Clinical trials: sponsored by Oslo University Hospital
Critical Illness, Communication
Communication With Mechanically Ventilated Intensive Care Patients
The overarching aim of this multicenter study is to develop a multimodule training intervention (COMMEC-ICU) for nurses working in ICUs, to increase nurses skills and knowledge and then improve communication for mechanically…
- Conditions
- Critical Illness, Communication, Intensive Care Unit Syndrome
- Trial name
- COMMEC-ICU (NCT06977555)
- Testing
- Communication Course and skills training
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Alcohol Consumption, Psychoactive Substance Use
AlcoTail - Implementation of Tailored Interventions
This study aims to investigate the implementation and real-world effects of an intervention for harmful use of alcohol and psychoactive medicinal drugs among hospital inpatients.
- Trial name
- NCT04957628
- Testing
- Harmful alcohol use treatment, Non-prescribed psychoactive medicinal use treatment
- Where
- Norway
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Osteoarthritis, Pain
Efficacy of Exercise on Quality of Life and Physical Function in Patients With Knee Osteoarthritis
The overall contribution of this study is to increase the knowledge of the efficacy of strength and aerobic exercise on knee related quality of life, knee pain, and physical function in patients with knee osteoarthritis (OA).
- Trial name
- NCT01682980
- Testing
- Strength training, Aerobic exercise
- Where
- Norway
- Volunteers
- 207 people
- Sponsor
- Oslo University Hospital
Coeliac Disease, Non Coeliac Gluten Sensitivity
A Blood Based Diagnostic Test for Coeliac Disease
Persons with coeliac disease treated with a gluten free diet will be asked to give blood for a new diagnostic blood test. In this test investigators will use multimerized HLA bound to different gliadin-peptides (tetramer) and…
- Trial name
- NCT02442219
- Where
- Norway
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Chronic Mesenteric Ischemia, Median Arcuate Ligament Syndrome
Intestinal Ischemia Biomarker in Patients With Chronic Mesenteric Ischemia
Plasma Alpha glutathione S transferase (Alpha GST) has been previously demonstrated to be raised in patients with chronic mesenteric ischemia (CMI) caused by atherosclerosis and in patients with median arcuate ligament syndrome…
- Conditions
- Chronic Mesenteric Ischemia, Median Arcuate Ligament Syndrome, Crohn Disease, Cholelithiasis
- Trial name
- NCT06468774
- Testing
- Laparoscopic surgery
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Atrial Fibrillation
The NORwegian Atrial Fibrillation Self-SCREENing
Atrial fibrillation (AF) is common, increases the risk of mortality, stroke and heart failure, and portending significant burden to patients, societal health and health economy. One of three AF cases are undiagnosed.
- Trial name
- NORSCREEN (NCT05914883)
- Testing
- Long-term continuous ECG monitoring
- Where
- Norway
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Oral Cavity Cancer, Sinonasal Cancer
Radiotherapy of Head and Neck Cancer Using an Intraoral Stent
Radiotherapy of oral cavity cancer and sinonasal cancer is associated with acute and late morbidity. Use of an intraoral stent will provide a larger distance between the tongue and palate and can reduce side-effects.
- Trial name
- NCT04330781
- Testing
- Intraoral stent, No intraoral stent
- Where
- Norway
- Volunteers
- 220 people
- Sponsor
- Oslo University Hospital
Aortobifemoral Bypass, Aortoiliac Occlusive Disease
Norwegian Laparoscopic Aortic Surgery Trial
Patients with severe atherosclerotic occlusive disease can be operated on with an aortobifemoral bypass(ABFB)through a median laparotomy. Since 1993, this operation has also been performed laparoscopically.
- Conditions
- Aortobifemoral Bypass, Aortoiliac Occlusive Disease, TASC Type D Lesions, Laparoscopic Versus Open Bifurcation Graft
- Trial name
- NLAST (NCT01793662)
- Testing
- Laparoscopic aortobifemoral bypass
- Where
- Norway
- Volunteers
- 126 people
- Sponsor
- Oslo University Hospital
Melanoma Stage IV, Head and Neck Squamous Cell Carcinoma
Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical Responders
This is a single-arm, single-center, open-label, phase IIa study evaluating the safety, feasibility and efficacy of Faecal Microbiota Transplant (FMT) to cancer patients not responding to ICI therapy, using ICI-responders as…
- Conditions
- Melanoma Stage IV, Head and Neck Squamous Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, MSI-High
- Trial name
- MITRIC (NCT05286294)
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Migraine, Chronic Migraine Headache
The Nordic Chronic Migraine Trial of CGRP Monoclonal Antibody and Onabotulinumtoxin A Dual Therapy Compared to CGRP mAbs Monotherapy
Migraine is characterized by attacks of throbbing, moderate or severe headache, often associated with nausea, vomiting, and/or sensitivity to light and/or sound.
