Clinical trials: sponsored by Odense University Hospital
Adjustment Disorder With Work Inhibition
Neurobiological Effects of Work-related Adjustment Disorder
INTRODUCTION: Stress is one of the greatest burdens of our society and often imply impairments in cognitive and emotional functions.
- Trial name
- NeuroWAD (NCT03334045)
- Testing
- PET/MR scans
- Where
- Denmark
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Non-small Cell Lung Cancer Stage III, Radiotherapy Side Effect
Heterogeneously Hypofractionated Radiotherapy for Locally Advanced NSCLC
Aim To test if proton therapy can improve survival compared to photon therapy in patients with locally advanced NSCLC who are not candidates for standard definitive chemo-radiotherapy.
- Conditions
- Non-small Cell Lung Cancer Stage III, Radiotherapy Side Effect, Frailty
- Trial name
- HERAN2 (NCT05548504)
- Testing
- Photon, Proton
- Volunteers
- 182 people
- Sponsor
- Odense University Hospital
Type 2 Diabetes
The Acute Effect of Low-carb Diet on the Plasma Fatty Acid Composition in Type 2 Diabetes
The investigators wishes to investigate the acute effect of a low carbohydrate meal on the plasma fatty acid (FA) composition compared with a control meal in a cross-over study of patients with type 2 diabetes (T2D).
- Trial name
- NCT05498688
- Testing
- Low carbohydrate
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Odense University Hospital
Type2 Diabetes, Insulin Resistance
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes
Type 2 diabetes are characterized by insulin resistance in skeletal muscle. Insulin resistance plays a major role for the increased risk of heart disease seen in type 2 diabetes.
- Trial name
- NCT03500016
- Testing
- High intensity interval training
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Combined Pituitary Hormone Deficiency Genetic Form, Combined Pituitary Hormone Deficiency
Incidence of cCPHD in Denmark - a National Observational Study
The pituitary gland is a small pea-sized gland that produces a variety of important hormones. Some children are born with a deficient production of two or more pituitary hormones.
- Trial name
- IcCPHD (NCT05334563)
- Where
- Denmark
- Volunteers
- 127 people
- Sponsor
- Odense University Hospital
Osteoarthritis, Hip, Osteoarthritis
Assessment of Polyethylene Wear, Migration and Clinical Outcome in Total Hip Replacement
The objective of the study is to investigate head penetration, cup migration, and clinical outcome in total hip replacements using a factorial design.
- Trial name
- NCT02196792
- Testing
- E-Poly liner, ArComXL liner, 32 mm femoral head
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Endoscopy, Education
Learning Small Bowel Capsule Endoscopy
This project is a prospective study investigating the education of medical doctors in gastroenterology with no prior experience to evaluate small bowel capsule endoscopies with a diagnostic sensitivity >90%
- Conditions
- Endoscopy, Education, Simulation, Small Bowel Disease
- Trial name
- NCT04186390
- Testing
- Simulation training in small bowel capsule endoscopy
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Infertility, Male
DNA Fragmentation - Effect on Pregnancy Rate
The purpose of this study is to determine whether Punalpin, an antioxidant, has a positive impact on DNA fragmentation in spermatozoa in male fertility patients with increased amount of DNA fragmentation in their spermatozoa.
- Trial name
- NCT05397314
- Testing
- Punalpin
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital
Metastatic Solid Tumor
PREcision Medicine in Cancer in Odense, Denmark
The traditional approach to cancer treatment has changes from using drugs approved for the specific cancer diagnosis to a tumor agnostic approach when treating solid tumors.
- Trial name
- PRECODE (NCT05385081)
- Testing
- genomic profiling
- Where
- Denmark
- Volunteers
- 900 people
- Sponsor
- Odense University Hospital
Non-small Cell Lung Cancer
Navelbine And Radiotherapy in Locally Advanced Lung Cancer
This study is an open label randomized multi-centre phase II trial in patients with inoperable locally advanced stage IIB-IIIB Non Small Cell Lung Cancer who fulfils the general criteria for curatively intended irradiation.
- Trial name
- NARLAL (NCT00887783)
- Testing
- Navelbine, 66 Gy/33F, 60 Gy/30F
- Where
- 6 sites in Denmark
- Volunteers
- 117 people
- Sponsor
- Odense University Hospital
Quality of Life, Reduction, Harm
Medication Use and Quality of Life Among Older People (Pilot)
This project will provide new evidence on how to optimize medication use among older people with limited life expectancy. This will be done by testing whether a patient-centered deprescribing intervention, focused on aligning…
- Trial name
- NCT04676984
- Testing
- Consultations
- Where
- Denmark
- Volunteers
- 3 people
- Sponsor
- Odense University Hospital
Cardiac Arrest, Neurological Complication
Bedside Monitoring of Cerebral Energy State During the Peri-cardiac Arrest Period
In comatose patients resuscitated from out of hospital cardiac arrest (OHCA), neurological injuries remain the leading cause of death.
- Conditions
- Cardiac Arrest, Neurological Complication, Post-Cardiorespiratory Arrest Coma
- Trial name
- MICA (NCT03095742)
- Testing
- Low MAP, High MAP
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Branch Retinal Vein Occlusion, Macular Edema
Navigated Laser In Branch Retinal Vein Occlusion Study
Branch retinal vein occlusion (BRVO) is often complicated by macular edema, possibly leading to severe visual loss or blindness.
- Trial name
- NIRVANA (NCT03651011)
- Testing
- Aflibercept Injection [Eylea], Navigated laser photocoagulation
- Where
- 2 sites in Denmark
- Volunteers
- 47 people
- Sponsor
- Odense University Hospital
Cardiac Arrest, Brain Injuries
A Combined Microdialysis and FDG-PET Study for Detection of Brain Injury After Cardiac Arrest
Brain injury remains the leading cause of death in comatose patients resuscitated from OHCA. One of the most challenging aspects in the treatment of a post-cardiac arrest patient is the assessment of the extent of brain damage.
- Trial name
- COMA-PROTECT (NCT04774055)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Malignant Glioma, Life Experiences
Treatment Decision-making in Patients With Recurrent High-grade Glioma
This qualitative study explores the lived experience of high-grade glioma patients and their close relatives at time of recurrence. With focus on the decision-making about treatment and care..
- Trial name
- NCT04013828
- Where
- 2 sites in Denmark
- Volunteers
- 29 people
- Sponsor
- Odense University Hospital
Primary Hyperparathyroidism
Preoperative Localization Strategies in Primary Hyperparathyroidism
The purpose of this project is to examine, in a non-inferiority study, whether the combination of conventional ultrasound and contrast-enhanced ultrasound (CEUS) can replace the radiation-based imaging modalities that are…
- Trial name
- CEUS-project (NCT04305561)
- Testing
- Contrast-enhanced ultrasound
- Where
- Denmark
- Volunteers
- 172 people
- Sponsor
- Odense University Hospital
Adipose Tissue Dysfunction Type 2 Diabetes Mellitus Bariatric Surgery
Adipose Tissue Dysfunction in Type 2 Diabetes and Its Reversibility by Bariatric Surgery
ABSTRACT Background: Insulin resistance (IR) plays a major role in the pathogenesis of type 2 diabetes (T2D). Adipose tissue (AT) dysfunction leading to systemic low-grade inflammation and ectopic lipid deposition plays an…
- Trial name
- ADIDYS (NCT05291013)
- Testing
- Gastric byspass
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Odense University Hospital
Weight Loss, Excess Skin
BODY-Q Longitudinal Result Study and Comparison With Normative Scores
Obesity is a global epidemic that has nearly tripled since 1975. Worldwide, over 650 million people live with obesity, and it is therefore a growing cause for concern.
- Trial name
- NCT05272215
- Testing
- Bariatric surgery, Body contouring surgery
- Where
- Denmark
- Volunteers
- 20,000 people
- Sponsor
- Odense University Hospital
Breast Cancer Lymphedema
Tacrolimus as Treatment of Breast Cancer-Related Lymphedema
BACKGROUND Breast cancer-related lymphedema is a severe and life-long side-effect to breast cancer treatment. The condition increases the risk of infections and decreases health-related quality of life (HR-QOL) in patients.
- Trial name
- NCT04541290
- Testing
- Protopic 0.1 % Topical Ointment
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Colon Cancer
CME Versus Standard Right Hemicolectomy for Right Sided Cancers
Our aim of this study is to compare the difference in lymph node yield in CME specimens versus those patients having a standard right hemicolectomy for right sided cancer .The secondary aim of this study was to investigate…
- Trial name
- NCT05230329
- Testing
- right sided hemicolectomy, laparoscopy
- Where
- Denmark
- Volunteers
- 330 people
- Sponsor
- Odense University Hospital