Clinical trials: sponsored by Peking University
Elderly, Noncardiac Surgery
Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients
Esketamine is frequently used during the perioperative period for supplemental analgesia. Small sample size trials showed that subanesthetic dose esketamine may decrease postoperative neurocognitive complications.
- Conditions
- Elderly, Noncardiac Surgery, Delayed Neurocognitive Recovery, Postoperative Delirium
- Trial name
- NCT07523334
- Testing
- Esketamine 1, Esketamine 2, Esketamine 3
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Solid Tumors
Clinical Application of 89Zr-s-C1 PET/CT Imaging in Solid Tumors
This project is driven by clinical needs and focuses on the mucin (MUC) family, key glycopeptide antigens involved in mediating immune evasion in solid tumors. We selected multiple members of this family as research subjects.
- Trial name
- NCT07529002
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Cancer Hospital & Institute
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Validation of RCC Predicting Model With Emulated-target Trial
This single-center study utilizes real-world data (2012-2024) from 4700 renal cell carcinoma (RCC) patients at Peking University Third Hospital to: (1) Develop and validate a prognostic prediction model specifically for RCC…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Tumor Thrombus, Prognosis
- Trial name
- RCCETT (NCT07117227)
- Testing
- Model-guided adjuvant treatment, No adjuvant treatment
- Where
- China
- Volunteers
- 4,700 people
- Sponsor
- Peking University Third Hospital
Gestational Weight Gain, Overweight and Obesity
Healthy Gestational Weight Gain Programme
This study aims to evaluate the efficacy of a multi-component lifestyle interventions during pregnancy on promoting appropriate gestational weight gain, preventing GDM, and improving pregnancy, delivery, and neonatal outcomes…
- Trial name
- NCT06370533
- Testing
- behavioral interventions
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University
Scoliosis Correction, Esketamine
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
Scoliosis correction surgery is associated with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and drug tolerance.
- Conditions
- Scoliosis Correction, Esketamine, Dexmedetomidine, Postoperative Analgesia
- Trial name
- NCT06062550
- Testing
- Esketamine
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University First Hospital
Anterior Cruciate Ligament (ACL) Tear
Effects of a Preoperative Cognitive-Behavioral Intervention on Kinesiophobia and Function in Anterior Cruciate Ligament Reconstruction
This study aims to systematically elucidate the integrative effects of psychological rehabilitation on the "brain-psychology-motor" triad in patients with anterior cruciate ligament (ACL) rupture.
- Trial name
- NCT07423767
- Testing
- Cognitive-Behavioral Intervention, Control group
- Where
- 2 sites in China
- Volunteers
- 44 people
- Sponsor
- Peking University Third Hospital
Invasive Pulmonary Fungal Disease
Blood mNGS for Diagnosing Invasive Pulmonary Fungal Disease in Hematologic Patients
The goal of this clinical trial is to learn whether a blood test called metagenomic next-generation sequencing (mNGS) can help diagnose invasive pulmonary fungal disease in patients with blood disorders.
- Trial name
- NCT07511595
- Testing
- Blood microbial metagenomic next-generation sequencing (mNGS)
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Primary Angle-Closure Glaucoma
Vitreous Zonule in Primary Angle-Closure Glaucoma
This study aims to investigate the role of the vitreous zonule (VZ) in the pathogenesis of primary angle-closure glaucoma (PACG) and to explore the feasibility of three-dimensional ultrasound biomicroscopy (3D-UBM) for imaging…
- Trial name
- NCT07523139
- Where
- China
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Epidural Analgesia, Labor Pain
Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia
Sufentanil-ropivacaine combination is commonly used for epidural labor anesthesia, but is associated with some adverse events. Dexmedetomidine and esketamine, each has been effectively used for neuraxial anesthesia in combination…
- Conditions
- Epidural Analgesia, Labor Pain, Sufentanil, Dexmedetomidine
- Trial name
- NCT07145775
- Testing
- sufentanil-ropivacaine combination, dexmedetomidine-esketamine-ropivacaine combination 1, dexmedetomidine-esketamine-ropivacaine combination 2
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University First Hospital
General Anesthesia, Surgery
Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery
For patients after surgery, quality of recovery has significant impacts on the prognosis, quality of life, and rational allocation of medical resources.
- Conditions
- General Anesthesia, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07308756
- Testing
- Dexmedetomidine, Esketamine, Dexmedetomidine-esketamine
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Peking University First Hospital
Laparoscopic Surgery, Visceral Pain, Postoperative
Anrikefon-based Patient-controlled Intravenous Analgesia After Laparoscopic Surgery
Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes.
- Conditions
- Laparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous Analgesia
- Trial name
- NCT07246785
- Testing
- High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Peking University First Hospital
Adenotonsillectomy, Children
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain.
- Conditions
- Adenotonsillectomy, Children, Intranasal Administration, Dexmedetomidine
- Trial name
- NCT07479602
- Testing
- Intranasal dexmedetomidine-esketamine
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
Metabolic Dysfunction-Associated Steatotic Liver Disease Infant Development
TUDCA in High-Risk Lactating Mothers Identified by Early Postpartum Milk Hydrophobicity Index
This is a randomized, double-blind, placebo-controlled Phase 2 proof-of-concept trial in mother-infant dyads. The study aims to evaluate the safety, tolerability, and biological effects of maternal oral tauroursodeoxycholic acid…
- Trial name
- MILK-HI-TUDCA (NCT07517276)
- Testing
- tauroursodeoxycholic acid (TUDCA)
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Primary Angle-closure Glaucoma
Kahook Dual Blade Goniotomy in Chronic Primary Angle-Closure Glaucoma
This prospective randomized controlled trial, conducted by the Ophthalmology Department of Peking University People's Hospital, aims to compare the intraocular pressure (IOP)-lowering efficacy and safety of two surgical…
- Trial name
- NCT07517302
- Testing
- Kahook Dual Blade (KDB) goniotomy, phacoemulsification with intraocular lens implantation combined with goniosynechialysis
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Peking University People's Hospital
Primary Immunodeficiency Diseases
Immunoglobulin Efficacy and Immune Profiling in Antibody Immunodeficiency
This study aims to systematically evaluate the dynamic alterations in peripheral immune subsets among patients with antibody Immunodeficiency undergoing Immunoglobulin therapy
- Trial name
- IEIPAI (NCT07516002)
- Volunteers
- 15 people
- Sponsor
- Peking University People's Hospital
Rectal Cancers, Pathological Complete Response
Predicting Pathological Complete Response in Rectal Cancer Using Machine Learning
This study aims to develop and validate a robust machine learning-based prediction model utilizing baseline clinical data and magnetic resonance imaging (MRI) features.
- Conditions
- Rectal Cancers, Pathological Complete Response, Neoadjuvant Chemoradiotherapy, Machine Learning
- Trial name
- NCT07509632
- Testing
- No interventions
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Peking University People's Hospital
Rheumatoid Arthritis
Prospective Cohort Study on Refractory Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic erosive arthritis. Without timely and appropriate treatment, it can lead to joint destruction and disability.
- Trial name
- NCT07126431
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Non-Small Cell Lung Cancer, Malignant Neoplasm
Cadherin 3(CDH3)-Targeted PET in Lung Malignant Tumors
Lung malignant tumors are a significant health threat with high incidence and mortality rates, and molecular imaging is crucial for early diagnosis, staging, prognosis evaluation, and therapeutic efficacy assessment.
- Conditions
- Non-Small Cell Lung Cancer, Malignant Neoplasm, Pulmonary Nodules, PET/CT
- Trial name
- NCT07487883
- Testing
- PET/CT scans
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Non-Small Cell Lung Cancer, PET/CT
FAP-targeted PET/NIR in Lung Malignant Tumors
Single center, prospective, diagnostic study. Patients with stage II-IIIB resectable NSCLC diagnosed by pathology were included.
- Conditions
- Non-Small Cell Lung Cancer, PET/CT, Neoadjuvant Therapy
- Trial name
- NCT07498933
- Testing
- PET/CT scans
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Gestational Diabetes Mellitus (GDM)
Digital Health Intervention for Early Identification and Prevention of Gestational Diabetes Mellitus
This study aims to develop and evaluate an early risk identification and digital health intervention strategy for gestational diabetes mellitus (GDM) among pregnant women in China.
- Trial name
- NCT07499622
- Testing
- Digital Health Lifestyle Intervention
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Peking University
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