Clinical trials: sponsored by Peking University
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Nanobody-Based CD19/CD22 Tandem Dual CAR-T Therapy for R/R B-ALL
To evaluate the efficacy and safety of Nanobody-Based CD19/CD22 Tandem Dual Chimeric Antigen Receptor (CAR) T-cell therapy in patients with relapsed or refractory B-ALL
- Trial name
- Phase I/II (NCT06880913)
- Testing
- Nanobody-Based CD19/CD22 Tandem Dual CAR-T
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Epithelial Tumors, Malignant
Evaluation of an EpCAM-Targeted Radiotracer in Epithelial Tumors
The goal of this prospective, single-arm clinical trial is to evaluate the imaging performance and safety of an EpCAM-targeted radiotracer, [68Ga]Ga-PN-EpC1, in patients with epithelial tumors.
- Trial name
- NCT07400263
- Testing
- [68Ga]Ga-PN-EpC1 PET/CT
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Acute Myeloid Leukemia (AML)
Digital PCR of CHIP and MR for MRD Monitoring After Allo-HSCT in AML
This prospective observational study aims to evaluate the clinical significance of measurable residual disease (MRD) monitoring using digital PCR (dPCR) in patients with acute myeloid leukemia (AML) following allogeneic…
- Trial name
- NCT07500441
- Testing
- Individualized Digital PCR (dPCR) monitoring
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Secondary Hypertension
Development and Validation of a KAP Questionnaire for Secondary Hypertension: Evaluating a Community Short-Video Intervention in Rural Beijing
This is a two-phase, non-randomized clinical trial conducted in eight communities in Miyun District, Beijing. The study first develops and validates a reliable 18-item questionnaire (Knowledge, Attitudes, and Practices [KAP]…
- Trial name
- KAP-SHORT (NCT07497841)
- Testing
- Short-Video Health Education for Secondary Hypertension
- Where
- China
- Volunteers
- 1,062 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Lung Cancer, OLV
Spontaneous Breathing Mode: A Risk for Hypoxemia During OLV?
Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch.
- Conditions
- Lung Cancer, OLV, Hypoxemia During Surgery
- Trial name
- OLV (NCT07494006)
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
Thyroid Associated Ophthalmopathy
A Study of IBI311 in Subjects With Steroid-resistant, Thyroid Associated Ophthalmopathy
This is an exploratory study of the efficacy and safety of IBI311, a modified anti-IGF-1R antibody, in patients with steroid-resistant, thyroid associated ophthalmopathy (TAO). This study includes two stages.
- Trial name
- NCT06269393
- Testing
- IBI311
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Peking University People's Hospital
Heart Failure
Nurse-Led mHealth for Vulnerable-Phase Heart Failure
Heart failure is a serious condition where the heart cannot pump blood as well as it should. After being discharged from the hospital, patients with heart failure are at high risk for readmission, especially in the first three…
- Trial name
- NCT07490470
- Testing
- Nurse-Led mHealth Multidisciplinary Management, Routine Outpatient Follow-Up
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Peking University First Hospital
PTSD
The Effectiveness of Group-Delivered Guided Written Exposure Therapy for PTSD and CPTSD Among Chinese Adolescents
The study aims to examine the effectiveness of the group-delivered guided written exposure therapy (GWE) for post-traumatic stress disorder (PTSD) and complex PTSD among Chinese adolescents with a randomized controlled trial.
- Trial name
- NCT06390293
- Testing
- Group-delivered guided written exposure therapy, Waiting-List (WL) condition
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Peking University
Neoplams
The Phase I Study of SIG001 Antibody on Cancer Therapy.
The goal of this clinical trial is to learn the safty characteristics of SIG001 Mab in cancer patients; It will also determine the Recommended Phase II dose of SIG001 Mab on cancer treatment, and pharmacological characteristics…
- Trial name
- NCT07486700
- Testing
- SIG001
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University
Breast Cancer, Early Stage
Ablation Compare With Surgery for Early Breast Cancer
Breast-conserving surgery has been widely used in clinical practice, but surgical incisions still impact postoperative patient satisfaction with breast appearance.
- Conditions
- Breast Cancer, Early Stage, Hormone Receptor Positive, Ablation
- Trial name
- NCT07484087
- Testing
- breast conserving surgery, cryo-thermal ablation
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Peking University People's Hospital
Osteoarthitis, Osteoporosis
Evaluation of Musculoskeletal Aging and Related Disorders Via Advanced Clinical Imaging
Study Overview This clinical research focuses on the development and validation of a multimodal artificial intelligence (AI) platform designed for the automated diagnosis and precise staging of two major musculoskeletal…
- Trial name
- NCT07474571
- Testing
- No Interventions
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Acupuncture Treatment, Hormone Receptor-Positive Breast Cancer
A Randomized Controlled Trial of Acupuncture for the Management of Hot Flashes in Patients With Hormone Receptor-Positive Breast Cancer
Hot flashes are among the most common and distressing adverse effects experienced by patients receiving endocrine therapy for hormone receptor-positive breast cancer.
- Conditions
- Acupuncture Treatment, Hormone Receptor-Positive Breast Cancer, Hot Flashes
- Trial name
- ACU-HRBC-HF (NCT07294339)
- Testing
- True Acupuncture
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Elderly, Surgery
Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio
The impact of anesthesia depths on early postoperative neurocognitive complications after total intravenous anesthesia (TIVA) remains controversial.
- Conditions
- Elderly, Surgery, Depth of Anesthesia, Total Intravenous Anesthesia
- Trial name
- NCT07479719
- Testing
- Light anesthesia, Deep anesthesia
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Osteosarcoma, Osteosarcoma Metastatic
Apatinib Combined With Liposomal Irinotecan for Refractory or Metastatic Osteosarcoma
In advanced osteosarcoma where traditional chemotherapy has failed, the multi-targeted tyrosine kinase inhibitor apatinib has become a mainstream systemic treatment option in China.
- Trial name
- NCT07479732
- Testing
- Liposomal Irinotecan, Apatinib in arm1
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Peking University People's Hospital
Breast Cancer, Early-stage Breast Cancer
Multigene Risk Score Combined With Ki-67 Dynamic Assessment in Stratified Neoadjuvant Endocrine Therapy Treatment With or Without CDK4/6 Inhibitors in HR+/HER2- Breast Cancer
This is a prospective, single-center, randomize-controlled study. The purpose of this study is to evaluate the efficacy of neoadjuvant CDK4/6 inhibitors in patients with high-risk EPclin multigene risk analysis and non-response…
- Trial name
- NeoMARS (NCT06650748)
- Testing
- Dalpiciclib, Letrozole
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Death Anxiety
The Effectiveness of an Online Self-Delivered Death Anxiety Intervention
The goal of this clinical trial is to examine the effectiveness of the online self-delivered death anxiety intervention developed by our team in the general population with a randomized controlled trial.
- Trial name
- NCT06801132
- Testing
- Online self-delivered death anxiety intervention, Waiting-List (WL) condition
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Peking University
HRD-negative Epithelial Ovarian Cancer
A Single-center, Dose-escalation Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Tumor Neoantigen-pulsed Autologous Dendritic Cell Injection (YS247) in Study Participants With HRD-negative Epithelial Ovarian Cancer
This is a single-center, open-label, dose-escalation, multiple-dose investigator-initiated exploratory study designed to evaluate the safety, tolerability and preliminary efficacy of tumor neoantigen-pulsed autologous dendritic…
- Trial name
- YS247 (NCT07455071)
- Testing
- Tumor Neoantigen-Sensitized Autologous Dendritic Cell Injection (YS247)
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
HER2-positive Breast Cancer
Pyrotinib Combined With Trastuzumab and Pertuzumab for Maintenance Therapy in HER2-Positive Advanced Breast Cancer
This is a Prospective, Single-Arm, Observational, Real-World Study. The purpose of this study is to evaluate the safety and efficacy of pyrotinib combined with trastuzumab and pertuzumab for maintenance therapy in HER2-positive…
- Trial name
- NCT07470203
- Testing
- Pyrotinib, Trastuzuma, Pertuzumab
- Volunteers
- 42 people
- Sponsor
- Peking University Cancer Hospital & Institute
Peritoneal (Metastatic) Cancer
Intraperitoneal PX in Combination With Nab-Paclitaxel in Patients With Peritoneal Metastatic Mucinous Adenocarcinoma
To evaluate the safety and tolerability of intraperitoneal PX in combination with nab-paclitaxel in patients with peritoneal metastatic mucinous adenocarcinoma, and to determine the maximum tolerated dose (MTD) and the…
- Trial name
- NCT07454031
- Testing
- intraperitoneal PX in combination with nab-paclitaxel
- Volunteers
- 22 people
- Sponsor
- Peking University
Diabetic Foot Disease, Diabete Mellitus
Detection of Diabetic Foot Skin Damage Using Plantar Mechanical Parameters
Diabetes represents one of the major chronic diseases, with diabetic ulcers being a significant adverse prognosis. Approximately 80% of lower limb amputations are attributed to diabetic foot ulcers, which constitute a primary…
- Conditions
- Diabetic Foot Disease, Diabete Mellitus, Mechanical Factor
- Trial name
- NCT07470255
- Testing
- Detection of the elastic modulus of the plantar skin
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
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