Clinical trials: sponsored by Peking University
Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits
Telitacicept for PGNMID: A Single-Arm Study
This single-center, prospective, single-arm study will evaluate the efficacy and safety of telitacicept in 10 adults with biopsy-proven proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID).
- Trial name
- NCT07111338
- Testing
- Telitacicept 160mg
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking University First Hospital
Obstructive Sleep Apnea, Auditory Processing Disorder
Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing
The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years.
- Trial name
- NCT07039500
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Adult, Intensive Care Unit
Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients
Delirium is common in septic patients, especially those receiving mechanical ventilation in the intensive care unit (ICU). Dexmedetomidine is a highly selective α2 adrenoreceptor agonist with anxiolytic, sedative, analgesic, and…
- Conditions
- Adult, Intensive Care Unit, Sepsis, Mechanical Ventilation
- Trial name
- NCT04876937
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University First Hospital
Elderly Patients, Malnutrition
Nutritional Intervention and Outcomes in Elderly After Hip Fracture Surgery
Hip fracture is one of the most frequently occurred injury in the elderly and usually requires surgical treatment. Malnutrition is common in elderly patients with hip fracture and is associated with worse outcomes.
- Conditions
- Elderly Patients, Malnutrition, Hip Fractures, Nutritional Intervention
- Trial name
- NCT04451538
- Testing
- Nutritional intervention group, Control group
- Where
- 3 sites in China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Elderly, Hip Fracture Surgery
Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery
Delirium is common in the elderly after hip fracture surgery, and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after hip fracture surgery, dexmedetomidine supplemented analgesia can…
- Conditions
- Elderly, Hip Fracture Surgery, Patient-controlled Analgesia, Dexmedetomidine
- Trial name
- NCT04955249
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Peking University First Hospital
Old Age, Knee Replacement Surgery
Nocturnal Low-dose Dexmedetomidine Infusion and Perioperative Sleep Quality
Sleep disturbances are prevalent in older patients with osteoarthrosis or fracture scheduled for knee or hip replacement surgery.
- Conditions
- Old Age, Knee Replacement Surgery, Hip Replacement Surgery, Dexmedetomidine
- Trial name
- NCT05246007
- Testing
- Dexmedetomidine, Normal Saline
- Where
- 2 sites in China
- Sponsor
- Peking University First Hospital
Elderly, Knee Arthroplasty
Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block
Delirium is common in the elderly after orthopedic surgery and is associated with worse outcomes. Continuous femoral nerve block is frequently used for postoperative analgesia after total knee arthoplasty.
- Conditions
- Elderly, Knee Arthroplasty, Nerve Block, Dexmedetomidine
- Trial name
- NCT03629483
- Testing
- Dexmedetomidine
- Volunteers
- 3 people
- Sponsor
- Peking University First Hospital
Personality, Patient Compliance
Distribution of Mood and Personality Characteristics and Their Influence on Treatment Compliance
This study intends to investigate the personality and psychological characteristics of OSA patients using classical standard scales and obtain treatment information and adherence data through prospective follow-up to summarize…
- Conditions
- Personality, Patient Compliance, Anxiety, Depression
- Trial name
- NCT07101796
- Testing
- continous positive airway pressure (CPAP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
HER2-expressing High-risk or Very High-risk NMIBC Without Visible Foci of Disease After TURBT
RC48 in Combination With Radiotherapy for HER2-Expressing NMIBC Patients
This study is an open, single-arm, single-center exploratory clinical study to explore the efficacy and safety of Disitamab Vedotin (RC-48) in combination with radiotherapy for the treatment of patients with HER2-expressing…
- Trial name
- NCT07100184
- Testing
- Disitamab Vedotin combined with Radiotherapy
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Breast Neoplasms, Mastectomy
Impact of Erector Spinae Plane Block on Chronic Postsurgical Pain in Breast Cancer Patients
Chronic postsurgical pain (CPSP) has an incidence of 46% in patients after breast cancer surgery, which seriously affects patients' physiological and psychological function, as well as quality of life.
- Conditions
- Breast Neoplasms, Mastectomy, Nerve Block, Dexmedetomidine
- Trial name
- NCT05494502
- Testing
- Erector spinae plane block, Control group
- Where
- 2 sites in China
- Volunteers
- 1,206 people
- Sponsor
- Peking University First Hospital
Older Patients, Cognitive Impairment
Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery
Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD).
