Clinical trials: sponsored by Peking University
Osteoarthritis, Knee
Evaluation of the Effect of Triamcinolone at Different Doses on LIA During TKA
To evaluate the efficacy and safety of different doses of triamcinolone for local infiltration analgesia during total knee replacement
- Trial name
- LIA;TKA (NCT05997238)
- Testing
- without triamcinolone, 20mg triamcinolone, 40mg triamcinolone
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Renal Cell Carcinoma (RCC), Renal Pelvic Urothelial Carcinoma
18F-N230A PET/CT Imaging of Nectin-4 Expression in Renal Tumors
Renal cell carcinoma and renal pelvic urothelial carcinoma are common malignant tumors of the urinary system. Accurate preoperative differentiation between these tumor types is important for treatment planning, while conventional…
- Trial name
- NCT07875959
- Testing
- 18F-N230A
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Renal Cell Carcinoma, Clear Cell Renal Cell Carcinoma
68Ga- and 18F-CAIX PET Imaging Study
This exploratory clinical imaging study will evaluate the safety, tolerability, biodistribution, lesion detection, and tumor uptake characteristics of 68Ga- and 18F-labeled carbonic anhydrase IX (CAIX)-targeted positron emission…
- Conditions
- Renal Cell Carcinoma, Clear Cell Renal Cell Carcinoma, Renal Tumor
- Trial name
- CAIX-PET (NCT07875946)
- Testing
- 68Ga-CAIX PET/CT, 18F-CAIX
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Retinitis Pigmentosa
Safety and Tolerability Study of Gene Editing Drug ZVS203e in Participants With Retinitis Pigmentosa
The purpose of this study is to evaluate the safety, tolerability and efficacy of a single escalating doses of ZVS203e administered via subretinal injection in participants with RP caused by RHO site-specific gene mutation…
- Trial name
- NCT05805007
- Testing
- ZVS203e
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Non-Small Cell Lung Cancer
MRD-Guided Aumolertinib-Based Adjuvant Therapy for Resected EGFR-Mutant NSCLC
Despite complete (R0) resection, patients with EGFR-mutant stage IIA-IIIB non-small cell lung cancer (NSCLC) still face a substantial risk of postoperative recurrence.
- Trial name
- NCT07873086
- Testing
- Aumolertinib, Pemetrexed, Carboplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Bietti's Crystalline Dystrophy
Safety and Tolerability of ZVS101e in Patients With Bietti 's Crystalline Dystrophy
The purpose of the study is to evaluate the safety and tolerability of an adeno-associated virus vector expressing CYP4V2 in patients with Bietti's crystalline dystrophy (BCD).
- Trial name
- NCT05714904
- Testing
- ZVS101e
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Older Patients, Surgery
Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery
Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse long-term outcomes.
- Conditions
- Older Patients, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07576543
- Testing
- Dex-Esk, Active tDCS
- Where
- 6 sites in China
- Volunteers
- 1,996 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Older Patients, Surgery
Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery
Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse outcomes.
- Conditions
- Older Patients, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07576517
- Testing
- Dex-Esk, Active tDCS
- Where
- 6 sites in China
- Volunteers
- 1,996 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Depressive Disorder, Major
Clinical Efficacy, Safety, and Applicability of Home-based Bright Light Therapy in Outpatient Adolescents With Major Depressive Disorder
Major Depressive Disorder (MDD) is a chronic disease characterized by a high prevalence, low cure rate, and significant disability.
- Trial name
- NCT06913309
- Testing
- Bright light therapy（High light intensity）, Bright light therapy（Low light intensity）
- Where
- 3 sites in China
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Scar
Disposable Noninvasive Skin Closure for Promoting Postoperative Wound Healing and Preventing Surgical Skin Scarring
The purpose of this study is to evaluate the efficacy and safety of a disposable noninvasive skin closure device in promoting postoperative wound healing and reducing surgical scar formation.
- Trial name
- NCT07849010
- Testing
- Disposable Noninvasive Skin Closure Device (Shanghai Zhizhong Medical Technology Co., Ltd. Catalog No.: 240430PFF)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Peking University Third Hospital
Acute Myeloid Leukemia, Adult
NAC for Hematopoietic Recovery in Low/Intermediate-Risk AML After CR: A Randomized Controlled Study
This prospective, single-center, randomized controlled clinical trial aims to evaluate whether N-acetyl-L-cysteine (NAC) can promote hematopoietic recovery after chemotherapy in patients with acute myeloid leukemia (AML), and to…
- Trial name
- 2026-07-06 (NCT07869342)
- Testing
- N-acetyl-L-cysteine (NAC)
- Volunteers
- 180 people
- Sponsor
- Peking University People's Hospital
Pilonidal Sinus Disease
VAAPS Combined With Loose Seton Drainage for Postoperative Self-Care: A Prospective Single-Arm Cohort Study
Pilonidal sinus is a chronic infection of the sacrococcygeal skin that mainly affects young adults. Traditional surgery leaves large wounds requiring weeks of daily dressing changes away from home.
- Trial name
- PKUPH-PS01 (NCT07855107)
- Testing
- VAAPS with Loose Seton Drainage
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Transgender, Gender Incongruence
China Gender-affirming Hormone Therapy Study
Data about transgender medical care, especially the gender-affirming hormone therapy (GAHT) is extremely insufficient in China. Few evidence exists in the physical and psychological effects of the hormonal treatment in Chinese…
- Trial name
- CGAHT (NCT05318755)
- Testing
- GAHT for transgender men, GAHT for transgender women
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Membranous Nephropathy
Combination of Rituximab and Cyclosporine in the Treatment of Primary Membranous Nephropathy
High-grade proteinuria is one of the key determinants of adverse renal prognosis in patients with primary membranous nephropathy (PMN).The main purpose of this study is to determine whether Rituximab combined with Cyclosporine is…
- Trial name
- NCT07861204
- Testing
- Rituximab combined with cyclosporine, rituximab
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking University First Hospital
Early Gastric Cancer
LECS Combined With LSNNS for Early Gastric Cancer (LENS Trial)
Early gastric cancer (EGC) is traditionally treated with either endoscopic resection or standard laparoscopic gastrectomy with formal lymph node dissection.
- Trial name
- LENS (NCT07857668)
- Testing
- Procedure: LECS combined with LSNNS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Postoperative Pain After Patellar Dislocation Surgery
Integrated Traditional Chinese and Western Medicine for Patellar Dislocation Pain: A Concurrent Non-Randomized Controlled Trial
This study is a concurrent non-randomized controlled pilot trial. We plan to recruit 80 patients following patellar dislocation surgery from Peking University Third Hospital in China, with at least 40 participants in each group.
- Trial name
- NCT07613346
- Testing
- Acupuncture, Voltaren
- Where
- China
- Volunteers
- 93 people
- Sponsor
- Peking University Third Hospital
Breast Cancer (Early Breast Cancer)
ADC Based Therapy Accroding to HER2 Heterogeneous
This study adopts a single-center, open-label, single-arm interventional design. It will enroll 88 patients with histologically confirmed HER2-positive early breast cancer who are suitable for surgery and neoadjuvant therapy, and…
- Trial name
- HER2level (NCT07844018)
- Testing
- HER2 target therapy
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Peking University People's Hospital
Melanoma, Acral Melanoma
A Study of QL1706 Combined With OH2 Injection in Perioperative Treatment of Stage III Resectable Acral Melanoma
This is a prospective, multicenter, open-label, 1:1 randomized phase II trial enrolling 76 patients with AJCC stage III surgically resectable acral melanoma.
- Trial name
- NCT07854522
- Testing
- Iparomlimab and Tuvonralimab Injection (QL1706), OH2 Injection(Recombinant Human GM-CSF Oncolytic Type II Herpes Simplex Virus)
- Volunteers
- 76 people
- Sponsor
- Peking University Cancer Hospital & Institute
Osteoporosis，Neurological Disorders
Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study
Epigenetic modification refers to the change of heritable gene expression occurring in the case of unchanged DNA sequence, including DNA methylation, epigenetic modification, RNAS, chromatin modification, etc.
- Trial name
- BONE (NCT03401619)
- Testing
- Exercise，Nutrition，Bisphosphonates，Statins，Calcitonin,Vitamin D，et al.
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Cutaneous T-Cell Lymphoma/Mycosis Fungoides/Sézary Syndrome
A Prospective Clinical Study of Zeprumetosta in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma
Patients with relapsed or refractory cutaneous T-cell lymphoma (R/R CTCL) face a poor prognosis and limited therapeutic options. Advanced or relapsed disease yields a 5-year overall survival rate of <50%.
- Trial name
- NCT07854639
- Testing
- Zeprumetostat Tablets
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Peking University First Hospital
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