Clinical trials: sponsored by Peking University
Systemic Lupus Erthematosus, Systemic Sclerosis (SSc)
Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases
Autoimmune diseases refer to a common category of diseases caused by the immune system reacting to self-antigens, leading to tissue damage.
- Conditions
- Systemic Lupus Erthematosus, Systemic Sclerosis (SSc), Inflammatory Myopathies, ANCA Associated Vasculitis (AAV)
- Trial name
- NCT06821659
- Testing
- anti-CD19 CAR-T cells
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Range of Motion, Articular
Application of a Wearable Device-Based Intelligent Rehabilitation System in the Rehabilitation of Patients With Frozen Shoulder
A Comparative Study of Traditional Rehabilitation and Remote Intelligent Rehabilitation: Exploring the Application Effectiveness of Intelligent Rehabilitation in Frozen Shoulder Rehabilitation
- Trial name
- NCT07422714
- Testing
- Artificial and intelligent combination of shoulder joint function exercise, Traditional rehabilitation training, Intelligent rehabilitation training
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University Third Hospital
Hepatoid Adenocarcinoma of Stomach
Perioperative Treatment of Hepatoid Adenocarcinoma of Stomach
The goal of this clinical trial is to learn if treatment modality including Disitamab Vedotin （RC48）, Oxaliplatin，Tegafur,Gimeracil and Oteracil Porassium Capsules （SOX）and Sindillimab works to treat locally advanced hepatoid…
- Trial name
- HASCHANGE01 (NCT06992362)
- Testing
- Perioperative treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Cancer Hospital & Institute
ACL Injury
Motor Imagery-Enhanced Rehabilitation Modulates Cortical Plasticity and Functional Recovery After ACL Reconstruction
Part 1: Neural Correlates of Motor Imagery in ACLR Patients This cross-sectional study aims to systematically compare differences in electroencephalographic (EEG) activity between patients who have returned to sport one year…
- Trial name
- NCT07833189
- Testing
- Motor Imagery Therapy (i.e., "mentally practicing movement"), conventional rehabilitation"
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Retroperitoneal Fibrosis
Study of Sirolimus in Idiopathic Retroperitoneal Fibrosis
Retroperitoneal fibrosis refers to a group of diseases characterized by hyperplasia of the fibrosclerotic tissues in the retroperitoneal space, which can compress the surrounding ureters and inferior vena cava and cause serious…
- Trial name
- NCT04047576
- Testing
- Sirolimus, Corticosteroid
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Peking University International Hospital
Systemic Lupus Erthematosus, Systemic Sclerosis (SSc)
Safety and Efficacy of Universal CD19-targeting CAR-γδT Cells in Refractory Autoimmune Diseases
Autoimmune diseases refer to a common category of diseases caused by the immune system reacting to self-antigens, leading to tissue damage.
- Conditions
- Systemic Lupus Erthematosus, Systemic Sclerosis (SSc), Sjogren Syndrome, ANCA Associated Vasculitis (AAV)
- Trial name
- NCT06828042
- Testing
- anti-CD19 CAR T cell therapy
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Rectal Cancers
Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal Cancer
Rectal cancer surgery has become increasingly effective, allowing many patients to avoid permanent colostomy. However, anastomotic leakage remains one of the most serious complications after rectal cancer surgery, especially in…
- Trial name
- PKUCH-R10 (NCT07833319)
- Testing
- methylene blue injection
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Peking University Cancer Hospital & Institute
Behçet's Syndrome, Behçet's Syndrome (BS)
Corticotropin for Behçet's Disease: A Multicenter Randomized Controlled TrialAcronym.
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone secreted by the anterior pituitary gland. It can stimulate adrenal cortical hyperplasia and the secretion of glucocorticoids, thereby exerting anti-inflammatory…
- Trial name
- NCT07833163
- Testing
- Repository Corticotropin Injection (ACTH)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Childhood Weight Management
Fangshan Active Nutrition Initiative
The goal of this study is to evaluate the effectiveness of a school-based weight management intervention delivered through a digital platform (WeChat) in preventing excessive weight gain and improving health behaviors in…
- Trial name
- FAN (NCT07519122)
- Testing
- Digital Intelligence Platform-based Multi-level Weight Management
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Peking University
Gastric Adenocarcinoma
Compare Neoadjuvant DOS Combined With Toripalimab Versus SOX Combined With Toripalimab in Locally Advanced Gastric Adenocarcinoma
This is a randomized, multicenter, controlled, adaptive phase II/III clinical study. The aim is to compare neoadjuvant chemotherapy with docetaxel, oxaliplatin, and S-1 (DOS) plus toripalimab versus oxaliplatin and S-1 (SOX) plus…
- Trial name
- RESOLVE-2 (NCT03691454)
- Testing
- Docetaxel+Oxaliplatin+S-1+Toripalimab, Oxaliplatin+S-1+Toripalimab
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Peking University
Childhood Obesity Prevention
Obesity Prevention in School-aged Children
This cluster-randomized trial will develop and test an intervention technology for school-aged children. The program combines digital health technology and personalized behavior intervention through a WeChat platform.
