Clinical trials: sponsored by Oslo University Hospital
Self Harm, Borderline Personality Disorder
Predictors of Clinical Course and Treatment Response in DBT Programmes
The project is a collaboration between The National Centre for Suicide Research and Prevention (NSSF) and clinical units with Dialectical Behaviour Therapy (DBT) programmes.
- Trial name
- NCT04318899
- Testing
- Dialectical Behaviour Therapy adapted for adolescents (DBT-A), Dialectical Behaviour Therapy - Standard version (DBT)
- Where
- 5 sites in Norway
- Volunteers
- 250 people
- Sponsor
- Oslo University Hospital
Hypertensive Disorder of Pregnancy, Preeclampsia
MumCare: Mum's Cardiovascular Health for Life
The goal of this randomized clinical trial study is to test the potential benefits of eHealth-assisted follow-up after pregnancy complications that confer and increased risk for premature cardiovascular (CV) disease.
- Conditions
- Hypertensive Disorder of Pregnancy, Preeclampsia, Gestational Hypertension, Gestational Diabetes
- Trial name
- MumCare (NCT05835596)
- Testing
- Access to MumCare app
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- Oslo University Hospital
Eating Disorders
Mealtime Anxiety in Eating Disorders
The goal of this observational study is to assess mealtime anxiety in patients with eating disorders receiving treatment at an in-patient unit. Anxiety wil be assessed using ecological momentary assessment (EMA).
- Trial name
- NCT05730348
- Testing
- Post mealtime activity
- Where
- Norway
- Volunteers
- 33 people
- Sponsor
- Oslo University Hospital
Colorectal Cancer, Colorectal Neoplasms Malignant
Simultaneous vs. Staged Resection of Colorectal Cancer With Synchronous Liver Metastases
The SYLMET Trial is a randomized trial to compare simultaneous and two-staged resection of primary colorectal and synchronous liver metastases.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms Malignant, Liver Metastasis Colon Cancer, Liver Metastases
- Trial name
- SYLMET (NCT06200831)
- Testing
- Staged resection, Simultaneous resection
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure
Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure may progress to acute respiratory distress syndrome, a life-threatening condition that often requires mechanical ventilation.
- Trial name
- SVALBARD (NCT07463885)
- Testing
- Spontaneous Ventilation Strategy, Controlled Ventilation Strategy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Heart Failure, Pacemaker DDD
Non-Invasive Method for Evaluation of Cardiac Resynchronization Therapy
Left bundle branch block (LBBB) exists in about 25% of patients with congestive heart failure and is associated with worsened prognosis.
- Conditions
- Heart Failure, Pacemaker DDD, Cardiomyopathies, Heart Diseases
- Trial name
- NIME-CRT (NCT05868616)
- Testing
- Cardiac Resynchronization Therapy (CRT)
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Acute Ischemic Stroke
Infarct Growth After Intravenous Tocilizumab in Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy - ILLUMINATE
The goal of this phase II, placebo-controlled intervention study is to investigate whether tocilizumab, an interleukin-6 (IL-6) receptor inhibitor, may have a neuroprotective effect by reducing infarct growth in adults with acute…
- Trial name
- Illuminate (NCT07870681)
- Testing
- Tociliuzumab
- Where
- 6 sites in Denmark, Norway
- Volunteers
- 156 people
- Sponsor
- Oslo University Hospital
Glaucoma
Trabeculectomy Versus MicroShunt Implantation in Glaucoma Surgery (TIGER)
Glaucoma is an eye disease causing vision loss if not treated adequately. The prevalence is around 1.5%, exponentially increasing to more than 10% in the elderly.
- Trial name
- NCT07869108
- Testing
- Preserflo MicroShunt, Trabeculectomy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Basal Cell Carcinoma, Gorlin Syndrome
Nevoid Basal Cell Carcinomas in Gorlin Syndrome
The overall aim of the project is to gain knowledge about the expected course of nevoid basal cell carcinomas and the usefulness of dermatoscopy in young individuals with Gorlin syndrome.
- Trial name
- NCT05898347
- Testing
- Active surveillance
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- Oslo University Hospital
Hemoperitoneum, Ascites
Free Fluid Detection With Telementored eFAST
This feasibility study will evaluate the accuracy of telementored eFAST (Extended Focused Assessment with Sonography in Trauma) in detecting abdominal free fluid in patients who have recently undergone liver surgery.
- Conditions
- Hemoperitoneum, Ascites, Intra-Abdominal Fluid Collection, Postoperative Complications
- Trial name
- NCT06594562
- Testing
- Telementored eFAST
- Where
- Norway
- Volunteers
- 34 people
- Sponsor
- Oslo University Hospital
Cleft Lip Palate
Quadratus Lumborum Block for Iliac Bone Harvest in Pediatric Cleft Alveolus Repair
This prospective, randomized, double-blinded controlled trial will investigate the effectiveness of a lateral quadratus lumborum (QL) block in 50 children aged 6-14 years undergoing iliac crest bone grafting for cleft alveolus…
- Trial name
- NCT07846761
- Testing
- Lateral quadratus lumborum block
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest
Mitral Valve Prolapse Arrhythmic Risk
Mitral valve prolapse (MVP) is common with a 2-3 % prevalence in the general association and generally associated with a favorable prognosis.
- Trial name
- MVP-Risk (NCT07830888)
- Testing
- Risk prediction model
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Diabetes, Obesity & Overweight
Exercise and Tissue-Specific Insulin Sensitivity in South Asian and Nordic Women With Previous Gestational Diabetes
South Asian women have a high risk of developing type 2 diabetes, and the risk is particularly high after gestational diabetes. This study examined whether eight weeks of supervised vigorous exercise improves insulin sensitivity…
- Trial name
- DIASA-Ex (NCT07843082)
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 43 people
- Sponsor
- Oslo University Hospital
Opioid Use, Affective Symptoms
Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial
1. To investigate and compare the affective short-term effects of opioid drugs: morphine, oxycodone and fentanyl, administered to the patients before the induction of general anesthesia. 2.
- Trial name
- AFFECT2 (NCT05639712)
- Testing
- Morphine 2.5 mg i.v., Morphine 5 mg i.v., Morphine 10 mg i.v.
- Where
- Norway
- Volunteers
- 1,014 people
- Sponsor
- Oslo University Hospital
Heart Failure (HF), Atrial Fibrillation (AF)
Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation
Heart failure and atrial fibrillation are two of the most common heart diseases globally. Nearly half of all patients with heart failure also have atrial fibrillation.
- Trial name
- HFcAF (NCT07436299)
- Where
- 15 sites in United States, Belgium and 8 more
- Volunteers
- 400 people
- Sponsor
- Oslo University Hospital
Idiopathic Normal Pressure Hydrocephalus (INPH)
Change in Cognition and Frailty After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus (iNPH)
The goal of this observational study is to describe changes in cognitive profile and frailty from pre shunt to one year after the shunt surgery and to identify clinical predictors of an improvement in terms of cognition and…
- Trial name
- NCT07642726
- Testing
- Ventriculoperitoneal shunt
- Where
- Norway
- Volunteers
- 276 people
- Sponsor
- Oslo University Hospital
Bipolar Disorder (BD)
The PEDAL Intervention - Reducing Affective Lability in Bipolar Disorder
PEDAL is a group-based intervention for patients with bipolar disorder that builds on the traditional group psychoeducational program (GPP) by adding digital tools and specific strategies to help manage rapid fluctuations between…
- Trial name
- PEDAL (NCT07239778)
- Testing
- Traditional group psychoeducation for bipolar disorder, Group psychoeducation with digital elements and focus on affective lability
- Where
- 4 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Spontaneous Coronary Artery Dissection, Myocardial Infarction (MI)
Norwegian Danish Spontaneous Coronary Artery Dissection Exercise Study
The goal of this randomized clinical trial is to determine whether a supervised high-intensity interval training (HIIT) program can safely improve cardiorespiratory fitness and overall health in adults who have previously had…
- Conditions
- Spontaneous Coronary Artery Dissection, Myocardial Infarction (MI), High Intensity Interval Training
- Trial name
- NorDen-SCAD Ex (NCT07785765)
- Testing
- High intensity interval training (HIIT)
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Distal Radius Fractures
Radiological Criteria for Instability in Distal Radius Fractures
The study examines whether there are radiological criteria that can give an indication if a dorsally displaced distal radius fracture remains stable without the needs for surgery after closed reduction in patients between 18 and…
- Trial name
- NCT06617780
- Testing
- X-ray (wrist)after 3 months and CT (wrist) the day after closed reduction
- Where
- Norway
- Volunteers
- 212 people
- Sponsor
- Oslo University Hospital
Anesthesia Practice
Exploring Medication Safety Practices in Anesthesia
Quality improvement project involving medication safety in anesthesia. The study explores medication safety practices in anesthesia using a mixed methods approach.
- Trial name
- NCT07740226
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital