Clinical trials: sponsored by Peking University
Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition, Pre-Term, Pre-Eclampsia
- Trial name
- ChiTwiMC (NCT06414655)
- Where
- 11 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Type 2 Diabetes
Evaluation of Efficacy and Safety of Combination Therapy of Henagliflozin Proline, Retagliptin and Metformin in New Diagnosed Type 2 Diabetes Patients
This study evaluated the efficacy and safety of initial combined treatment of Henggliptin, Retagliptin and Metformin by including new type 2 diabetes patients.
- Trial name
- NCT06417489
- Testing
- Combination therapy, Sequential treatment group
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
Effect of Drug, Toxicity, Drug
Apatinib Plus IE Chemotherapy (Ifosfamide and Etoposide) for Relapsed or Refractory Osteosarcoma
Apatinib has led to positive responses in the treatment of osteosarcoma refractory to first-line chemotherapy. However, apatinib demonstrates only short-lived activity, and the disease control of musculoskeletal lesions is worse…
- Trial name
- AIEO (NCT04824352)
- Testing
- apatinib
- Where
- 2 sites in China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
Biomarker, Progression
Soluble B7-H3 as a Biomarker for Osteosarcoma
Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies.
- Conditions
- Biomarker, Progression, Osteosarcoma, Surveillance
- Trial name
- NCT05942456
- Testing
- ELISA: enzyme-linked immunosorbent assay
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Malignant Solid Tumors
Evaluate the Safety and Tolerability of JCXH-212 Monotherapy and Combined With Toripalimab in the Treatment of Malignant Solid Tumors
To evaluate the safety and tolerability of JCXH-212 monotherapy and combined with Toripalimab in patients with malignant solid tumors; to determine the maximum tolerated dose (MTD), and to evaluate the dose-limiting toxicity…
- Trial name
- NCT05579275
- Testing
- JCXH-212 Injection
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Neoplasms Malignant
Significance of Benign Lymph Node Enlargement in Colorectal Cancer
The objective of this observational study was to investigate the clinical significance of benign mesenteric lymph node （BLNE） enlargement in patients with colorectal cancer.
- Trial name
- NCT06410729
- Testing
- Observational study, no intervention
- Volunteers
- 2,270 people
- Sponsor
- Peking University Third Hospital
Diabetes Mellitus, Type 2
The Efficacy and Safety of Insulin Degludec/Liraglutide Combination (IDegLira) in Patients With Type 2 Diabetes
The study aims to evaluate the efficacy and safety of IDegLira in type 2 diabetes who have failed premixed insulin therapy. The study plans to enroll 256 participants with inadequate glycemic control despite twice-daily…
- Trial name
- NCT06408532
- Testing
- IDegLira, Premixed insulin
- Volunteers
- 256 people
- Sponsor
- Peking University People's Hospital
HER2-positive Locally Advanced Resectable Gastric Cancer
Phase 2 Trial of KN026+KN046±XELOX in HER2-positive Locally Advanced GC
This is a multicenter II study to compare KN026 and KN046 versus Oxaliplatin, Capecitabine combined KN026 and KN046 in patients with HER2-positive locally advanced resectable gastric cancer or gastroesophageal junction…
- Trial name
- NCT06023758
- Testing
- KN026, KN046, XELOX
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Peking University
Acute Promyelocytic Leukemia, Induction Therapy
Optimum Induction Therapy of Low-risk APL
Despite the high cure probability for acute promyelocytic leukemia (APL), a minority of patients will relapse and the risk factors for relapse are unclear.
- Conditions
- Acute Promyelocytic Leukemia, Induction Therapy, Oral
- Trial name
- NCT05832320
- Testing
- Etoposide, Daunorubicin
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Peking University People's Hospital
Guided Tissue Regeneration, Extracellular Matrix Scaffold of Small Intestinal Submucosa
The Efficacy of Guided Tissue Regeneration With Extracellular Matrix Scaffold of Small Intestinal Submucosa (SIS) Membrane: a Randomized Controlled Clinical Trial
The most commonly used barrier membrane material in guided tissue regeneration is absorbable collagen membrane. Although the collagen membrane has a good barrier effect, it lacks the growth factors needed for periodontal tissue…
- Trial name
- NCT05789914
- Testing
- Flap surgery+bone graft+guided tissue regeneration
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University
Empathy
Empathy Training for Psychology Students Trainees
This study aims to examine the effectiveness of empathy training for psychology student trainees who plan to become mental health practitioners.
- Trial name
- NCT06352034
- Testing
- Empathy Training
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University
Liver Metastases, Colorectal Cancer
Dynamic ctDNA Detection for Colorectal Cancer Liver Metastases
Evaluating the value of dynamic monitoring of a colorectal cancer liver metastasis cohort underwent curative resection after receiving multipoint ctDNA detecting in predicting recurrence prognosis and guiding adjuvant…
- Conditions
- Liver Metastases, Colorectal Cancer, Surgery, Circulating Tumor DNA
- Trial name
- NCT06404593
- Testing
- Blood sampling
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Peking University Cancer Hospital & Institute
Diabetic Peripheral Neuropathy
Needle-Free Subcutaneous Injector and Conventional Intramuscular Injection of Mecobalamin in Diabetes Peripheral Neuropathy
The evaluation for efficacy and safety of needle-free subcutaneous injector and conventional intramuscular injection of mecobalamin for diabetic neuropathy.
- Trial name
- NCT06400888
- Testing
- needle-free subcutaneous injector for Mecbl, intramuscular injection of Mecbl
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
PTSD, Insomnia, Secondary
Written Exposure Therapy and App-Delivered Mindfulness Meditation for PTSD in China: A Pilot Study
The goal of this study is to use a pilot RCT to assess the effectiveness of Written Exposure Therapy (WET) and a mindfulness-based app (MBA) for managing PTSD and comorbid insomnia in China.
- Trial name
- NCT06394700
- Testing
- written exposure therapy, Written Exposure Therapy plus Mindfulness-Based App (WET + MBA), Minimal Contact Control (MCC)
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Peking University
VHL Syndrome, Renal Cell Carcinoma
Establishment of a Multidimensional Prediction Model for the Natural Course of VHL Disease-related Renal Cell Carcinoma
VHL syndrome is a rare hereditary tumor syndrome caused by mutation of tumor suppressor gene VHL. One of the most important clinical manifestations and main cause of death is VHL-related renal cell carcinoma (RCC).
- Trial name
- NCT06391879
- Testing
- Single cell sequencing, whole genome and metabolomic sequencing
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University First Hospital
Advanced Solid Tumor
Chimeric Antigen Receptor T Cells Targeting claudin18.2 in Solid Tumors.
An open label, single/multiple dose exploratory clinical study to evaluate the safety, efficacy, and pharmacokinetics of autologous humanized anti-claudin18.2 chimeric antigen receptor T cell in advanced solid tumor.
- Trial name
- NCT03874897
- Testing
- CAR-CLDN18.2 T-Cells, PD-1 Monoclonal Antibody, Chemotherapy
- Where
- 3 sites in China
- Volunteers
- 134 people
- Sponsor
- Peking University
Heart Failure With Reduced Ejection Fraction, Renal Insufficiency, Chronic
SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency
In the treatment of heart failure (HF), SGLT-2 inhibitor (SGLT-2i) can significantly improve the clinical outcome and quality of life related to HF.
- Trial name
- NCT05737186
- Testing
- SGLT-2 inhibitor
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Peking University People's Hospital
Prostate Adenocarcinoma
Exploration of the Value of PSMA PET/CT in Dynamic Monitoring of the Efficacy of Novel Endocrine Therapy in Patients With Metastatic Hormone Sensitive Prostate Cancer
1. Based on the treatment response and prognosis of mHSPC patients with novel endocrine therapy, a PSMA PET whole-body tumor burden classification was constructed to guide treatment and evaluate prognosis. 2.
- Trial name
- NCT06387238
- Testing
- PSMA PET/CT
- Volunteers
- 150 people
- Sponsor
- Peking University First Hospital
Diabetic Ulcers, Diabetic Ulcers in Necrosis Stable Stage
Sterile Wound Care Liquid Dressing in Treatment of Diabetic Ulcer in Necrosis Stable Stage: a Randomized Control Trial
This study aimed to investigate methods for promoting infection control, reducing tissue edema, and preventing excessive spread in diabetes foot ulcers in the necrosis stable stage.
- Trial name
- NCT05975827
- Testing
- Sterile Wound Care Liquid Dressing
- Volunteers
- 28 people
- Sponsor
- Peking University Third Hospital
Bronchoscopy, Atelectasis
Pulmonary Ventilation After Fiberoptic Bronchoscopy Using EIT
Background: Fiber bronchoscopy is a routine operation in intensive care unit (ICU), but it may cause local collapse of the lung.
- Conditions
- Bronchoscopy, Atelectasis, Mechanical Ventilation
- Trial name
- NCT05875662
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
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