Clinical trials: sponsored by Peking University First Hospital
NMIBC, MIBC
A Multicenter Prospective Cohort Study on Monitoring Recurrence of Urothelial Carcinoma Based on Detection of Urinary Microscopic Residual Disease (MRD)
This was a multicenter, prospective, non-interventional, observational cohort study, and the enrolled patients were divided into four cohorts: cohort I was patients with high-risk upper tract urothelial carcinoma (UTUC) (pT3-4 or…
- Conditions
- NMIBC, MIBC, UTUC
- Trial name
- NCT06991868
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University First Hospital
Hemodialysis Complication
Effect of the Postbiotics on Complications Treatment in Elderly Hemodialysis Patients
The purpose of the trial is to explore the effect of exogenous postbiotics supply on the quality of life and nutritional status of elderly hemodialysis patients.
- Trial name
- NCT06975995
- Testing
- Yi'en Yuan Honey Fermented Drink
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Fungal Disease
Azole Susceptibility and Resistance Mechanisms Surveys in Pathogenic Fungi by the CARST-fungi (2023-2024)
The China Antifungal Resistance Surveillance Trial (CARST-fungi) study, which has been starting in July 2019, is a multi-center, prospective, observational, and laboratory-based study of pathogenic fungal isolates causing IFDs.
- Trial name
- NCT06969703
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Postoperative Complications, Long-term Outcome
Prophylactic Penehyclidine Hydrochloride Inhalation and 3-year Outcome After Surgery
Postoperative pulmonary complications (PPCs) are major causes of postoperative morbidity, mortality, and prolonged hospital stay.The incidence of PPCs may be as high as 41% to 75% in high-risk patients.
- Trial name
- NCT03868709
- Testing
- Penehyclidine inhalation
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Peking University First Hospital
Prostate Cancer
Evaluation of Transrectal Perilesional Biopsy in Diagnosis of Prostate Cancer
The goal of this single-center randomized controlled trial (RCT) is to evaluate the efficacy and safety of different transrectal prostate biopsy schemes, including transrectal perilesional/regional systematic biopsy (PB/RSB) and…
- Trial name
- NCT06482658
- Testing
- Transrectal perilesional/regional systematic biopsy (PB/RSB), Combination of transrectal systematic biopsy and targeted biopsy
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Peking University First Hospital
Alzheimer's Disease Dementia
Efficacy of HellenCare in Early-Stage Alzheimer's Disease
The goal of this clinical trial is to evaluate whether HellenCare, a multicomponent nutraceutical, improves cognitive and functional outcomes in patients with early-stage Alzheimer's disease (AD).
- Trial name
- NCT06895525
- Testing
- HellenCare
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Liver Cancer, Radiofrequency Ablation
Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation
Percutaneous radiofrequency ablation is a commonly treatment for patients with liver cancer that cannot be surgically resected. During the procedure, patients need to keep awake and cooperate with the procedure, including deep…
- Conditions
- Liver Cancer, Radiofrequency Ablation, Esketamine, Dexmedetomidine
- Trial name
- NCT06003218
- Testing
- Dexmedetomidine-esketamine combination, Remifentanil, Oxycodone
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Peking University First Hospital
Radiation Therapy, Targeted Therapy
SABR Combined with Axitinib and Toripalimab in Recurrent or Metastatic RCC
This is a prospective, single-center clinical trial designed to evaluate the safety and efficacy of combining stereotactic ablative body radiotherapy (SABR) with the targeted therapy Axitinib and the immunotherapy Toripalimab in…
- Conditions
- Radiation Therapy, Targeted Therapy, Immunotherapy, Renal Cancer Metastatic
- Trial name
- NCT06889649
- Testing
- Stereotactic Ablative Body Radiotherapy (SABR), TORIPALIMAB INJECTION(JS001 ), Axitinib (VEGF-TKI)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Adults, Major Noncardiac Surgery
Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia…
- Conditions
- Adults, Major Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06859892
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Peking University First Hospital
Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy
Effect of Urine-guided Hydration on Acute Kidney Injury After CRS-HIPEC
Acute renal injury (AKI) is a common complication after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), and is associated with worse outcomes.
- Conditions
- Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, Hydration, Diuresis
- Trial name
- NCT05939193
- Testing
- Urine-guided hydration, Routine hydration, Forced administration of furosemide
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Peking University First Hospital
Epidural Analgesia, Analgesic Effect
Epidural Analgesia and Maternal Fever During Labor
Women who receive epidural analgesia during labor are more likely to develop fever than those who do not. Maternal fever during labor can produce various harmful effects on both mothers and infants.
