL092) works in treating patients with leiomyosarcoma that has spread from where it first started to other places in the body (metastatic) or that cannot be removed by surgery…
- Conditions
- Metastatic Leiomyosarcoma, Unresectable Leiomyosarcoma, Bone Sarcoma, Translocation-associated Soft Tissue Sarcoma
- Trial name
- NCT06571734
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Northwestern University
Type I Achalasia, Type II Achalasia
PREcision MEDicine In Achalasia (PREMEDIA)
The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions.
- Conditions
- Type I Achalasia, Type II Achalasia, EGJ Outflow Obstruction Without Spastic/Hypercontractile Features
- Trial name
- PREMEDIA (NCT07293650)
- Testing
- Standard Myotomy, Tailored Short Myotomy
- Where
- 16 sites in United States
- Volunteers
- 372 people
- Sponsor
- Northwestern University
Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features
PREcision MEDicine In Achalasia (PREMEDIA) - Cohort
The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM) in patients with difficulty swallowing due to certain conditions.
- Conditions
- Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features, Jackhammer Esophagus, Distal Esophageal Spasm
- Trial name
- PREMEDIA (NCT07293689)
- Where
- 16 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Kidney Calculi, Kidney Diseases
Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure
Stone disease is a common condition, affecting approximately 9% of Americans in 2007. It causes great morbidity and is also a costly condition, estimated to cost the US healthcare system approximately 3.79 billion dollars in…
- Conditions
- Kidney Calculi, Kidney Diseases, Nephrolithiasis, Urolithiasis
- Trial name
- NCT05100017
- Testing
- Methocarbamol, Oxybutynin
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Northwestern University
Urinary Incontinence, Overactive Bladder Syndrome
Examining the Effects of Intra-detrusor Botox at Time of HoLEP in Men With Overactive Bladder Symptoms
The objective of our multi-center randomized single-blind study is to examine the safety and effect of intra-detrusor OnabotulinumtoxinA injections at the time of holium laser enucleation of the prostate (HoLEP) in men with…
- Conditions
- Urinary Incontinence, Overactive Bladder Syndrome, Overactive Bladder, Urologic Diseases
- Trial name
- NCT05878951
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Northwestern University
Castration-Sensitive Prostate Carcinoma, Metastatic Prostate Carcinoma
FDG-PET-Guided Metastasis Directed Radiation Therapy for the Treatment of Metastatic Hormone Sensitive Prostate Cancer, The PRTY Trial
This phase II trial compares the effect of FDG-positron emission tomography (PET)-guided metastasis directed radiation therapy (MDRT) in combination with standard treatments to standard treatments alone in treating patients with…
- Conditions
- Castration-Sensitive Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
- Trial name
- NCT06244004
- Testing
- Antiandrogen Therapy, Bone Scan, Computed Tomography
- Where
- 6 sites in United States
- Volunteers
- 125 people
- Sponsor
- Northwestern University
Ventral Hernia, Ventral Hernia Repair
Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release
This study is comparing two ways to manage pain after a major hernia repair surgery called "transversus abdominis release." One method uses an epidural, a small tube placed in the back that delivers pain medicine directly around…
- Conditions
- Ventral Hernia, Ventral Hernia Repair, Postoperative Pain
- Trial name
- EASE-TAR (NCT07840183)
- Testing
- Bupivicaine, Fentanyl, Thoracic epidural analgesia
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Metastatic Differentiated Thyroid Gland Carcinoma, Metastatic NUT Carcinoma
Enfortumab Vedotin for the Treatment of Unresectable or Metastatic Radioiodine Refractory Differentiated Thyroid Cancer, Anaplastic Thyroid Cancer, Medullary Thyroid Cancer, or NUT Carcinoma
This trial tests how well giving enfortumab vedotin works for the treatment of differentiated thyroid cancer that does not respond to treatment with radioiodine (refractory), anaplastic thyroid cancer, medullary thyroid cancer or…
- Conditions
- Metastatic Differentiated Thyroid Gland Carcinoma, Metastatic NUT Carcinoma, Metastatic Thyroid Gland Anaplastic Carcinoma, Metastatic Thyroid Gland Medullary Carcinoma
- Trial name
- NCT07863765
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Northwestern University
Inguinal Hernia Unilateral, Inguinal Hernia Bilateral
Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males
This is a prospective, single-center, two-arm Phase 1 safety and feasibility trial evaluating anti-estrogen therapy in men age 50 years and older with symptomatic unilateral inguinal hernias.
- Conditions
- Inguinal Hernia Unilateral, Inguinal Hernia Bilateral, Inguinal Hernia Without Obstruction or Gangrene, Inguinal Hernia, Without Mention of Obstruction or Gangrene
- Trial name
- RIGHT (NCT07604272)
- Testing
- Fulvestrant, Anastrozole (ARIMIDEX™)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University