Clinical trials: sponsored by Peking University First Hospital
Atrophic Gastritis With Low-grade Intraepithelial Neoplasia
Fuzheng Nizeng Formula for Chronic Atrophic Gastritis With Low-grade Intraepithelial Neoplasia, a Multicenter Randomized Controlled Trial
Fuzheng Nizeng Formula (FZNZ) is derived from the classic formula Liujunzi Decoction. Former pilot study found that FZNZ promoted the recovery of gastric atrophy and relieve the relative symptoms.
- Trial name
- NCT06324825
- Testing
- Fuzhegn Nizeng Decoction, Moluodan granules
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Peking University First Hospital
Renal Cell Carcinoma, Clear Cell, Somatic
Fruquintinib Plus Everolimus as 2nd Line Therapy of ccRCC Patients Progressed Post IO and TKI Therapy
This study will assess the efficacy and safety profile of fruquintinib in combination with everolimus as second line therapy of clear cell renal cell carcinoma patients who progressed after immunotherapy and tyrosine kinase…
- Trial name
- NCT06317298
- Testing
- Fruquintinib and Everolimus
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Peking University First Hospital
Potassium Imbalance, Cardiac Arrhythmia
The Effect of Potassium Lowering Drugs on Cardiac Electrical Stability in Hemodialysis Patients (ART Study)
This study is a multicenter, prospective and randomized controlled study. The experiment includes a 1-week screening period (1 week before dialysis) and a 7-week treatment period (1-4 weeks of dose drip period and 5-7 weeks of…
- Conditions
- Potassium Imbalance, Cardiac Arrhythmia, Dialysis; Complications
- Trial name
- NCT06242041
- Testing
- sodium zirconium cyclic silicate
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Peking University First Hospital
Heart Failure
Heart Failure Treatment Pattern Analysis of HF Patients in HF Centers and Non-HF Centers in China
This is a retrospective, researcher-initiated, database-based study that will retrospectively observe the treatment and medication patterns of about 22,500 patients with heart failure from 25 heart failure centers and 25…
- Trial name
- NCT06099028
- Testing
- no intervention
- Where
- China
- Volunteers
- 22,500 people
- Sponsor
- Peking University First Hospital
COPD
Evaluate the Accuracy of a COPD Screening Algorithm Model
Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases. Early detection and treatment are critical to prevent the deterioration of COPD.
- Trial name
- NCT06109974
- Where
- 5 sites in China
- Volunteers
- 400 people
- Sponsor
- Peking University First Hospital
Multiple Myeloma, Renal Injury
A Clinical Study on the Whole-course Management (BCD-KPD-AutoHSCT) Scheme for Patients With RIMM
Multiple myeloma (MM) is still an incurable hematological tumor, and renal involvement is the main factor of poor prognosis. The recovery of renal function can partially reverse its poor outcome.
- Trial name
- NCT06203145
- Testing
- Bortezomib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
COPD
Detect and Infer the Severity of COPD by Intelligent Terminal Device
Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases. Early detection and treatment are critical to prevent the deterioration of COPD.
- Trial name
- NCT05551169
- Where
- 10 sites in China
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Pregnancy Related
Dexmedetomidine-Ropivacine Versus Sufentanil-Ropivacaine for Epidural Labor Analgesia
Sufentanil-ropivacaine combination is commonly used for epidural labor anesthesia, but is associated with some adverse events. Dexmedetomidine is a high selective alpha2-adrenoceptor agonist.
- Trial name
- NCT05698407
- Testing
- Dexmedetomidine, Sufentanil
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Postoperative Nausea and Vomiting, Benzodiazepine
Remimazolam and Postoperative Nausea and Vomiting in High-risk Patients
This trial aims to explore whether the intraoperative use of remimazolam can reduce the incidence of postoperative nausea and vomiting (PONV) in high-risk patients.
- Conditions
- Postoperative Nausea and Vomiting, Benzodiazepine, High-risk Patients
- Trial name
- NCT04861337
- Testing
- Remimazolam
- Where
- 10 sites in China
- Volunteers
- 552 people
- Sponsor
- Peking University First Hospital
Prostate Cancer
A Phase II Neoadjuvant Study of Darolutamide Plus ADT in Men With Localized Prostate Cancer
Scientific Rationale: High risk localized prostate cancer (PCa) is associated with higher rates of biochemical recurrence, clinical recurrence, metastasis and PCa-specific death.
