Clinical trials: sponsored by Oslo University Hospital
Posttraumatic Stress Disorder (PTSD)
Two-week Intensive Outpatient Trauma Treatment.
The objective of the study is to obtain knowledge about the treatment of patients who are offered intensive trauma treatment at Nydalen DPS (NDPS) and Søndre Oslo DPS (SODPS).
- Trial name
- NCT07565311
- Testing
- Prolonged exposure and EMDR
- Where
- Norway
- Volunteers
- 42 people
- Sponsor
- Oslo University Hospital
Oligodendroglioma, Oligodendroglioma, Anaplastic
PRO-GLIO: PROton Versus Photon Therapy in IDH-mutated Diffuse Grade II and III GLIOmas
Proton therapy is a powerful tool enabling oncologists to spare normal tissue around the target for irradiation much better than what can be achieved with photon irradiation.
- Conditions
- Oligodendroglioma, Oligodendroglioma, Anaplastic, Diffuse Astrocytoma, IDH-Mutant
- Trial name
- PRO-GLIO (NCT05190172)
- Testing
- Radiation therapy
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Oslo University Hospital
Ischemia, Blood Circulation Disorder
Detecting Tissue Ischemia in Reconstruction Flaps by a Novel CO2 Biosensor (DIMENSION-study)
The investigators will test if changes in CO2 is detected postoperatively in ischemic tissue in a reconstructed flap. IscAlert is measuring continuously CO2 in muscular and subcutaneous tissue.
- Conditions
- Ischemia, Blood Circulation Disorder, Biosensing Techniques, Surgery
- Trial name
- DIMENSION (NCT05487820)
- Testing
- IscAlert
- Where
- Norway
- Volunteers
- 160 people
- Sponsor
- Oslo University Hospital
Ischemia, Blood Circulation Disorder
Early Discovery of Ischemia After Replantation Surgery of the Extremities
Investigators will test if changes in CO2 is detected postoperatively in ischemic tissue in a replanted extremity of a traumatically amputated upper or lower extremity.
- Conditions
- Ischemia, Blood Circulation Disorder, Carbon Dioxide, Biosensing Techniques
- Trial name
- EDIR (NCT05297266)
- Testing
- IscAlert
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Pancreatic Cancer, Pancreatic Neoplasms
Monitoring of patIents With Microdialysis Following Pancreaticoduodenectomy
A pancreaticoduodenectomy is performed in patient with pancreatic cancer. The most common and serious complication is leakage between the intestine and the remnant pancreas after this procedure. It occurs in 20-30%.
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Biliary Tract Cancer, Duodenal Cancer
- Trial name
- MINIMUM (NCT03631173)
- Testing
- Surgical og radiological intervention, antibiotics
- Where
- Norway
- Volunteers
- 201 people
- Sponsor
- Oslo University Hospital
Low Back Pain
Epigenetic and Molecular Biomarkers in Chronic Low Back Pain and Modic Changes
In the present study the investigators aim to examine the presence of bacteria in the disc and Modic Changes (MCs) (bone). A prospective study with 1-year follow-up of two patient populations undergoing elective spinal surgery…
- Trial name
- NCT03406624
- Testing
- Biopsy
- Where
- 4 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Celiac Disease, Food Intolerance
Immunosafe-CeD: Are Partially Hydrolysed Gluten Harmful to Celiac Disease Patients?
The study will compare the immune response in CeD patients to wheat and barley gluten at high doses (1 gram), and also investigate the reponses to low dose barley gluten and also hydrolyzed, malted barley and placebo.
- Trial name
- NCT06151782
- Testing
- Wheat gluten 1000 mg, Barley gluten 1000 mg, Barley gluten 50 mg
- Where
- 2 sites in Germany, Norway
- Volunteers
- 33 people
- Sponsor
- Oslo University Hospital
Chronic Mesenteric Ischemia
Investigation of Chronic Intestinal Ischemia
Patients suspected of chronic mesenteric ischemia caused by atherosclerosis or median arcuate ligament syndrome shall be investigated with trans mucosal and transserosal laser Doppler flowmeter and visible light spectroscopy.
- Trial name
- NCT02914912
- Where
- 2 sites in Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pain
Predicting Pain After Ambulatory Gynaecological Laparoscopies
As day surgery is increasingly preferred over in-hospital treatment due to feasibility and reduced economic costs, it is important to evaluate patient-related outcomes such as comfort and safety after discharge.
- Trial name
- POP-Matrix (NCT07308444)
- Where
- Norway
- Volunteers
- 487 people
- Sponsor
- Oslo University Hospital
Radius Fracture Distal, Rebound Pain
Ropivacaine Concentration and Rebound Pain
The goal of this clinical trial is to see if the concentration of a local anesthetic (ropivacaine) in peripheral nerve block is related to the severness of pain after surgery of distal radius fractures in adults.
