Clinical trials: sponsored by Peking University First Hospital
COPD Exacerbation, Air Pollution
Salvational Intervention for Reducing AECOPD Under Severe Air Pollution
This is a multi-center, prospective, randomized and standard treatment parallel control clinical trial.A total of 764 stable COPD patients according to GOLD will be recruited and equally divided into two parallel groups…
- Trial name
- SIRCAP (NCT03083067)
- Testing
- Budesonide/formoterol, tiotropium bromide
- Where
- 11 sites in China
- Volunteers
- 402 people
- Sponsor
- Peking University First Hospital
COPD, FEV1
Predictive Value of Inflammatory Biomarkers and FEV1 for COPD
This is a multi-center, prospective, cohort study. A total of 10,000 people aged 40～75 without lung disease will be recruited and followed for 3 years.
- Trial name
- PIFCOPD (NCT03532893)
- Testing
- No intervention
- Where
- 10 sites in China
- Volunteers
- 10,385 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
COVID-19
COVID-19 Surveillance Based on Smart Wearable Device
This is a prospective, multi-center cohort study. 200 subjects with COVID-19will be included . Wearable device's physiological parameters and clinical data will be continually collected , the investigators aim to explore whether…
- Trial name
- COVID-19SWD (NCT04459637)
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Peking University First Hospital
Delirium, Postoperative Complications
Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium
Surgery is one of the major treatment methods for patients with malignant tumor. And, alone with ageing process, more and more elderly patients undergo surgery for malignant tumor.
- Conditions
- Delirium, Postoperative Complications, Postoperative Cognitive Dysfunction
- Trial name
- NCT02662257
- Testing
- Sevoflurane, Propofol
- Where
- 17 sites in China
- Volunteers
- 1,228 people
- Sponsor
- Peking University First Hospital
Aged, Neoplasms
Impact of Anesthesia Maintenance Methods on Long-term Survival
Surgery is one of the major treatment methods for patients with malignant tumor. And, alone with the ageing process, more and more elderly patients undergo surgery for malignant tumor.
- Conditions
- Aged, Neoplasms, Surgical Procedure, Operative, Anesthesia, Inhalation
- Trial name
- NCT02660411
- Testing
- Sevoflurane, Propofol
- Where
- 17 sites in China
- Volunteers
- 1,228 people
- Sponsor
- Peking University First Hospital
Bladder Cancer, Bladder Neoplasms
Pembrolizumab Monotherapy Following Tri-modality Treatment for Selected Patients With Muscle-invasive Bladder Cancer
This is a Phase II, single-arm, study of pembrolizumab as maintenance therapy in muscle-invasive bladder cancer (MIBC) participants who have received maximum TURBT and tri-modality treatment (TMT) and achieved CR.
- Conditions
- Bladder Cancer, Bladder Neoplasms, Bladder Tumors, Urinary Bladder Cancer
- Trial name
- NCT05072600
- Testing
- Pembrolizumab
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Peking University First Hospital
Perinatal Depression, Ketamine
Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression
Postpartum depression is common in mothers early after childbirth and produces harmful effects not only on mothers, but also on infants and young children.
- Conditions
- Perinatal Depression, Ketamine, Cesarean Delivery, Postpartum Depression
- Trial name
- NCT03336541
- Testing
- Ketamine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Peking University First Hospital
Peritoneal Dialysis, Acute Kidney Injury
Intensive Versus Regular Dosage For PD In AKI.
This is a multicenter, pilot RCT study, aiming to compare intensive dosage and regular dosage of PD for AKI patients with indications for dialysis.
- Trial name
- NCT03438877
- Testing
- Intensive dosage of PD, Regular dosage of PD
- Where
- 7 sites in China
- Volunteers
- 6 people
- Sponsor
- Peking University First Hospital
Peritonitis
Change Trend of Effluent Eosinophil During Peritoneal Dialysis-Related Peritonitis
A multi-center prospective cohort study will be conducted to explore the change trend of eosinophil in peritoneal dialysis effluent during peritoneal dialysis-associated peritonitis, and to explore the relationship between…
- Trial name
- NCT04594421
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Renal Anemia
Different Doses of Roxadustat Treatment for Anemia in Peritoneal Dialysis Patients
A multi-center, randomized, controlled study to evaluate the effect of different doses of roxadustate on hemoglobin target-met in peritoneal dialysis patients
- Trial name
- NCT04454879
- Testing
- Roxadustat
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Glomerulonephritis, IGA, Kidney Diseases
Trial of Plasma Exchange for Severe Crescentic IgA Nephropathy
Crescentic IgA nephropathy (CreIgAN) has a poor prognosis despite aggressive immunosuppressive therapy. The efficacy of plasma exchange (PE) in CreIgAN is not well defined.