- Trial name
- NCT06029036
- Testing
- Darolutamide+ADT
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Peking University First Hospital
IgA Nephropathy, Proteinuria in Nephrotic Range
Registry of IgA Nephropathy in Chinese Children
This study tries to identify the safe and effective treatment option for IgA nephropathy in children. Investigators will perform prospective registration study among 25 pediatric nephrology medical centers in China.
- Conditions
- IgA Nephropathy, Proteinuria in Nephrotic Range, Immunosuppressive Treatment
- Trial name
- RACC (NCT03015974)
- Testing
- Corticosteroid, Cyclophosphamide, Mycophenolate mofetil
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Peking University First Hospital
Bullous Pemphigoid
Efficacy and Safety of Dupilumab in Patients With Bullous Pemphigoid
This study was designed to be a retrospective, multicentre, observational study to evaluate the efficacy and safety of dupilumab in the treatment of bullous pemphigoid and to find predictors of efficacy.
- Trial name
- NCT05649579
- Testing
- Dupilumab
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Peking University First Hospital
Primary Cutaneous Lymphoma
TreAtments and outComes in paTients With prImary CutAneous Lymphoma
In order to further improve the diagnosis and treatment level of primary cutaneous lymphoma in China, the National Clinical Center for Skin and Immune Diseases established a standardized diagnosis and treatment center for primary…
- Trial name
- TACTICAL (NCT05518851)
- Where
- 5 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Peking University First Hospital
Renal Insufficiency, Chronic
Chinese Cohort Study of Chronic Kidney Disease
This study aimed to explore underlying mechanisms of chronic kidney disease progression and its association with adverse consequences.
- Trial name
- C-STRIDE (NCT03041987)
- Testing
- Demographic factors, biomedical measurements, drugs used for controlling metabolic disorders, etc
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Peking University First Hospital
Peritoneal Dialysis
A Multi-center Prospective Cohort Study Based on Peritoneal Dialysis Telemedicine-assisted Platform
Increasing the proportion of patients on peritoneal dialysis (PD) may relieve the financial burden caused by the growing number of patients with end-stage renal disease (ESRD).
- Trial name
- PDTAP (NCT03571451)
- Where
- 27 sites in China
- Volunteers
- 7,000 people
- Sponsor
- Peking University First Hospital
Advanced Non-squamous Non-small-cell Lung Cancer, Recurrent Non-Squamous Non-Small Cell Lung Cancer
Efficacy and Safety of Nab-paclitaxel-Lenvatinib-Pembrolizumab as Second-line Treatment in Advanced NSCLC Patients
The goal of this clinical trial is to evaluate the efficacy and safety of albumin-bound paclitaxel-lenvatinib-pembrolizumab in advanced nonsquamous NSCLC patients after progression to first-line anti-PD-1/L1 inhibitor with…
- Conditions
- Advanced Non-squamous Non-small-cell Lung Cancer, Recurrent Non-Squamous Non-Small Cell Lung Cancer, Metastatic Non-squamous Non Small Cell Lung Cancer
- Trial name
- NCT06028633
- Testing
- pembrolizumab, lenvatinib, albumin-bound paclitaxel
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Peking University First Hospital
Chronic Atrophic Gastritis
Treatment of Atrophic Gastritis After HP Eradication With Modified Liujunzi Decoction Based on Syndrome Differentiation
This is an observational cohort study of clinical efficacy study.The purpose of this topic is to evaluate the efficacy and safety of Modified Liujunzi Decoction based on syndrome differentiation in patients with chronic atrophic…
- Trial name
- NCT05388890
- Testing
- MLD, WFC
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Peking University First Hospital
COPD
Early Warning Value of Consumer Wearable Devices in AECOPD
This is a prospective, multi-center cohort study. 150 subjects with COPD and in stable stage will be included. Wearable device's physiological parameters will be continually collected, the investigators aim to explore whether…
- Trial name
- EWVCWDC (NCT05974670)
- Testing
- Consumer wearable device
- Where
- 7 sites in China
- Volunteers
- 150 people
- Sponsor
- Peking University First Hospital
Cadasil, Blood Brain Barrier Defect
MRI Study of Blood-brain Barrier Function in CADASIL
Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB).
- Trial name
- NCT05902039
- Testing
- MRI
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Neoplasm of Lung
Multimodalitic Imaging in the N-stage of Lung Cancer
This study aims to evaluate the diagnostic efficacy and differences between 18F-FDG PET/CT and MR STIR sequences combined with EBUS-TBNA, 18F-FDG PET/CT combined with EBUS-TBNA, and MR STIR sequences combined with EBUS-TBNA …
- Trial name
- NCT05840094
- Testing
- 18F-FDG, MR STIR, EBUS-TBNA
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital