Clinical trials: sponsored by Ottawa Hospital Research Institute
Tobacco Dependence, COPD Asthma
Cytisine vs Nicotine Replacement Therapy
Tobacco is the most preventable cause of disease and death in Canada. Although the tobacco use rate has substantially gone down in the general population, significant differences exist between sub-populations in Canada, for…
- Conditions
- Tobacco Dependence, COPD Asthma, Mental Illness, Substance Use
- Trial name
- NCT03249428
- Testing
- Cytisine, Nicotine replacement therapy (NRT)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Tobacco Use, Substance Use
Tobacco-Concurrent Addictions in At-Risk Youth in Ottawa
According to the 2015 Ontario Student Drug Use and Health Survey (OSDUHS), there has been a significant increase in the number of secondary school youth who use poly-substances.
- Conditions
- Tobacco Use, Substance Use, Cannabis Use
- Trial name
- TCAY-Ottawa (NCT04812613)
- Where
- Canada
- Volunteers
- 520 people
- Sponsor
- Ottawa Hospital Research Institute
Knee Osteoarthritis (Knee OA), Knee Pain Chronic
Advanced Brain Imaging-TKA (fMRI-TKA)
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities.
- Conditions
- Knee Osteoarthritis (Knee OA), Knee Pain Chronic, Brain Network Connectivity, Patient Satisfaction
- Trial name
- fMRI-TKA (NCT07464080)
- Testing
- fMRI Brain Scan
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Surgery-Complications, Disability Physical
The STRIVE Before Surgery Pilot Trial
The STRIVE Before Surgery Trial evaluates three pragmatic elements (recruitment, adherence, and follow-up) associated with participating in a home-based multimodal prehabilitation program supported through an online platform.
- Trial name
- NCT06042491
- Testing
- Prehabilitation intervention
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- Ottawa Hospital Research Institute
Bipolar Disorder, Mania
Clocks in Sync - Circadian Rhythm and Bipolar Mania
The sleep-wake cycle is severely disrupted during an episode of mania. Often mania is treated with medications that can come with significant side effects.
- Trial name
- CIS (NCT06504342)
- Testing
- Blue-blocking glasses, Time-restricted eating, Lightly tinted glasses
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Reconstruction
The Use of Alloderm Versus Dermacell in Immediate Implant Based Breast Reconstruction
Breast reconstruction after mastectomy has been shown to provide psychosocial benefits to breast cancer patients and is considered an integral part of breast cancer treatment.
- Trial name
- REaCT-ADM (NCT03064893)
- Testing
- Alloderm, Dermacell
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Ottawa Hospital Research Institute
Lung Cancer, Gastric Cancer
The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III
Despite enormous advances in thoracic surgery and oncology, two critical issues concern patients undergoing curative-intent surgery for lung, gastric and esophageal cancer: first, a majority (~60%) of patients experience minor…
- Conditions
- Lung Cancer, Gastric Cancer, Esophageal Cancer
- Trial name
- POISE (NCT04871412)
- Testing
- Vitamin D3 Drops, Coriolus Versicolor, Trident SAP 66:33 Lemon
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Achalasia, Paraesophageal Hernia
Minimally Invasive Surgery of the Gastro-esophageal Junction
This study will assess short and long term outcomes of individuals undergoing minimally invasive surgery of the gastro-esophageal junction (MISGEJ).
- Conditions
- Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula
- Trial name
- MISGEJ (NCT01799967)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Granulomatosis With Polyangiitis, Microscopic Polyangiitis (MPA)
Safe Effective Therapy With Low-Dose Glucocorticoid in ANCA-Associated Vasculitis (SAFE-LOW)
The purpose of this study is to determine the safety and efficacy of a therapeutic regimen consisting of 4 weeks of glucocorticoids given with a combination of the usual induction agents for ANCA-associated vasculitis.
- Trial name
- SAFE-LOW (NCT06983821)
- Testing
- Cyclophosphamide, Standard of Care (SOC), Prednisone
- Where
- 2 sites in Canada
- Volunteers
- 36 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thromboembolism, Blood Clot
Statins for Venous Event Reduction in Patients With Venous Thromboembolism
The standard or usual treatment for patients diagnosed with deep vein thrombosis or pulmonary embolism is treatment with blood thinners (called anticoagulants).