- Conditions
- Glomerulonephritis, IGA, Kidney Diseases, Acute Renal Insufficiency, Rapidly Progressive Glomerulonephritis
- Trial name
- RESCUE (NCT02647255)
- Testing
- Plasma Exchange (PE), Methylprednisolone pulse
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Peking University First Hospital
Rectal Neoplasms Malignant
A Study on the Efficacy of a Novel Approach to Achieving Laparoscopic Distal Rectal Transection for Rectal Cancers
The wide application of ISR and DST has greatly improved the anal preservation rate for low rectal cancers, but the technical difficulty has also been obviously increased because of the limited pelvic space.
- Trial name
- NCT05067413
- Testing
- Transanterior obturator nerve gateway approach, Total mesorectal excision approach
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Gestational Diabetes, Induction of Labor Affected Fetus / Newborn
The Best Timing of Delivery in Women With GDM Study
The investigatiors aimed to conduct a well-designed RCT to firstly focus on GDM women controlled with only diet and exercise, and provide an optimize process on their timing and mode of delivery
- Trial name
- NCT03928899
- Testing
- New procedure
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Penehyclidine, Postoperative Nausea and Vomiting
Penehyclidine for Prevention of Nausea and Vomiting After Bimaxillary Surgery
Postoperative nausea and vomiting (PONV) is a common complication after surgery. Patients undergoing orthognathic surgery are reported to have a high rate of PONV, especially those undergoing bimaxillary surgery.
- Conditions
- Penehyclidine, Postoperative Nausea and Vomiting, Bimaxillar Surgery
- Trial name
- NCT04454866
- Testing
- Single injection of penehyclidine, Continuous infusion of penehyclidine
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Peking University First Hospital
Peritoneal Dialysis-associated Peritonitis, Vitamin D Deficiency
The Effects of Oral Vitamin D Supplementation on the Prevention of Peritoneal Dialysis-related Peritonitis
This is a pilot randomized, controlled trial of Vitamin D supplementation in patients on peritoneal dialysis to determine the feasibility of a future full-scale RCT exploring if oral administration of vitamin D3 could reduce the…
- Trial name
- NCT03264625
- Testing
- Cholecalciferol (2000iu qd), Routine therapy for PD
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Smoking Cessation
Early Health Warning Intervention in Tobacco Control
This is a multi-center, randomized, controlled intervention clinical trial. A total of 1000 current smokers with rapid decline in lung function will be recruited and equally divided into two groups, comprehensive smoking…
- Trial name
- NCT04996329
- Testing
- early health warning intervention
- Where
- 10 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Cardiovascular Diseases, Cohort Studies
A Cohort Study of Chronic Cardiovascular Diseases
This prospective cohort study aims to establish cohorts of patients with chronic cardiovascular disease, including refractory and secondary hypertension, coronary heart disease, atrial fibrillation, ventricular arrhythmias…
- Trial name
- NCT04996342
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University First Hospital
Chronic Hepatitis C, Chronic Hepatitis B
The Efficacy and Safety of 12-week SOF/VEL Regimen Combined With Prophylactic Use of TAF for Treatment-naïve Genotype 1-6 HCV/HBV Co-infection Adult Patients With or Without Compensated Cirrhosis in China
Subjects can be classified into two groups, Group 1 include non-cirrhotic patients, Group 2 include cirrhotic patients. All the patients will be received prophylactically TAF for 4 weeks before using SOF/VEL once daily for 12…
- Trial name
- BDTAF (NCT04997564)
- Testing
- Tenofovir Alafenamide 25 MG, Sofosbuvir / Velpatasvir
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University First Hospital
Parturition, Analgesia, Obstetrical
Neuraxial Labor Analgesia and the Incidence of Postpartum Depression
Postpartum depression (PPD) affects approximately 15% of women during the first year after giving birth, and is common across cultures. The etiology of postpartum depression is not totally clear.
- Conditions
- Parturition, Analgesia, Obstetrical, Depression, Postpartum
- Trial name
- NCT02823418
- Testing
- No neuraxial labor analgesia, Neuraxial labor analgesia
- Volunteers
- 599 people
- Sponsor
- Peking University First Hospital
Carcinoma, Non-Small-Cell Lung, Surgery--Complications
Dexamethasone, Flurbiprofen Axetil and Delirium After Lung Cancer Surgery
Delirium is a common complication in elderly patients after surgery. And its occurrence is associated with worse outcomes. The causes of delirium are multifactorial but may include pain, stress response and inflammation.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Surgery--Complications, Dexamethasone, Flubiprofen Axetil
- Trial name
- NCT03200600
- Testing
- Dexamethasone, Normal saline, Flurbiprofen axetil
- Where
- 2 sites in China
- Volunteers
- 126 people
- Sponsor
- Peking University First Hospital