Clinical trials: sponsored by Peking University
Emotional Distress, Depression, Anxiety
Temporal Dynamics of Mindfulness Intervention for Emotional Distress: Daily Interventions and Assessments
This research aims to adopt a complex systems perspective to thoroughly examine the impact of online mindfulness interventions on changes in emotional distress, with a particular focus on the mechanisms of action.
- Trial name
- NCT06919406
- Testing
- Mindfulness Intervention for emotional distress(MIED）
- Volunteers
- 100 people
- Sponsor
- Peking University
Alzheimer&Amp;#39;s Disease (AD)
Clinical Study on Lymphaticovenous Anastomosis（LVA） for the Treatment of Alzheimer's Disease（AD）
The goal of this clinical trial is to explore the safety and efficacy of Lymphaticovenous Anastomosis (LVA) for the Treatment of Alzheimer's Disease (AD). The main questions it aims to answer are: 1.
- Trial name
- LVA; AD (NCT06918145)
- Testing
- Lymphaticovenous Anastomosis
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Prostate Cancer
Evaluation of Transrectal Perilesional Biopsy in Diagnosis of Prostate Cancer
The goal of this single-center randomized controlled trial (RCT) is to evaluate the efficacy and safety of different transrectal prostate biopsy schemes, including transrectal perilesional/regional systematic biopsy (PB/RSB) and…
- Trial name
- NCT06482658
- Testing
- Transrectal perilesional/regional systematic biopsy (PB/RSB), Combination of transrectal systematic biopsy and targeted biopsy
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Peking University First Hospital
Alzheimer's Disease Dementia
Efficacy of HellenCare in Early-Stage Alzheimer's Disease
The goal of this clinical trial is to evaluate whether HellenCare, a multicomponent nutraceutical, improves cognitive and functional outcomes in patients with early-stage Alzheimer's disease (AD).
- Trial name
- NCT06895525
- Testing
- HellenCare
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Endometrial Cancer, Mobile Applications
Application-Assisted Weight Management in Endometrial Cancer Fertility Preservation
This study is a single-center, prospective, randomized controlled trial targeting endometrial cancer (EC) patients undergoing fertility-sparing treatment at Peking University People's Hospital from March 2025 to March 2027.
- Conditions
- Endometrial Cancer, Mobile Applications, Weight Management
- Trial name
- NCT06901778
- Testing
- DEAR weight management, Standardized discharge care plan and follow-up schedule, Implementation of the weight management mobile health application
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Peking University People's Hospital
Systemic Lupus Erythematosus, Inflammatory Myopathy
BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases
The objective of this study is to evaluate the efficacy and safety of BCMA/CD19 chimeric antigen receptor (CAR)-modified T cells in the treatment of autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Inflammatory Myopathy, Systemic Sclerosis (SSc), ANCA-associated Vasculitis
- Trial name
- NCT06794008
- Testing
- BCMA-CD19 CAR-T therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Liver Cancer, Radiofrequency Ablation
Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation
Percutaneous radiofrequency ablation is a commonly treatment for patients with liver cancer that cannot be surgically resected. During the procedure, patients need to keep awake and cooperate with the procedure, including deep…
- Conditions
- Liver Cancer, Radiofrequency Ablation, Esketamine, Dexmedetomidine
- Trial name
- NCT06003218
- Testing
- Dexmedetomidine-esketamine combination, Remifentanil, Oxycodone
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Peking University First Hospital
Normal Cognition, Cardiovascular Risk Factors
Cardiovascular Risk Factors and Cognitive Trajectories
The cognitive trajectory varies among non-demented older adults. In a 12-year follow-up study, we found approximately 5% participants presented rapid cognitive decline.
- Conditions
- Normal Cognition, Cardiovascular Risk Factors, Cognitive Change, Cerebral Blood Flow
- Trial name
- NCT05441865
- Where
- China
- Volunteers
- 3,372 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Locally Advanced Rectal Cancer
Preoperative Chemoradiotherapy Combined With Consolidation or Induction NALIRIFOX in Rectal Cancer.
The Efficacy and Safety of Long-Course Preoperative Chemoradiotherapy Combined with Consolidation or Induction NALIRIFOX Chemotherapy in the Treatment of Locally Advanced Rectal Cancer: A Prospective, Multicenter, Phase II Study.
- Trial name
- NCT06894797
- Testing
- Concurrent Chemoradiotherapy（Radiation + Capecitabine）, irinotecan hydrochloride liposome injection, Oxaliplatin
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Peking University Cancer Hospital & Institute
Relapsed B-cell Non-Hodgkin Lymphoma, Refractory B-cell Non-Hodgkin Lymphoma
A Study of LUCAR-20SP in Subjects With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
This is a prospective, single-arm, open-label, exploratory clinical study of LUCAR-20SP in adult subjects with relapsed/refractory B-cell non-Hodgkin lymphoma.
