Clinical trials: sponsored by Peking University
Colorectal Adenocarcinoma Metastatic in the Liver
Retlirafusp Alfa Plus Targeted Therapy and Chemotherapy for Unresectable Colorectal Liver-Limited Metastases
This is a single-center, open-label, exploratory phase II trial to evaluate efficacy and safety of Retlirafusp alfa (PD-L1/TGF-βRII bispecific fusion protein) combined with standard first-line targeted-chemotherapy as conversion…
- Trial name
- NCT07815288
- Testing
- Retlirafusp alfa Combined with Targeted Therapy and Chemotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Cancer Hospital & Institute
Stress Urinary Incontinence (SUI)
The Effect of Different Delivery Positions on Pelvic Floor Function.
This study is a prospective, multicenter, randomized controlled trial. Baseline data will be collected from eligible subjects recruited during the third trimester of pregnancy.
- Trial name
- NCT07081321
- Testing
- Lithotomy position, Lateral Position, Upright Position
- Where
- China
- Volunteers
- 1,992 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Post Operative Delirium
The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults
The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults.
- Trial name
- NCT07424170
- Testing
- Preoperative physical activity level
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Acute Leukemia, Myelodysplastic Syndromes
Sirolimus+Ruxolitinib+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to CNI
Graft-versus-host disease (GVHD) is an important complication after transplantation, with an incidence of 40-60%, which can increase non-relapse mortality if poorly controlled.
- Conditions
- Acute Leukemia, Myelodysplastic Syndromes, Severe Aplastic Anemia (SAA)
- Trial name
- NCT07796620
- Testing
- Sirolimus, Ruxolitinib, MMF
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Emotional Distress, Depression
The Dynamic Mechanism of Mindfulness Intervention for Emotional Distress (MIED) Based on Ecological Moment Measurement
The goal of this clinical trial is to examine how a mindfulness-based intervention (MIED) affects the moment-to-moment, lagged relationships between mechanism variables at the levels of feelings, thoughts, and behaviors and…
- Conditions
- Emotional Distress, Depression, Anxiety
- Trial name
- NCT07809737
- Testing
- Mindfulness Intervention for emotional distress(MIED）
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University
Adverse Drug Reactions, Clinical Decision Support
Multi-Agent Collaborative ADR Prediction With Human-Machine Decision Comparison
This study develops a multi-agent collaborative prediction model to forecast adverse drug reactions using real-world clinical medical records.
- Trial name
- NCT07808866
- Testing
- Retrospective medical record data analysis only, no clinical intervention
- Where
- 2 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Peking University Third Hospital
Polycystic Ovary Syndrome
Multimodal Ocular Diagnosis-Guided Precision Acupuncture and Lifestyle Intervention for PCOS
This study is designed as a prospective, multicenter, parallel-group randomized controlled trial to evaluate the effectiveness of a "precision acupuncture + personalized lifestyle" intervention, guided by dynamic multimodal risk…
- Trial name
- NCT07809503
- Testing
- Model-Guided Precision Acupuncture, Personalized Lifestyle Intervention, Conventional Acupuncture
- Where
- 2 sites in China
- Volunteers
- 210 people
- Sponsor
- Peking University Third Hospital
Neuromyelitis Optica Spectrum Disorder (NMOSD)
Efficacy and Safety of Low-Dose IL-2 in Neuromyelitis Optica Spectrum Disorder
Interleukin-2 (IL-2) is an essential cytokine for T-cell proliferation. Low-dose IL-2 has been shown to increase the proportion of regulatory T cells (Tregs), negatively regulate effector T cells such as Th17 and Tfh cells, and…
- Trial name
- NCT07809724
- Testing
- IL-2 (interleukin 2)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Polycystic Ovary Syndrome
Acupuncture for Insulin Resistance in Women With Polycystic Ovary Syndrome
This two-stage clinical research programme aims to evaluate the preliminary effectiveness and safety of acupuncture for improving insulin resistance in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07806656
- Testing
- Active Acupuncture, Lifestyle Management
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Peking University Third Hospital
Multidimensional Tubal Function Assessment and Individualized Treatment Strategies for Tubal Factor Infertility
Comprehensive Assessment System for Fallopian Tube Function and Clinical Study on Individualized Treatment Strategies
This clinical study aims to develop a comprehensive system to evaluate tubal function and to optimize individualized treatment strategies for patients with tubal factor infertility (caused by hydrosalpinx, obstruction, or…
- Trial name
- NCT07808229
- Testing
- Optimize the techniques and plans for fallopian tube reconstruction surgery
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University People's Hospital
Emotional Distress, Anxiety
Mindfulness Intervention for Emotional Distress: An EEG Study
This is a randomized controlled trial examining the efficacy and neural mechanisms of a standardized Mindfulness Intervention for Emotional Distress (MIED) in adults with subclinical emotional distress.