- Trial name
- NorMig (NCT07040813)
- Testing
- CGRP mAbs and onabotulinumtoxin A
- Where
- 6 sites in Norway
- Volunteers
- 450 people
- Sponsor
- Oslo University Hospital
Inclusion Body Myositis (IBM), Feasibility Study
Exercise as Treatment for Patients With Inclusion Body Myositis
There is little knowledge about exercise for patients with inclusion body myositis (IBM). Patients with IBM have limited access to rehabilitation and physiotherapy resources, despite a significant need for these services due to…
- Trial name
- NCT06644482
- Testing
- Exercise group in a hospital setting
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Celiac Disease
Gluten Challenge in Celiac Disease
Up till 30 participants with celiac disease on a glutenfree diet are asked to consume gluten containing cookies or bread for 3 days. Questionnaires and sampling of blood is done before, during and after.
- Trial name
- NCT02464150
- Testing
- Gluten challenge
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Oslo University Hospital
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction
BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function
The study aims to investigate whether oral betablocker (BB) therapy is superior to no such treatment following an acute myocardial infarction (AMI).
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- BETAMI (NCT03646357)
- Testing
- Non-betablocker, Betablocker
- Where
- 20 sites in Norway
- Volunteers
- 2,895 people
- Sponsor
- Oslo University Hospital
Breast Cancer
Improved Breast Cancer Therapy (I-BCT-1) in the Neoadjuvant and Metastatic Setting
The purpose of the study is to investigate the molecular biology of the tumor in relation to treatment response to chemotherapy, in particular paclitaxel compared to the combination paclitaxel and carboplatin.
- Trial name
- NCT02546232
- Testing
- Carboplatin, Paclitaxel
- Where
- Norway
- Volunteers
- 196 people
- Sponsor
- Oslo University Hospital
Head and Neck Squamous Cell Carcinoma
REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck Tumors
Each subject will participate in the trial until death, drop out, or loss-to follow-up from the time the subject signs the Informed Consent Form (ICF) through the final contact.
- Trial name
- REPORT (NCT03317327)
- Testing
- Nivolumab, Radiotherapy (RT)
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Renal Transplant Recipients, Non-functioning Pituitary Adenoma
Implementing eHealth Interventions Into Regular Clinical Practice
The purpose with this study is to test a digital patient-provider communication tool for symptom and needs management among patients with chronic health conditions.
- Trial name
- InvolveMe (NCT04218721)
- Testing
- InvolveMe
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- Oslo University Hospital
Caregiver Stress Syndrome
The Caregiver Pathway - An Intervention to Support Caregivers of Critically Ill Patients
The aim of the project is to test the efficacy of a systematic intervention for individual follow-up of caregivers at the intensive care unit during a 12 month randomized controlled trial.
- Trial name
- NCT04839406
- Testing
- Structured support of caregivers at the ICU
- Where
- Norway
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Health Care Providers, Stress
Digital Stress Management Intervention for Health Care Providers
The purpose with this study is to test if the app-based stress management program StressProffen, can be of interest and support for stress management among health care providers.
- Conditions
- Health Care Providers, Stress, Psychological
- Trial name
- NCT05607758
- Testing
- StressProffen©™
- Where
- Norway
- Volunteers
- 117 people
- Sponsor
- Oslo University Hospital
Critical Illness
Precision Sedation in Intensive Care
Being critically ill and in need of mechanical ventilation is painful and distressing, and patients rarely have the capacity to communicate to express their needs.
- Trial name
- SENSE (NCT06991777)
- Testing
- Precision sedation in intensive care using neurophysiologic and respiratory targets.
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Eosinophilic Esophagitis
Eosinophilic Esophagitis: Towards Improved Management
The current project aims to improve the care for children and adolescents with eosinophilic esophagitis in a collaborative effort involving pediatric units at Oslo Unversity Hospital and Helse Bergen, Norway.
- Trial name
- EoStim (NCT06991881)
- Testing
- Biobank sampling for new biomarkers
- Where
- 2 sites in Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital