Clinical trials: sponsored by Ottawa Hospital Research Institute
Venous Thromboembolism, Cancer
Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters
The purpose of the full trial is to determine the efficacy and safety of prophylactic dose rivaroxaban to prevent VTE among cancer patients with CVC.
- Trial name
- TRIM-Line (NCT05029063)
- Testing
- Rivaroxaban 10 MG
- Where
- 11 sites in Canada
- Volunteers
- 1,828 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis of the Shoulder
Unravelling the Etiology of Shoulder Osteoarthritis
Osteoarthritis (OA) is a progressive disease resulting from the degradation of synovial joint articular cartilage over time. The hallmark symptom is diffuse aching and progressive pain made worse with activity.
- Trial name
- UESOA (NCT04634773)
- Testing
- Low-dose CT, T1Rho MRI, Motion Analysis
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Massive Rotator Cuff Tear
Lower Trapezius Tendon Transfer vs Partial Cuff Repair in Massive Rotator Cuff Tears
Very large tears of the shoulder tendons (the 'rotator cuff') that are not surgically repairable and in the absence of significant shoulder arthritis are common in older patients, and are associated with significant pain and…
- Trial name
- TENET (NCT07051889)
- Testing
- Lower Trapezius Tendon Transfer, Partial Rotator Cuff Repair
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Rotator Cuff Tear
Outcome Following Surgery to Repair Rotator Cuff Tears
There are two ways in which surgeons repair rotator cuff tears. An open method involves making an incision (cut) 5-6 inches in length in the skin and repairing the tear with the skin open, while the arthroscopic method involves…
- Trial name
- NCT00260949
- Testing
- Arthroscopic repair of rotator cuff tear
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Ottawa Hospital Research Institute
BPPV, Benign Paroxysmal Positional Vertigo
Clinical Trial of Vit D and Calcium for Recurrent BPPV
Randomized double blind placebo controlled trial of vitamin D supplements, with or without calcium supplementation, versus placebo in reduction of recurrences in BPPV.
- Conditions
- BPPV, Benign Paroxysmal Positional Vertigo, Vertigo, Vertigo, Peripheral
- Trial name
- NCT05863949
- Testing
- vitamin D +/- calcium
- Volunteers
- 860 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
Post-operative Radiation With IMRT in the Management of Stage IIB-III Breast Cancer
Research has shown that treatment with conventional radiation techniques and chemotherapy following mastectomy or breast conserving surgery has resulted in better rates of locoregional control and overall survival in stage…
- Trial name
- NCT00508352
- Testing
- Helical tomotherapy IMRT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Airway Extubation
Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool
Expeditious, safe extubation is vitally important in the care of Intensive Care Unit (ICU) patients, as prolonged mechanical ventilation harms patients and failed extubation (i.e.
- Trial name
- NCT04708509
- Testing
- Extubation Advisor
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Ottawa Hospital Research Institute
Fluid Therapy
Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients
The aim of the FLUID Trial is to conduct a pragmatic, multi-centre, open label randomized cluster cross-over trial (RCT) to determine whether fluid administration with 0.9% saline as compared to Ringer's lactate decreases death…
- Trial name
- FLUID (NCT04512950)
- Testing
- Ringer's lactate, 0.9% saline
- Where
- 7 sites in Canada
- Volunteers
- 43,626 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Kidney Injury, Renal Replacement Therapy
Albumin To Enhance Recovery After Acute Kidney Injury
Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses)…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
- Trial name
- ALTER-AKI (NCT04705896)
- Testing
- 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL)
- Where
- 16 sites in Canada
- Volunteers
- 856 people
- Sponsor
- Ottawa Hospital Research Institute
SARS-CoV-2, Covid19
Assessing the Mother-to-infant Transmission Capabilities of COVID-19 Infection Among Pregnant Women in Ontario, Canada
In order to assess the mother-to-infant and potential vertical transmission of SARS-CoV-2 infection in pregnant women, maternal and neonatal biological samples were prospectively collected from women with confirmed or suspected…
- Conditions
- SARS-CoV-2, Covid19, Corona Virus Infection, Infectious Disease Transmission, Vertical
- Trial name
- COPE (NCT04913948)
- Testing
- No intervention
- Where
- 12 sites in Canada
- Volunteers
- 246 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Arrest
Biphasic Defibrillation Study: Trial to Compare Fixed Versus Escalating Energy
This study will compare the effect of constant low-level energy [150 joules] to an escalating energy [200-300-360 joules] regimen of biphasic waveform defibrillation on multiple patient outcomes.
- Trial name
- NCT00212992
- Testing
- Fixed lower-energy defibrillation, Escalating higher-energy defibrillation
- Where
- Canada
- Volunteers
- 221 people
- Sponsor
- Ottawa Hospital Research Institute
Autism Spectrum Disorder, Asthma
Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)
FACT 4 Child is a follow up study of mothers who participated in the Folic Acid Clinical Trial (NCT01355159) and their children at 4-6 years of age to determine the effect of high dose folic acid supplementation on social…
- Conditions
- Autism Spectrum Disorder, Asthma, Executive Dysfunction, Emotional Problem
- Trial name
- NCT03269110
- Testing
- SRS 2, CBCL, BRIEF-P
- Where
- 58 sites in Australia, Canada and 2 more
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Chronic Obstructive Pulmonary Disease, COPD
Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary Disease (COPD) Need Antibiotics and Steroids?
The goal of this clinical trial is to see if the use of two simple blood tests: C reactive protein and eosinophils, can reduce the use of steroids and antibiotics in patients with flares of chronic obstructive pulmonary disease…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Exacerbation of COPD, AECOPD
- Trial name
- Bidex (NCT06929767)
- Testing
- biomarker-guided decision making, GOLD recommendations
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Hospital Research Institute
Cannabis Use, Marijuana Use
Cannabis Use in Pregnancy and Downstream Effects on Maternal and Infant Health
With perinatal cannabis use rising in Canada, robust data on short-term and long-term effects on newborns are urgently needed. However, past barriers to obtain robust data included limited sample sizes, low self-reporting and no…
- Trial name
- CUPiD (NCT05309226)
- Testing
- Cannabis use in pregnancy or cannabis exposure in utero
- Where
- 4 sites in Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Arrest
Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios.
STUDY OBJECTIVES The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 30:2 versus the old 15:2 chest compression to ventilation International Resuscitation Guidelines, in a…
- Trial name
- NCT00380757
- Testing
- bystander CPR using 30:2 ratio vs 15:2 ratio
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Abdominal Cancer
Characterizing Postoperative T and B Cell Dysfunction in Cancer Surgery Patients, Using COVID-19 as a Model Antigen
The Auer Lab research program studies how surgery affects the immune system and how this can lead to suppression in cancer patients which can lead to cancer reoccurrence.
- Trial name
- NCT06925906
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Atrial Fibrillation
RAFF4 Trial: Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department
The objective is to compare IV vernakalant to IV procainamide for the ED management of acute AF patients. If vernakalant proves to be more effective, faster, and safer than IV procainamide, this will give clinicians an important…
- Trial name
- NCT04485195
- Testing
- Vernakalant, Procainamide
- Where
- 14 sites in Canada
- Volunteers
- 350 people
- Sponsor
- Ottawa Hospital Research Institute
Hypertension
Dietary Counseling or Potassium Supplement to Increase Potassium Intake in Patients With High Blood Pressure
High blood pressure is the leading cause of cardiovascular disease worldwide. Many medicines are available to lower blood pressures successfully, as well as many non-medical options, such as dietary changes.
- Trial name
- NCT03809884
- Testing
- Dietary Counselling, Potassium Citrate
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer, Chronic Pain
Reducing Pain and Disability After Breast Cancer Surgery
The purpose of this study is to determine if the combination of thoracic paravertebral block and multimodal analgesia will decrease chronic pain and arm morbidity in patients undergoing breast cancer surgery with lymph node…
- Trial name
- RELIeF (NCT01089933)
- Testing
- Thoracic Paravertebral Block (TPVB), Local Anesthetic
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- Ottawa Hospital Research Institute
Syncope
SW-RCT Implementation of Canadian Syncope Risk Score Based Practice Recommendations
Syncope is a common reason for emergency department (ED) presentation. While often benign, some patients have serious and life-threatening underlying causes, both cardiac and non-cardiac, which may or may not be apparent at the…
- Trial name
- NCT04972071
- Testing
- Knowledge translation (KT) of the CSRS based practice recommendations
- Where
- 15 sites in Canada
- Volunteers
- 14,400 people
- Sponsor
- Ottawa Hospital Research Institute