- Conditions
- Emotional Distress, Anxiety, Depression, Stress (Psychology)
- Trial name
- MIED-RCT (NCT07692269)
- Testing
- MIED, PMR
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking University
Outpatients or Inpatients With Depression
A Multicenter Real-World Study Evaluating the Efficacy and Safety of Shugan Jieyu Capsules in the Treatment of Depression
To observe the efficacy and safety of Shugan Jieyu Capsules in treating patients with varying degrees of depression in real-world clinical settings, and to provide data references for optimizing integrated traditional Chinese and…
- Trial name
- NCT07785284
- Testing
- Shugan Jieyu Capsules
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University
Obstructive Sleep Apnea, Surgery
Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA
Patients with obstructive sleep apnea (OSA) are at increased risk of developing sleep disturbances after surgery. Dexmedetomidine is a highly selective α2-adrenergic agonist with sedative, analgesic, and anxiolytic effects.
- Conditions
- Obstructive Sleep Apnea, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06566482
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
CPTSD, Compelx Post-traumatic Stress Disorder
The Effectiveness of Guided Written Exposure Therapy for Complex PTSD in Adolescents
This study aims to examine the effectiveness of group Guided Written Exposure Therapy for Complex Post-Traumatic Stress Disorder (GWE-C) among Chinese adolescents through a randomized controlled trial.
- Trial name
- NCT07325734
- Testing
- Group Guided Written Exposure Therapy for CPTSD (GWE-C), Supportive Group
- Where
- 4 sites in China
- Volunteers
- 130 people
- Sponsor
- Peking University
Hepatocellular Carcinoma (HCC)
GPC3-Targeted PET Imaging of 18F-X12 in Hepatocellular Carcinoma
This is a diagnostic study. This clinical trial aims to evaluate the diagnostic performance and safety of the novel radiotracer 18F-X12 in patients with hepatocellular carcinoma (HCC), and to provide evidence supporting a new…
- Trial name
- NCT07795437
- Testing
- 18F-X12 PET/CT
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Difficult-to-treat Rheumatoid Arthritis, Rheumatoid Arthritis
Efficacy and Safety of Telitacicept in the Treatment of Refractory Rheumatoid Arthritis
This study is a multicenter, open-label, randomized controlled trial designed to preliminarily evaluate the efficacy and safety of telitacicept in patients with refractory rheumatoid arthritis during a 24-week treatment period…
- Trial name
- NCT07796516
- Testing
- Telitacicept 160mg, Standard therapy
- Where
- 47 sites in China
- Volunteers
- 420 people
- Sponsor
- Peking University People's Hospital
Critical Care Medicine, Mortality Prediction
Clinical Validation of a Pre-trained and Fine-tuned Model for Analyzing Time-Series Electronic Health Records in Critical Care
The goal of this observational study is to validate the generalization capability and predictive performance of the "Time-Series Electronic Health Record Foundation Model (EHR Foundation Model)", which was pre-trained on a…
- Trial name
- NCT07795450
- Where
- China
- Volunteers
- 4,800 people
- Sponsor
- Peking University People's Hospital
IgG4-related Disease
BCT301 in Treating Refractory/Recurrent IgG4-related Disease
This is an investigator initiated trial to assess the safety and efficacy of BCT301 cell Injection (CAR-iT cells derived from chemically induced pluripotent stem cells) in patients with refractory/recurrent IgG4-related disease.
- Trial name
- NCT07793903
- Testing
- BCT301 Cell Injection
- Volunteers
- 6 people
- Sponsor
- Peking University Third Hospital
Salt-Sensitivity of Blood Pressure, Hypertension
Salt Sensitivity Evaluation Via N-of-1 Trials (SENSE-Salt)
Study Title: Determining the Presence of Salt Sensitivity in Individuals With Elevated Blood Pressure Through Dietary Salt Interventions: A Series of N-of-1 Trials Objective: To evaluate whether there are differences in blood…
- Trial name
- SENSE-Salt (NCT07614724)
- Testing
- High-Sodium Diet, Low-Sodium Diet
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Peking University
Refractory Systemic Lupus Erythematosus
IM19 CAR-T Cell Therapy in Refractory Systemic Lupus Erythematosus (SLE)
The study is a single-arm, open-label clinical trial intended to recruit 6 refractory SLE subjects who meet the inclusion and exclusion criteria.
- Trial name
- NCT06513429
- Testing
- IM19 CAR-T cells
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Peking University Third Hospital
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