Clinical trials: sponsored by Ohio State University Comprehensive Cancer Center
Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Recurrent Acute Lymphoblastic Leukemia
Anti-CD19/20/22 Chimeric Antigen Receptor T Cells (TriCAR19.20.22 T Cells) for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma, Acute Lymphoblastic Leukemia, and Chronic Lymphocytic Leukemia
This phase I trial tests the safety, side effects and best dose of anti-CD19/20/22 chimeric antigen receptor (CAR) T cells (TriCAR19.20.22 T cells) and how well they work in treating patients with non-Hodgkin lymphoma, acute…
- Conditions
- Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Recurrent Acute Lymphoblastic Leukemia, Recurrent Chronic Lymphocytic Leukemia, Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive
- Trial name
- NCT07166419
- Testing
- Autologous Anti-CD19/CD20/CD22 CAR T-cells, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoking-Related Carcinoma
Smoking Cessation Intervention Development for Homeless Youth
This trial develops a contextually tailored and optimized smoking cessation intervention and studies smoking motivations and motivations to quit smoking in homeless youth.
- Trial name
- NCT06754215
- Testing
- Focus Group, Interview, Smoking Cessation Intervention
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cancer Survivors, Obesity
Inspiratory Muscle Training in Obese Breast Cancer Survivors
The investigators propose a randomized controlled trial to determine the effectiveness of inspiratory muscle training in improving exercise tolerance among stage 0-III obese breast cancer survivors.
- Conditions
- Cancer Survivors, Obesity, Breast Cancer
- Trial name
- IMOCS (NCT05193149)
- Testing
- Inspiratory muscle training, Exercise training
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco-Related Carcinoma
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco [SLT]).
- Trial name
- NCT06249984
- Testing
- Biospecimen Collection, Carbon Monoxide Measurement, Smokeless Tobacco Use
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Lung Cancer, Breast Cancer
Telemedicine-mHealth Symptom Cluster Intervention for Advanced Cancer Patients: Finding Our Center Under Stress (FOCUS)
This clinical trial studies whether a telemedicine-mobile health (mHealth) intervention, Finding Our Center Under Stress (FOCUS), improves symptom management in patients with cancer that may have spread from where it first…
- Conditions
- Lung Cancer, Breast Cancer, Prostate Cancer, Multiple Myeloma
- Trial name
- FOCUS (NCT07102212)
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma
Hyperthermic Intraperitoneal Chemotherapy With Cisplatin During Surgery or Cisplatin Before Surgery for the Treatment of Stage III or IV Ovarian, Fallopian Tube or Peritoneal Cancer
This phase I trial studies the side effects of hyperthermic intraepithelial chemotherapy with cisplatin after surgery or cisplatin before surgery in treating patients with stage III or IV ovarian, fallopian tube or peritoneal…
- Conditions
- Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma
- Trial name
- NCT05415709
- Testing
- Carboplatin, Cisplatin, Cytoreductive Surgery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco-Related Carcinoma
Informing Oral Nicotine Pouch Regulations to Promote Public Health
This clinical trial evaluates the characteristics of oral nicotine pouches (ONPs) to determine if they are a comparable substitute to cigarette or smokeless tobacco (ST) products.
- Trial name
- NCT06315881
- Testing
- Biospecimen Collection, Cigarette, Nicotine Oral Pouch
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Advanced Ovarian Carcinoma, Recurrent Ovarian Carcinoma
Effects of a Probiotic Intervention on the Gut and Vaginal Microbiome in Patients With Advanced or Recurrent Ovarian Cancer Undergoing Treatment With Platinum Chemotherapy
This clinical trial evaluates the effects a probiotic intervention has on the gut and vaginal microbiome in patients undergoing chemotherapy for ovarian cancer that may have spread from where it first started to nearby tissue…
- Conditions
- Advanced Ovarian Carcinoma, Recurrent Ovarian Carcinoma, Stage II Ovarian Cancer AJCC v8, Stage III Ovarian Cancer AJCC v8
- Trial name
- NCT07144826
- Testing
- Biospecimen Collection, Probiotic, Questionnaire Administration
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco-Related Carcinoma
THRIVE Study: Understanding How Oral Nicotine Pouches Affect Public Health
Although nicotine pouches have been gaining popularity over the last few years, little known about how nicotine pouch users actually use these products. This study will be comprised of adults who use nicotine pouches.
