Clinical trials: sponsored by Ottawa Hospital Research Institute
Breast Cancer
An Integrated Consent Model Study to Compare Two Standard of Care Schedules for Monitoring Cardiac Function in Patients Receiving Trastuzumab for Early Stage Breast Cancer
Several large adjuvant trastuzumab trials have demonstrated improved overall survival in participants with early stage breast cancer, with a 33% decrease in risk of death.
- Trial name
- OTT 15-05 (NCT02696707)
- Testing
- LVEF 3 month, LVEF 4 month
- Where
- 4 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
Utilizing MyChart to Assess the Effectiveness of Interventions for Vasomotor Symptoms: A Feasibility Study
Vasomotor symptoms (VMS) are a common consequence of systemic therapies for breast cancer. Breast cancer treatments can cause VMS in approximately 30% of postmenopausal women and 95% of premenopausal women with early stage breast…
- Trial name
- NCT05222464
- Testing
- Standard of care treatments
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
Multicentre Study to Determine the Feasibility of Using an Integrated Consent Model to Compare Three Standard of Care Regimens for The Treatment of Triple-Negative Breast Cancer in the Neoadjuvant/Adjuvant Setting (REaCT-TNBC)
Triple-negative breast cancer (TNBC) is a term applied to breast cancer cases that have <1% expression of the estrogen receptor (ER) and the progesterone receptor (PR) and do not over express HER2.
- Trial name
- OTT15-04 (NCT02688803)
- Testing
- Dose dense AC-P, Dose dense AC, FEC-D
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Ottawa Hospital Research Institute
Gestational Diabetes Mellitus (GDM)
The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (EAGER Pilot Trial)
The EAGER pilot trial is designed to assess the feasibility of a Canadian, multicentre prospective randomized open-label blinded end-point (PROBE) clinical trial addressing whether induction of labour (IOL) at 38 weeks' gestation…
- Trial name
- EAGER Pilot (NCT06641141)
- Testing
- Induction of Labour
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Ottawa Hospital Research Institute
Neck Injuries
A Pragmatic Evaluation of the Canadian C-Spine Rule by Paramedics
Each year, half a million patients with a potential neck (c-spine) injury are transported to Ontario emergency departments (ED). Less than 1% of all these patients actually have a neck bone fracture.
- Trial name
- NCT02786966
- Testing
- Canadian C-Spine Rule
- Where
- Canada
- Volunteers
- 3,646 people
- Sponsor
- Ottawa Hospital Research Institute
Peyronies Disease
Title Fractioned CO2 Laser in the Treatment of Chronic Phase Peyronie's Disease
Peyronie's Disease (PD) is a fibrosing disorder of the penis where scar tissue (composed of excessive and disorganized collagen) known as a "plaque," forms along the shaft of the penis.
- Trial name
- NCT07177833
- Testing
- Fractional CO2 laser
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Penile Numbness
Vacuum Therapy for the Treatment of Penile Numbness/Sensory Changes
This is a prospective, uncontrolled, Hypothesis generating study. A total of eight adult male participants experiencing penile insensitivity will be recruited through the Ottawa Hospital's Men's Health Clinic.
- Trial name
- NCT07171567
- Testing
- Vacuum erection device
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Ottawa Hospital Research Institute
Thromboembolic Disease Recurrent, Deep Vein Thrombosis
Clinical Predictors for Venous Thromboembolism in Patients With a History of Thrombosis (PREDICTORS)
Patients with a history of blood clots are at risk of developing additional clots in the future. Doctors use a tool called a clinical decision rule to tell them how likely it is that a patient has a blood clot and if they should…
- Conditions
- Thromboembolic Disease Recurrent, Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- PREDICTORS (NCT02297373)
- Where
- 9 sites in Canada, Netherlands and 1 more
- Volunteers
- 744 people
- Sponsor
- Ottawa Hospital Research Institute
Peyronie's Disease
Microneedle Treatment of Chronic Phase Peyronie's Disease: A Pilot Clinical Trial
Peyronie's Disease (PD) is a disorder of the penis where scar tissue (composed of excessive and disorganized collagen) known as a "plaque," forms along the shaft of the penis.
- Trial name
- NCT07128420
- Testing
- Application of 3 sessions of microneedle therapy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Anterior Wall Myocardial Infarction
The Enhanced Angiogenic Cell Therapy - Acute Myocardial Infarction Trial
This will be the first clinical trial to include a strategy designed to enhance the function of autologous progenitor cells by overexpressing eNOS, and the first to use combination gene and cell therapy for the treatment of…
- Trial name
- ENACT-AMI (NCT00936819)
- Testing
- Plasma-Lyte A and 25% Autologous Plasma, Autologous EPCs, Autologous EPCs Transfected with human eNOS
- Where
- 3 sites in Canada
- Volunteers
- 47 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma
CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies
The investigators propose an early phase study defined as a phase I/II trial assessing safety, feasibility and efficacy of CLIC-1901 autologous anti-CD19 Chimeric Antigen Receptor T cells (CAR-T) cells for participants with…
- Conditions
- Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia
- Trial name
- CLIC-01 (NCT03765177)
- Testing
- CLIC-1901
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
SVT, Thrombosis
A Pilot Trial Comparing Full Dose Rivaroxaban to Prophylactic Dose Rivaroxaban in Patients With Superficial Vein Thrombosis in the Leg
The goal of this clinical trial, called a pilot study or a feasibility study, is to test the study plan and to find out whether enough participants will join a larger study and accept the study procedures.
- Conditions
- SVT, Thrombosis, Superficial Vein Thrombosis
- Trial name
- RIVA-SVT (NCT06965998)
- Testing
- Full dose rivaroxaban, Low dose rivaroxaban
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Covid19, Acute Respiratory Distress Syndrome
Cellular Immuno-Therapy for COVID-19 ARDS Randomized Clinical Trial
This is a Phase 2 multicenter randomized (2:1), placebo-controlled trial to evaluate early signs of efficacy of allogeneic, umbilical cord-derived (UC) mesenchymal stromal cells (MSCs) in patients with COVID-19 and Acute…
- Trial name
- CIRCA-19 RCT (NCT04865107)
- Testing
- UC-MSCs
- Where
- 4 sites in Canada
- Volunteers
- 22 people
- Sponsor
- Ottawa Hospital Research Institute
Hematologic Malignancy
Cold Versus Room Temperature Storage of Platelets for Bleeding in Hematologic Malignancy - a Pilot Trial
This is a pilot trial to discover the feasibility of recruiting 50 pts over the course of 12 months. The trial is testing the efficacy of using cold-stored vs.
- Trial name
- CoVeRTS-HM (NCT05820126)
- Testing
- Cold-stored platelet concentrate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Liver Neoplasms, Hepatectomy
Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections
Major liver resection is associated with substantial intraoperative blood loss and subsequently blood transfusions. Blood transfusion in elective liver surgery is a significant factor of perioperative morbidity and mortality, as…
- Conditions
- Liver Neoplasms, Hepatectomy, Blood Transfusion, Blood Loss, Surgical
- Trial name
- PRICE2 (NCT03651154)
- Testing
- Hypovolemic Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 440 people
- Sponsor
- Ottawa Hospital Research Institute
Type 2 Diabetes (T2DM), Hypoglycemia (Diabetic)
Personalized Hypoglycemia Outpatient Treatment - a Feasibility Study
This study will offer two study interventions designed to bring on a mild low blood sugar (capillary blood glucose result 3.0 to 3.8 mmol/L), in order to study the effectiveness of each study participant's personal choice of…
- Trial name
- PHOT (NCT07094529)
- Testing
- Recumbent Exercise Bike to induce mild hypoglycemia, Delaying food to induce mild hypoglycemia,
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Hospital Research Institute
Bronchopulmonary Dysplasia
Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is a common and chronic lung disease that occurs in preterm infants following ventilator and oxygen therapy and is associated with long-term health consequences.
- Trial name
- NCT04255147
- Testing
- Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells
- Where
- 2 sites in Canada
- Volunteers
- 9 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thromboembolism, Urologic Cancer
VTE Prevention With Rivaroxaban in Genitourinary Cancer Patients Receiving Systemic Therapy
Patients with genitourinary cancers (ex: bladder, testicular, kidney) are at high risk of developing blood clots if they receive systemic therapy (ex: chemotherapy, immunotherapy).
- Trial name
- PREVENT-GU (NCT05920343)
- Testing
- Rivaroxaban 10 MG
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Hospital Research Institute
Bronchopulmonary Dysplasia (BPD), ELGAN (22-28SA)
Mesenchymal Stromal Cell Therapy to Prevent Bronchopulmonary Dysplasia in Extreme Preterm Infants
This clinical trial aims to evaluate the safety and efficacy of mesenchymal stromal cell (MSC) therapy in extreme preterm infants to prevent bronchopulmonary dysplasia, the main respiratory complication of preterm birth.
- Trial name
- HULC-2 (NCT07058025)
- Testing
- Human Allogenic Umbilical Cord Mesenchymal Stromal Cells
- Where
- 8 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thromboembolism, Cancer
Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters
The purpose of the full trial is to determine the efficacy and safety of prophylactic dose rivaroxaban to prevent VTE among cancer patients with CVC.
- Trial name
- TRIM-Line (NCT05029063)
- Testing
- Rivaroxaban 10 MG
- Where
- 11 sites in Canada
- Volunteers
- 1,828 people
- Sponsor
- Ottawa Hospital Research Institute