- Trial name
- NCT06950372
- Testing
- Ropivacaine concentration low, Ropivacaine concentration high
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Celiac Disease
Gluten Challenge in Celiac Disease - Which Formulation of Gluten Gives the Best Response?
The goal of this clinical trial is to evaluate the immune response to gluten in patients with celiac disease (CeD) by comparing different forms of gluten administration.
- Trial name
- SHAKE (NCT07039773)
- Testing
- Vital wheat gluten
- Where
- 2 sites in Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Celiac Disease, Irritable Bowel Syndrome
Effect of FODMAP Restriction on Persistent GI-symptoms in Coeliac Patients
The first aim of the study is to investigate the prevalence of persistent gastrointestinal symptoms and compliance with gluten-free diet and the intake of FODMAP in adult celiac patients.
- Conditions
- Celiac Disease, Irritable Bowel Syndrome, Diet Modification, Gluten Sensitivity
- Trial name
- NCT03678935
- Testing
- Low FODMAP diet
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Severe Aortic Stenosis, Iron-deficiency
Intravenous Iron Supplement for Iron Deficiency in Patients With Severe Aortic Stenosis
Iron deficiency is a prevalent nutritional deficiency and a common cause of anemia. Although iron deficiency is traditionally linked to anemia, iron deficiency is prevalent even in the absence of anaemia and in itself limits…
- Trial name
- IIISAS (NCT04206228)
- Testing
- Intravenous iron isomaltoside
- Where
- Norway
- Volunteers
- 149 people
- Sponsor
- Oslo University Hospital
Non-Muscle Invasive Bladder Neoplasms, Urinary Bladder Neoplasms
BladMetrix Urine Test for Monitoring Recurrence in Non-Muscle Invasive Bladder Cancer
This observational study evaluates the urine test BladMetrix for monitoring bladder cancer recurrences in people with non muscle invasive bladder cancer (NMIBC) who are in follow-up after surgery.
- Conditions
- Non-Muscle Invasive Bladder Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Bladder
- Trial name
- BladMetrix (NCT07511517)
- Testing
- BladMetrix urine test
- Where
- 6 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Anterior Shoulder Dislocation, Shoulder Dislocation Closed Traumatic
Shoulder Dislocation: Assessment of Lesions, Trajectories and Outcomes (SALTO)
The goal of this prospective observational cohort study is to provide epidemiological and prognostic data from a defined urban population and to improve understanding of risk factors and long-term outcomes following first-time…
- Conditions
- Anterior Shoulder Dislocation, Shoulder Dislocation Closed Traumatic, First Time Shoulder Dislocation, Shoulder Instability
- Trial name
- SALTO (NCT07486440)
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Sepsis Syndrome, Sepsis
Sepsis: From Syndrome to Personalized Care
This is a prospective, observational study designed to examine the performance of biomarkers, molecular biological methods and other analysis in blood from patient with suspected sepsis in the Emergency department, as well as…
- Conditions
- Sepsis Syndrome, Sepsis, Sepsis, Severe, Septic Shock
- Trial name
- NCT04203979
- Where
- Norway
- Volunteers
- 1,950 people
- Sponsor
- Oslo University Hospital
Chronic Low-back Pain
The Lumbar Interbody Fusion vs. Multidisciplinary Rehabilitation (LIFEHAB) Trial
The goal of this randomized controlled trial is to compare lumbar interbody fusion surgery with multidisciplinary rehabilitation in participants aged 20-65 years with persisting (≥ one year) low back pain.
- Trial name
- LIFEHAB (NCT06169488)
- Testing
- Lumbar Interbody Fusion, Multidisciplinary rehabilitation
- Where
- 5 sites in Norway
- Volunteers
- 202 people
- Sponsor
- Oslo University Hospital
Postoperative Complications, Delayed Emergence From Anesthesia
EEG-based Depth of Anesthesia-monitoring, Effects on Dosage and Cognition
Depth of anesthesia-monitoring based on EEG changes demands knowledge about the effects of the different anesthetic medications on EEG waveforms.
- Conditions
- Postoperative Complications, Delayed Emergence From Anesthesia, Cognitive Dysfunction
- Trial name
- NCT04529304
- Testing
- Bilateral Bispectral Index and EEG
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Eye Diseases
Correlation Between Exhaled Propofol Concentration With Plasma Concentration in Children
Children due for elective eye surgery in propofol based anesthesia will be kept at steady state propofol infusion for maintenance, ventilation via endotracheal tube.
- Trial name
- NCT04150432
- Testing
- Edmon
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- Oslo University Hospital
Bile Duct Stones
Cholecystectomy With Intraoperative Management of Bile Duct Stones in Norway - the BILNOR Study
The BILNOR study is a prospective multicenter observational study evaluating how common bile duct stones are best managed in patients undergoing cholecystectomy.
- Trial name
- Bilnor (NCT07449897)
- Where
- Norway
- Volunteers
- 340 people
- Sponsor
- Oslo University Hospital