Clinical trials: sponsored by Ottawa Hospital Research Institute
Myeloproliferative Neoplasm (MPN), Essential Thrombocythemia (ET)
Assessing Feasibility of Thromboprophylaxis With Apixaban in JAK2-positive Myeloproliferative Neoplasm Patients
Myeloproliferative neoplasms (MPNs) are blood disorders that occur when the body makes too many white or red blood cells, or platelets.
- Conditions
- Myeloproliferative Neoplasm (MPN), Essential Thrombocythemia (ET), JAK2 Mutation, Polycythemia Vera (PV)
- Trial name
- AIRPORT-MPN (NCT04243122)
- Testing
- Apixaban 2.5 MG Oral Tablet [ELIQUIS], Aspirin 81 mg
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Ottawa Hospital Research Institute
Pre-Eclampsia
FACT Biomarker Subgroup Analysis
The FACT Biomarker Subgroup Analysis is a pilot study of mothers who participated in the Folic Acid Clinical Trial (FACT, NCT01355159).
- Trial name
- NCT03981029
- Testing
- 4.0mg Folic Acid received through participation in FACT (NCT01355159)
- Where
- 4 sites in Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Anterior Shoulder Instability
Approach to Shoulder Instability
The primary research question is to determine whether patients who undergo a stabilization of the shoulder using a novel decision-making algorithm (ISIS Score) have improved disease-specific quality of life at 1 year…
- Trial name
- NCT02060227
- Testing
- Open Latarjet procedure, Arthroscopic Bankart repair
- Where
- 2 sites in Canada
- Volunteers
- 78 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis, Shoulder
TSA Techniques in Glenohumeral OA
Osteoarthritis (OA) of the shoulder is a disease resulting from the wearing down of cartilage over time. OA can produce pain and dysfunction at the affected joint and is a growing occurrence in an aging population.
- Trial name
- NCT02966886
- Testing
- Eccentric Reaming, Augmented Glenoid Component Implantation, Posterior Glenoid Bone Grafting
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis Shoulder
TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion
This study will compare total shoulder arthroplasty (TSA) with an augmented glenoid component and reverse shoulder arthroplasty (RSA) procedures, in participants with advanced glenohumeral osteoarthritis aged 65 years and older…
- Trial name
- SERVASA15 (NCT05487274)
- Testing
- Total Shoulder Arthroplasty + augmented glenoid component, Reverse Shoulder Arthroplasty
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Ottawa Hospital Research Institute
Total Shoulder Arthroplasty
Diagnostic Accuracy of Synovial Biopsy for Implant-Related Shoulder Infections
The purpose of this study is to determine the efficacy of retrieving tissue samples via an x-ray guided needle that is inserted into the infected tissue in the shoulder.
- Trial name
- NCT02143245
- Testing
- Synovial Biopsy, Open Tissue Biopsy
- Where
- 4 sites in Canada
- Volunteers
- 118 people
- Sponsor
- Ottawa Hospital Research Institute
COPD, Asthma
The UCAP 2 Pilot Study
Our research group has found that Canadians with undiagnosed asthma or chronic obstructive pulmonary disease (COPD) have increased respiratory symptoms and worse health-related quality of life.
- Trial name
- NCT06014840
- Testing
- Assessment and Treatment provided to participant by a respirologist using evidence-based guidelines for asthma or COPD
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Chronic Obstructive Pulmonary Disease
Validating the Use of Frailty Measurements to Predict Care & Quality of Life
The aim of this research program is to validate frailty measurements as a risk stratification tool to predict deteriorations in patient-reported outcomes, to gain a better understanding of patient preferences for care within…
- Trial name
- NCT06325241
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Pneumococcal Vaccines, Immunization Coverage
Reminder Emails to Improve Pneumococcal Vaccine Completion at 12 Months of Age
The goal of this clinical trial is to assess the effectiveness of enhanced email reminders in improving vaccine coverage at the 12-month visit in CANImmunize app users.
- Trial name
- NCT06000397
- Testing
- Enhanced reminders, Standard CANImmunize notifications
- Where
- Canada
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Disease Due to BK Polyomavirus, Kidney Transplant Infection
Quinolone Prophylaxis for the Prevention of BK Virus Infection in Kidney Transplantation: A Pilot Study
Primary Research Questions: Efficacy, safety and feasibility of a 3-month course of levofloxacin in a pilot study will be assessed. 1.