- Trial name
- NCT06313957
- Testing
- LUCAR-20SP cells
- Where
- 3 sites in China
- Volunteers
- 42 people
- Sponsor
- Peking University Cancer Hospital & Institute
HCC
Phase I Study of OriC902 in Treatment of Advanced HCC
This is a Phase I clinical study evaluating the safety, pharmacokinetics, and initial efficacy of a GPC3-targeted chimeric antigen receptor autologous T cell injection (OriC902) in GPC3-positive advanced hepatocellular carcinoma…
- Trial name
- NCT06891742
- Testing
- OriC902
- Where
- 2 sites in China
- Volunteers
- 44 people
- Sponsor
- Peking University
Radiation Therapy, Targeted Therapy
SABR Combined with Axitinib and Toripalimab in Recurrent or Metastatic RCC
This is a prospective, single-center clinical trial designed to evaluate the safety and efficacy of combining stereotactic ablative body radiotherapy (SABR) with the targeted therapy Axitinib and the immunotherapy Toripalimab in…
- Conditions
- Radiation Therapy, Targeted Therapy, Immunotherapy, Renal Cancer Metastatic
- Trial name
- NCT06889649
- Testing
- Stereotactic Ablative Body Radiotherapy (SABR), TORIPALIMAB INJECTION(JS001 ), Axitinib (VEGF-TKI)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
HER2 Positive or Suspicious Positive Tumors
Research for the Molecular Imaging of the HER2 Targeting Tracer
To use the molecular PET radionuclide (Ga-68 or F-18) labelled HER2 Affibody to detect the expression of HER2 in the primary and metastatic lesions in patients with HER2 positive or suspicious positive tumors; to detect the…
- Trial name
- NCT04547309
- Testing
- 68Ga/18F-HER2 Affibody PET/CT scan
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Cancer Hospital & Institute
Adults, Major Noncardiac Surgery
Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia…
- Conditions
- Adults, Major Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06859892
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Peking University First Hospital
Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy
Effect of Urine-guided Hydration on Acute Kidney Injury After CRS-HIPEC
Acute renal injury (AKI) is a common complication after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), and is associated with worse outcomes.
- Conditions
- Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, Hydration, Diuresis
- Trial name
- NCT05939193
- Testing
- Urine-guided hydration, Routine hydration, Forced administration of furosemide
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Peking University First Hospital
Locally Advanced Cervical Cancer
A Clinical Study of Pelvic Concurrent Chemoradiotherapy Combined with CT-guided Intracavitary Brachytherapy with Adaptive Simultaneous Dose Escalation for Locally Advanced Cervical Cancer
The standard treatment for locally advanced cervical cancer is cisplatin-based concurrent chemoradiotherapy with external beam radiotherapy (EBRT) and Brachytherapy (BT).
- Trial name
- NCT06882473
- Testing
- Brachytherapy and CT-guided online adaptive external beam pelvic radiotherapy are delivered on the same day
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Stress Reduction
AI-Guided Stress Management Breathing Practices Via a Wearable Device
This study explores the effectiveness of AI-guided breathing practices for stress management in adults. In this randomized controlled trial, 120 participants will be recruited and assigned to an intervention group (n=90) or a…
- Trial name
- NCT06881875
- Testing
- AI-guided breathing practices, Progressive muscle relaxation
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University
Multiple Myeloma, Newly Diagnosed
KPD Consolidation After ASCT in NDMM Patients
This study aims to evaluate the efficacy and safety of post-transplant consolidation therapy with the KPD regimen (carfilzomib, pomalidomide, and dexamethasone) versus no consolidation, followed by maintenance therapy, in…
- Trial name
- NCT06879379
- Testing
- KPD (carfilzomib, pomalidomide, and dexamethasone) consolidation
- Where
- 3 sites in China
- Volunteers
- 202 people
- Sponsor
- Peking University People's Hospital
Neuroendocrine Neoplasm
Sintilimab Combined With IBI310 and Surufatinib for the Treatment of G3-NET and NEC (NESSIE)
This is a phase II, single arm, open-label, multicenter study to evaluate the efficacy and safety of Sintilimab combined with IBI310 and Surufatinib for the treatment of high-grade advanced-neuroendocrine neoplasm
- Trial name
- NESSIE (NCT05165407)
- Testing
- Sintilimab, IBI310, Surufatinib
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Peking University
Neuroendocrine Carcinoma
Nab-paclitaxel Combined with Bevacizumab in the Treatment of Metastatic Extrapulmonary Neuroendocrine Carcinoma
This is an open-label, phase II study evaluating efficacy and safety of Nab-paclitaxel Combined With Bevacizumab for unresectable Recurrent or metastatic extrapulmonary neuroendocrine carcinoma.
- Trial name
- NCT04705519
- Testing
- Nab-paclitaxel Combined With Bevacizumab
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Peking University
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