Clinical trials: sponsored by Peking University
Small Cell Lung Carcinoma
Exploration of Treatment Strategies After Concurrent Chemoradiotherapy for LS-SCLC Guided by MRD
This study plans to enroll limited-stage small cell lung cancer (LS-SCLC) patients who have achieved disease control after concurrent chemoradiotherapy (cCRT).
- Trial name
- NCT07357532
- Testing
- Adebrelimab Injection, Apatinib Mesylate Tablets
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Peking University Cancer Hospital & Institute
Sleep Apnea, Obstructive
The Effect of Telemedicine-Based APAP Management on 24-Hour Ambulatory Blood Pressure in Patients With Obstructive Sleep Apnea
Epidemiological studies have shown that OSA is closely related to the occurrence and development of cardiovascular diseases, especially hypertension.
- Trial name
- NCT06064630
- Testing
- Automatic continuous positive airway pressure
- Where
- China
- Volunteers
- 344 people
- Sponsor
- Peking University People's Hospital
NSCLC Stage IV, EGFR Positive Non-small Cell Lung Cancer
Firmonertinib 160 mg in Patients With EGFR-Mutant Advanced NSCLC Demonstrating SD After 8 Week Induction With Firmonertinib 80 mg
This study evaluates the efficacy and safety of Firmonertinib 160 mg once daily in patients with EGFR-mutant, advanced NSCLC who achieve stable disease after first-line Firmonertinib 80 mg for 8 weeks.
- Conditions
- NSCLC Stage IV, EGFR Positive Non-small Cell Lung Cancer, EGFR-TKI Sensitizing Mutation
- Trial name
- NCT07298148
- Testing
- Firmonertinib 160mg
- Volunteers
- 28 people
- Sponsor
- Peking University Cancer Hospital & Institute
Ovariancancer, Platinum-sensitive Recurrent
Clinical Study of EZH2 Inhibitor Combined With PARP Inhibitor in the Treatment of Patients With Advanced or Recurrent Epithelial Ovarian Cancer.
This study evaluates the efficacy and safety of Zeprumetostat in combination with Fuzuloparib for the treatment of patients with advanced or recurrent ovarian epithelial carcinoma, with the primary endpoint being Objective…
- Trial name
- NCT07339553
- Testing
- Treatment
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Cesarean Section Complications
Effect of Preoperative Oral Energy Drinks Compared to Warming Matress on Body Temperature During Combined Spinal-epidural Anesthesia for Elective Cesarean Delivery.
It is not known which is better for intraoperative temperature protection, warming matress or preoperative oral functional drinks in elective cesarean section.
- Trial name
- NCT06017076
- Testing
- Oral energy drinks, Warming matress
- Where
- China
- Volunteers
- 302 people
- Sponsor
- Peking University People's Hospital
Breast Neoplasms、Lung Neoplasms、Pancreatic Neoplasms
68Ga-PFA2 PET Imaging for the Diagnosis of Annexin A2-Positive Tumors
Tumor metastasis and invasion are the leading causes of cancer-related deaths, with over 90% of cancer patients dying from distant metastasis.
- Trial name
- NCT07331532
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking University First Hospital
Breast Cancer
Hand and Foot Bath for Taxane-Induced Peripheral Neurotoxicity
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity of taxane-based agents, with an incidence of 57%-83%.
- Trial name
- NCT07344974
- Testing
- Traditional Chinese medicine (TCM) hand and foot baths, Methylcobalamin (methylB12)
- Volunteers
- 78 people
- Sponsor
- Peking University Cancer Hospital & Institute
Esophageal Squamous Cell Carcinoma (ESCC), Esophageal Fistula
Standardized Management of Esophageal Fistula in Esophageal Squamous Cell Carcinoma
This prospective, multi-center, observational registry study (PKU-ESCC-EF) aims to evaluate the safety and effectiveness of a standardized diagnosis and treatment protocol for esophageal fistula (EF) in patients with advanced…
- Trial name
- PKU-ESCC-EF (NCT07353541)
- Testing
- Standardized Management Protocol for Esophageal Fistula
- Volunteers
- 32 people
- Sponsor
- Peking University Cancer Hospital & Institute
HIPEC, Gastro Intestinal Cancer
Effects of HIPEC on Postoperative Bowel Motility and Complications
This retrospective cohort study was conducted at our institution, involving patients with gastric cancer, appendiceal mucinous neoplasm, or colon cancer who underwent CRS with or without HIPEC between January 2017 and December…
- Conditions
- HIPEC, Gastro Intestinal Cancer, Adhesion Prevention, Bowel Functions
- Trial name
- NCT07353177
- Testing
- Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
- Where
- China
- Volunteers
- 193 people
- Sponsor
- Peking University People's Hospital
Hematopoietic Stem Cell Transplantation, Transplant Complication
Cardiovascular Outcomes and Risk Evaluation Among Recipients of Hematopoietic Stem Cell Transplantation
This is a prospective, multicenter observational study for recipients of hematopoietic stem cell transplantation. Patients who underwent hematopoietic stem cell transplantation at the participating centers will be entrolled in…
- Conditions
- Hematopoietic Stem Cell Transplantation, Transplant Complication, Cardiovascular Events
- Trial name
- CORE-HCT (NCT07349498)
- Where
- 16 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Peking University People's Hospital
R/R Aggressive B-cell Lymphoma
An Open and Dose-escalation Early Clinical Study of CD19 and CD20 CAR-T Cell Therapy for Relapsed or Refractory Aggressive B-cell Lymphoma
To observe the efficacy and safety of dual-target chimeric antigen receptor T cells in the treatment of refractory or relapsed aggressive B-cell lymphoma
- Trial name
- NCT07344818
- Testing
- CAR-T cell therapy
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Peking University People's Hospital
Anterior Cruciate Ligament Injuries
Effect of Visual-Guided Balance Training on Knee Motor Function and Biomechanical Characteristics After ACL Reconstruction
This study aims to investigate the improvement effect of visual-guided balance training on the knee joint function and gait performance of patients after ACLR, and to clarify the advantages of this training program compared to…
- Trial name
- NCT07306221
- Testing
- Traditional group, Intervention Group
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Rheumatoid Arthritis
Proximod, a Selective Sphingosine-1-phosphate Receptor 1 Modulator in Patients With Moderate-to-severe Active Rheumatoid Arthritis: a Double-blind, Randomised, Placebo-controlled, Phase 2 Trial.
The goal of this multicenter, randomized, double-blind, placebo-controlled phase 2 clinical trial is to evaluate the efficacy and safety of proximod in active rheumatoid arthritis patients with inadequate response or intolerance…
- Trial name
- PROXIMA (NCT07335952)
- Testing
- proximod 5mg daily, proximod 10mg daily
- Where
- 20 sites in China
- Volunteers
- 179 people
- Sponsor
- Peking University People's Hospital
Non Suicidal Self Injury, Cognitive Behavior Therapy
Evidence-based Digital CBT for Nonsuicidal Self-Injury
To evaluate if evidence-based digital cognitive behaviour therapy for adolescents is an efficacious treatment when delivered as an adjunctive treatment to treatment as usual, compared to a control group consisting of treatment as…
- Trial name
- NCT07337473
- Testing
- Evidence-based digital cognitive behaviour therapy, Health Education
- Volunteers
- 100 people
- Sponsor
- Peking University Sixth Hospital
Chronic Hepaititis B
Immunomodulatory Therapy and Predictors of Clinical Cure in Chronic Hepatitis B
Achieving clinical cure, defined as hepatitis B surface antigen (HBsAg) seroclearance, represents a major research focus and an ideal therapeutic goal for chronic hepatitis B (CHB).
- Trial name
- NCT07328711
- Testing
- Hepatitis B Immunoglobulin (HBIg)
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Peking University People's Hospital
Critical Illness, Ventilated Patients
Critical Illness After Hematopoietic Cell Transplantation
This is a prospective, multicenter observational trial for patients who develop critical illness after hematopoietic cell transplantation.
- Conditions
- Critical Illness, Ventilated Patients, Hematopoetic Stem Cell Transplantation, Transplant Complication
- Trial name
- CARE-HCT (NCT07328724)
- Where
- 6 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Peking University People's Hospital
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Incidence of Postoperative Delirium
Delirium is a frequently occurred cerebral complication in elderly patients after surgery, and its occurrence is associated with worse outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012984
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Patient With Cardiovascular-kidney-metabolic Syndrome
A Prospective Cohort Study on Prognostic Factors in Patients With Cardiovascular-kidney-metabolic Syndrome
Patients with Cardiovascular-kidney-metabolic syndrome (CKM) will be prospectively enrolled. We will conduct comprehensive analyses, including transcriptomics, proteomics, and metabolomics, using various types of samples such as…
- Trial name
- NCT07327606
- Where
- China
- Volunteers
- 4,526 people
- Sponsor
- Peking University Third Hospital
Interstitial Lung Disease (ILD), Connective Tissue Disease-associated Interstitial Lung Disease
A Study to Test Tetrandrine Tablets for Connective Tissue Disease-Related Lung Disease
This study evaluates the efficacy and safety of tetrandrine tablets (60 mg, three times daily) compared to placebo in adult patients with connective tissue disease-related interstitial lung disease.
- Trial name
- NCT07319598
- Testing
- Tetrandrine Tablets
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Endometrium Cancer
Comparative Study on the Effect of Diet Interventions on Weight Loss in Overweight Endometrial Cancer Patients Undergoing Fertility-sparing Treatment
In this study, overweight and obese patients with endometrial cancer treated with fertility- sparing therapy were randomly divided into three groups.
- Trial name
- NCT07318727
- Testing
- Multi-Professional Guided '5+2' Intermittent Fasting, Low-energy Balanced Diet, Routine Care for Self-weight Management.
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Peking University People's Hospital
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