- Conditions
- Epidural Analgesia, Analgesic Effect, Fever
- Trial name
- NCT04940091
- Testing
- Epidural analgesia
- Where
- 8 sites in China
- Volunteers
- 1,051 people
- Sponsor
- Peking University First Hospital
Healthy Adult Subjects
A Study on the Safety, Tolerability and Pharmacokinetics of WS-0101 Tablets in Chinese Healthy Subjects
This study is an open-label, placebo-controlled, first-in-human clinical trial in healthy adults, designed to assess the safety, tolerability, and PK characteristics of various doses of WS-0101 following different light power…
- Trial name
- NCT06857799
- Testing
- Light Power Density and Light Duration 40 mW/cm²*1000s, Light Power Density and Light Duration 80 mW/cm²*1000s
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Anesthesia, Extubation
Anesthesia Quality Improvement and Patients With Planned ICU Admission
Intensive care unit (ICU) is an important part of perioperative management for high-risk patients but is associated with higher medical costs. Improper ICU admission may produce overtreatment without beneficial effects.
- Conditions
- Anesthesia, Extubation, Intensive Care Unit, Postoperative Complications
- Trial name
- NCT05626153
- Testing
- Routine anesthesia care, Improved anesthesia care
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Peritoneal Dialysis, Polycystic Kidney Diseases
The Factors Affecting IPP in Peritoneal Dialysis Patients with Polycystic Kidney Disease
Background: Polycystic kidney disease (PKD) is the most common hereditary kidney disease. Peritoneal dialysis (PD) in such patients is restricted because the significantly enlarged kidneys and liver may lead to the increase of…
- Trial name
- NCT06841224
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Alzheimer's Disease
Rivastigmine Mini-Tablet for Alzheimer's Disease
The objective of this study is to evaluate the efficacy and safety of rivastigmine mini-tablets in individuals diagnosed with mild to moderate Alzheimer's disease (AD).
- Trial name
- NCT06828289
- Testing
- Rivastigmine Mini-Tablet, Donepezil Hydrochloride
- Volunteers
- 1,000 people
- Sponsor
- Peking University First Hospital
Neoplasms, Gynaecological Oncology
Impact of Pharmacy Services on Gynaecology Chemotherapy Safety
What was studied? We wanted to see whether having pharmacists closely involved in cancer care improves medication safety and reduces severe side effects for patients with gynecologic cancers (like ovarian or uterine cancer)…
- Trial name
- NCT06826950
- Testing
- comprehensive pharmaceutical care, Routine pharmaceutical services
- Where
- China
- Volunteers
- 629 people
- Sponsor
- Peking University First Hospital
Upper Tract Urothelial Carcinoma
HEFTME System for Adjuvant Therapeutic Selection of Locally Advanced UTUC Postoperatively：A Perspective Cohort Study
This multicenter, real-world study introduces a novel Hematoxylin-eosin staining(H\&E)-based four tumor microenvironment (TME) system (HEFTME system) assisting in prognostic prediction and precise adjuvant treatment selection for…
- Trial name
- NCT06798246
- Testing
- Chemotherapy, Immunotherapy, ADC
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Cesarean Delivery, Esketamine
Different Doses of Dexmedetomidine Combined With Esketamine in Women Undergoing Cesarean Delivery
Esketamine is a commonly used analgesic during cesarean delivery, but may produce transient neuropsychiatric symptoms. Dexmedetomidine has both sedative and analgesic effects.
- Conditions
- Cesarean Delivery, Esketamine, Neuropsychiatric Symptoms, Dexmedetomidine
- Trial name
- NCT06613243
- Testing
- Esketamine 0.2 mg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.1 µg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.15 µg/kg
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University First Hospital
Neoplasms
PET Imaging of 68Ga-Her2-affibody in Tumors with High Her2 Expression
This project uses HER2 protein as the target group of radiodrugs to explore the diagnostic efficacy, safety and metabolic characteristics of 68Ga-Her2-affibody in the expression status of HER2, aiming to provide a new imaging…
- Trial name
- NCT06289517
- Testing
- 68Ga-Her2-affibody
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Prenatal Depression, Ketamine
Effect of Low-dose Esketamine on Maternal Depression at 3 Years After Childbirth
Postpartum depression refers to the depression after childbirth, which is a common mental disorder in women. The pathogenesis of postpartum depression is not fully understood, and may be related to a variety of factors.
- Conditions
- Prenatal Depression, Ketamine, Postpartum Depression
- Trial name
- NCT05698394
- Testing
- Esketamine
- Where
- 4 sites in China
- Volunteers
- 364 people
- Sponsor
- Peking University First Hospital