Clinical trials: sponsored by Oslo University Hospital
Malignant Peripheral Nerve Sheath Tumour (MPNST)
A Study of Pembrolizumab in Patients With Malignant Peripheral Nerve Sheath Tumor (MPNST), Not Eligible for Curative Surgery
This is phase II, single arm, open-label, interventional trial of pembrolizumab (MK-3475) in subjects with metastatic or locally advanced/unresectable or metastatic malignant peripheral nerve sheath tumour (MPNST).
- Trial name
- NCT02691026
- Testing
- Pembrolizumab
- Where
- Norway
- Volunteers
- 8 people
- Sponsor
- Oslo University Hospital
Sleep Disordered Breathing, Sleep Apnea
Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac rhythm disturbance in adults, with prevalence expected to rise significantly the coming decades.
- Conditions
- Sleep Disordered Breathing, Sleep Apnea, Paroxysmal Atrial Fibrillation
- Trial name
- NCT02727192
- Testing
- PAP (CPAP or ASV)
- Where
- Norway
- Volunteers
- 109 people
- Sponsor
- Oslo University Hospital
Trauma Injury
Impairing Drugs and Alcohol as Risk Factors for Traumatic Injuries
Impairing drugs and alcohol are major risk factors for traumatic injuries. Still there is to date little knowledge to what extent these factors affect the epidemiology of trauma.
- Trial name
- IDART (NCT03773614)
- Where
- Norway
- Volunteers
- 5,000 people
- Sponsor
- Oslo University Hospital
Stroke
Cognitive Training After Stroke : Effects and Mechanisms
Stroke is a major cause of severe cognitive and physical disability. Despite the high and increasing incidence, and large health, economic, social and personal consequences, studies designed to remedy cognitive impairments and…
- Trial name
- NCT04932304
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Oslo University Hospital
Pregnancy
The Clinical Carbetocin Myocardium Trial
Randomized comparison of different cardiotoxicity of carbetocin and oxytocin.
- Trial name
- CMT (NCT02528136)
- Testing
- Carbetocin, Oxytocin
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Hemodynamic Changes in Pregnancy
Validation of a Non-invasive Hemodynamic Monitor (NexFin) in Pregnant Women
Blood pressure and cardiac output can be measured invasively in pregnant women. Non-invasive monitoring devices are desirable, but until now, no equipment has proven validity.
- Trial name
- NCT01861132
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Knee Injuries
Effects of Intraarticular IL1-Ra on Pain and Inflammatory Mediators After Knee Arhroscopy
This project investigates the relation between acute pain and local inflammation. Pain reported by the patients for knee arthroscopy are compared with local changes in inflammatory mediators by using microdialysis technique.
- Trial name
- NCT01997138
- Testing
- Anakinra 100 mg in 2 ml saline IA
- Where
- Norway
- Sponsor
- Oslo University Hospital
Chronic Pain
The Effectiveness of Individual Placement and Support in Chronic Pain Patients
Individual Placement and support (IPS) is an evidence-based approach originally developed to help people with severe mental disorders to obtain and maintain employment.
- Trial name
- IPSinPain (NCT02697656)
- Testing
- IPS, Self-help, Treatment as usual
- Where
- Norway
- Volunteers
- 65 people
- Sponsor
- Oslo University Hospital
Breast Cancer Surgery
Pre-operative Hypnosis to Prevent Side Effects After Surgery
The aim of the pilot study is to translate and feasibility test a brief hypnosis intervention in 8-10 patients that are about to undergo thoracic surgery and in 4-5 patients about to undergo breast cancer surgery.
- Trial name
- PREVENTpilot (NCT04300283)
- Testing
- Hypnosis
- Where
- Norway
- Volunteers
- 14 people
- Sponsor
- Oslo University Hospital
Heart Transplant Recipients
Intravenous Iron Supplement for Iron Deficiency in Cardiac Transplant Recipients
Iron deficiency is prevalent in heart transplant recipients, and may be associated with reduced functional capacity. The IronIC trial is designed to assess the effect of intravenous iron isomaltoside on exercise capacity, muscle…
- Trial name
- IronIC (NCT03662789)
- Testing
- Iron Isomaltoside 1000
- Where
- Norway
- Volunteers
- 102 people
- Sponsor
- Oslo University Hospital
Ischemia, Blood Circulation Disorder
New Method for Real-time Detection of Tissue Ischemia
This is a prospective, single arm, open, single centre clinical investigation designed to examine the feasibility and safety of the IscAlert™ device in patients scheduled for limb (arm/leg) surgery with tourniquet.