- Conditions
- Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome
- Trial name
- SAVER (NCT04319627)
- Testing
- Rosuvastatin Calcium
- Where
- 31 sites in Canada, France and 4 more
- Volunteers
- 2,700 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
Evaluating the Dose Timing (Morning vs Evening) of Endocrine Therapy and Its Effects on Tolerability and Compliance
Endocrine therapy is an established treatment for hormone receptor-positive breast cancer, but can cause significant side effects with deterioration in quality of life.
- Trial name
- NCT04864405
- Testing
- Morning administration of endocrine therapy, Evening administration of endocrine therapy
- Where
- 2 sites in Canada
- Volunteers
- 245 people
- Sponsor
- Ottawa Hospital Research Institute
Hematologic Neoplasms
Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial)
It is hypothesized that a strategy using prophylactic oral and intravenous Tranexamic Acid (TXA) with therapeutic platelet transfusions (if required) is safe and more effective than prophylactic platelet transfusions in patients…
- Trial name
- PATH (NCT04448184)
- Testing
- Tranexamic Acid
- Where
- 12 sites in Canada
- Volunteers
- 662 people
- Sponsor
- Ottawa Hospital Research Institute
Sinusitis, Nasal Polyps
Pilot Study of The EPIC Trial
Chronic sinusitis is one of the most common chronic diseases in North America, with over 5% of the Canadian population affected by the disease. Until now, treatment with surgery has been performed only in the operating room.
- Trial name
- NCT02533206
- Testing
- Endoscopic Polypectomy Performed in Clinic, Functional Endoscopic Sinus Surgery (FESS)
- Where
- 5 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Syncope
REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT
Syncope (fainting) is a common reason for emergency department (ED) presentation. Fainting can be caused by heart conditions such as irregular heart rhythm (arrhythmia) that can be life-threatening, structural heart problems, or…
- Trial name
- REMOSYNCED (NCT05066347)
- Testing
- Cardiophone Plus
- Where
- Canada
- Volunteers
- 580 people
- Sponsor
- Ottawa Hospital Research Institute
Neuromuscular Disease
B3 for NMD: Bench to Bedside and Back
Background: Neuromuscular diseases (NMD) represent a broad group of rare genetic and acquired disorders, affecting over 300,000 people in Canada.
- Trial name
- NCT04417023
- Testing
- B3 for NMD: Bench to Bedside and Back
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Neuromuscular Diseases
MYO-SHARE: MYO-MRI in Neuromuscular Diseases
Neuromuscular Diseases (NMDs) affect > 7 million people worldwide. NMDs are often difficult to accurately diagnose, with over 200 different genetic causes with overlapping clinical presentations.
- Trial name
- MYO-SHARE (NCT04866459)
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Ottawa Hospital Research Institute
Sinusitis, Nasal Polyps
In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps
Chronic rhinosinusitis, also called chronic sinusitis, is a very common life-long disease affecting over 5% of the Canadian population.
- Trial name
- NCT02975310
- Testing
- Endoscopic polypectomy in clinic (EPIC), Endoscopic Sinus Surgery (ESS), General Anesthesia
- Where
- 4 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Ottawa Hospital Research Institute
Hip Dysplasia
Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology
At present, it is not clear whether performing a hip arthroscopy at the same time as a PAO improves patient outcomes after surgery compared to a PAO alone.
- Trial name
- NCT03481010
- Testing
- PAO with hip arthroscopy, PAO without hip arthroscopy
- Where
- 7 sites in United States, Canada
- Volunteers
- 204 people
- Sponsor
- Ottawa Hospital Research Institute
Nicotine Dependence, Substance Use Disorders
Healthy People Initiative (HPI)
Addictions do not occur in isolation. Tackling addictions requires addressing social determinants such as isolation, homelessness, marginalization, and unemployment.
- Trial name
- HPI (NCT03506867)
- Testing
- Life skills, training, education and work/volunteer opportunities, Usual Care
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
Evaluating Whether Integration of Prognostic and Predictive Algorithms Into Routine Clinical Practice Effect Whether Oncologists Order Multigene Assays in Patients With Early Stage Breast Cancer
A broad range of prognostic and predictive tools are available for patients with newly diagnosed early stage breast cancer. These range from free and publicly available mathematical algorithms, through to expensive genomic tests.
- Trial name
- REaCT-Algorith (NCT04131933)
- Where
- 6 sites in Canada
- Volunteers
- 602 people
- Sponsor
- Ottawa Hospital Research Institute