Clinical trials: sponsored by Peking University
ITP - Immune Thrombocytopenia
TPO-RA Plus Baricitinib vs. TPO-RA for ITP
This is a prospective, randomized, controlled trial. ITP patients who failed prior full-does TPO-RA monotheray for 14 days. Patients are randomly assigned at a 1:1 ratio to receive baricitinib plus TPO-RA or TPO-RA alone.
- Trial name
- NCT07669675
- Testing
- Baricitinib, TPO-RA
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Advanced Colorectal Cancer
Sintilimab Plus Gossypol Acetate in Advanced Colorectal Cancer
This is a single-center, open-label, single-arm, exploratory phase II clinical trial designed to evaluate the preliminary efficacy and safety of sintilimab in combination with oral gossypol acetate in patients with advanced…
- Trial name
- NCT07656766
- Testing
- Sintilimab, Gossypol Acetate
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Peking University People's Hospital
Quantitative Flow Reserve, Minimally Invasive Coronary Surgery
The Impact of Preoperative Quantitative Flow Reserve (QFR) on Early Postoperative Radial Artery Graft Outcomes in Coronary Artery Bypass Grafting
The goal of this observational study is to learn about the long-term effects of Quantitative Flow Reserve (QFR) assessment in patients undergoing Coronary Artery Bypass Grafting (CABG).
- Conditions
- Quantitative Flow Reserve, Minimally Invasive Coronary Surgery, Radial Artery
- Trial name
- QFR-RADIAL (NCT07669987)
- Testing
- Observational
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking University Third Hospital
Laparoscopic Colorectal Surgery, Postoperative Analgesia
Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting
Postoperative nausea and vomiting (PONV) is common after surgery and impede rapid recovery after surgery. Patients who undergo laparoscopic colorectal surgery are more likely to develop PONV due to the pneumoperitoneum…
- Conditions
- Laparoscopic Colorectal Surgery, Postoperative Analgesia, Oliceridine, Morphine
- Trial name
- NCT06411665
- Testing
- Oliceridine, Morphine
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Peking University First Hospital
Elderly Patients, Cancer Surgery
Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery
With aging population, more older patients will receive major surgery for cancer. Older patients are at increased risk of postoperative neurocognitive complications including delayed neurocognitive recovery (dNCR), which is…
- Conditions
- Elderly Patients, Cancer Surgery, Hypothermia, Accidental, Targeted Temperature Management
- Trial name
- NCT07655687
- Testing
- Target temperature management, Routine thermal management
- Where
- 2 sites in China
- Volunteers
- 1,512 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Cancer Surgery, Intraoperative Hypothermia
Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival
Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor.
- Conditions
- Cancer Surgery, Intraoperative Hypothermia, Targeted Temperature Management, Postoperative Delirium
- Trial name
- NCT06256354
- Testing
- Routine thermal management, Target temperature management
- Where
- 36 sites in China
- Volunteers
- 3,992 people
- Sponsor
- Peking University First Hospital
Immune Thrombocytopenic Purpura
Atorvastatin Combined With NAC Plus Romiplostim for Management of ITP
This is a prospective, single-arm, open-lable, single-center study and we aimed to determine whether atorvastatin combined with N-acetyl-L-cysteine (NAC) plus romiplostim could induce sustained response off-treatment (SRoT) in…
- Trial name
- NCT07662525
- Testing
- atorvastatin, NAC, and romiplostim
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Advanced or Recurrent Solid Tumors
EVM16 Injection as a Single and Combination With Tislelizumab in Solid Tumors
The goal of this clinical trial is to learn the side effects, safety and effect of a tumor vaccine (EVM16) alone or in combined with an anti-PD-1 antibody (tislelizumab) .
- Trial name
- NCT06541639
- Testing
- EVM16, Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 78 people
- Sponsor
- Peking University
Peritoneal Dialysis
Predicting Peritoneal Kt/Vurea Based on Single-Exchange Dialysate Effluent
Background: Peritoneal dialysis (PD) adequacy is routinely evaluated using the urea clearance index (Kt/Vurea), a key indicator of small-solute clearance and treatment adequacy.
- Trial name
- NCT07659067
- Testing
- Single-Exchange Dialysate Effluent-Based Prediction of Peritoneal Kt/Vurea
- Volunteers
- 300 people
- Sponsor
- Peking University First Hospital
Multiple Myeloma, Multiple Myeloma and Malignant Plasma Cell Neoplasms
68Ga-BCMA PET/CT in Multiple Myeloma
This is a prospective, multicenter diagnostic imaging study designed to evaluate the diagnostic accuracy and clinical utility of BCMA-targeted positron emission tomography/computed tomography (PET/CT) in patients with multiple…
- Conditions
- Multiple Myeloma, Multiple Myeloma and Malignant Plasma Cell Neoplasms, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT07319897
- Testing
- 68Ga-BCMA PET/CT
- Where
- 5 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Cutaneous T-Cell Lymphoma, Mycosis Fungoides (MF)
Efficacy and Safety of Benvitimod Cream in Cutaneous T-Cell Lymphoma
Background: CTCL is a rare type of non-Hodgkin lymphoma that primarily affects the skin, causing red patches, plaques, and severe itching.