- Conditions
- Ischemia, Blood Circulation Disorder, Carbon Dioxide, Biosensing Techniques
- Trial name
- ISCALERT (NCT04893473)
- Testing
- IscAlert
- Where
- Norway
- Sponsor
- Oslo University Hospital
Hip Fractures, Femoral Neck Fractures
Undisplaced Femoral Neck Fractures 2 Hansson Pins or 3 Pins Interlocked in Plate (Pinloc) Using RSA
Femoral neck fractures represent about half of the hip fractures and are further divided into displaced and undisplaced fractures. Displaced femoral neck fractures are almost always treated surgically with arthroplasty.
- Trial name
- NCT02699619
- Testing
- Pinloc, 2 Hansson pins
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Impaired Glucose Tolerance, Insulin Sensitivity
Effects of Glucose Lowering Agents in South Asian Women With Impaired Glucose Tolerance or Impaired Fasting Glucose
This study will test the effect of four common oral anti-diabetic agents on hepatic insulin sensitivity in South Asian women with impaired glucose tolerance or impaired fasting glucose.
- Conditions
- Impaired Glucose Tolerance, Insulin Sensitivity, Glucose Metabolism Disorders
- Trial name
- DIASA3 (NCT04662866)
- Testing
- Metformin capsule 500 mg, Empagliflozin encapsulated tablet 10 mg, Pioglitazone encapsulated tablet 30 mg, Linagliptin encapsulated tablet 5 mg
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Oslo University Hospital
Type1 Diabetes Mellitus, Enterovirus
The Diabetes Virus Detection and Intervention Trial
A randomized, double-blind, placebo-controlled study in 96 children and adolescents age 6-15 newly diagnosed with type 1 diabetes to describe the influence of antiviral treatment (Pleconaril and Ribavirin) on progression of…
- Trial name
- DiViDInt (NCT04838145)
- Testing
- Ribavirin + Pleconaril
- Where
- Norway
- Volunteers
- 96 people
- Sponsor
- Oslo University Hospital
Non-small Cell Lung Cancer
Combinatory ImmunoTherapy-1 (Com-IT-1) Irradiation and PD-1 Blockade in Locally Advanced / Advanced NSCLC
In this study, the investigators will investigate toxicity in patients treated with a Programmed cell death protein 1 (PD-1) inhibitor and radiotherapy.
- Trial name
- COM-IT-1 (NCT03644823)
- Testing
- Atezolizumab, Radiotherapy
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Oslo University Hospital
Cancer
Thoracal Radiotherapy and Tarceva
The purpose of this study is to determine if erlotinib given orally along with concurrent palliative irradiation to lung cancer improves local control compared to those treated with radiotherapy alone.
- Trial name
- ThoRaT (NCT02714530)
- Testing
- Erlotinib, Radiation
- Where
- 2 sites in Norway
- Volunteers
- 118 people
- Sponsor
- Oslo University Hospital
Genital Lichen Planus
Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT
To compare the effect and side effects of photodynamic treatment and traditional topical steroid treatment in female genital erosive lichen planus
- Trial name
- NCT01282515
- Testing
- clobetasol propionate 0,05% ointment, hexaminolevulinate
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Hypothyroidism, Biomarkers
Identification of Non-responders to Levothyroxine Therapy
The purpose of this study is to assess differential effects of T4 and T3 on cell and tissue level
- Conditions
- Hypothyroidism, Biomarkers, Endocrine System Diseases
- Trial name
- NCT03627611
- Testing
- Levothyroxin, Liothyronine
- Where
- Norway
- Volunteers
- 69 people
- Sponsor
- Oslo University Hospital
Plantar Fasciitis
Gastrocnemius Recession vs. Conservative Treatment for Chronic Plantar Fasciitis
The purpose of the study is to compare the clinical results for patients suffering from plantar fasciitis treated with gastrocnemius recession vs. conservative treatment.
- Trial name
- NCT02116478
- Testing
- surgical proximal medial gastrocnemius recession
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Endometriosis Related Pain, Quality of Life
Bowel ENDOmetriosis; Evaluation of Diagnostics and Quality of Life
Endometriosis on the bowel is a benign condition that can cause major complaints and severely affect the quality of life of women of fertile age.
- Conditions
- Endometriosis Related Pain, Quality of Life, Pain, Chronic, Bowel Dysfunction
- Trial name
- ENDO (NCT03779256)
- Testing
- 2D transvaginal ultrasound
- Where
- 3 sites in Australia, Austria and 1 more
- Volunteers
- 207 people
- Sponsor
- Oslo University Hospital