Clinical trials: sponsored by Peking University
HER2-positive Breast Cancer
Pyrotinib Combined With Trastuzumab and Pertuzumab for Maintenance Therapy in HER2-Positive Advanced Breast Cancer
This is a Prospective, Single-Arm, Observational, Real-World Study. The purpose of this study is to evaluate the safety and efficacy of pyrotinib combined with trastuzumab and pertuzumab for maintenance therapy in HER2-positive…
- Trial name
- NCT07470203
- Testing
- Pyrotinib, Trastuzuma, Pertuzumab
- Volunteers
- 42 people
- Sponsor
- Peking University Cancer Hospital & Institute
Peritoneal (Metastatic) Cancer
Intraperitoneal PX in Combination With Nab-Paclitaxel in Patients With Peritoneal Metastatic Mucinous Adenocarcinoma
To evaluate the safety and tolerability of intraperitoneal PX in combination with nab-paclitaxel in patients with peritoneal metastatic mucinous adenocarcinoma, and to determine the maximum tolerated dose (MTD) and the…
- Trial name
- NCT07454031
- Testing
- intraperitoneal PX in combination with nab-paclitaxel
- Volunteers
- 22 people
- Sponsor
- Peking University
Diabetic Foot Disease, Diabete Mellitus
Detection of Diabetic Foot Skin Damage Using Plantar Mechanical Parameters
Diabetes represents one of the major chronic diseases, with diabetic ulcers being a significant adverse prognosis. Approximately 80% of lower limb amputations are attributed to diabetic foot ulcers, which constitute a primary…
- Conditions
- Diabetic Foot Disease, Diabete Mellitus, Mechanical Factor
- Trial name
- NCT07470255
- Testing
- Detection of the elastic modulus of the plantar skin
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Prostate Cancer (Diagnosis)
Comparison of TB+PB and TB+6SB for Prostate Cancer Diagnosis
The goal of this randomized controlled trial (RCT) is to evaluate the diagnostic efficacy of two novel prostate biopsy schemes, including targeted and perilesional biopsy (TB+PB) and combination of sextant-systematic biopsy and…
- Trial name
- NCT07460843
- Testing
- TB+PB, TB+6SB
- Where
- China
- Volunteers
- 592 people
- Sponsor
- Peking University First Hospital
Type 1 Diabetes Mellitus
Establishment of Screening Pathway for High-Risk Population of Type 1 Diabetes
This study aims to establish a system for identifying and screening high-risk individuals for type 1 diabetes (T1D) and a standardized management pathway for high-risk individuals. It is a prospective cohort study.
- Trial name
- NCT07468474
- Testing
- Gene polymorphic detection
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Palmoplantar Pustulosis
Efficacy and Tolerability of Deucravacitinib in the Management of Palmoplantar Pustulosis
The goal of this clinical trial is to investigate the efficacy and safety of Deucravacitinib in patients with moderate-to-severe palmoplantar pustulosis.
- Trial name
- NCT07000630
- Testing
- Deucravacitinib
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Peking University First Hospital
Diabetes Mellitus
A Clinical Study of iPSC-Derived Islet Cells for Diabetes Mellitus Therapy
This is a single-arm, open-label clinical trial designed to assess the safety and therapeutic efficacy of iPSC-derived islet cell infusion in patients with diabetes mellitus.
- Trial name
- NCT07464119
- Testing
- iPSC-derived islet cell
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Rheumatoid Arthritis (RA)
A RWS of SC MTX in Chinese RA Patients
Design: A prospective, single-arm, multicenter, real-world study that does not interfere with the patient's treatment plan Primary Objective: 1.
- Trial name
- MTX-RWS-I (NCT07463937)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University People's Hospital
Patellar Tendinopathy
Bilateral Lower Limb Biomechanics During Side-Cutting in Unilateral Patellar Tendinopathy
Patellar tendinopathy (PT) is a common overuse injury in sports that involve jumping and directional changes. The biomechanical differences between individuals with PT and healthy controls during side-cutting, as well as whether…
- Trial name
- NCT07463560
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Rotator Cuff Tear
Research and Clinical Validation of a Wearable Device-Based Remote Rehabilitation System for Postoperative Rotator Cuff Injury
This study included patients who underwent their first shoulder rotator cuff surgery at Peking University Third Hospital, diagnosed with small to medium rotator cuff tears based on MRI results.
- Trial name
- NCT07412184
- Testing
- Wearable device rehabilitation, Offline Traditional Rehabilitation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Peking University Third Hospital
MCL, Relapsed or Refractory Mantle Cell Lymphoma (MCL)
Glofitamab Combined With Lenalidomide in High Risk Patients With Relapsed or Refractory Mantle Cell Lymphoma
A single-arm, open-label, multi-center clinical study of glofitamab combined with lenalidomide in high risk patients with relapsed or refractory Mantle Cell Lymphoma previously treated with a BTK Inhibitor.
- Trial name
- NCT07460362
- Testing
- Glofitamab, Lenalidomide
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Peking University Third Hospital
Systemic AL Amyloidosis
Rapid dFLC Response Predict CHR in AL Amyloidosis
Light chain amyloidosis (AL amyloidosis) is a rare plasma cell dyscrasia characterized by the deposition of insoluble amyloid fibrils in multiple organ systems.
- Trial name
- NCT06627309
- Testing
- Dara IV, Bortezomib (drug), Dexamethasone
- Where
- 8 sites in China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Lung Cancer (NSCLC), Lung Cancer (SCLC)
PD-L1 Targeting Peptide Probe for PET Imaging of Solid Tumor
The objective of this study is to construct a noninvasive approach using radiolabbled peptide 68Ga-cPP-BCH PET/CT to detect the PD-L1 expression of tumor lesion in patients with lung cancer, melanoma and other solid tumor to…
- Conditions
- Lung Cancer (NSCLC), Lung Cancer (SCLC), Melanoma (Skin Cancer), Melanoma Metastatic
- Trial name
- NCT07442292
- Volunteers
- 40 people
- Sponsor
- Peking University Cancer Hospital & Institute
Diabetic Foot Ulcer (DFU), Diabete Mellitus
AI-Based Diabetic Foot Recurrence Cohort
Diabetic foot ulcer (DFU) is a major adverse outcome of diabetes, which itself is one of the most significant chronic diseases. The recurrence of DFU involves multiple risk factors, including altered foot loading patterns…
- Conditions
- Diabetic Foot Ulcer (DFU), Diabete Mellitus, Diabetic Foot Ulcer Treatment, Artificial Intelligence (AI) in Diagnosis
- Trial name
- NCT07452354
- Testing
- Researchers predefined groups based on risk stratification to formulate personalized follow-up strategies.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Cardiovascular-Kidney-Metabolic Syndrome
Construction of a Comprehensive Health Management Platform for Patients With Cardiovascular-Kidney-Metabolic Syndrome
Cardiovascular-Kidney-Metabolic (CKM) syndrome underscores the pathophysiologic interplay among metabolic risk factors, chronic kidney disease (CKD) and the cardiovascular system.
- Trial name
- NCT07452029
- Testing
- Comprehensive Health Management Platform, Post-examination follow-up management
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Acute Myeloid Leukemia, Myelodysplastic Syndromes
IFN-α in Relapse Prevention.
To investigate the efficacy of interferon-α prophylaxis in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with TP53 mutation who were negative for minimal residual disease (MRD) by flow cytometry…
- Trial name
- NCT07449286
- Testing
- IFN-α
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Urothelial Carcinoma
Nectin-4 Specific LMW PET Probe Imaging in Urothelial Carcinoma
To evaluate the ability of [68Ga]N188 to detect nectin-4 overexpression in patients with urothelial carcinoma, especially in patients with recurrent or advanced bladder cancer.
- Trial name
- NCT05321316
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Lung Neoplasms, Neoadjuvant Therapy
To Conduct Multi-omics Integrated Studies in Peripheral Blood, Such as Fragment Omics, Metabolomics and Epigenetics, and Establish Non-invasive Dynamic Follow-up Monitoring Programs During Perioperative and Postoperative Periods (Observational Study)
This project aims to innovatively integrate multi-omics data, including plasma metabolomics, radiomics, and cfDNA multi-level information, combined with survival data (e.g., RFS), to establish a novel multidimensional approach…
- Conditions
- Lung Neoplasms, Neoadjuvant Therapy, Immunotherapy, Minimal Residual Disease
- Trial name
- NCT07291921
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Hysteroscopic Surgery
Supraglottic Jet Oxygenation Ventilation During Hysteroscopic Surgery
Hysteroscopic surgery is widely used in the diagnosis and treatment of gynecological diseases. Because its operation process can cause anxiety and pain in patients, it needs to be performed under anesthesia.
- Trial name
- NCT07110428
- Testing
- NCgroup, SJOVgroup
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Shenzhen Hospital
Diabetic Wound, Wound Infection
Randomized Controlled Trial on the Efficacy and Safety of Xiang Lei Ointment in Diabetic-related Ulcer Management
Diabetes is one of the major chronic diseases. Diabetic ulcers are important adverse outcomes of diabetes. Approximately 80% of lower - limb amputations are caused by diabetic foot ulcers, which are the main causes of disability…
- Conditions
- Diabetic Wound, Wound Infection, Wound Heal
- Trial name
- NCT06841237
- Testing
- Xiang Lei Ointment plus Clinical standard treatment protocols, Clinical standard treatment protocols
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Peking University Third Hospital
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