Clinical trials: sponsored by Oslo University Hospital
Hepatitis B, Chronic
The Norwegian Nucleoside Analogue Stop Study
Globally, an estimated 257 million individuals have chronic hepatitis B-virus infection (CHB). In the absence of treatment 15-40% of these will progress to liver cirrhosis and/or hepatocellular carcinoma.
- Trial name
- Nuc-Stop (NCT03681132)
- Testing
- Stop of therapy
- Where
- 11 sites in Denmark, Ethiopia and 2 more
- Volunteers
- 127 people
- Sponsor
- Oslo University Hospital
Plantar Fascitis
Plantar Fasciopathy and the Effectiveness of Radial Extracorporeal Shockwave Therapy, Physical Training or Usual Care
The purpose of this study is to evaluate whether radial extracorporeal shockwave therapy (rESWT), sham- rESWT or standardised exercise program is more effective on change in heel pain than usual care in the treatment of plantar…
- Trial name
- NCT03472989
- Testing
- Radial extracorporeal shock wave, Standardized high-load exercise program, Usual care
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Postoperative Pain, Pediatric ALL
Pediatric Pain Management - an Intervention Study
This study will explore nurses' pediatric postoperative pain management knowledge and clinical practices. The aim is to evaluate if a tailored educational intervention will improve nurses' knowledge and attitudes of pain…
- Trial name
- NCT03385681
- Testing
- Tailored Educational Intervention
- Where
- 6 sites in Norway
- Volunteers
- 876 people
- Sponsor
- Oslo University Hospital
Hereditary Pancreatic Cancer
The PREPAIRD Study: Personalized Surveillance for Early Detection of Pancreatic Cancer in High Risk Individuals
The objective of this national and multidisciplinary project is to establish and evaluate a personalized surveillance program (SP) for early diagnosis of pancreatic cancer (PC) and its precursors in individuals with a hereditary…
- Trial name
- PREPAIRD (NCT05740111)
- Testing
- Annual surveillance
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Metastatic Colorectal Cancer
Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal Cancer
The purpose of the study is to investigate the effect and side effects of personalized cancer treatment in patients with metastatic colorectal cancer (bowel cancer).
- Trial name
- EVIDENT (NCT05725200)
- Testing
- Alectinib, Cetuximab, Crizotinib
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
COVID-19, Emerging Infectious Disease
EU SolidAct: An Adaptive Pandemic and Emerging Infection Platform Trial
EU SolidAct is a randomized, multifactorial, adaptive platform trial for COVID-19 and emerging infectious diseases and pandemics.
- Trial name
- Bari-SolidAct (NCT04891133)
- Testing
- Baricitinib
- Where
- 92 sites in Austria, Belgium and 13 more
- Volunteers
- 290 people
- Sponsor
- Oslo University Hospital
Neuromuscular Diseases in Children
Mechanical Insufflation -Exsufflation in Children With NMD and Weak Cough
Neuromuscular diseases (NMD) in children are severe, possibly life-threatening orphan conditions. The children are vulnerable and often subject to rapid deterioration of pulmonary function due to impaired ability to clear airway…
- Trial name
- NCT04081116
- Testing
- Symmetric settings (high pressures/fast rate), Asymmetric settings (Pi<Pe/Ti>Te), Preinclusion settings
- Where
- 4 sites in Norway
- Volunteers
- 77 people
- Sponsor
- Oslo University Hospital
Perineum; Wound, Postoperative Complications
Reconstruction After Abdominoperineal Resection With Robot-assisted Harvest of VRAM Flap
Non-randomized study of robot-assisted perineal reconstruction with rectus abdominis muscle flap in patients operated with abdominoperineal resection for irradiated locally advanced rectal or anal cancer.
- Conditions
- Perineum; Wound, Postoperative Complications, Rectal Neoplasms, Rectus Abdominis Hernia
- Trial name
- NCT05689775
- Testing
- Reconstruction with robot-assisted rectus abdominis muscle flap
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Labor (Obstetrics)--Complications, Labor; Prolonged, First Stage
BUSCLAB - Buscopan to Prevent Slow Progress in Labor
To study the effect of Butylscopolamine Bromide on duration of the active phase of first stage of labor in first time mothers who cross the alert-line for labor dystocia, according to the WHO partograph.
- Trial name
- NCT03961165
- Testing
- Butylscopolamine Bromide 20 MG/ML, Sodium Chloride 9mg/mL
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Occupational Exposure, Environmental Exposure
FeNO Hairdressers Pilot
A 5-day cohort diurnal FeNO study of exposed and unexposed to airway irritants during hair treatments and commuting.
- Trial name
- NCT05507944
- Testing
- FeNO measurement
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Cervix Cancer
Plan of the Day Radiotherapy
The study objectives are to improve the treatment of LACC patients and to increase knowledge of the potential benefit of the plan-of-the-day concept on side effects during and after radiotherapy.
- Trial name
- NCT05634681
- Testing
- Plan of the day, Standard plan
- Where
- Norway
- Volunteers
- 190 people
- Sponsor
- Oslo University Hospital
Descemet Stripping Automated Endothelial Keratoplasty (DSAEK), Descemet Membrane Endothelial Keratoplasty (DMEK)
DSAEK/DMEK and Cystoid Macular Edema - the Role for Topical NSAIDs (Nepafenac) (DMEC)
The DMEC trial is a randomized clinical two-arm trial comparing inflammation and cystoid macular edema for the medication regimens postoperative topical NSAIDs and steroids to only postoperative topical steroids in patients…
- Trial name
- DMEC (NCT05072262)
- Testing
- Nepafenac Ophthalmic, Dexamethasone Ophthalmic
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Oslo University Hospital
Cataract Surgery
Cataract Surgery and Inflammation - the Role for Preoperative NSAIDs (Pre-CIN)
The pre-CIN trial is a randomized clinical three-arm trial comparing inflammation and cystoid macular edema for the medication regimens preoperative and postoperative topical NSAIDs to only postoperative topical NSAIDs to…
- Trial name
- pre-CIN (NCT05331690)
- Testing
- Nepafenac Ophthalmic, Dexamethasone Ophthalmic
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Glaucoma
NorMIGS - a Study of Micro-invasive Glaucoma Surgery
NorMIGS is a non-randomized clinical study of intraocular pressure lowering effect and complications after Preserflo microshunt implantation versus other types of glaucoma surgery.
- Trial name
- NorMIGS (NCT05340647)
- Testing
- Preserflo microshunt, Trabeculectomy, Other MIGS
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Hip Pain Chronic, Hip Bursitis
Validation of the Norwegian VISA-G Questionnaire
The aim of this study is to translate, cross-cultural adapt and validate the Norwegian VISA-G (VISA-N-G) questionnaire. The study will test the psychometric properties for the VISA-N-G in terms of test-retest reliability…
- Trial name
- NCT04289922
- Where
- Norway
- Volunteers
- 93 people
- Sponsor
- Oslo University Hospital
Spinal Cord Injuries, Urinary Bladder, Overactive
Prevention of Bladder Dysfunction in Acute Spinal Cord Injury
This study is a double blind, randomized, placebo controlled trial to explore the effect of early treatment with Onabotulinumtoxin A in patients with acute complete motor spinal cord injury (SCI) on the development of neurogenic…
- Trial name
- BOT-SCI (NCT01698138)
- Testing
- Onabotulinumtoxin A
- Where
- 2 sites in Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Rectal Cancer
Computer Navigation-assisted Surgery for Locally Advanced and Recurrent Rectal Cancer
The aim of this study is to investigate feasibility of computer navigation-assisted surgery in particularly difficult cases of locally advanced (LARC) and recurrent (LRRC) rectal cancer where the standard surgical strategy is…
- Trial name
- NAVI-LARRC (NCT04512937)
- Testing
- Computer-assisted navigation surgery
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Epilepsy, GLUT1DS1
Long-term Treatment With the Ketogenic Diet in Epilepsy
This study will provide a comprehensive assessment of long-term treatment with the ketogenic diet, a medical diet with high fat and low carbohydrate intake, focusing on safety and cardiovascular implications.
- Conditions
- Epilepsy, GLUT1DS1, PDH Deficiency
- Trial name
- NCT04646850
- Testing
- Color duplex ultrasound of the carotid arteries
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Systemic Sclerosis
Safety and Efficacy of Anaerobic Cultivated Human Intestinal Microbiome Transplantation in Systemic Sclerosis (ReSScue)
This study evaluates the effect of intestinal microbiota therapy on gastro-intestinal symptoms in patients with systemic sclerosis (SSc).
- Trial name
- ReSScue (NCT04300426)
- Testing
- "ACHIM" as solute (10^9 intestinal microbes/ml)
- Where
- 4 sites in Norway
- Volunteers
- 75 people
- Sponsor
- Oslo University Hospital
Photobiomodulation, Age-Related Macular Degeneration
Photobiomodulation for Dry Age Related Macula Degeneration
The study will investigate the effect of photobiomodulation treatment on the risk of developing late age related macula degeneration (AMD) in the study eye in patients with wet AMD in the fellow eye.
- Trial name
- NCT05507840
- Testing
- Valeda machine
- Volunteers
- 121 people
- Sponsor
- Oslo University Hospital