- Trial name
- NCT07203300
- Testing
- multicomponent, tiered intervention
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Peking University
Chest Pain Center, Chest Pain
Silent Deployment and Prospective Evaluation of Zhunxin Agent for Emergency Chest Pain Assessment
The goal of this prospective, multicenter observational study is to evaluate how well Zhunxin Agent, an artificial intelligence system for chest pain assessment, performs in real-world emergency department settings.
- Trial name
- NCT07829536
- Volunteers
- 10,000 people
- Sponsor
- Peking University Health Science Center
Cardiovascular Diseases
Cardiovascular Risk Assessment and Dynamic Monitoring-based Prevention Trial
The CRITICALLY study is a cluster randomized trial that will evaluate the effectiveness of a risk-based dynamic monitoring strategy for the primary prevention of cardiovascular high-risk Chinese adults.
- Trial name
- CRITICALLY (NCT05919056)
- Testing
- Frequent and automatic cardiovascular risk assessment, Dynamic risk monitoring, Regular GP visits
- Where
- China
- Volunteers
- 22,032 people
- Sponsor
- Peking University
Severe Aplastic Anemia, Hematopoietic Cell Transplant
Thiotepa-Based Conditioning for Haploidentical Hematopoietic Stem Cell Transplantation in Older Patients With Severe Aplastic Anemia
This prospective, single-center observational cohort study will follow participants aged 50 years or older with severe or very severe aplastic anemia who receive haploidentical hematopoietic stem cell transplantation with a…
- Trial name
- NCT07819812
- Testing
- Thiotepa
- Volunteers
- 20 people
- Sponsor
- Peking University People's Hospital
Immunoglobulin G4-Related Disease, Janus Kinase Inhibitors
Tofacitinib in the Treatment of IgG4 Related Diseases
This study is a single centre, open label, randomized controlled study to compare the efficacy and safety between steroids plus tofacitinib and steroids alone in active IgG4-related diseases patients.
- Trial name
- NCT07827469
- Testing
- Tofacitinib 5mg Oral Tablet, Prednisone 5mg
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Peking University People's Hospital
Hypotension After Spinal Anesthesia
ED50/ED90 of Phenylephrine Infusion for Preventing Spinal Anesthesia-Induced Hypotension: Supine vs Left-Tilt 15°
The purpose of this study is to determine the 50% and 90% effective doses (ED50 and ED90) of prophylactic phenylephrine infusion for preventing spinal anesthesia-induced hypotension during elective cesarean delivery, in the…
- Trial name
- NCT07824713
- Testing
- Phenylephrine hydrochloride infusion
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
SARS-CoV-2 Infection, Hematologic Malignancy
Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors
The goal of this observational study is to compare the immune function and infection mechanism of patients with hematologic tumors and those people without underlying diseases after infection with SARS-CoV-2.
- Trial name
- NCT05683353
- Testing
- None intervention
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Calcaneal Fractures
Sustentaculum Tali Screw Fixation Mode and Postoperative Foot-Ankle Function in Calcaneal Fractures
This is an observational, ambidirectional cohort study. Calcaneal fractures are the most common tarsal bone fractures, and most are intra-articular fractures involving the subtalar joint.
- Trial name
- NCT07822698
- Testing
- Screw Tip Position Relative to the Sustentaculum Tali
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Peking University Third Hospital
Rotator Cuff Injuries, Postoperative Pain
Effect of a Posterior Shoulder Pillow on Pain and Sleep Quality After Rotator Cuff Repair
The goal of this clinical study is to learn if using a special pillow placed behind the shoulder can help to reduce pain and improve sleep for patients after surgery to repair a torn rotator cuff.
- Conditions
- Rotator Cuff Injuries, Postoperative Pain, Sleep Quality
- Trial name
- NCT07372222
- Testing
- Posterior Shoulder Pillow, Conventional Rehabilitation Protocol
- Volunteers
- 126 people
- Sponsor
- Peking University Third Hospital
Severe Aplastic Anemia (SAA)
Peripheral Blood Versus Bone Marrow Plus Peripheral Blood Grafts for Haploidentical Transplantation in Severe Aplastic Anemia
Severe aplastic anemia is a life-threatening bone marrow failure disorder. Haploidentical hematopoietic stem cell transplantation has become an important curative treatment option for patients who do not have an HLA-matched…
- Trial name
- PB-Graft Haplo (NCT07629947)
- Testing
- G-CSF-Primed Peripheral Blood Stem Cell Graft, G-CSF-Primed Bone Marrow Plus Peripheral Blood Stem Cell Graft
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking University People's Hospital
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