- Conditions
- Older Patients, Cognitive Impairment, Repetitive Transcranial Magnetic Stimulation, Delayed Neurocognitive Recovery
- Trial name
- NCT06482749
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- 3 sites in China
- Volunteers
- 568 people
- Sponsor
- Peking University First Hospital
Metastatic Gastrointestinal Stromal Tumors (GIST)
A Study of Regorafenib Combined With Envafolimab for Metastatic Gastrointestinal Stromal Tumors With Kit Gene Exon 17 Mutation That Failed Standard Treatment
This study is a multicenter, prospective, randomized controlled Phase II clinical trial. The primary endpoint is to evaluate the efficacy and safety of regorafenib combined with envafolimab compared to physician's choice in…
- Trial name
- NCT06772233
- Testing
- regorafenib combined with envafolimab, Control Group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Gastrointestinal Tumors
Phase 1 Trial of AZD6422 in CLDN18.2+ GI Tumors
This is a FTiH, Phase 1 IIT to evaluate the safety, feasibility, cellular kinetics (CK), pharmacodynamics (PD), immunogenicity, and preliminary antitumor activity of AZD6422 in adult participants with advanced or metastatic…
- Trial name
- NCT05981235
- Testing
- AZD6422 CLDN18.2 CAR-T product
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking University
Older Patients, Orthopedic Surgery
Buccal Acupuncture for Delirium Treatment in Older Patients Recovering From Orthopedic Surgery
This study is designed to test the hypothesis that, for older orthopedic patients who developed postoperative delirium, combining buccal acupuncture with routine care will shorten delirium duration and relieve delirium severity.
- Conditions
- Older Patients, Orthopedic Surgery, Postoperative Delirium, Acupuncture
- Trial name
- NCT05537155
- Testing
- Buccal acupuncture in addition to routine care, Routine care
- Sponsor
- Peking University First Hospital
Antithrombotic Therapy, Perioperative Care
Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy
The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic antithrombotic therapy before…
- Conditions
- Antithrombotic Therapy, Perioperative Care, Perioperative Outcomes
- Trial name
- NCT04852406
- Testing
- Protocol-based management of perioperative antithrombotic therapy, Routine management of perioperative antithrombotic therapy
- Where
- China
- Volunteers
- 526 people
- Sponsor
- Peking University First Hospital
Urinary Catheter, Catheter-related Bladder Discomfort
Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort
Catheter-related bladder discomfort (CRBD) is common in patients awaking from general anesthesia with an urinary catheter. We suppose that that use of dexmedetomidine and/or esketamine during anesthesia may reduce the occurrence…
- Conditions
- Urinary Catheter, Catheter-related Bladder Discomfort, Dexmedetomidine, Esketamine
- Trial name
- NCT06399185
- Testing
- Normal saline, Dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 1,740 people
- Sponsor
- Peking University First Hospital
Lung Cancer, Surgery
Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery
Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging.
- Conditions
- Lung Cancer, Surgery, Blood Pressure Management, Dexamethasone
- Trial name
- NCT04209218
- Testing
- Dexamethasone, Targeted blood pressure management, Routine blood presure management
- Where
- China
- Volunteers
- 1,988 people
- Sponsor
- Peking University First Hospital
Elderly, Surgery
Dexmedetomidine and Outcomes of Elderly Admitted to ICU After Surgery
Sleep disorder and delirium are common problems in intensive care unit (ICU) patients, and may lead to poor prognosis. The investigators' previous study showed that nighttime infusion of low-dose dexmedetomidine improved the…
- Conditions
- Elderly, Surgery, Intensive Care Unit, Dexmedetomidine
- Trial name
- NCT04204798
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 1,410 people
- Sponsor
- Peking University First Hospital
Breast Cancer, Perioperative Period
Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality
Breast cancer patients often have sleep disturbances during the perioperative period. Dexmedetomidine is a highly selective alpha 2-adrenoceptor agonist with sedative, anxiolytic, and analgesic effects.
- Conditions
- Breast Cancer, Perioperative Period, Dexmedetomidine, Esketamine
- Trial name
- NCT05732064
- Testing
- Dexmedetomidine, Esketamine, Normal saline
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking University First Hospital
Elderly, Orthopedic Surgery
Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery
Delirium is common in the elderly after orthopedic surgery and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after orthopedic surgery, dexmedetomidine supplemented intravenous…
- Conditions
- Elderly, Orthopedic Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03629262
- Testing
- Dexmedetomidine
- Where
- 2 sites in China
- Volunteers
- 712 people
- Sponsor
- Peking University First Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.