- Trial name
- NCT01353339
- Testing
- Levofloxacin
- Where
- 11 sites in Canada
- Volunteers
- 154 people
- Sponsor
- Ottawa Hospital Research Institute
Lymphedema, Seroma
Breaststroke Swimming After Breast Cancer Treatment/Surgery as a Means of Treatment for Seroma, Lymphedema, and Chronic Arm and Chest Pain
Following surgery and treatment for breast cancer, many patients experience swelling of lymph nodes (lymphedema) or accumulation of fluid (seroma) that can cause pain, restrict movement, and reduce quality of life.
- Conditions
- Lymphedema, Seroma, Pain, Postoperative, Pain, Chest
- Trial name
- NCT04080934
- Testing
- Swimming
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- Ottawa Hospital Research Institute
Vascular Diseases, Peripheral Artery Disease
The ALOFT Pilot Trial
The ALOFT Pilot Trial will evaluate three pragmatic elements (recruitment, adherence, and follow-up) of neuraxial versus general anesthesia for lower limb revascularization surgery that are necessary to support a successful…
- Conditions
- Vascular Diseases, Peripheral Artery Disease, Surgery
- Trial name
- NCT06067789
- Testing
- neuraxial anesthesia
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Ottawa Hospital Research Institute
Ischemic Stroke, Acute Ischemic Stroke
Virtual Intervention Stroke Initiative
The goal of this clinical trial is to determine if patients admitted to a primary stroke centre, such as the general internal medicine service of the Ottawa Hospitals General Campus, for acute ischemic stroke would benefit from a…
- Trial name
- VISION (NCT05875389)
- Testing
- Virtual assessment
- Volunteers
- 80 people
- Sponsor
- Ottawa Hospital Research Institute
Amyotrophic Lateral Sclerosis
Evaluation of Palliative Care for Patients With ALS and Their Caregivers
Rationale: Amyotrophic lateral sclerosis (ALS) is a degenerative illness which currently has no medical cure. It is routinely accompanied by a significant symptom burden including high levels of distress in patients and their…
- Trial name
- NCT04257760
- Testing
- Palliative Care consultation outside standard of care
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Complication, Myocardial Infarction
Cellular precOnditioning for Post-Surgical Myocardial Ischemic Complications - Observational Study
The goal of this observational study is to collect health data on people who are at high risk of having heart complications and are having a surgery that is not on the heart.
- Conditions
- Cardiac Complication, Myocardial Infarction, Myocardial Ischemia, Myocardial Injury
- Trial name
- COSMIC (NCT05762601)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Ottawa Hospital Research Institute
Polycystic Ovary Syndrome, Obesity
Correlating Improvement in PCOS Symptoms to the Percentage of Body Weight Lost in Females Also Living With Obesity
The goal of this clinical trial is to study the effects of a intensive weight loss program (STREAM) in patients living with PCOS.
- Trial name
- FLOWERS-PCOS (NCT06325449)
- Testing
- STREAM program
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Arrest
Survey of Attitudes and Factors Associated With CPR in an Older Population
The goal of this study is to conduct a survey to better understand the factors associated with undertaking cardiopulmonary resuscitation (CPR) training and performing CPR in an emergency situation.
- Trial name
- NCT00665288
- Where
- Canada
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
SARS-CoV2 Infection, Covid19
Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination Prospective Cohort Study
The PLAN-V Study is an Ontario-based prospective, longitudinal study that will consist of extensive biosampling and detailed data collection from pregnant women/individuals, who have received the COVID-19 vaccine during their…
- Conditions
- SARS-CoV2 Infection, Covid19, Vaccine Reaction, Pregnancy Related
- Trial name
- PLAN-V (NCT05115617)
- Where
- 7 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Asthma, COPD
Undiagnosed COPD and Asthma Population Study (UCAP)
Previous population health studies suggest that up to 10% of Canadian adults have undiagnosed asthma or COPD- these people are currently undiagnosed and untreated, even though they may have significant respiratory symptoms.
- Trial name
- NCT03148210
- Testing
- Treatment strategy using evidence-based guidelines for asthma or COPD, Smoking Cessation, Participant Education
- Where
- 15 sites in Canada
- Volunteers
- 508 people
- Sponsor
- Ottawa Hospital Research Institute
Patent Ductus Arteriosus After Premature Birth
PDA Treatment With Ibuprofen and Changes in Tissue Oxygenation.
Babies who are born very prematurely are often born with murmurs in the heart. In preterm babies, one of the most common causes of murmur is the presence of a PDA.
- Trial name
- NCT05325177
- Testing
- Standard Dose Ibuprofen, High Dose Ibuprofen
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute