Clinical trials: sponsored by Peking University
Obstructive Sleep Apnea, Hypertension
The Effect of Sleep Apnea and Hypertension on Gut Microbiome
Obstructive sleep apnea (OSA) and hypertension are closely associated diseases. Here we characterized the differences in the gut microbiome which is affected by the two diseases, when the two diseases coexist or are present…
- Conditions
- Obstructive Sleep Apnea, Hypertension, Gut Microbiome
- Trial name
- NCT05266131
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University First Hospital
Chronic Insomnia
Digital Cognitive Behavioral Therapy for Insomnia for Chronic Insomnia in Breast Cancer Survivors
To explore the efficacy of dCBT-I therapy for chronic insomnia among breast cancer survivors in China, we propose to conduct a randomized, parallel controlled clinical study in breast cancer survivors using a smartphone Chinese…
- Trial name
- NCT05813392
- Testing
- Digital Cognitive Behavioral Therapy for Insomnia
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Peking University First Hospital
Oligometastatic Disease, Ureter Cancer
Radiotherapy Combined with Systemic Therapy Versus Systemic Therapy for Oligometastatic UTUCs
This study was a prospective, open-label, phase II randomised controlled clinical study, enrolling patients with primary oligometastatic uroepithelial carcinoma, oligometastasis was defined as ≤3 organs, and the number of…
- Conditions
- Oligometastatic Disease, Ureter Cancer, Renal Pelvic Carcinoma
- Trial name
- NCT06652022
- Testing
- Systematic therapy combined with radiotherapy, Systematic drug treatment
- Where
- 2 sites in China
- Volunteers
- 102 people
- Sponsor
- Peking University First Hospital
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Safety and Effectiveness Evaluation of Spinal Laminectomy Robot
The purpose of this clinical trial is to evaluate the effectiveness and safety of this spinal robot in assisting doctors to perform laminectomy in spinal surgery under the premise of ensuring the safety of the subjects and…
- Trial name
- NCT06593574
- Testing
- Robotic laminectomy, Traditional laminectomy
- Where
- 3 sites in China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
Obstructive Sleep Apnea, Inflammation
A Community Study of the Risk for Obstructive Sleep Apnea and Respiratory Inflammation in an Adult Chinese Population
We aimed to investigate the relationship between obstructive sleep apnea (OSA) risk and respiratory inflammation evaluated by the exhaled breath condensate （EBC）interleukin-6 IL-6 and plasma SP-D, based on the Berlin…
- Conditions
- Obstructive Sleep Apnea, Inflammation, Exhaled Breath Condensate, Surveys and Questionnaires
- Trial name
- NCT04832711
- Where
- China
- Volunteers
- 1,270 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
IVF
Levofloxacin Plus Metronidazole Suppositories Versus Levofloxacin Co-administered with Metronidazole Tablets in Chronic Endometritis
This is a single randomised controlled trial. The investigators plan to randomise 800 participants to the levofloxacin plus metronidazole suppositories versus levofloxacin co-administered with metronidazole tablets for the…
- Trial name
- NCT06650540
- Testing
- Levofloxacin Plus Metronidazole Suppositories, Levofloxacin co-administered with Metronidazole tablets
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Peking University Third Hospital
Diabetes Mellitus, Gut Microbiota
Correlation Between Gut Microbiota and Pancreatic Β-Cell Function in Diabetic Patients
The gut microbiota plays a crucial role in digestion, metabolism, nutrition, and immune regulation in the human body. In recent years, numerous studies have indicated that the gut microbiota and its metabolites are closely…
- Trial name
- NCT06645223
- Testing
- No Interventions
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Allergic Bronchopulmonary Aspergillosis
Multicenter Registration Study on Allergic Bronchopulmonary Aspergillosis
To understand the current diagnosis and treatment status of ABPA patients, observe their clinical characteristics, prognosis, and treatment outcomes, and identify the relevant factors for poor prognosis in patients.
- Trial name
- NCT06645210
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Amyotrophic Lateral Sclerosis (ALS)
An IIT Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of a Single Intrathecal Injection of SNUG01 in Patients with Amyotrophic Lateral Sclerosis
This is a multicenter, open-label, single-arm investigator-initiated clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of SNUG01 in patients with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- ALS (NCT06645197)
- Testing
- SNUG01
- Where
- 5 sites in China
- Volunteers
- 7 people
- Sponsor
- Peking University Third Hospital
PTSD, Subclinical PTSD
The Effectiveness of Written Exposure Therapy for PTSD
Study 1: The goal of this study is to use a pilot RCT to assess the effectiveness of Written Exposure Therapy (WET) and a mindfulness-based app (MBA) for managing PTSD and comorbid insomnia in China.
- Trial name
- NCT05421494
- Testing
- written exposure therapy-revised version, minimal contact control
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Peking University
Biliary Tract Neoplasms, Gastric Cancer
Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics
This a prospective real-world navigation study using tumor DNA sequencing technology to sequence genes of previously treated and refractory gastrointestinal tumors, which are generally considered to be highly heterogeneous and…
- Conditions
- Biliary Tract Neoplasms, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Colorectal Cancer
- Trial name
- VISIONARY (NCT04584008)
- Testing
- FGFR Inhibitor, IDH1 Inhibitor, HER2 Inhibitor, PARP Inhibitor, BRAF Inhibitor, MEK Inhibitor, ICIs, EGFR-TKIs, NTRK-TKI, and et. al., Other Therapy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University
Cancer
EGFR Mutation Targeting Molecular Probe for PET Imaging
In this project, investigators plan to develop a F-18 labeled molecular probe in order to detect the EGFR mutation tumor lessions in patients to identify patients benefiting fromTKIs treatment, and evaluate its efficacy in…
- Trial name
- EGFR-PET (NCT06641674)
- Testing
- 18F-LF13
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Cancer Hospital & Institute
Phrenic Paralysis, Shoulder Joint Surgery
The Effect of Brachial Plexus Block on Diaphragm Movement
The purpose of this study is to quickly evaluate the degree of phrenic nerve block by observing the changes of diaphragm movement through ultrasound, and to find the best scheme for clinical application by controlling the…
- Conditions
- Phrenic Paralysis, Shoulder Joint Surgery, Rotator Cuff Injury
- Trial name
- NCT06640621
- Testing
- Different concentration of ropivacaine for single brachial plexus block
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Total Knee Anthroplasty, Robotic Surgery
Early Clinical and Radiological Outcomes of a Novel Robotic TKA System
This study aimed to evaluate the early clinical and radiological outcomes of robot assisted total knee arthroplasty, and to determine the efficiency and safety of its bone resection and implant positioning of the novel robot…
- Trial name
- RA-TKA (NCT06638047)
- Testing
- robotic-assisted TKA, CI-TKA
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Peking University Third Hospital
COVID-19
Tetrandrine Tablets Used in Hospitalized Adults With COVID-19
The primary objective of this study is to evaluate the effectiveness of tetrandrine tablets in preventing the progression of COVID-19 from severe to critical.
- Trial name
- NCT05697029
- Testing
- Tetrandrine
- Where
- China
- Sponsor
- Peking University Third Hospital
Asthma Exacerbations
A Cohort Study of Risk Factors and Prognosis for Frequent Acute Asthma Exacerbations Phenotype
Acute asthma exacerbations are an important public health problem and a major cause of disease progression and healthcare burden for people with asthma. Frequent acute exacerbations are likely to be a distinct asthma phenotype.
- Trial name
- NCT06621056
- Testing
- not applicable for observational research
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Thrombocytopenia, Stem Cell Transplant Complications
Efficacy and Safety of Avatrombopag in the Treatment of Thrombocytopenia After Haplo-HSCT
In this study, investigators aim to evaluate the efficacy of avatrombopag in thrombocytopenic patients after haploidentical hematopoietic stem cell transplantation (haplo-HSCT) through a prospective, multi-center, double-blinded…
- Trial name
- Haplo-HSCT (NCT06202625)
- Testing
- avatrombopag
- Where
- 14 sites in China
- Volunteers
- 142 people
- Sponsor
- Peking University People's Hospital
Monoclonal Gammopathy of Renal Significance
Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone Therapy for Patients with MIDD
This is an open-label, multicenter, Phase 2 study in subjects with newly diagnosed monoclonal immunoglobulin deposition disease treated with daratumumab, bortezomib, cyclophosphamide, and dexamethasone.
- Trial name
- NCT06418477
- Testing
- Dara-CyBorD
- Where
- 3 sites in China
- Volunteers
- 20 people
- Sponsor
- Peking University People's Hospital
Emotional Distress
Mechanisms of Mindfulness Intervention: Cognitive Flexibility Dose Manipulation
This study hopes to: 1. explore whether an increase in the dosage of cognitive flexibility intervention corresponds to greater effectiveness of mindfulness intervention in alleviating emotional distress. 2.
- Trial name
- NCT06622122
- Testing
- Mindfulness Intervention for Emotional Distress(MIED)-normal version, Mindfulness Intervention for Emotional Distress(MIED)-increase cognitive flexibility
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University
Cardiac Surgery, Dexmedetomidine
Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery
A retrospective study showed that intraoperative dexmedetomidine administration was associated with decreased risk of 1-year mortality after cardiac surgery.
- Conditions
- Cardiac Surgery, Dexmedetomidine, Long-term Outcome, Mortality
- Trial name
- NCT03289325
- Testing
- dexmedetomidine hydrochloride for injection, 0.9% sodium chloride for injection
- Where
- 2 sites in China
- Volunteers
- 285 people
- Sponsor
- Peking University First Hospital
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