Clinical trials: sponsored by Ottawa Hospital Research Institute
Periprosthetic Infection
"Debridement PhagE AnTibiotics for PJI"
Total joint replacement (TJR) has revolutionized care provided for patients suffering from disabling joint pain. Unfortunately, periprosthetic joint infection (PJI) remains a devastating complication and the leading cause of…
- Trial name
- DePHEAT-PJI (NCT07698002)
- Testing
- The investigational product specifically targeting P. aeruginosa (DP-QB-PSA-005) and that targeting S. aureus (DP-QB-STA-005), each formed of a mixture of 5 bacteriophages.
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Depression, Anxiety, Distress, Emotional
PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL)
The goal of this multi-centre phase I/II open-label, single-arm study is to determine the safety, feasibility, therapeutic dose, and preliminary efficacy of psilocybin microdosing to treat psychological distress among patients…
- Trial name
- NCT04754061
- Testing
- Psilocybin
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Kidney Transplant; Complications, Surgery
The PROAKTIVE Trial
The PRO-Active rehabilitation prior to Kidney Transplantation to ImproVe patient-centered recovery Evaluation trial tests an approach where people are supported to exercise, improve diet, and receive emotional support at home…
- Trial name
- NCT07696624
- Testing
- Pro-hab program
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
A Randomized Trial Evaluating Personalized vs Guideline-based Well Follow-up Strategies for Patients With Early-stage Breast Cancer
After breast cancer patients complete the acute phase of their treatment (i.e. surgery, chemotherapy and/or radiation therapy), they are routinely followed in clinic every 3-6 months for several years.
- Trial name
- NCT05365230
- Testing
- On-demand personalized follow-up care, Guideline-based follow-up care (standard of care)
- Where
- Canada
- Volunteers
- 261 people
- Sponsor
- Ottawa Hospital Research Institute
Early-stage Breast Cancer
Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy
The goal of this randomized, pragmatic clinical trial is to evaluate the omission of granulocyte colony-stimulating factors (G-CSF) in breast cancer patients receiving paclitaxel portion of dose-dense adriamycin-cyclophosphamide…
- Trial name
- REaCT-OGF (NCT05753618)
- Testing
- Granulocyte Colony-Stimulating Factor (G-CSF), Omission of Granulocyte Colony-Stimulating Factor (G-CSF)
- Where
- 3 sites in Canada
- Volunteers
- 242 people
- Sponsor
- Ottawa Hospital Research Institute
Early-stage Breast Cancer
Comparing a Single-Dose vs. Twice Yearly Zoledronate in Patients With Early Stage Breast Cancer (REaCT-ZOL)
REaCT ZOL will compare one 4 mg dose of Zoledronate vs. one 4 mg dose of Zoledronate given every 6 months for 3 years.
- Trial name
- REaCT-ZOL (NCT03664687)
- Testing
- Zoledronate
- Where
- 6 sites in Canada
- Volunteers
- 211 people
- Sponsor
- Ottawa Hospital Research Institute
Colonic Neoplasms, Inflammatory Bowel Diseases
IBD Neoplasia Surveillance RCT
We will conduct a multicenter, parallel-group, non-inferiority RCT in persons with IBD undergoing colorectal neoplasia screening with high-definition white light colonoscopy, comparing a strategy of sampling visible lesions alone…
- Conditions
- Colonic Neoplasms, Inflammatory Bowel Diseases, Dysplasia
- Trial name
- NCT05809999
- Testing
- Standard colonoscopy with targeted biopsies
- Where
- 11 sites in Canada
- Volunteers
- 1,411 people
- Sponsor
- Ottawa Hospital Research Institute
Surgery Complications
The ACCELERATE Pilot Trial
The Advancing Cognition and Cognitive reserve before ELective surgery to Enhance cognitive Recovery And TrajEctories (ACCELERATE) Pilot Trial estimates whether our novel, coach-supported cognitive prehabilitation strategy will…
- Trial name
- NCT07655414
- Testing
- Cognitive Prehabilitation
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thromboembolism
Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism
Apixaban and rivaroxaban have been compared to standard therapy for treatment of acute symptomatic venous thromboembolism (VTE) in randomized controlled trials (RCTs), and are both approved by Health Canada.
- Trial name
- COBRRA (NCT03266783)
- Testing
- Apixaban, Rivaroxaban
- Where
- 19 sites in Australia, Canada and 1 more
- Volunteers
- 2,760 people
- Sponsor
- Ottawa Hospital Research Institute
Germ Cell Cancer
A Simplified Regimen to Prevent Nausea and Vomiting Using Netupitant/Palonosetron in Germ Cell Cancer Patients Receiving Chemotherapy
This is a single-site, open-label, randomized pilot feasibility study conducted at The Ottawa Hospital Cancer Centre. A total of 10 participants will be randomized 1:1 to either the experimental or control arm.
- Trial name
- SPARROW-GC (NCT07662200)
- Testing
- Netupitant/Palonosetron Hydrochloride, Ondansetron (Control), Aprepitant
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Elective Colon Surgery
Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery
The REaCT NSQIP will compare oral antibiotics vs. no antibiotics, which are two standards of care treatments for preoperative preparation of the bowel prior to colorectal surgery
- Trial name
- REaCT-NSQIP (NCT03663504)
- Testing
- No Preparation, Neomycin and Flagyl
- Where
- 6 sites in Canada
- Volunteers
- 630 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy
The activity of trastuzumab in early-stage, HER2-positive breast cancer, has been demonstrated in many studies, with meta-analyses showing that in combination with a variety of chemotherapy backbones, trastuzumab reduces the risk…
- Trial name
- NCT04928261
- Testing
- Trastuzumab
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Ottawa Hospital Research Institute
Joint Infection
Bacteriophage Clinical Trial for Periprosthetic Joint Infection of Multidrug Resistant Pseudomonas Aeruginosa
This is a single patient study (SPS) that aims to test the bacteriophage treatment as an experimental treatment on a patient suffering from chronic periprosthetic joint infection (PJI) of the right hip.
- Trial name
- NCT06798168
- Testing
- Combining bacteriophage therapy with antibiotics for a case with hip PJI
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer
The current standard of care for stage 1 hormone receptor-positive (HR+) breast cancer consists of breast-conserving surgery followed by adjuvant radiotherapy (RT) and endocrine therapy (ET) for at least 5 years.
- Trial name
- NCT04921137
- Testing
- No endocrine therapy, Endocrine therapy
- Where
- 8 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Ottawa Hospital Research Institute
Hip Osteoarthritis, Hip Arthritis
Evaluating XPERIENCE™ Advanced Surgical Irrigation
A prospective, multi-center, double-arm, parallel, interventional, randomized, controlled clinical trial to assess the rate of periprosthetic joint infection (PJI) in patients undergoing primary total knee arthroplasty (TKA)…
- Conditions
- Hip Osteoarthritis, Hip Arthritis, Knee Osteoarthritis, Knee Arthritis
- Trial name
- XPERIENCE (NCT05543941)
- Testing
- XPERIENCE Advanced Surgical Irrigation, Dilute Betadine
- Where
- 8 sites in Canada
- Volunteers
- 7,600 people
- Sponsor
- Ottawa Hospital Research Institute
Knee Osteoarthritis, Knee Arthritis
Intra-Operative Adductor Canal Blocks
Adductor canal blocks (ACB) have been recommended in total knee arthroplasty (TKA) to provide better control of post-operative pain, facilitate early ambulation, and reduce length of stay in the hospital.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Anesthesia
- Trial name
- NCT05601427
- Testing
- aACB, sACB
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Stroke
TeleRehab for Stroke Patients Using Mobile Technology
Post-stroke communication deficits (PSCD) are a common symptom of patients having sustained a stroke. These deficits include difficulty to produce or understand language, motor speech disorders and cognitive-communication…
- Trial name
- NCT02615132
- Testing
- iPad
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Type 2 Diabetes
Pancreatic Insulin Production Capacity (PIPC) - a Feasibility Study
The standard treatment for Type 2 diabetes involves management of the disease based on average of blood glucose control over the past few months.
- Trial name
- PIPC (NCT06462170)
- Testing
- Boost Original meal replacement shake
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Ottawa Hospital Research Institute
Thoracic Cancer, Complication,Postoperative
Variability and Post-op AEs: Does Preoperative CardioPulmonary Variability Assessment Identify Risk of Postoperative Adverse Events Following Thoracic Surgery
Major thoracic surgery is high risk as it carries a significant risk of postoperative Adverse Events (AEs), where patients experience complications and do not recover as expected.
- Trial name
- CPVA (NCT07016022)
- Testing
- CardioPulmonary Variability Assessment
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Ottawa Hospital Research Institute
Airway Extubation
Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support
Timely and safe extubation in critically ill patients is vitally important as prolonged mechanical ventilation and failed attempts at extubation are associated with increased morbidity, mortality, costs, intensive care unit (ICU)…
- Trial name
- LEADS (NCT05506904)
- Testing
- Extubation Advisor
- Where
- 12 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute