Clinical trials: active, sponsored by Peking University
Diminished Ovarian Reserve (DOR)
Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Diminished Ovarian Reserve
A multi-center, prospective, randomised controlled clinical trial (1:1 treatment ratio), designed to investigate the efficacy and safety of autologous SVF in improving the pregnancy outcome of infertile patients with DOR.
- Trial name
- aSVF-DOR (NCT07901218)
- Testing
- Lower abdominal liposuction and preparation of SVF, Ovarian injection, Conventional ART treatment
- Where
- 4 sites in China
- Volunteers
- 260 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Disease, Coronary Artery Bypass Grafting
Roxadustat and Myocardial Injury After Off-Pump Coronary Artery Bypass Surgery
Myocardial injury and infarction are common after cardiac surgery and are associated with worse perioperative outcomes. Hypoxia-inducible factor (HIF) is an important metabolic regulator that protects the myocardium.
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Hypoxia-Inducible Factor 1, Alpha Subunit, Prolyl-Hydroxylase Inhibitors
- Trial name
- NCT07912801
- Testing
- Roxadustat
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Parturients, Accidental Puncture of Dura During Anaesthesia
Epidural Hydroxyethyl Starch for Post-Dural Puncture Headache in Parturients
The incidence of accidental dural puncture (ADP) among parturients receiving neuraxial labor analgesia has been reported to range from 1% to 1.5%.
- Conditions
- Parturients, Accidental Puncture of Dura During Anaesthesia, Epidural Filling, Hydroxyethyl Starch
- Trial name
- NCT07914790
- Testing
- Epidural hydroxyethyl starch, No epidural hydroxyethyl starch
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- Peking University First Hospital
MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer
Perioperative Cadonilimab (AK104) in Locally Advanced MSI-H/dMMR Gastric or Gastroesophageal Junction and Colorectal Adenocarcinoma
The goal of this phase 2 clinical trial is to learn whether a medicine called cadonilimab (AK104) can safely and effectively treat certain stomach and colon cancers when it is given before and after surgery.
- Trial name
- NCT04556253
- Testing
- AK104, Radical Surgery
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Peking University
Acute Lymphoblastic Leukemia, Hematopoietic Stem Cell Transplantation
Busulfan-Based Versus TBI-Based Conditioning for Adult ALL-CR2 Allo-HSCT
This is an multicenter, non-inferiority randomized controlled trial. Adult patients (14-65 years) with acute lymphoblastic leukemia in second complete remission (CR2) scheduled for allogeneic hematopoietic stem-cell…
- Trial name
- NCT07919470
- Testing
- Chemotherapy-based Conditioning Regimen, TBI-based conditioning
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking University People's Hospital
Esophageal Squamous Cell Carcinoma (ESCC), Esophageal Fistula
Standardized Management of Esophageal Fistula in Esophageal Squamous Cell Carcinoma
This prospective, multi-center, observational registry study (PKU-ESCC-EF) aims to evaluate the safety and effectiveness of a standardized diagnosis and treatment protocol for esophageal fistula (EF) in patients with advanced…
- Trial name
- PKU-ESCC-EF (NCT07353541)
- Testing
- Standardized Management Protocol for Esophageal Fistula
- Volunteers
- 32 people
- Sponsor
- Peking University Cancer Hospital & Institute
Lung Neoplasms
Application of Generative Artificial Intelligence in Perioperative Personalized Rehabilitation for Older Adults With Lung Cancer
This study will evaluate whether a generative artificial intelligence (AI)-based rehabilitation support system can help older adults with lung cancer recover after lung surgery.
- Trial name
- NCT07915193
- Testing
- AI-guided personalized rehabilitation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Cancer Hospital & Institute
Older Patients, Noncardiac Surgery
Intranasal Dexmedetomidine-esketamine Combination and Postoperative Cognitive Recovery in Older Patients
Postoperative neurocognitive disorders, including postoperative delirium (POD) and delayed neurocognitive recovery (dNCR), are common in older patients undergoing surgery and are associated with worse outcomes.
- Conditions
- Older Patients, Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07914803
- Testing
- Intranasal dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 732 people
- Sponsor
- Peking University First Hospital
Prostate Cancer
Evaluation of Perilesional Biopsy in Diagnosis of Prostate Cancer
The goal of this multicenter randomized controlled trial (RCT) is to evaluate the efficacy of different prostate biopsy schemes, including perilesional biopsy (PB) and combination of systematic biopsy and targeted biopsy (TB+SB).
- Trial name
- NCT06482645
- Testing
- TB+PB, TB+SB
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Peking University First Hospital
IVF Outcome
Trigger Timing in Ovarian Stimulations
The gonadotrophin-releasing hormone (GnRH) antagonist protocol is widely used in in vitro fertilisation (IVF) for its flexibility and ability to reduce the risk of ovarian hyperstimulation syndrome (OHSS).
- Trial name
- NCT04163133
- Testing
- 1-2 days later trigger than regular timing
- Where
- China
- Volunteers
- 834 people
- Sponsor
- Peking University Third Hospital
Esophageal Squamous Cell Carcinoma
QL1706 Plus Celecoxib in Advanced Esophageal Squamous Cell Carcinoma
This is a multicenter，single-arm, Simon's two-stage phase II clinical trial to evaluate the efficacy and safety of QL1706 (a dual PD-1 and CTLA-4 antibody) combined with celecoxib in patients with advanced esophageal squamous…
- Trial name
- QICE-ESCC (NCT07049185)
- Testing
- QL1706 Plus Celecoxib Group
- Where
- 3 sites in China
- Volunteers
- 35 people
- Sponsor
- Peking University Cancer Hospital & Institute
Old Age; Debility, Digestive Cancer
Perioperative Multicomponent Rehabilitation and Outcomes in Elderly Patients With Frailty
The study is designed to investigate the effect of a perioperative multicomponent rehabilitation pathway on early and long-term outcomes in elderly patients with frailty recovering from surgery for digestive cancer.
- Conditions
- Old Age; Debility, Digestive Cancer, Surgery, Nutrition Therapy
- Trial name
- NCT04715581
- Testing
- Preoperative nutritional optimization, Perioperative exercise training, Postoperative exercise training
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Peking University First Hospital
Laparoscopic Surgery, Visceral Pain, Postoperative
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery
Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes.
- Conditions
- Laparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous Analgesia
- Trial name
- NCT07525986
- Testing
- High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon
- Where
- 4 sites in China
- Volunteers
- 140 people
- Sponsor
- Peking University First Hospital
Sleep Apnea, Obstructive, Sleep Staging
Development and Clinical Validation of Artificial Intelligence Algorithms for Sleep Staging and Obstructive Sleep Apnea Screening Based on a Large-Scale Model Trained on Multimodal Physiological Signals From Diverse Populations
In recent years, wearable and contactless devices, including smart rings, smart bands/watches, and smart mattresses, have developed rapidly and can continuously collect multidimensional data such as heart rate, oxygen saturation…
- Conditions
- Sleep Apnea, Obstructive, Sleep Staging, Screening
- Trial name
- NCT07908160
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Elderly, Cancer Surgery
Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
Along with aging population, cancer incidence and mortality are increasing. However, despite advances in oncology and surgery, long-term survival of cancer patients is far from optimal.
- Conditions
- Elderly, Cancer Surgery, Dexmedetomidine, Long-Term Survivors
- Trial name
- NCT06030804
- Testing
- Dexmedetomidine
- Where
- 40 sites in China
- Volunteers
- 4,532 people
- Sponsor
- Peking University First Hospital
Periarticular Bone Defect, Proximal Humerus Fracture
Magnesium Alloy Scaffold With Controlled Degradation for Periarticular Bone Defects
This prospective, multi-center, randomized controlled clinical trial is designed to evaluate the effectiveness and safety of a biodegradable magnesium alloy scaffold with controlled degradation for the treatment of periarticular…
- Conditions
- Periarticular Bone Defect, Proximal Humerus Fracture, Distal Radius Fracture, Tibial Plateau Fracture
- Trial name
- MgScaf-PBD (NCT07906730)
- Testing
- Magnesium Alloy Scaffold, Calcium Sulfate Bone Graft Substitute
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Injuries, Recovery Quality
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction
Background: Arthroscopic anterior cruciate ligament reconstruction (ACLR) is a common orthopedic surgery. Postoperative pain, inflammatory response and opioid-related adverse events impair early recovery quality.
- Conditions
- Anterior Cruciate Ligament Injuries, Recovery Quality, Auricular Vagus Nerve Stimulation
- Trial name
- NCT07904949
- Testing
- Experimental-Active taVNS
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Peking University Third Hospital
Hemophagocytic Lymphohistiocytosis (HLH)
Hemophagocytic Lymphohistiocytosis After Allogeneic Stem Cell Transplantation
Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory complication that can occur after allogeneic hematopoietic stem cell transplantation.
- Trial name
- HSCT-HLH (NCT07905066)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University People's Hospital
Urothelial Carcinoma of the Renal Pelvis and Ureter, Neoadjuvant Therapy
Neoadjuvant Disitamab Vedotin, Toripalimab, and Radiotherapy for High-risk UTUC ( LUXUS07.1 )
This is an open-label, single-arm, single-cohort, prospective clinical study evaluating neoadjuvant antibody-drug conjugate therapy combined with immunotherapy and sequential radiotherapy followed by radical surgery in patients…
- Trial name
- LUXUS0701 (NCT07720921)
- Testing
- Neoadjuvant radiotherapy, ADC + PD1 monoclonal antibody
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University First Hospital
Ankylosing Spondylitis (AS)
Ivarmacitinib With or Without Celecoxib for Ankylosing Spondylitis
Background: Ankylosing spondylitis (AS) is a chronic, progressive inflammatory disease mainly affecting the spine and sacroiliac joints, causing pain, stiffness, structural damage, and functional disability.
- Trial name
- NCT07894497
- Testing
- Ivarmacitinib with celecoxib, Ivarmacitinib Monotherapy
- Volunteers
- 138 people
- Sponsor
- Peking University Third Hospital