- Trial name
- THRIVE (NCT07503925)
- Testing
- Biospecimen Collection, Nicotine Oral Pouch, Survey Administration
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco-Related Carcinoma
Manipulating E-Cigarette Nicotine to Promote Public Health
This clinical trial explores the manipulation of e-cigarette (EC) nicotine to promote public health. Researchers are trying to understand and gather information about how the strength, form, and structure of nicotine in products…
- Trial name
- NCT06448351
- Testing
- Biospecimen Collection, Carbon Monoxide Measurement, Vaping session
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Diffuse Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
Nanochip Technology in Monitoring Treatment Response and Detecting Relapse in Participants With Diffuse Large B-Cell Lymphoma
This trial studies how well nanochip technology (immuno-tethered lipoplex nanoparticle [ILN] biochip) works in monitoring treatment response and in detecting relapse in participants with diffuse large B-cell lymphoma.
- Conditions
- Diffuse Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type, Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma
- Trial name
- NCT03656835
- Testing
- Molecular Nanotechnology
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Weighted Blanket Use to Reduce Anxiety in Oncology Patients
This clinical trial compares the effect of using weighted blankets versus regular blankets during first time infusions (e.g. chemotherapy, targeted therapy etc.) to decrease adverse side effects such as anxiety and distress in…
- Trial name
- NCT06089408
- Testing
- Best Practice, Supportive Care, Survey Administration
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Healthy Diet, Nutrition Aspect of Cancer
Metabolism and Absorption of Anthocyanins From Extract and Whole Blueberry Powder Confections in Healthy Adults
This trial studies how well a group of compounds found in blueberries called anthocyanins are absorbed into the body from 2 different types of blueberry confections (blueberry extract and whole blueberry powder).
- Trial name
- NCT04329962
- Testing
- Blueberry Powder Food Product, Dietary Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Head and Neck Carcinoma of Unknown Primary, Locally Recurrent Head and Neck Squamous Cell Carcinoma
Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer
This phase I trial is to find out the possible side effects of pembrolizumab and radiation therapy before and during surgery in treating patients with head and neck squamous cell cancer that remains despite treatment (persistent)…
- Conditions
- Head and Neck Carcinoma of Unknown Primary, Locally Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT04754321
- Testing
- External Beam Radiation Therapy, Intraoperative Radiation Therapy, Pembrolizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Carcinoma, Malignant Digestive System Neoplasm
Studying the Workflow of the American College of Surgeons Geriatric Surgery Program to Improve Clinical Outcomes in Older Adults Undergoing Surgery at the James Cancer Hospital
This study examines how the American College of Surgeons Geriatric Surgery Verification Program, also called the ACS GSV Program, is implemented at the James Cancer Hospital.
- Conditions
- Breast Carcinoma, Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Genitourinary System Neoplasm
- Trial name
- NCT07606287
- Testing
- Serious Illness Conversation Program training, ACS Geriatric Surgery Verification Program Implementation
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Web-based Lifestyle Program, mHealth and EMA Intervention, to Improve Weight Loss in Rural Stage I-III Postmenopausal Breast and Endometrial Cancer Survivors, HERO-C Trial
This clinical trial identifies the needs and preferences of rural stage I-III postmenopausal breast and endometrial cancer survivors and evaluates the impact of an adaptive, online program, mobile (m)Health + ecological momentary…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Endometrial Carcinoma
- Trial name
- NCT07723235
- Testing
- Aerobic Exercise, Biospecimen Collection, Dietary Intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco-Related Carcinoma
Oral Nicotine Product Messaging to Communicate Risk of Use for Young Adults
This clinical trial tests the effect of different types of oral nicotine pouch (ONP) messaging to communicate risk of using these products for young adults.
- Trial name
- NCT07702435
- Testing
- Behavioral Intervention, Survey Administration
- Where
- United States
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colonic Neoplasms
Strategies for Optimizing a Mailed FIT Program in Appalachia
The proposed study is examining strategies for optimizing mailed fecal immunochemical test (FIT) programs. In doing so, it will assess the efficacy of two promising strategies, FIT kit materials and patient navigation delivery…
- Trial name
- NCT07173985
- Testing
- Standard FIT kit, Enhanced FIT kit, Telephone patient navigation
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Carcinoma
Genetic Counseling Patient Preference Intervention Versus Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer
This stage I clinical trial compares a genetic counseling patient preference (GCPP) intervention via EHR MyChart patient portal to conventional genetic counseling for women at elevated risk for breast cancer.
- Trial name
- NCT05325151
- Testing
- Educational Intervention, Genetic Counseling, Survey Administration
- Where
- United States
- Volunteers
- 874 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer, Radiation Therapy Patient
A Pilot Study to Evaluate the Effectiveness of Focused Massage on Pain, Mobility, and Quality of Life During Radiation Treatment for Patients With Breast Cancer
The goal of this interventional study is to to evaluate the effectiveness and acceptability of a focused upper body massage when offered after radiation treatments to participants diagnosed with breast cancer.
- Trial name
- NCT07447700
- Testing
- upper body massage
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Ohio State University Comprehensive Cancer Center