- Trial name
- BEST-CTCL (NCT07658924)
- Testing
- Benvitimod Cream
- Volunteers
- 35 people
- Sponsor
- Peking University First Hospital
cGVHD
Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD
The study plan aims to include patients who have been diagnosed with steroid-refractory chronic GVHD in the liver following allogeneic hematopoietic stem cell transplantation.
- Trial name
- NCT06364319
- Testing
- anti-CD25 rhMAb, Prednisone, Ruxolitinib
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Malignancies
IASO207 Injection in the Treatment of Relapsed/Refractory B-cell Malignancies
This is a single-center, open-label, exploratory clinical study to evaluate the efficacy and safety of IASO207 Injection in patients with Relapsed/Refractory B-cell Malignancies。
- Trial name
- NCT07574346
- Testing
- IASO207 Injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Peking University People's Hospital
SCLC, SCLC, Extensive Stage
68Ga-PFD3 PET Imaging for the Diagnosis and Evaluation of Small Cell Lung Cancer
This study aims to investigate and evaluate the safety and performance of a novel probe, PFD3, for the diagnosis and assessment of patients with small cell lung cancer (SCLC).
- Conditions
- SCLC, SCLC, Extensive Stage, SCLC, Limited Stage, Small Cell Lung Cancer
- Trial name
- NCT07508852
- Testing
- Sequential [18F]-FDG PET/CT, [68Ga]Ga-PFD3 PET/CT scan
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Gastrointestinal Cancer, Colorectal (Colon or Rectal) Cancer
Non-Operative Management and Following Immunotherapy for Colorectal Cancer and Other GI Cancers
This is a single-center, bidirectional (retrospective and prospective) registry study aimed at evaluating the safety and efficacy of Non-Operative Management (NOM) and Organ-Preserving Functional Surgery (OPFS) in patients with…
- Conditions
- Gastrointestinal Cancer, Colorectal (Colon or Rectal) Cancer, Stomach (Gastric) Cancer
- Trial name
- NOMIC (NCT07656740)
- Testing
- NOM, RO
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Cancer Hospital & Institute
Perioperative/Postoperative Complications, Anaphylaxis
Diagnosis and Allergen Identification of Perioperative Anaphylaxis
Perioperative anaphylaxis may lead to fatal respiratory and/or circulatory events, yet both clinical diagnosis and management are challenging.
- Conditions
- Perioperative/Postoperative Complications, Anaphylaxis, Tryptase, Allergens
- Trial name
- NCT06793163
- Where
- 6 sites in China
- Volunteers
- 115 people
- Sponsor
- Peking University First Hospital
Esophageal Squamous Cell Carcinoma
Precision Medicine for Immunotherapy-Resistant Advanced Esophageal Cancer
This study is an open-label, biomarker-integrated umbrella trial designed to evaluate the clinical efficacy of molecular subtype- and genomic biomarker-guided precision therapies in patients with advanced esophageal cancer…
- Trial name
- ESCC-PT (NCT07653451)
- Testing
- Afatinib + Toripalimab, Dalpiciclib + Pyrotinib, Camrelizumab + Apatinib
- Volunteers
- 90 people
- Sponsor
- Peking University Cancer Hospital & Institute
End Stage Renal Disease on Dialysis
Coated Aldehyde Oxystarch for Protein-Bound Uremic Toxin Reduction in End-Stage Renal Disease
The goal of this clinical trial is to learn if Coated Aldehyde Oxystarch (Xiqing) works to reduce protein-bound uremic toxins (PBUTs) in adults with end-stage renal disease (ESRD).
- Trial name
- NCT07653711
- Testing
- Coated Aldehyde Oxystarch
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Dietary Sodium Intake, Peritoneal Dialysis (PD)
A Novel Equation for Estimating Sodium Intake in Peritoneal Dialysis.
This study aims to develop a novel equation for estimating sodium intake in anuric peritoneal dialysis patients, and then to validate its precision and accuracy.
- Trial name
- NCT05955417
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Prostate Cancer, Metastatic Prostate Cancer
Clinically Actionable Tumor-Associated Antigens in Prostate Cancer
The goal of this observational study is to evaluate and validate the expression and prognostic value of 15 ADC-targetable membrane proteins (PSMA, B7-H3, STEAP1, TROP2, KLK2, HER2, TF, HER3, DLL3, SEZ6, STEAP2, MUC1, NECTIN4…
- Conditions
- Prostate Cancer, Metastatic Prostate Cancer, Metastatic Prostate Cancer (mCRPC)
- Trial name
- NCT07597369
- Testing
- Immunohistochemistry (IHC) Staining and Analysis
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Peking University First Hospital
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