Clinical trials: sponsored by Peking University First Hospital
Dietary Sodium Intake, Peritoneal Dialysis (PD)
A Novel Equation for Estimating Sodium Intake in Peritoneal Dialysis.
This study aims to develop a novel equation for estimating sodium intake in anuric peritoneal dialysis patients, and then to validate its precision and accuracy.
- Trial name
- NCT05955417
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Parturients, Depressive Symptoms
Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression
Esketamine has rapid-onset antidepressant effects and may reduce postpartum depression in parturients with prenatal depressive symptoms. However, its adverse neuropsychiatric symptoms limits clinical application.
- Conditions
- Parturients, Depressive Symptoms, Esketamine, Dexmedetomidine
- Trial name
- NCT07639099
- Testing
- Esketamine-dexmedetomidine combination
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Peking University First Hospital
Prostate Cancer, Metastatic Prostate Cancer
Clinically Actionable Tumor-Associated Antigens in Prostate Cancer
The goal of this observational study is to evaluate and validate the expression and prognostic value of 15 ADC-targetable membrane proteins (PSMA, B7-H3, STEAP1, TROP2, KLK2, HER2, TF, HER3, DLL3, SEZ6, STEAP2, MUC1, NECTIN4…
- Conditions
- Prostate Cancer, Metastatic Prostate Cancer, Metastatic Prostate Cancer (mCRPC)
- Trial name
- NCT07597369
- Testing
- Immunohistochemistry (IHC) Staining and Analysis
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Peking University First Hospital
Multiple System Atrophy, Parkinson's Disease
Prospective Multicenter Registry Study of Multiple System Atrophy in China
Multiple system atrophy is a rare, rapidly progressive neurodegenerative disease characterized by variable combinations of parkinsonism, cerebellar ataxia, and autonomic dysfunction.
- Conditions
- Multiple System Atrophy, Parkinson's Disease, Atypical Parkinsonism
- Trial name
- MSA Registry S (NCT07644013)
- Where
- China
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Prostate Cancer
Evaluation of Perilesional Biopsy in Diagnosis of Prostate Cancer
The goal of this multicenter randomized controlled trial (RCT) is to evaluate the efficacy of different prostate biopsy schemes, including perilesional biopsy (PB) and combination of systematic biopsy and targeted biopsy (TB+SB).
- Trial name
- NCT06482645
- Testing
- TB+PB, TB+SB
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Peking University First Hospital
Prostate Cancer
Optimizing Prostate Biopsy Schemes in Men With Multiple MRI Visible Lesions
The goal of this randomized controlled trial (RCT) is to evaluate the efficacy of different prostate biopsy schemes in prostate cancer diagnosis among men with multiple MRI visible lesions, including combination of targeted and…
- Trial name
- NCT06841211
- Testing
- Targeted and perilesional biopsy (TPLBx), Combined targeted and systematic biopsy (CTSBx)
- Where
- China
- Volunteers
- 572 people
- Sponsor
- Peking University First Hospital
Thrombosis, Cardiovascular Diseases
A Phase I SAD/MAD and Liver Effect Study of Vitalangio in Venous Thromboembolism Patients .
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a new drug, Vitalangio1, in healthy male and female volunteers aged 18 to 55 years old.
- Trial name
- NCT07618351
- Testing
- Experimental: Food effect group, Active Comparator: Multiple dose group
- Where
- China
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Older Adults, Cognitive Impairment
Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment
Patients with cognitive decline are frequently comorbid with sleep disorders which may in turn aggravate cognitive decline. Sedative dose dexmedetomidine improved sleep quality but incresed bradycardia and hypotension; low dose…
- Conditions
- Older Adults, Cognitive Impairment, Sleep Disorders, Dexmedetomidine
- Trial name
- NCT07610343
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
Diagnostic Value of 68Ga-Pentixafor PET/CT in Adrenal Tumors With Aldosterone and Cortisol Cosecretion
The goal of this observational study is to evaluate the diagnostic accuracy of 68 68 Ga-Pentixafor-CXCR4 PET/CT in identifying the dominant side of hormone excess in adult patients (aged 18-80 years) with primary aldosteronism…
- Trial name
- NCT07605156
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University First Hospital
Postoperative Complications
Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and Morbidity
In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits…
- Trial name
- NCT01884298
- Where
- China
- Sponsor
- Peking University First Hospital
Anesthesia
General Anesthetic Mode and Postoperative Complications
The relationship between anesthetic medication and postoperative major cardiac and cerebral complications will be studied using logistic regression model.
- Trial name
- NCT03335579
- Testing
- inhalation or propofol ,epidural or general anesthesia, remifentanil or sufentanil
- Volunteers
- 50,000 people
- Sponsor
- Peking University First Hospital
Postoperative Pain
Analgesia Comparison of Nalbuphine and Morphine for Laparoscopic Myomectomy
to compare the analgesia and side effect of nalbuphine and morphine for elective Laparoscopic myomectomy.
- Trial name
- NCT03288428
- Testing
- Nalbuphine, Morphine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Peripheral Artery Disease
The Value of Super-resolution Ultrasound Imaging for Peripheral Artery Disease
Peripheral artery disease (PAD) is a chronic atherosclerotic disorder characterized by stenosis or occlusion of the extracranial arteries distal to the aortic arch, most commonly affecting the lower extremities.
- Trial name
- NCT07374601
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Prostate Cancer
Comprehensive Evaluation of MRI-AI in Prostate Cancer Diagnosis
The goal of this real-world prospective diagnostic study is to comprehensively evaluate the value of MRI artificial intelligence (MRI-AI) in assisting the diagnosis of prostate cancer (PCa).
- Trial name
- NCT06575361
- Testing
- Combination of targeted biopsy and systematic biopsy
- Where
- China
- Volunteers
- 365 people
- Sponsor
- Peking University First Hospital
Helicobacter Pylori Infection
Simplified Dual Regimen Guided by Fecal Clarithromycin Resistance Gene Detection for First-line H. Pylori Eradication
To investigate the efficacy, safety, and compliance of a simplified strategy using vonoprazan plus clarithromycin for first-line treatment in patients with Helicobacter pylori infection, among those infected with strains without…
- Trial name
- NCT07439445
- Testing
- Vonoprazan 20 mg twice daily + clarithromycin 500 mg twice daily for 14 days
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
Upper Tract Urothelial Carcinoma Receiving Kidney-sparing Therapy, Upper Tract Urothelial Carcinoma
Multimodal Kidney-Sparing Strategy for High-Risk Upper Tract Urothelial Carcinoma
UTUC is a cancer that develops in the lining of the kidney or ureter. The standard treatment is radical nephroureterectomy, which removes the kidney and ureter.
- Trial name
- NCT07504939
- Testing
- SBRT
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Peking University First Hospital
Atherosclerotic Cardiovascular Disease (ASCVD), Secondary Prevention
Aspirin 50 mg vs. 100 mg in Elderly Cardiovascular Disease Patients
Elderly patients with cardiovascular disease face a high risk of both thrombotic and bleeding events when receiving antithrombotic therapy.
- Conditions
- Atherosclerotic Cardiovascular Disease (ASCVD), Secondary Prevention, Cardiovascular Diseases
- Trial name
- LAPIS (NCT07542860)
- Where
- China
- Volunteers
- 5,448 people
- Sponsor
- Peking University First Hospital
Radiation Therapy, Metastatic Renal Cancer
CAIX PET/ CT Guided Radiation Therapy in CcRCC.
This is a prospective, single-arm study in adults with recurrent or metastatic clear cell renal cell carcinoma (ccRCC). Participants will receive standard systemic therapy (targeted therapy plus anti-PD-1 immunotherapy) and…
- Conditions
- Radiation Therapy, Metastatic Renal Cancer, Recurrent Renal Cell Cancer
- Trial name
- COSTAR-002 (NCT07540260)
- Testing
- PETCT-guided radiation therapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
Multiple Myeloma
PET Imaging Study of 68Ga-NB381 in Multiple Myeloma
Multiple myeloma (MM) predominantly affects the elderly, often presenting insidiously and with a rising incidence rate. Current diagnostic methods primarily rely on invasive bone marrow biopsies, which can lead to false-negative…
- Trial name
- NCT06385652
- Testing
- 68Ga-NB381
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital